Putative ARP2/3 complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-related protein 2/3 complex subunit 1, putative

Species:

Leishmania major

UniProt:

Q4QDV0_LEIMA

TriTrypDb:

LmjF.18.0920 , LMJLV39_180014700 , LMJSD75_180014600

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005885	Arp2/3 protein complex	2	7
GO:0032991	protein-containing complex	1	7

Expansion

Sequence features

Q4QDV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDV0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007015	actin filament organization	5	7
GO:0008064	regulation of actin polymerization or depolymerization	6	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0030029	actin filament-based process	2	2
GO:0030036	actin cytoskeleton organization	3	2
GO:0030832	regulation of actin filament length	5	7
GO:0030833	regulation of actin filament polymerization	7	7
GO:0032271	regulation of protein polymerization	6	7
GO:0032535	regulation of cellular component size	4	7
GO:0032956	regulation of actin cytoskeleton organization	5	7
GO:0032970	regulation of actin filament-based process	4	7
GO:0033043	regulation of organelle organization	5	7
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	7
GO:0043254	regulation of protein-containing complex assembly	5	7
GO:0044087	regulation of cellular component biogenesis	4	7
GO:0045010	actin nucleation	6	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0051128	regulation of cellular component organization	4	7
GO:0051493	regulation of cytoskeleton organization	6	7
GO:0065007	biological regulation	1	7
GO:0065008	regulation of biological quality	2	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0090066	regulation of anatomical structure size	3	7
GO:0097435	supramolecular fiber organization	4	7
GO:0110053	regulation of actin filament organization	6	7
GO:1902903	regulation of supramolecular fiber organization	5	7

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	7
GO:0005198	structural molecule activity	1	2
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0008092	cytoskeletal protein binding	3	7
GO:0044877	protein-containing complex binding	2	2
GO:0051015	actin filament binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.683
CLV_C14_Caspase3-7	594	598	PF00656	0.555
CLV_NRD_NRD_1	234	236	PF00675	0.644
CLV_NRD_NRD_1	450	452	PF00675	0.698
CLV_NRD_NRD_1	50	52	PF00675	0.602
CLV_PCSK_KEX2_1	234	236	PF00082	0.644
CLV_PCSK_KEX2_1	450	452	PF00082	0.698
CLV_PCSK_KEX2_1	50	52	PF00082	0.602
CLV_PCSK_SKI1_1	380	384	PF00082	0.361
DEG_APCC_DBOX_1	607	615	PF00400	0.654
DEG_SCF_TRCP1_1	342	347	PF00400	0.500
DEG_SIAH_1	85	93	PF03145	0.576
DEG_SPOP_SBC_1	247	251	PF00917	0.564
DEG_SPOP_SBC_1	79	83	PF00917	0.679
DOC_CDC14_PxL_1	175	183	PF14671	0.513
DOC_CDC14_PxL_1	385	393	PF14671	0.593
DOC_MAPK_gen_1	512	521	PF00069	0.628
DOC_MAPK_HePTP_8	509	521	PF00069	0.646
DOC_MAPK_MEF2A_6	176	183	PF00069	0.381
DOC_MAPK_MEF2A_6	512	521	PF00069	0.628
DOC_PP1_RVXF_1	378	385	PF00149	0.368
DOC_USP7_MATH_1	11	15	PF00917	0.642
DOC_USP7_MATH_1	146	150	PF00917	0.732
DOC_USP7_MATH_1	246	250	PF00917	0.694
DOC_USP7_MATH_1	291	295	PF00917	0.588
DOC_USP7_MATH_1	412	416	PF00917	0.618
DOC_USP7_MATH_1	592	596	PF00917	0.608
DOC_WW_Pin1_4	162	167	PF00397	0.650
DOC_WW_Pin1_4	24	29	PF00397	0.730
DOC_WW_Pin1_4	327	332	PF00397	0.447
DOC_WW_Pin1_4	352	357	PF00397	0.697
DOC_WW_Pin1_4	416	421	PF00397	0.498
DOC_WW_Pin1_4	573	578	PF00397	0.570
DOC_WW_Pin1_4	71	76	PF00397	0.555
LIG_14-3-3_CanoR_1	234	239	PF00244	0.623
LIG_14-3-3_CanoR_1	252	257	PF00244	0.593
LIG_14-3-3_CanoR_1	297	304	PF00244	0.641
LIG_14-3-3_CanoR_1	380	385	PF00244	0.404
LIG_14-3-3_CanoR_1	426	431	PF00244	0.675
LIG_14-3-3_CanoR_1	470	474	PF00244	0.667
LIG_14-3-3_CanoR_1	477	486	PF00244	0.656
LIG_14-3-3_CanoR_1	540	546	PF00244	0.791
LIG_14-3-3_CanoR_1	565	573	PF00244	0.787
LIG_14-3-3_CanoR_1	615	620	PF00244	0.659
LIG_CSL_BTD_1	133	136	PF09270	0.574
LIG_CSL_BTD_1	328	331	PF09270	0.567
LIG_FHA_1	117	123	PF00498	0.555
LIG_FHA_1	210	216	PF00498	0.572
LIG_FHA_1	234	240	PF00498	0.601
LIG_FHA_1	275	281	PF00498	0.465
LIG_FHA_1	427	433	PF00498	0.630
LIG_FHA_1	437	443	PF00498	0.669
LIG_FHA_1	451	457	PF00498	0.834
LIG_FHA_1	470	476	PF00498	0.574
LIG_FHA_1	573	579	PF00498	0.766
LIG_FHA_2	123	129	PF00498	0.580
LIG_FHA_2	235	241	PF00498	0.667
LIG_LIR_Nem_3	172	178	PF02991	0.559
LIG_LIR_Nem_3	347	353	PF02991	0.578
LIG_LIR_Nem_3	429	433	PF02991	0.497
LIG_MYND_1	21	25	PF01753	0.739
LIG_REV1ctd_RIR_1	519	528	PF16727	0.630
LIG_SH2_STAT5	205	208	PF00017	0.451
LIG_SH2_STAT5	315	318	PF00017	0.477
LIG_SH3_1	623	629	PF00018	0.829
LIG_SH3_3	130	136	PF00018	0.575
LIG_SH3_3	22	28	PF00018	0.674
LIG_SH3_3	350	356	PF00018	0.584
LIG_SH3_3	579	585	PF00018	0.655
LIG_SH3_3	623	629	PF00018	0.825
LIG_SH3_4	421	428	PF00018	0.515
LIG_SUMO_SIM_anti_2	575	582	PF11976	0.742
LIG_SUMO_SIM_par_1	180	187	PF11976	0.484
LIG_UBA3_1	580	589	PF00899	0.765
MOD_CDK_SPK_2	416	421	PF00069	0.498
MOD_CK1_1	162	168	PF00069	0.615
MOD_CK1_1	209	215	PF00069	0.583
MOD_CK1_1	242	248	PF00069	0.658
MOD_CK1_1	576	582	PF00069	0.659
MOD_CK1_1	80	86	PF00069	0.699
MOD_CK2_1	547	553	PF00069	0.772
MOD_Cter_Amidation	586	589	PF01082	0.563
MOD_GlcNHglycan	125	128	PF01048	0.427
MOD_GlcNHglycan	15	18	PF01048	0.699
MOD_GlcNHglycan	153	156	PF01048	0.625
MOD_GlcNHglycan	161	164	PF01048	0.608
MOD_GlcNHglycan	197	200	PF01048	0.489
MOD_GlcNHglycan	208	211	PF01048	0.572
MOD_GlcNHglycan	293	296	PF01048	0.739
MOD_GlcNHglycan	331	334	PF01048	0.459
MOD_GlcNHglycan	342	345	PF01048	0.407
MOD_GlcNHglycan	366	371	PF01048	0.734
MOD_GlcNHglycan	537	540	PF01048	0.656
MOD_GlcNHglycan	585	588	PF01048	0.648
MOD_GlcNHglycan	589	592	PF01048	0.605
MOD_GlcNHglycan	601	604	PF01048	0.602
MOD_GlcNHglycan	83	86	PF01048	0.678
MOD_GSK3_1	205	212	PF00069	0.527
MOD_GSK3_1	242	249	PF00069	0.770
MOD_GSK3_1	280	287	PF00069	0.571
MOD_GSK3_1	340	347	PF00069	0.553
MOD_GSK3_1	36	43	PF00069	0.575
MOD_GSK3_1	366	373	PF00069	0.794
MOD_GSK3_1	412	419	PF00069	0.659
MOD_GSK3_1	5	12	PF00069	0.619
MOD_GSK3_1	541	548	PF00069	0.776
MOD_GSK3_1	572	579	PF00069	0.650
MOD_GSK3_1	583	590	PF00069	0.730
MOD_GSK3_1	592	599	PF00069	0.532
MOD_GSK3_1	615	622	PF00069	0.745
MOD_GSK3_1	77	84	PF00069	0.723
MOD_NEK2_1	122	127	PF00069	0.525
MOD_NEK2_1	274	279	PF00069	0.473
MOD_NEK2_1	413	418	PF00069	0.536
MOD_NEK2_1	596	601	PF00069	0.663
MOD_PIKK_1	436	442	PF00454	0.707
MOD_PIKK_1	498	504	PF00454	0.745
MOD_PK_1	252	258	PF00069	0.587
MOD_PKA_1	234	240	PF00069	0.636
MOD_PKA_1	450	456	PF00069	0.696
MOD_PKA_2	233	239	PF00069	0.734
MOD_PKA_2	296	302	PF00069	0.559
MOD_PKA_2	450	456	PF00069	0.716
MOD_PKA_2	469	475	PF00069	0.692
MOD_PKA_2	476	482	PF00069	0.683
MOD_PKA_2	541	547	PF00069	0.718
MOD_PKA_2	614	620	PF00069	0.654
MOD_PKB_1	613	621	PF00069	0.658
MOD_Plk_1	264	270	PF00069	0.510
MOD_Plk_1	596	602	PF00069	0.599
MOD_Plk_2-3	394	400	PF00069	0.588
MOD_Plk_4	234	240	PF00069	0.636
MOD_Plk_4	380	386	PF00069	0.525
MOD_Plk_4	596	602	PF00069	0.599
MOD_Plk_4	63	69	PF00069	0.527
MOD_ProDKin_1	162	168	PF00069	0.649
MOD_ProDKin_1	24	30	PF00069	0.719
MOD_ProDKin_1	327	333	PF00069	0.447
MOD_ProDKin_1	352	358	PF00069	0.698
MOD_ProDKin_1	416	422	PF00069	0.508
MOD_ProDKin_1	573	579	PF00069	0.566
MOD_ProDKin_1	71	77	PF00069	0.571
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.578
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.604
TRG_ER_diArg_1	449	451	PF00400	0.693
TRG_ER_diArg_1	49	51	PF00400	0.567
TRG_ER_diArg_1	612	615	PF00400	0.753
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H8	Leptomonas seymouri	37%	100%
A0A3Q8IA03	Leishmania donovani	89%	100%
A4H9K0	Leishmania braziliensis	70%	100%
A4HXW5	Leishmania infantum	89%	100%
E9ARM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%