GPI mannosyltransferase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mannosyltransferase-II, putative

Species:

Leishmania major

UniProt:

Q4QDU6_LEIMA

TriTrypDb:

LmjF.18.0960 , LMJLV39_180015100 , LMJSD75_180015000

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005789	endoplasmic reticulum membrane	4	7
GO:0016020	membrane	2	7
GO:0031090	organelle membrane	3	7
GO:0031501	mannosyltransferase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	7
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4QDU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDU6

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	7
GO:0006505	GPI anchor metabolic process	6	7
GO:0006506	GPI anchor biosynthetic process	6	7
GO:0006629	lipid metabolic process	3	7
GO:0006643	membrane lipid metabolic process	4	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006661	phosphatidylinositol biosynthetic process	6	7
GO:0006664	glycolipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009247	glycolipid biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0019637	organophosphate metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	7
GO:0046467	membrane lipid biosynthetic process	4	7
GO:0046474	glycerophospholipid biosynthetic process	5	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1903509	liposaccharide metabolic process	4	7

Molecular functions
Term	Name	Level	Count
GO:0000009	alpha-1,6-mannosyltransferase activity	6	7
GO:0000030	mannosyltransferase activity	5	7
GO:0003824	catalytic activity	1	7
GO:0004376	glycolipid mannosyltransferase activity	6	7
GO:0016740	transferase activity	2	7
GO:0016757	glycosyltransferase activity	3	7
GO:0016758	hexosyltransferase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	373	377	PF00656	0.736
CLV_NRD_NRD_1	151	153	PF00675	0.527
CLV_NRD_NRD_1	183	185	PF00675	0.346
CLV_NRD_NRD_1	217	219	PF00675	0.582
CLV_NRD_NRD_1	278	280	PF00675	0.346
CLV_NRD_NRD_1	529	531	PF00675	0.527
CLV_NRD_NRD_1	613	615	PF00675	0.354
CLV_PCSK_FUR_1	276	280	PF00082	0.372
CLV_PCSK_KEX2_1	151	153	PF00082	0.527
CLV_PCSK_KEX2_1	183	185	PF00082	0.346
CLV_PCSK_KEX2_1	276	278	PF00082	0.402
CLV_PCSK_KEX2_1	475	477	PF00082	0.471
CLV_PCSK_KEX2_1	529	531	PF00082	0.551
CLV_PCSK_KEX2_1	613	615	PF00082	0.354
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.471
CLV_PCSK_SKI1_1	183	187	PF00082	0.420
CLV_PCSK_SKI1_1	219	223	PF00082	0.529
CLV_PCSK_SKI1_1	400	404	PF00082	0.521
CLV_PCSK_SKI1_1	530	534	PF00082	0.546
CLV_PCSK_SKI1_1	654	658	PF00082	0.488
CLV_PCSK_SKI1_1	69	73	PF00082	0.492
DEG_APCC_DBOX_1	3	11	PF00400	0.696
DEG_APCC_DBOX_1	493	501	PF00400	0.704
DEG_APCC_DBOX_1	68	76	PF00400	0.412
DEG_Nend_UBRbox_1	1	4	PF02207	0.699
DEG_SCF_FBW7_2	209	215	PF00400	0.791
DOC_AGCK_PIF_1	565	570	PF00069	0.354
DOC_CDC14_PxL_1	136	144	PF14671	0.412
DOC_CKS1_1	209	214	PF01111	0.756
DOC_CKS1_1	289	294	PF01111	0.412
DOC_CYCLIN_yCln2_LP_2	357	360	PF00134	0.674
DOC_CYCLIN_yCln2_LP_2	439	445	PF00134	0.514
DOC_CYCLIN_yCln2_LP_2	578	584	PF00134	0.412
DOC_MAPK_gen_1	183	190	PF00069	0.546
DOC_MAPK_gen_1	2	9	PF00069	0.696
DOC_MAPK_gen_1	218	227	PF00069	0.651
DOC_MAPK_gen_1	480	488	PF00069	0.717
DOC_MAPK_gen_1	529	535	PF00069	0.249
DOC_MAPK_gen_1	557	564	PF00069	0.393
DOC_MAPK_gen_1	613	622	PF00069	0.554
DOC_PP1_RVXF_1	31	38	PF00149	0.422
DOC_PP2B_LxvP_1	254	257	PF13499	0.636
DOC_PP2B_LxvP_1	357	360	PF13499	0.739
DOC_PP2B_LxvP_1	493	496	PF13499	0.741
DOC_PP2B_LxvP_1	578	581	PF13499	0.412
DOC_PP2B_LxvP_1	87	90	PF13499	0.524
DOC_PP4_FxxP_1	190	193	PF00568	0.546
DOC_USP7_MATH_1	379	383	PF00917	0.717
DOC_USP7_MATH_1	455	459	PF00917	0.691
DOC_USP7_MATH_1	462	466	PF00917	0.610
DOC_USP7_MATH_1	468	472	PF00917	0.553
DOC_WW_Pin1_4	205	210	PF00397	0.748
DOC_WW_Pin1_4	288	293	PF00397	0.412
DOC_WW_Pin1_4	337	342	PF00397	0.681
DOC_WW_Pin1_4	656	661	PF00397	0.385
LIG_14-3-3_CanoR_1	107	111	PF00244	0.573
LIG_14-3-3_CanoR_1	197	204	PF00244	0.700
LIG_14-3-3_CanoR_1	330	335	PF00244	0.698
LIG_14-3-3_CanoR_1	346	354	PF00244	0.614
LIG_14-3-3_CanoR_1	400	405	PF00244	0.680
LIG_14-3-3_CanoR_1	409	419	PF00244	0.497
LIG_14-3-3_CanoR_1	454	464	PF00244	0.558
LIG_14-3-3_CanoR_1	483	487	PF00244	0.681
LIG_14-3-3_CanoR_1	654	660	PF00244	0.417
LIG_APCC_ABBA_1	298	303	PF00400	0.429
LIG_APCC_ABBA_1	39	44	PF00400	0.581
LIG_BRCT_BRCA1_1	429	433	PF00533	0.346
LIG_CaM_NSCaTE_8	560	567	PF13499	0.420
LIG_DLG_GKlike_1	330	338	PF00625	0.629
LIG_eIF4E_1	559	565	PF01652	0.354
LIG_FHA_1	148	154	PF00498	0.346
LIG_FHA_1	209	215	PF00498	0.755
LIG_FHA_1	300	306	PF00498	0.357
LIG_FHA_1	369	375	PF00498	0.691
LIG_FHA_1	483	489	PF00498	0.594
LIG_FHA_1	57	63	PF00498	0.362
LIG_FHA_1	639	645	PF00498	0.306
LIG_FHA_2	250	256	PF00498	0.615
LIG_FHA_2	53	59	PF00498	0.462
LIG_FHA_2	96	102	PF00498	0.594
LIG_GBD_Chelix_1	416	424	PF00786	0.514
LIG_GBD_Chelix_1	67	75	PF00786	0.420
LIG_LIR_Apic_2	189	193	PF02991	0.522
LIG_LIR_Gen_1	105	115	PF02991	0.544
LIG_LIR_Gen_1	44	53	PF02991	0.419
LIG_LIR_Gen_1	569	578	PF02991	0.289
LIG_LIR_Gen_1	682	692	PF02991	0.417
LIG_LIR_Nem_3	105	111	PF02991	0.544
LIG_LIR_Nem_3	11	16	PF02991	0.698
LIG_LIR_Nem_3	434	438	PF02991	0.367
LIG_LIR_Nem_3	44	50	PF02991	0.436
LIG_LIR_Nem_3	563	568	PF02991	0.399
LIG_LIR_Nem_3	569	573	PF02991	0.375
LIG_LIR_Nem_3	682	688	PF02991	0.417
LIG_LYPXL_S_1	551	555	PF13949	0.546
LIG_LYPXL_yS_3	552	555	PF13949	0.346
LIG_MYND_1	491	495	PF01753	0.752
LIG_NRBOX	661	667	PF00104	0.412
LIG_PCNA_PIPBox_1	328	337	PF02747	0.703
LIG_Pex14_1	406	410	PF04695	0.651
LIG_RPA_C_Fungi	273	285	PF08784	0.514
LIG_SH2_NCK_1	220	224	PF00017	0.571
LIG_SH2_NCK_1	42	46	PF00017	0.597
LIG_SH2_PTP2	166	169	PF00017	0.514
LIG_SH2_SRC	103	106	PF00017	0.624
LIG_SH2_STAP1	129	133	PF00017	0.382
LIG_SH2_STAP1	301	305	PF00017	0.412
LIG_SH2_STAT3	129	132	PF00017	0.385
LIG_SH2_STAT3	453	456	PF00017	0.473
LIG_SH2_STAT5	127	130	PF00017	0.412
LIG_SH2_STAT5	166	169	PF00017	0.513
LIG_SH2_STAT5	301	304	PF00017	0.430
LIG_SH2_STAT5	315	318	PF00017	0.412
LIG_SH2_STAT5	334	337	PF00017	0.542
LIG_SH2_STAT5	42	45	PF00017	0.616
LIG_SH2_STAT5	52	55	PF00017	0.447
LIG_SH2_STAT5	520	523	PF00017	0.412
LIG_SH2_STAT5	568	571	PF00017	0.412
LIG_SH2_STAT5	594	597	PF00017	0.402
LIG_SH3_1	206	212	PF00018	0.695
LIG_SH3_1	356	362	PF00018	0.699
LIG_SH3_3	131	137	PF00018	0.410
LIG_SH3_3	206	212	PF00018	0.695
LIG_SH3_3	335	341	PF00018	0.491
LIG_SH3_3	35	41	PF00018	0.514
LIG_SH3_3	356	362	PF00018	0.699
LIG_SH3_3	444	450	PF00018	0.422
LIG_SH3_3	485	491	PF00018	0.611
LIG_SH3_3	513	519	PF00018	0.514
LIG_SUMO_SIM_anti_2	679	685	PF11976	0.402
LIG_SUMO_SIM_par_1	507	512	PF11976	0.412
LIG_SUMO_SIM_par_1	580	586	PF11976	0.514
LIG_SUMO_SIM_par_1	640	645	PF11976	0.327
LIG_SxIP_EBH_1	381	390	PF03271	0.709
LIG_TRAF2_1	98	101	PF00917	0.517
LIG_TRFH_1	13	17	PF08558	0.585
LIG_TRFH_1	37	41	PF08558	0.422
LIG_ULM_U2AF65_1	613	618	PF00076	0.422
LIG_WRC_WIRS_1	187	192	PF05994	0.412
LIG_WRC_WIRS_1	391	396	PF05994	0.447
MOD_CK1_1	205	211	PF00069	0.685
MOD_CK1_1	26	32	PF00069	0.346
MOD_CK1_1	304	310	PF00069	0.422
MOD_CK1_1	337	343	PF00069	0.570
MOD_CK1_1	563	569	PF00069	0.514
MOD_CK1_1	672	678	PF00069	0.425
MOD_CK2_1	207	213	PF00069	0.789
MOD_CK2_1	232	238	PF00069	0.619
MOD_CK2_1	249	255	PF00069	0.440
MOD_CK2_1	409	415	PF00069	0.412
MOD_CK2_1	95	101	PF00069	0.529
MOD_GlcNHglycan	25	28	PF01048	0.343
MOD_GlcNHglycan	342	345	PF01048	0.637
MOD_GlcNHglycan	457	460	PF01048	0.588
MOD_GlcNHglycan	464	467	PF01048	0.515
MOD_GlcNHglycan	470	473	PF01048	0.460
MOD_GlcNHglycan	565	568	PF01048	0.514
MOD_GSK3_1	228	235	PF00069	0.582
MOD_GSK3_1	330	337	PF00069	0.635
MOD_GSK3_1	345	352	PF00069	0.602
MOD_GSK3_1	386	393	PF00069	0.658
MOD_GSK3_1	420	427	PF00069	0.390
MOD_GSK3_1	52	59	PF00069	0.521
MOD_GSK3_1	638	645	PF00069	0.303
MOD_GSK3_1	669	676	PF00069	0.421
MOD_NEK2_1	128	133	PF00069	0.385
MOD_NEK2_1	23	28	PF00069	0.389
MOD_NEK2_1	249	254	PF00069	0.480
MOD_NEK2_1	420	425	PF00069	0.424
MOD_NEK2_1	602	607	PF00069	0.275
MOD_NEK2_1	627	632	PF00069	0.492
MOD_NEK2_1	642	647	PF00069	0.295
MOD_NEK2_1	655	660	PF00069	0.412
MOD_NEK2_1	76	81	PF00069	0.466
MOD_NEK2_2	301	306	PF00069	0.412
MOD_NEK2_2	560	565	PF00069	0.514
MOD_PIKK_1	128	134	PF00454	0.518
MOD_PKA_1	183	189	PF00069	0.514
MOD_PKA_2	106	112	PF00069	0.448
MOD_PKA_2	183	189	PF00069	0.514
MOD_PKA_2	196	202	PF00069	0.438
MOD_PKA_2	23	29	PF00069	0.275
MOD_PKA_2	3	9	PF00069	0.510
MOD_PKA_2	345	351	PF00069	0.540
MOD_PKA_2	482	488	PF00069	0.569
MOD_PKA_2	602	608	PF00069	0.465
MOD_PKA_2	672	678	PF00069	0.412
MOD_Plk_1	229	235	PF00069	0.554
MOD_Plk_1	237	243	PF00069	0.492
MOD_Plk_4	183	189	PF00069	0.424
MOD_Plk_4	249	255	PF00069	0.608
MOD_Plk_4	3	9	PF00069	0.510
MOD_Plk_4	301	307	PF00069	0.412
MOD_Plk_4	330	336	PF00069	0.629
MOD_Plk_4	386	392	PF00069	0.653
MOD_Plk_4	482	488	PF00069	0.439
MOD_Plk_4	560	566	PF00069	0.412
MOD_Plk_4	642	648	PF00069	0.514
MOD_Plk_4	679	685	PF00069	0.423
MOD_ProDKin_1	205	211	PF00069	0.697
MOD_ProDKin_1	288	294	PF00069	0.412
MOD_ProDKin_1	337	343	PF00069	0.609
MOD_ProDKin_1	656	662	PF00069	0.385
MOD_SUMO_for_1	404	407	PF00179	0.585
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.317
TRG_DiLeu_BaLyEn_6	623	628	PF01217	0.275
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.514
TRG_ENDOCYTIC_2	166	169	PF00928	0.412
TRG_ENDOCYTIC_2	243	246	PF00928	0.477
TRG_ENDOCYTIC_2	435	438	PF00928	0.275
TRG_ENDOCYTIC_2	520	523	PF00928	0.412
TRG_ENDOCYTIC_2	528	531	PF00928	0.412
TRG_ENDOCYTIC_2	552	555	PF00928	0.362
TRG_ENDOCYTIC_2	559	562	PF00928	0.368
TRG_ENDOCYTIC_2	663	666	PF00928	0.412
TRG_ER_diArg_1	1	4	PF00400	0.625
TRG_ER_diArg_1	151	153	PF00400	0.385
TRG_ER_diArg_1	182	184	PF00400	0.412
TRG_ER_diArg_1	275	278	PF00400	0.494
TRG_ER_diArg_1	381	384	PF00400	0.657
TRG_ER_diArg_1	528	530	PF00400	0.385
TRG_ER_diArg_1	613	616	PF00400	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL0	Leptomonas seymouri	51%	100%
A0A3S7WV16	Leishmania donovani	91%	100%
A4H9K3	Leishmania braziliensis	74%	100%
A4HXW9	Leishmania infantum	91%	100%
E9ARN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%