Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDU7_LEIMA

TriTrypDb:

LmjF.18.0950 , LMJLV39_180015000 , LMJSD75_180014900

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.679
CLV_NRD_NRD_1	331	333	PF00675	0.558
CLV_NRD_NRD_1	36	38	PF00675	0.614
CLV_NRD_NRD_1	39	41	PF00675	0.604
CLV_PCSK_FUR_1	329	333	PF00082	0.547
CLV_PCSK_FUR_1	36	40	PF00082	0.590
CLV_PCSK_KEX2_1	322	324	PF00082	0.555
CLV_PCSK_KEX2_1	329	331	PF00082	0.527
CLV_PCSK_KEX2_1	36	38	PF00082	0.614
CLV_PCSK_KEX2_1	39	41	PF00082	0.604
CLV_PCSK_KEX2_1	77	79	PF00082	0.730
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.541
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.518
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.678
CLV_PCSK_PC7_1	325	331	PF00082	0.625
CLV_PCSK_PC7_1	73	79	PF00082	0.649
CLV_PCSK_SKI1_1	181	185	PF00082	0.418
CLV_PCSK_SKI1_1	194	198	PF00082	0.395
CLV_PCSK_SKI1_1	73	77	PF00082	0.584
DEG_SPOP_SBC_1	23	27	PF00917	0.497
DEG_SPOP_SBC_1	270	274	PF00917	0.403
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.581
DOC_MAPK_gen_1	279	288	PF00069	0.302
DOC_PP2B_LxvP_1	116	119	PF13499	0.579
DOC_USP7_MATH_1	102	106	PF00917	0.647
DOC_USP7_MATH_1	125	129	PF00917	0.734
DOC_USP7_MATH_1	167	171	PF00917	0.537
DOC_USP7_MATH_1	18	22	PF00917	0.495
DOC_USP7_MATH_1	245	249	PF00917	0.494
DOC_WW_Pin1_4	163	168	PF00397	0.630
DOC_WW_Pin1_4	214	219	PF00397	0.510
DOC_WW_Pin1_4	24	29	PF00397	0.637
DOC_WW_Pin1_4	271	276	PF00397	0.445
DOC_WW_Pin1_4	343	348	PF00397	0.461
LIG_14-3-3_CanoR_1	247	251	PF00244	0.494
LIG_14-3-3_CanoR_1	290	295	PF00244	0.360
LIG_14-3-3_CanoR_1	323	328	PF00244	0.551
LIG_14-3-3_CanoR_1	71	76	PF00244	0.584
LIG_14-3-3_CanoR_1	78	82	PF00244	0.557
LIG_BRCT_BRCA1_1	133	137	PF00533	0.641
LIG_FHA_1	224	230	PF00498	0.445
LIG_FHA_1	272	278	PF00498	0.439
LIG_FHA_1	77	83	PF00498	0.544
LIG_FHA_1	93	99	PF00498	0.732
LIG_FHA_2	217	223	PF00498	0.509
LIG_LIR_Gen_1	134	143	PF02991	0.558
LIG_LIR_Nem_3	134	140	PF02991	0.586
LIG_LIR_Nem_3	26	32	PF02991	0.583
LIG_PDZ_Class_3	359	364	PF00595	0.533
LIG_Pex14_1	351	355	PF04695	0.385
LIG_SH2_CRK	190	194	PF00017	0.464
LIG_SH2_GRB2like	190	193	PF00017	0.458
LIG_SH2_NCK_1	306	310	PF00017	0.552
LIG_SH2_SRC	355	358	PF00017	0.419
LIG_SH2_STAT5	131	134	PF00017	0.557
LIG_SH2_STAT5	287	290	PF00017	0.346
LIG_SH2_STAT5	355	358	PF00017	0.401
LIG_SH3_3	117	123	PF00018	0.642
LIG_SH3_3	124	130	PF00018	0.537
LIG_SH3_3	135	141	PF00018	0.545
LIG_SH3_3	224	230	PF00018	0.464
LIG_TRAF2_1	219	222	PF00917	0.469
LIG_TRAF2_1	333	336	PF00917	0.453
LIG_WRC_WIRS_1	19	24	PF05994	0.477
MOD_CDK_SPK_2	343	348	PF00069	0.461
MOD_CK1_1	152	158	PF00069	0.727
MOD_CK1_1	165	171	PF00069	0.650
MOD_CK2_1	130	136	PF00069	0.632
MOD_CK2_1	216	222	PF00069	0.457
MOD_CK2_1	299	305	PF00069	0.521
MOD_CK2_1	77	83	PF00069	0.632
MOD_Cter_Amidation	320	323	PF01082	0.627
MOD_Cter_Amidation	327	330	PF01082	0.511
MOD_GlcNHglycan	104	107	PF01048	0.600
MOD_GlcNHglycan	109	112	PF01048	0.581
MOD_GlcNHglycan	169	172	PF01048	0.572
MOD_GlcNHglycan	261	264	PF01048	0.443
MOD_GlcNHglycan	300	304	PF01048	0.500
MOD_GlcNHglycan	5	8	PF01048	0.649
MOD_GlcNHglycan	92	95	PF01048	0.748
MOD_GSK3_1	132	139	PF00069	0.618
MOD_GSK3_1	148	155	PF00069	0.794
MOD_GSK3_1	163	170	PF00069	0.707
MOD_GSK3_1	18	25	PF00069	0.598
MOD_GSK3_1	236	243	PF00069	0.407
MOD_GSK3_1	3	10	PF00069	0.694
MOD_GSK3_1	51	58	PF00069	0.619
MOD_GSK3_1	67	74	PF00069	0.617
MOD_GSK3_1	92	99	PF00069	0.666
MOD_NEK2_1	1	6	PF00069	0.734
MOD_NEK2_1	107	112	PF00069	0.665
MOD_NEK2_1	22	27	PF00069	0.626
MOD_NEK2_1	259	264	PF00069	0.401
MOD_NEK2_1	269	274	PF00069	0.366
MOD_NEK2_1	30	35	PF00069	0.634
MOD_NEK2_1	51	56	PF00069	0.617
MOD_NEK2_1	76	81	PF00069	0.545
MOD_PIKK_1	216	222	PF00454	0.534
MOD_PIKK_1	64	70	PF00454	0.677
MOD_PK_1	323	329	PF00069	0.546
MOD_PK_1	71	77	PF00069	0.498
MOD_PKA_1	39	45	PF00069	0.516
MOD_PKA_1	77	83	PF00069	0.632
MOD_PKA_2	246	252	PF00069	0.500
MOD_PKA_2	39	45	PF00069	0.702
MOD_PKA_2	46	52	PF00069	0.691
MOD_PKA_2	7	13	PF00069	0.687
MOD_PKA_2	77	83	PF00069	0.588
MOD_PKB_1	214	222	PF00069	0.549
MOD_PKB_1	37	45	PF00069	0.516
MOD_PKB_1	69	77	PF00069	0.503
MOD_Plk_4	46	52	PF00069	0.661
MOD_Plk_4	7	13	PF00069	0.634
MOD_Plk_4	77	83	PF00069	0.614
MOD_ProDKin_1	163	169	PF00069	0.624
MOD_ProDKin_1	214	220	PF00069	0.515
MOD_ProDKin_1	24	30	PF00069	0.640
MOD_ProDKin_1	271	277	PF00069	0.448
MOD_ProDKin_1	343	349	PF00069	0.453
MOD_SUMO_for_1	265	268	PF00179	0.452
TRG_DiLeu_BaEn_1	255	260	PF01217	0.373
TRG_ENDOCYTIC_2	190	193	PF00928	0.458
TRG_ER_diArg_1	329	332	PF00400	0.559
TRG_ER_diArg_1	36	39	PF00400	0.615
TRG_ER_diArg_1	69	72	PF00400	0.670
TRG_NLS_MonoCore_2	36	41	PF00514	0.517
TRG_NLS_MonoExtN_4	320	326	PF00514	0.523
TRG_NLS_MonoExtN_4	36	42	PF00514	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I846	Leptomonas seymouri	55%	100%
A0A3Q8ID30	Leishmania donovani	89%	79%
A4H9K5	Leishmania braziliensis	77%	77%
A4HXW8	Leishmania infantum	90%	100%
E9ARN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BRT0	Trypanosoma cruzi	38%	100%