UTP--glucose-1-phosphate uridylyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-glucose pyrophosphorylase

Species:

Leishmania major

UniProt:

Q4QDU3_LEIMA

TriTrypDb:

LmjF.18.0990 , LMJLV39_180015400 , LMJSD75_180015300

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDU3

PDB structure(s): 2oef_A , 2oeg_A , 4j18_A , 4m28_A , 4m2a_A , 4m2b_A , 5nzg_A , 5nzh_A , 5nzh_B , 5nzi_A , 5nzj_A , 5nzk_A , 5nzl_A , 5nzm_A

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0005976	polysaccharide metabolic process	4	2
GO:0005977	glycogen metabolic process	6	2
GO:0006011	UDP-glucose metabolic process	4	12
GO:0006073	obsolete cellular glucan metabolic process	5	2
GO:0006091	generation of precursor metabolites and energy	3	2
GO:0006112	energy reserve metabolic process	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009225	nucleotide-sugar metabolic process	4	12
GO:0009987	cellular process	1	12
GO:0015980	energy derivation by oxidation of organic compounds	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	2
GO:0044042	glucan metabolic process	5	2
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2
GO:0044264	obsolete cellular polysaccharide metabolic process	4	2
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity	7	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0051748	UTP-monosaccharide-1-phosphate uridylyltransferase activity	6	12
GO:0070569	uridylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.480
CLV_C14_Caspase3-7	46	50	PF00656	0.551
CLV_C14_Caspase3-7	465	469	PF00656	0.552
CLV_C14_Caspase3-7	56	60	PF00656	0.488
CLV_C14_Caspase3-7	99	103	PF00656	0.541
CLV_NRD_NRD_1	248	250	PF00675	0.321
CLV_PCSK_KEX2_1	229	231	PF00082	0.385
CLV_PCSK_KEX2_1	248	250	PF00082	0.321
CLV_PCSK_KEX2_1	277	279	PF00082	0.274
CLV_PCSK_KEX2_1	442	444	PF00082	0.297
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.385
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.311
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.297
CLV_PCSK_SKI1_1	104	108	PF00082	0.280
CLV_PCSK_SKI1_1	126	130	PF00082	0.311
CLV_PCSK_SKI1_1	140	144	PF00082	0.268
CLV_PCSK_SKI1_1	20	24	PF00082	0.499
CLV_PCSK_SKI1_1	213	217	PF00082	0.276
CLV_PCSK_SKI1_1	229	233	PF00082	0.398
CLV_PCSK_SKI1_1	277	281	PF00082	0.279
CLV_PCSK_SKI1_1	400	404	PF00082	0.280
CLV_PCSK_SKI1_1	442	446	PF00082	0.342
CLV_PCSK_SKI1_1	95	99	PF00082	0.280
DEG_Nend_UBRbox_2	1	3	PF02207	0.724
DOC_CYCLIN_yClb5_NLxxxL_5	305	314	PF00134	0.492
DOC_MAPK_DCC_7	406	416	PF00069	0.495
DOC_MAPK_gen_1	101	109	PF00069	0.495
DOC_MAPK_gen_1	237	246	PF00069	0.541
DOC_PP1_RVXF_1	237	243	PF00149	0.522
DOC_PP2B_LxvP_1	328	331	PF13499	0.480
DOC_PP4_FxxP_1	473	476	PF00568	0.570
DOC_USP7_MATH_1	387	391	PF00917	0.492
DOC_USP7_MATH_1	488	492	PF00917	0.514
DOC_USP7_MATH_1	54	58	PF00917	0.505
DOC_USP7_MATH_1	60	64	PF00917	0.504
DOC_USP7_UBL2_3	140	144	PF12436	0.503
DOC_WW_Pin1_4	343	348	PF00397	0.567
DOC_WW_Pin1_4	484	489	PF00397	0.600
LIG_14-3-3_CanoR_1	118	128	PF00244	0.505
LIG_14-3-3_CanoR_1	261	265	PF00244	0.541
LIG_14-3-3_CanoR_1	443	447	PF00244	0.508
LIG_FHA_1	261	267	PF00498	0.558
LIG_FHA_1	305	311	PF00498	0.471
LIG_FHA_1	325	331	PF00498	0.350
LIG_FHA_1	42	48	PF00498	0.488
LIG_FHA_1	457	463	PF00498	0.528
LIG_FHA_1	74	80	PF00498	0.504
LIG_FHA_2	103	109	PF00498	0.476
LIG_FHA_2	248	254	PF00498	0.480
LIG_FHA_2	318	324	PF00498	0.452
LIG_FHA_2	379	385	PF00498	0.480
LIG_FHA_2	94	100	PF00498	0.528
LIG_GBD_Chelix_1	77	85	PF00786	0.292
LIG_LIR_Apic_2	185	189	PF02991	0.567
LIG_LIR_Apic_2	471	476	PF02991	0.554
LIG_LIR_Gen_1	105	114	PF02991	0.482
LIG_LIR_Gen_1	193	199	PF02991	0.480
LIG_LIR_Gen_1	294	304	PF02991	0.467
LIG_LIR_Nem_3	105	109	PF02991	0.482
LIG_LIR_Nem_3	193	198	PF02991	0.480
LIG_LIR_Nem_3	294	299	PF02991	0.467
LIG_LIR_Nem_3	374	379	PF02991	0.480
LIG_LIR_Nem_3	396	402	PF02991	0.560
LIG_LYPXL_yS_3	147	150	PF13949	0.505
LIG_MAD2	167	175	PF02301	0.541
LIG_PTB_Apo_2	178	185	PF02174	0.423
LIG_PTB_Phospho_1	178	184	PF10480	0.423
LIG_SH2_CRK	195	199	PF00017	0.480
LIG_SH2_CRK	214	218	PF00017	0.480
LIG_SH2_STAP1	195	199	PF00017	0.480
LIG_SH2_STAT3	116	119	PF00017	0.555
LIG_SH2_STAT5	116	119	PF00017	0.535
LIG_SH2_STAT5	195	198	PF00017	0.492
LIG_SH2_STAT5	265	268	PF00017	0.541
LIG_SH2_STAT5	393	396	PF00017	0.505
LIG_SUMO_SIM_anti_2	155	162	PF11976	0.483
LIG_SUMO_SIM_par_1	278	285	PF11976	0.551
LIG_SUMO_SIM_par_1	314	320	PF11976	0.541
LIG_SUMO_SIM_par_1	384	391	PF11976	0.482
LIG_SUMO_SIM_par_1	412	418	PF11976	0.506
LIG_SUMO_SIM_par_1	459	465	PF11976	0.507
LIG_SUMO_SIM_par_1	96	102	PF11976	0.541
LIG_TRAF2_1	320	323	PF00917	0.423
LIG_WRC_WIRS_1	130	135	PF05994	0.480
LIG_WRC_WIRS_1	29	34	PF05994	0.388
LIG_WRC_WIRS_1	293	298	PF05994	0.552
MOD_CDK_SPK_2	343	348	PF00069	0.567
MOD_CK1_1	132	138	PF00069	0.480
MOD_CK1_1	341	347	PF00069	0.461
MOD_CK2_1	153	159	PF00069	0.525
MOD_CK2_1	317	323	PF00069	0.452
MOD_CK2_1	37	43	PF00069	0.520
MOD_CK2_1	434	440	PF00069	0.570
MOD_CK2_1	93	99	PF00069	0.532
MOD_GlcNHglycan	135	138	PF01048	0.334
MOD_GlcNHglycan	200	203	PF01048	0.274
MOD_GlcNHglycan	284	287	PF01048	0.267
MOD_GlcNHglycan	343	346	PF01048	0.397
MOD_GlcNHglycan	364	367	PF01048	0.294
MOD_GlcNHglycan	417	420	PF01048	0.388
MOD_GlcNHglycan	468	471	PF01048	0.591
MOD_GlcNHglycan	49	52	PF01048	0.349
MOD_GlcNHglycan	8	11	PF01048	0.447
MOD_GSK3_1	129	136	PF00069	0.482
MOD_GSK3_1	300	307	PF00069	0.552
MOD_GSK3_1	335	342	PF00069	0.517
MOD_GSK3_1	37	44	PF00069	0.493
MOD_GSK3_1	456	463	PF00069	0.532
MOD_GSK3_1	464	471	PF00069	0.416
MOD_GSK3_1	484	491	PF00069	0.582
MOD_N-GLC_1	133	138	PF02516	0.389
MOD_N-GLC_1	481	486	PF02516	0.559
MOD_NEK2_1	107	112	PF00069	0.498
MOD_NEK2_1	129	134	PF00069	0.494
MOD_NEK2_1	198	203	PF00069	0.480
MOD_NEK2_1	215	220	PF00069	0.480
MOD_NEK2_1	282	287	PF00069	0.467
MOD_NEK2_1	304	309	PF00069	0.492
MOD_NEK2_1	317	322	PF00069	0.492
MOD_NEK2_1	362	367	PF00069	0.513
MOD_NEK2_1	458	463	PF00069	0.547
MOD_NEK2_1	481	486	PF00069	0.577
MOD_NEK2_1	73	78	PF00069	0.522
MOD_NEK2_2	260	265	PF00069	0.560
MOD_PKA_1	442	448	PF00069	0.452
MOD_PKA_2	247	253	PF00069	0.521
MOD_PKA_2	260	266	PF00069	0.541
MOD_PKA_2	282	288	PF00069	0.467
MOD_PKA_2	442	448	PF00069	0.452
MOD_Plk_1	107	113	PF00069	0.492
MOD_Plk_1	335	341	PF00069	0.549
MOD_Plk_2-3	102	108	PF00069	0.496
MOD_Plk_2-3	292	298	PF00069	0.532
MOD_Plk_2-3	43	49	PF00069	0.557
MOD_Plk_2-3	62	68	PF00069	0.389
MOD_Plk_2-3	93	99	PF00069	0.539
MOD_Plk_4	102	108	PF00069	0.480
MOD_Plk_4	138	144	PF00069	0.505
MOD_Plk_4	260	266	PF00069	0.551
MOD_Plk_4	300	306	PF00069	0.543
MOD_Plk_4	434	440	PF00069	0.524
MOD_Plk_4	73	79	PF00069	0.510
MOD_Plk_4	93	99	PF00069	0.350
MOD_ProDKin_1	343	349	PF00069	0.567
MOD_ProDKin_1	484	490	PF00069	0.616
MOD_SUMO_rev_2	2	8	PF00179	0.642
MOD_SUMO_rev_2	437	444	PF00179	0.541
MOD_SUMO_rev_2	99	106	PF00179	0.510
TRG_DiLeu_BaEn_1	276	281	PF01217	0.560
TRG_DiLeu_BaEn_2	122	128	PF01217	0.590
TRG_DiLeu_BaEn_2	237	243	PF01217	0.511
TRG_ENDOCYTIC_2	147	150	PF00928	0.480
TRG_ENDOCYTIC_2	151	154	PF00928	0.480
TRG_ENDOCYTIC_2	195	198	PF00928	0.480
TRG_ENDOCYTIC_2	212	215	PF00928	0.462
TRG_ENDOCYTIC_2	302	305	PF00928	0.560
TRG_ENDOCYTIC_2	421	424	PF00928	0.471
TRG_ER_diArg_1	372	375	PF00400	0.530
TRG_NES_CRM1_1	56	69	PF08389	0.532
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H7	Leptomonas seymouri	78%	100%
A0A0S4JER9	Bodo saltans	57%	100%
A0A1X0P7U0	Trypanosomatidae	68%	100%
A0A3S7WUZ9	Leishmania donovani	96%	100%
A0A422P1Z6	Trypanosoma rangeli	63%	100%
A4HXX2	Leishmania infantum	96%	100%
C9ZZT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AI58	Leishmania braziliensis	86%	100%
E9ARN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O35156	Cricetulus griseus	36%	97%
O59819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	99%
O64459	Pyrus pyrifolia	37%	100%
P08800	Dictyostelium discoideum	31%	97%
P19595	Solanum tuberosum	36%	100%
P32861	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	99%
P38709	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P57751	Arabidopsis thaliana	35%	100%
P78811	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	98%
P79303	Sus scrofa	35%	97%
Q07130	Bos taurus	36%	97%
Q16851	Homo sapiens	36%	97%
Q43772	Hordeum vulgare	37%	100%
Q54YZ0	Dictyostelium discoideum	35%	98%
Q59KI0	Candida albicans (strain SC5314 / ATCC MYA-2876)	39%	99%
Q8SSC5	Encephalitozoon cuniculi (strain GB-M1)	37%	100%
Q91ZJ5	Mus musculus	36%	97%
Q9LKG7	Astragalus penduliflorus	37%	100%
Q9M9P3	Arabidopsis thaliana	35%	100%
Q9SDX3	Musa acuminata	36%	100%
V5B6M0	Trypanosoma cruzi	60%	100%