Der GTPase-activating protein YihI

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDU4_LEIMA

TriTrypDb:

LmjF.18.0980 , LMJLV39_180015300 , LMJSD75_180015200

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.747
CLV_C14_Caspase3-7	24	28	PF00656	0.727
CLV_NRD_NRD_1	10	12	PF00675	0.599
CLV_NRD_NRD_1	101	103	PF00675	0.531
CLV_NRD_NRD_1	110	112	PF00675	0.462
CLV_NRD_NRD_1	13	15	PF00675	0.589
CLV_NRD_NRD_1	4	6	PF00675	0.593
CLV_NRD_NRD_1	41	43	PF00675	0.651
CLV_NRD_NRD_1	95	97	PF00675	0.474
CLV_PCSK_FUR_1	14	18	PF00082	0.545
CLV_PCSK_FUR_1	99	103	PF00082	0.630
CLV_PCSK_KEX2_1	10	12	PF00082	0.601
CLV_PCSK_KEX2_1	101	103	PF00082	0.555
CLV_PCSK_KEX2_1	110	112	PF00082	0.514
CLV_PCSK_KEX2_1	140	142	PF00082	0.615
CLV_PCSK_KEX2_1	16	18	PF00082	0.600
CLV_PCSK_KEX2_1	4	6	PF00082	0.595
CLV_PCSK_KEX2_1	41	43	PF00082	0.670
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.615
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.603
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.670
CLV_PCSK_SKI1_1	118	122	PF00082	0.509
CLV_PCSK_SKI1_1	16	20	PF00082	0.541
CLV_PCSK_SKI1_1	5	9	PF00082	0.644
CLV_PCSK_SKI1_1	74	78	PF00082	0.530
CLV_PCSK_SKI1_1	83	87	PF00082	0.287
DOC_USP7_MATH_1	21	25	PF00917	0.683
DOC_USP7_UBL2_3	15	19	PF12436	0.614
DOC_USP7_UBL2_3	37	41	PF12436	0.684
DOC_USP7_UBL2_3	70	74	PF12436	0.653
LIG_14-3-3_CanoR_1	17	26	PF00244	0.628
LIG_14-3-3_CanoR_1	42	49	PF00244	0.646
LIG_LIR_Gen_1	162	171	PF02991	0.619
LIG_LIR_Nem_3	162	168	PF02991	0.600
LIG_SH2_STAT3	116	119	PF00017	0.459
LIG_SH2_STAT5	116	119	PF00017	0.459
MOD_CK1_1	130	136	PF00069	0.616
MOD_CK2_1	130	136	PF00069	0.539
MOD_Cter_Amidation	39	42	PF01082	0.655
MOD_Cter_Amidation	8	11	PF01082	0.607
MOD_GlcNHglycan	27	31	PF01048	0.689
MOD_GSK3_1	17	24	PF00069	0.609
MOD_PK_1	22	28	PF00069	0.649
MOD_PKA_1	22	28	PF00069	0.663
MOD_PKA_1	41	47	PF00069	0.644
MOD_PKA_2	41	47	PF00069	0.628
MOD_SUMO_for_1	106	109	PF00179	0.471
MOD_SUMO_for_1	120	123	PF00179	0.456
MOD_SUMO_rev_2	133	142	PF00179	0.579
TRG_DiLeu_BaEn_1	138	143	PF01217	0.585
TRG_DiLeu_LyEn_5	138	143	PF01217	0.614
TRG_ER_diArg_1	10	12	PF00400	0.599
TRG_ER_diArg_1	4	6	PF00400	0.593
TRG_ER_diArg_1	48	51	PF00400	0.688
TRG_ER_diArg_1	99	102	PF00400	0.530
TRG_NLS_Bipartite_1	4	20	PF00514	0.595
TRG_NLS_MonoCore_2	13	18	PF00514	0.612
TRG_NLS_MonoExtC_3	14	19	PF00514	0.595
TRG_NLS_MonoExtN_4	11	18	PF00514	0.596
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9L1	Leptomonas seymouri	70%	97%
A0A0S4JFM3	Bodo saltans	38%	100%
A0A1X0P6Y6	Trypanosomatidae	45%	99%
A0A3S7WUY3	Leishmania donovani	93%	99%
A4H9K6	Leishmania braziliensis	83%	99%
A4HXX1	Leishmania infantum	93%	99%
C9ZZT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ARN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
V5B6M9	Trypanosoma cruzi	45%	100%