Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania major

UniProt:

Q4QDU2_LEIMA

TriTrypDb:

LmjF.18.1000 , LMJLV39_180015500 , LMJSD75_180015400

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	33
GO:0110165	cellular anatomical entity	1	33

Expansion

Sequence features

Q4QDU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDU2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006862	nucleotide transport	6	7
GO:0009987	cellular process	1	7
GO:0015748	organophosphate ester transport	5	7
GO:0015931	nucleobase-containing compound transport	5	7
GO:0035352	NAD transmembrane transport	4	2
GO:0043132	NAD transport	7	2
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0055085	transmembrane transport	2	7
GO:0071702	organic substance transport	4	7
GO:0071705	nitrogen compound transport	4	7
GO:1901679	nucleotide transmembrane transport	3	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0015215	nucleotide transmembrane transporter activity	4	2
GO:0015605	organophosphate ester transmembrane transporter activity	3	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:0051724	NAD transmembrane transporter activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.361
CLV_NRD_NRD_1	377	379	PF00675	0.354
CLV_NRD_NRD_1	389	391	PF00675	0.295
CLV_NRD_NRD_1	399	401	PF00675	0.284
CLV_NRD_NRD_1	77	79	PF00675	0.320
CLV_PCSK_KEX2_1	160	162	PF00082	0.526
CLV_PCSK_KEX2_1	389	391	PF00082	0.346
CLV_PCSK_KEX2_1	79	81	PF00082	0.304
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.526
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.313
CLV_PCSK_SKI1_1	198	202	PF00082	0.277
CLV_PCSK_SKI1_1	274	278	PF00082	0.551
CLV_PCSK_SKI1_1	405	409	PF00082	0.258
CLV_PCSK_SKI1_1	65	69	PF00082	0.341
CLV_PCSK_SKI1_1	79	83	PF00082	0.299
DEG_APCC_DBOX_1	242	250	PF00400	0.580
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.361
DOC_CYCLIN_yCln2_LP_2	337	343	PF00134	0.351
DOC_CYCLIN_yCln2_LP_2	68	74	PF00134	0.411
DOC_MAPK_gen_1	272	279	PF00069	0.270
DOC_PP1_RVXF_1	239	245	PF00149	0.580
DOC_PP2B_LxvP_1	258	261	PF13499	0.444
DOC_PP2B_LxvP_1	49	52	PF13499	0.361
DOC_USP7_MATH_1	168	172	PF00917	0.385
DOC_USP7_MATH_1	19	23	PF00917	0.548
DOC_USP7_MATH_1	24	28	PF00917	0.482
DOC_USP7_MATH_1	297	301	PF00917	0.453
DOC_USP7_MATH_1	324	328	PF00917	0.375
DOC_USP7_MATH_1	33	37	PF00917	0.467
DOC_USP7_MATH_1	369	373	PF00917	0.588
DOC_USP7_MATH_1	413	417	PF00917	0.353
DOC_USP7_UBL2_3	379	383	PF12436	0.590
DOC_WW_Pin1_4	187	192	PF00397	0.360
DOC_WW_Pin1_4	312	317	PF00397	0.364
DOC_WW_Pin1_4	349	354	PF00397	0.473
DOC_WW_Pin1_4	371	376	PF00397	0.592
DOC_WW_Pin1_4	5	10	PF00397	0.584
DOC_WW_Pin1_4	83	88	PF00397	0.629
LIG_14-3-3_CanoR_1	198	206	PF00244	0.481
LIG_14-3-3_CanoR_1	378	383	PF00244	0.537
LIG_14-3-3_CanoR_1	44	52	PF00244	0.283
LIG_Actin_WH2_2	147	162	PF00022	0.419
LIG_BRCT_BRCA1_1	141	145	PF00533	0.256
LIG_BRCT_BRCA1_1	384	388	PF00533	0.543
LIG_Clathr_ClatBox_1	144	148	PF01394	0.411
LIG_FHA_1	139	145	PF00498	0.353
LIG_FHA_1	300	306	PF00498	0.446
LIG_FHA_1	332	338	PF00498	0.325
LIG_FHA_1	368	374	PF00498	0.583
LIG_FHA_1	37	43	PF00498	0.381
LIG_IRF3_LxIS_1	71	77	PF10401	0.509
LIG_LIR_Gen_1	209	219	PF02991	0.566
LIG_LIR_Gen_1	43	52	PF02991	0.347
LIG_LIR_Gen_1	430	438	PF02991	0.345
LIG_LIR_Gen_1	53	62	PF02991	0.318
LIG_LIR_Nem_3	209	215	PF02991	0.566
LIG_LIR_Nem_3	218	222	PF02991	0.538
LIG_LIR_Nem_3	247	253	PF02991	0.478
LIG_LIR_Nem_3	263	269	PF02991	0.353
LIG_LIR_Nem_3	335	341	PF02991	0.308
LIG_LIR_Nem_3	385	391	PF02991	0.530
LIG_LIR_Nem_3	421	427	PF02991	0.370
LIG_LIR_Nem_3	43	49	PF02991	0.344
LIG_LIR_Nem_3	430	434	PF02991	0.266
LIG_LIR_Nem_3	53	58	PF02991	0.295
LIG_LIR_Nem_3	66	72	PF02991	0.385
LIG_NRBOX	133	139	PF00104	0.256
LIG_NRBOX	182	188	PF00104	0.351
LIG_PALB2_WD40_1	50	58	PF16756	0.317
LIG_Pex14_1	266	270	PF04695	0.299
LIG_Pex14_1	288	292	PF04695	0.293
LIG_Pex14_2	219	223	PF04695	0.471
LIG_Pex14_2	425	429	PF04695	0.333
LIG_REV1ctd_RIR_1	405	413	PF16727	0.468
LIG_SH2_CRK	126	130	PF00017	0.513
LIG_SH2_CRK	212	216	PF00017	0.578
LIG_SH2_CRK	250	254	PF00017	0.332
LIG_SH2_NCK_1	204	208	PF00017	0.631
LIG_SH2_SRC	12	15	PF00017	0.405
LIG_SH2_SRC	153	156	PF00017	0.391
LIG_SH2_STAP1	172	176	PF00017	0.353
LIG_SH2_STAT5	143	146	PF00017	0.332
LIG_SH2_STAT5	153	156	PF00017	0.342
LIG_SH2_STAT5	270	273	PF00017	0.311
LIG_SH2_STAT5	278	281	PF00017	0.300
LIG_SH3_3	277	283	PF00018	0.432
LIG_SUMO_SIM_anti_2	182	188	PF11976	0.372
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.344
LIG_SUMO_SIM_anti_2	416	421	PF11976	0.378
LIG_SUMO_SIM_par_1	185	190	PF11976	0.341
LIG_TRAF2_2	9	14	PF00917	0.369
LIG_UBA3_1	144	151	PF00899	0.487
LIG_WW_1	9	12	PF00397	0.370
MOD_CDK_SPxxK_3	371	378	PF00069	0.406
MOD_CK1_1	170	176	PF00069	0.346
MOD_CK1_1	205	211	PF00069	0.618
MOD_CK1_1	331	337	PF00069	0.304
MOD_CK1_1	36	42	PF00069	0.395
MOD_CK1_1	371	377	PF00069	0.573
MOD_GlcNHglycan	103	106	PF01048	0.355
MOD_GlcNHglycan	172	175	PF01048	0.505
MOD_GlcNHglycan	20	24	PF01048	0.743
MOD_GlcNHglycan	246	249	PF01048	0.344
MOD_GlcNHglycan	26	29	PF01048	0.667
MOD_GlcNHglycan	262	265	PF01048	0.255
MOD_GlcNHglycan	33	36	PF01048	0.665
MOD_GlcNHglycan	58	61	PF01048	0.351
MOD_GSK3_1	139	146	PF00069	0.329
MOD_GSK3_1	166	173	PF00069	0.277
MOD_GSK3_1	19	26	PF00069	0.488
MOD_GSK3_1	198	205	PF00069	0.539
MOD_GSK3_1	211	218	PF00069	0.553
MOD_GSK3_1	31	38	PF00069	0.443
MOD_GSK3_1	324	331	PF00069	0.288
MOD_GSK3_1	367	374	PF00069	0.571
MOD_GSK3_1	378	385	PF00069	0.498
MOD_GSK3_1	40	47	PF00069	0.368
MOD_GSK3_1	429	436	PF00069	0.293
MOD_GSK3_1	79	86	PF00069	0.567
MOD_N-GLC_1	413	418	PF02516	0.351
MOD_N-GLC_1	44	49	PF02516	0.548
MOD_NEK2_1	138	143	PF00069	0.385
MOD_NEK2_1	167	172	PF00069	0.384
MOD_NEK2_1	206	211	PF00069	0.579
MOD_NEK2_1	4	9	PF00069	0.498
MOD_NEK2_1	408	413	PF00069	0.494
MOD_NEK2_1	429	434	PF00069	0.245
MOD_NEK2_1	74	79	PF00069	0.486
MOD_PKA_1	378	384	PF00069	0.406
MOD_PKA_1	79	85	PF00069	0.561
MOD_PKA_2	79	85	PF00069	0.561
MOD_Plk_1	139	145	PF00069	0.375
MOD_Plk_1	357	363	PF00069	0.406
MOD_Plk_1	413	419	PF00069	0.375
MOD_Plk_4	139	145	PF00069	0.355
MOD_Plk_4	208	214	PF00069	0.601
MOD_Plk_4	324	330	PF00069	0.317
MOD_Plk_4	332	338	PF00069	0.295
MOD_Plk_4	357	363	PF00069	0.556
MOD_Plk_4	50	56	PF00069	0.252
MOD_Plk_4	86	92	PF00069	0.559
MOD_ProDKin_1	187	193	PF00069	0.360
MOD_ProDKin_1	312	318	PF00069	0.359
MOD_ProDKin_1	349	355	PF00069	0.473
MOD_ProDKin_1	371	377	PF00069	0.592
MOD_ProDKin_1	5	11	PF00069	0.586
MOD_ProDKin_1	83	89	PF00069	0.632
MOD_SUMO_rev_2	300	305	PF00179	0.330
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.411
TRG_ENDOCYTIC_2	126	129	PF00928	0.480
TRG_ENDOCYTIC_2	212	215	PF00928	0.571
TRG_ENDOCYTIC_2	250	253	PF00928	0.316
TRG_ER_diArg_1	241	244	PF00400	0.489
TRG_ER_diArg_1	388	390	PF00400	0.494
TRG_ER_diArg_1	78	81	PF00400	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S5	Leptomonas seymouri	24%	100%
A0A0N1IBB8	Leptomonas seymouri	58%	93%
A0A0N1IHK9	Leptomonas seymouri	26%	100%
A0A0S4JF45	Bodo saltans	37%	100%
A0A0S4JH99	Bodo saltans	27%	88%
A0A0S4JIT1	Bodo saltans	26%	100%
A0A1X0NN16	Trypanosomatidae	24%	100%
A0A1X0NQB5	Trypanosomatidae	26%	100%
A0A1X0P6Z0	Trypanosomatidae	44%	100%
A0A3Q8IC78	Leishmania donovani	27%	100%
A0A3Q8IS12	Leishmania donovani	26%	100%
A0A3R7L1P3	Trypanosoma rangeli	24%	100%
A0A3S7WUZ5	Leishmania donovani	94%	100%
A0A422NGL1	Trypanosoma rangeli	25%	100%
A0A422P0Q3	Trypanosoma rangeli	45%	100%
A4H690	Leishmania braziliensis	27%	100%
A4H9K7	Leishmania braziliensis	81%	98%
A4HQI4	Leishmania braziliensis	27%	100%
A4HUL3	Leishmania infantum	26%	100%
A4HXX3	Leishmania infantum	94%	100%
C9ZVP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZZS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AHZ3	Leishmania infantum	26%	100%
E9ANB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ARN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AU97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q094	Leishmania major	26%	92%
Q4QHB2	Leishmania major	27%	100%
V5BTU3	Trypanosoma cruzi	26%	100%
V5DDT9	Trypanosoma cruzi	24%	100%
V5DN72	Trypanosoma cruzi	46%	100%