LeishMANIAdb
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PhoD domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PhoD domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QDT9_LEIMA
TriTrypDb:
LmjF.18.1030 * , LMJLV39_180015900 * , LMJSD75_180015800 *
Length:
777

Annotations

LeishMANIAdb annotations

PhoD domain containing alkaline phosphatase. Based on distant Eukaryotic orthologs, an N-terminal signal peptide is likely.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 3, no: 7
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

Q4QDT9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDT9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 222 226 PF00656 0.440
CLV_C14_Caspase3-7 27 31 PF00656 0.378
CLV_NRD_NRD_1 104 106 PF00675 0.597
CLV_NRD_NRD_1 164 166 PF00675 0.653
CLV_NRD_NRD_1 534 536 PF00675 0.515
CLV_NRD_NRD_1 581 583 PF00675 0.580
CLV_NRD_NRD_1 744 746 PF00675 0.412
CLV_PCSK_FUR_1 162 166 PF00082 0.644
CLV_PCSK_KEX2_1 104 106 PF00082 0.540
CLV_PCSK_KEX2_1 164 166 PF00082 0.653
CLV_PCSK_KEX2_1 534 536 PF00082 0.522
CLV_PCSK_KEX2_1 581 583 PF00082 0.582
CLV_PCSK_KEX2_1 744 746 PF00082 0.454
CLV_PCSK_KEX2_1 773 775 PF00082 0.431
CLV_PCSK_PC1ET2_1 773 775 PF00082 0.431
CLV_PCSK_PC7_1 160 166 PF00082 0.636
CLV_PCSK_PC7_1 769 775 PF00082 0.437
CLV_PCSK_SKI1_1 330 334 PF00082 0.591
CLV_PCSK_SKI1_1 44 48 PF00082 0.663
CLV_PCSK_SKI1_1 475 479 PF00082 0.492
CLV_PCSK_SKI1_1 627 631 PF00082 0.569
CLV_PCSK_SKI1_1 656 660 PF00082 0.774
CLV_PCSK_SKI1_1 671 675 PF00082 0.508
CLV_PCSK_SKI1_1 95 99 PF00082 0.551
DEG_APCC_DBOX_1 329 337 PF00400 0.412
DEG_APCC_DBOX_1 460 468 PF00400 0.321
DEG_APCC_DBOX_1 559 567 PF00400 0.383
DEG_SCF_FBW7_1 290 297 PF00400 0.469
DOC_CKS1_1 291 296 PF01111 0.471
DOC_CKS1_1 368 373 PF01111 0.340
DOC_CKS1_1 575 580 PF01111 0.383
DOC_CKS1_1 646 651 PF01111 0.480
DOC_CYCLIN_yCln2_LP_2 611 617 PF00134 0.292
DOC_MAPK_DCC_7 164 173 PF00069 0.467
DOC_MAPK_gen_1 162 172 PF00069 0.459
DOC_MAPK_gen_1 427 437 PF00069 0.349
DOC_MAPK_gen_1 459 467 PF00069 0.338
DOC_MAPK_gen_1 534 540 PF00069 0.316
DOC_MAPK_MEF2A_6 164 173 PF00069 0.498
DOC_MAPK_MEF2A_6 718 727 PF00069 0.372
DOC_MAPK_NFAT4_5 718 726 PF00069 0.268
DOC_PP1_RVXF_1 473 479 PF00149 0.282
DOC_PP1_RVXF_1 608 614 PF00149 0.375
DOC_PP2B_LxvP_1 336 339 PF13499 0.350
DOC_PP2B_LxvP_1 52 55 PF13499 0.379
DOC_PP4_FxxP_1 530 533 PF00568 0.342
DOC_PP4_FxxP_1 575 578 PF00568 0.373
DOC_PP4_FxxP_1 599 602 PF00568 0.375
DOC_USP7_MATH_1 120 124 PF00917 0.603
DOC_USP7_MATH_1 146 150 PF00917 0.494
DOC_USP7_MATH_1 16 20 PF00917 0.648
DOC_USP7_MATH_1 294 298 PF00917 0.464
DOC_USP7_MATH_1 508 512 PF00917 0.296
DOC_USP7_MATH_1 746 750 PF00917 0.734
DOC_USP7_MATH_1 762 766 PF00917 0.635
DOC_USP7_UBL2_3 40 44 PF12436 0.382
DOC_WW_Pin1_4 108 113 PF00397 0.387
DOC_WW_Pin1_4 150 155 PF00397 0.445
DOC_WW_Pin1_4 164 169 PF00397 0.483
DOC_WW_Pin1_4 173 178 PF00397 0.523
DOC_WW_Pin1_4 270 275 PF00397 0.483
DOC_WW_Pin1_4 290 295 PF00397 0.502
DOC_WW_Pin1_4 367 372 PF00397 0.414
DOC_WW_Pin1_4 529 534 PF00397 0.352
DOC_WW_Pin1_4 574 579 PF00397 0.424
DOC_WW_Pin1_4 642 647 PF00397 0.504
DOC_WW_Pin1_4 662 667 PF00397 0.374
DOC_WW_Pin1_4 758 763 PF00397 0.712
LIG_14-3-3_CanoR_1 162 168 PF00244 0.510
LIG_14-3-3_CanoR_1 325 333 PF00244 0.405
LIG_14-3-3_CanoR_1 337 343 PF00244 0.436
LIG_14-3-3_CanoR_1 397 407 PF00244 0.453
LIG_14-3-3_CanoR_1 548 552 PF00244 0.360
LIG_14-3-3_CanoR_1 582 592 PF00244 0.362
LIG_14-3-3_CanoR_1 688 692 PF00244 0.344
LIG_14-3-3_CanoR_1 745 753 PF00244 0.701
LIG_Actin_WH2_2 533 550 PF00022 0.328
LIG_AP2alpha_1 22 26 PF02296 0.427
LIG_BIR_II_1 1 5 PF00653 0.392
LIG_BIR_III_2 183 187 PF00653 0.421
LIG_BIR_III_4 364 368 PF00653 0.358
LIG_BRCT_BRCA1_1 18 22 PF00533 0.377
LIG_BRCT_BRCA1_1 227 231 PF00533 0.415
LIG_BRCT_BRCA1_1 707 711 PF00533 0.271
LIG_Clathr_ClatBox_1 170 174 PF01394 0.479
LIG_Clathr_ClatBox_1 563 567 PF01394 0.264
LIG_deltaCOP1_diTrp_1 410 415 PF00928 0.317
LIG_deltaCOP1_diTrp_1 452 457 PF00928 0.303
LIG_EH1_1 231 239 PF00400 0.354
LIG_FHA_1 478 484 PF00498 0.345
LIG_FHA_1 593 599 PF00498 0.373
LIG_FHA_1 714 720 PF00498 0.349
LIG_FHA_2 129 135 PF00498 0.499
LIG_FHA_2 25 31 PF00498 0.375
LIG_FHA_2 305 311 PF00498 0.391
LIG_FHA_2 584 590 PF00498 0.253
LIG_FHA_2 678 684 PF00498 0.289
LIG_HCF-1_HBM_1 265 268 PF13415 0.337
LIG_LIR_Apic_2 149 154 PF02991 0.442
LIG_LIR_Apic_2 30 35 PF02991 0.404
LIG_LIR_Apic_2 597 602 PF02991 0.368
LIG_LIR_Gen_1 228 238 PF02991 0.475
LIG_LIR_Gen_1 252 261 PF02991 0.355
LIG_LIR_Gen_1 410 419 PF02991 0.380
LIG_LIR_Gen_1 452 458 PF02991 0.345
LIG_LIR_Gen_1 595 602 PF02991 0.340
LIG_LIR_Gen_1 726 736 PF02991 0.301
LIG_LIR_Nem_3 228 234 PF02991 0.493
LIG_LIR_Nem_3 252 256 PF02991 0.375
LIG_LIR_Nem_3 265 271 PF02991 0.493
LIG_LIR_Nem_3 348 354 PF02991 0.360
LIG_LIR_Nem_3 355 361 PF02991 0.355
LIG_LIR_Nem_3 410 415 PF02991 0.328
LIG_LIR_Nem_3 452 457 PF02991 0.320
LIG_LIR_Nem_3 524 528 PF02991 0.387
LIG_LIR_Nem_3 542 547 PF02991 0.323
LIG_LIR_Nem_3 595 599 PF02991 0.329
LIG_LIR_Nem_3 726 731 PF02991 0.301
LIG_LIR_Nem_3 76 82 PF02991 0.349
LIG_LYPXL_yS_3 503 506 PF13949 0.291
LIG_MYND_1 527 531 PF01753 0.361
LIG_NRBOX 463 469 PF00104 0.325
LIG_NRBOX 718 724 PF00104 0.365
LIG_NRBOX 729 735 PF00104 0.319
LIG_PALB2_WD40_1 410 418 PF16756 0.298
LIG_PCNA_PIPBox_1 237 246 PF02747 0.357
LIG_Pex14_2 22 26 PF04695 0.427
LIG_Pex14_2 331 335 PF04695 0.339
LIG_Pex14_2 521 525 PF04695 0.355
LIG_PTB_Apo_2 590 597 PF02174 0.309
LIG_SH2_CRK 107 111 PF00017 0.356
LIG_SH2_CRK 151 155 PF00017 0.453
LIG_SH2_CRK 422 426 PF00017 0.363
LIG_SH2_CRK 82 86 PF00017 0.310
LIG_SH2_NCK_1 151 155 PF00017 0.423
LIG_SH2_SRC 380 383 PF00017 0.316
LIG_SH2_SRC 620 623 PF00017 0.375
LIG_SH2_STAP1 216 220 PF00017 0.382
LIG_SH2_STAP1 354 358 PF00017 0.382
LIG_SH2_STAP1 380 384 PF00017 0.289
LIG_SH2_STAT5 322 325 PF00017 0.457
LIG_SH2_STAT5 354 357 PF00017 0.362
LIG_SH2_STAT5 422 425 PF00017 0.458
LIG_SH2_STAT5 520 523 PF00017 0.412
LIG_SH2_STAT5 539 542 PF00017 0.310
LIG_SH2_STAT5 562 565 PF00017 0.385
LIG_SH2_STAT5 706 709 PF00017 0.386
LIG_SH3_2 646 651 PF14604 0.480
LIG_SH3_2 666 671 PF14604 0.333
LIG_SH3_3 274 280 PF00018 0.497
LIG_SH3_3 643 649 PF00018 0.514
LIG_SH3_3 663 669 PF00018 0.365
LIG_SUMO_SIM_anti_2 7 12 PF11976 0.617
LIG_SUMO_SIM_par_1 166 176 PF11976 0.475
LIG_SUMO_SIM_par_1 385 390 PF11976 0.334
LIG_SUMO_SIM_par_1 718 724 PF11976 0.364
LIG_SUMO_SIM_par_1 731 738 PF11976 0.372
LIG_TYR_ITIM 501 506 PF00017 0.277
LIG_UBA3_1 598 603 PF00899 0.314
LIG_UBA3_1 673 677 PF00899 0.331
LIG_WRC_WIRS_1 332 337 PF05994 0.431
LIG_WRC_WIRS_1 391 396 PF05994 0.374
LIG_WRC_WIRS_1 522 527 PF05994 0.338
MOD_CDC14_SPxK_1 532 535 PF00782 0.363
MOD_CDC14_SPxK_1 668 671 PF00782 0.386
MOD_CDK_SPK_2 529 534 PF00069 0.335
MOD_CDK_SPxK_1 367 373 PF00069 0.345
MOD_CDK_SPxK_1 529 535 PF00069 0.332
MOD_CDK_SPxK_1 645 651 PF00069 0.433
MOD_CDK_SPxK_1 665 671 PF00069 0.372
MOD_CDK_SPxxK_3 108 115 PF00069 0.315
MOD_CDK_SPxxK_3 574 581 PF00069 0.411
MOD_CK1_1 295 301 PF00069 0.452
MOD_CK1_1 511 517 PF00069 0.349
MOD_CK1_1 616 622 PF00069 0.347
MOD_CK1_1 645 651 PF00069 0.552
MOD_CK1_1 765 771 PF00069 0.642
MOD_CK2_1 270 276 PF00069 0.458
MOD_CK2_1 583 589 PF00069 0.441
MOD_CK2_1 709 715 PF00069 0.385
MOD_CMANNOS 305 308 PF00535 0.587
MOD_GlcNHglycan 1 4 PF01048 0.588
MOD_GlcNHglycan 122 125 PF01048 0.806
MOD_GlcNHglycan 297 300 PF01048 0.718
MOD_GlcNHglycan 48 51 PF01048 0.593
MOD_GlcNHglycan 510 513 PF01048 0.534
MOD_GlcNHglycan 515 518 PF01048 0.586
MOD_GlcNHglycan 698 701 PF01048 0.547
MOD_GSK3_1 116 123 PF00069 0.454
MOD_GSK3_1 146 153 PF00069 0.468
MOD_GSK3_1 194 201 PF00069 0.387
MOD_GSK3_1 290 297 PF00069 0.560
MOD_GSK3_1 320 327 PF00069 0.471
MOD_GSK3_1 507 514 PF00069 0.320
MOD_GSK3_1 641 648 PF00069 0.517
MOD_GSK3_1 705 712 PF00069 0.372
MOD_GSK3_1 753 760 PF00069 0.716
MOD_LATS_1 639 645 PF00433 0.462
MOD_N-GLC_1 325 330 PF02516 0.600
MOD_N-GLC_1 398 403 PF02516 0.541
MOD_N-GLC_1 420 425 PF02516 0.562
MOD_N-GLC_1 592 597 PF02516 0.493
MOD_N-GLC_1 677 682 PF02516 0.609
MOD_N-GLC_1 709 714 PF02516 0.501
MOD_N-GLC_1 95 100 PF02516 0.667
MOD_N-GLC_2 748 750 PF02516 0.419
MOD_NEK2_1 113 118 PF00069 0.423
MOD_NEK2_1 256 261 PF00069 0.328
MOD_NEK2_1 331 336 PF00069 0.355
MOD_NEK2_1 4 9 PF00069 0.574
MOD_NEK2_1 46 51 PF00069 0.536
MOD_NEK2_1 513 518 PF00069 0.377
MOD_NEK2_1 558 563 PF00069 0.343
MOD_NEK2_1 566 571 PF00069 0.391
MOD_NEK2_1 66 71 PF00069 0.286
MOD_NEK2_1 723 728 PF00069 0.347
MOD_NEK2_1 734 739 PF00069 0.304
MOD_NEK2_1 753 758 PF00069 0.578
MOD_NEK2_2 146 151 PF00069 0.462
MOD_NEK2_2 194 199 PF00069 0.393
MOD_NEK2_2 267 272 PF00069 0.339
MOD_NEK2_2 594 599 PF00069 0.321
MOD_PIKK_1 325 331 PF00454 0.404
MOD_PIKK_1 398 404 PF00454 0.406
MOD_PIKK_1 694 700 PF00454 0.270
MOD_PIKK_1 73 79 PF00454 0.399
MOD_PKA_1 640 646 PF00069 0.477
MOD_PKA_2 163 169 PF00069 0.522
MOD_PKA_2 194 200 PF00069 0.412
MOD_PKA_2 324 330 PF00069 0.475
MOD_PKA_2 547 553 PF00069 0.368
MOD_PKA_2 687 693 PF00069 0.438
MOD_PKA_2 746 752 PF00069 0.718
MOD_PKA_2 768 774 PF00069 0.641
MOD_Plk_1 420 426 PF00069 0.431
MOD_Plk_1 566 572 PF00069 0.402
MOD_Plk_1 592 598 PF00069 0.296
MOD_Plk_1 627 633 PF00069 0.396
MOD_Plk_1 709 715 PF00069 0.360
MOD_Plk_1 723 729 PF00069 0.369
MOD_Plk_1 73 79 PF00069 0.420
MOD_Plk_2-3 390 396 PF00069 0.363
MOD_Plk_4 146 152 PF00069 0.467
MOD_Plk_4 194 200 PF00069 0.391
MOD_Plk_4 225 231 PF00069 0.417
MOD_Plk_4 233 239 PF00069 0.387
MOD_Plk_4 331 337 PF00069 0.361
MOD_Plk_4 4 10 PF00069 0.668
MOD_Plk_4 521 527 PF00069 0.384
MOD_Plk_4 613 619 PF00069 0.327
MOD_Plk_4 677 683 PF00069 0.342
MOD_Plk_4 723 729 PF00069 0.380
MOD_Plk_4 762 768 PF00069 0.647
MOD_ProDKin_1 108 114 PF00069 0.394
MOD_ProDKin_1 150 156 PF00069 0.441
MOD_ProDKin_1 164 170 PF00069 0.485
MOD_ProDKin_1 173 179 PF00069 0.523
MOD_ProDKin_1 270 276 PF00069 0.486
MOD_ProDKin_1 290 296 PF00069 0.501
MOD_ProDKin_1 367 373 PF00069 0.413
MOD_ProDKin_1 529 535 PF00069 0.349
MOD_ProDKin_1 574 580 PF00069 0.417
MOD_ProDKin_1 642 648 PF00069 0.506
MOD_ProDKin_1 662 668 PF00069 0.369
MOD_ProDKin_1 758 764 PF00069 0.713
TRG_DiLeu_BaEn_1 715 720 PF01217 0.305
TRG_DiLeu_BaEn_2 251 257 PF01217 0.398
TRG_DiLeu_BaEn_2 473 479 PF01217 0.343
TRG_DiLeu_BaLyEn_6 109 114 PF01217 0.337
TRG_DiLeu_BaLyEn_6 166 171 PF01217 0.466
TRG_DiLeu_BaLyEn_6 370 375 PF01217 0.408
TRG_DiLeu_BaLyEn_6 460 465 PF01217 0.348
TRG_DiLeu_BaLyEn_6 524 529 PF01217 0.379
TRG_DiLeu_BaLyEn_6 554 559 PF01217 0.317
TRG_DiLeu_LyEn_5 691 696 PF01217 0.341
TRG_ENDOCYTIC_2 107 110 PF00928 0.361
TRG_ENDOCYTIC_2 253 256 PF00928 0.350
TRG_ENDOCYTIC_2 268 271 PF00928 0.415
TRG_ENDOCYTIC_2 422 425 PF00928 0.337
TRG_ENDOCYTIC_2 503 506 PF00928 0.291
TRG_ENDOCYTIC_2 82 85 PF00928 0.328
TRG_ER_diArg_1 104 106 PF00400 0.383
TRG_ER_diArg_1 160 163 PF00400 0.454
TRG_ER_diArg_1 458 461 PF00400 0.363
TRG_ER_diArg_1 533 535 PF00400 0.325
TRG_ER_diArg_1 580 582 PF00400 0.434
TRG_ER_diArg_1 743 745 PF00400 0.659
TRG_NES_CRM1_1 702 715 PF08389 0.321
TRG_NLS_MonoExtN_4 581 586 PF00514 0.268
TRG_NLS_MonoExtN_4 769 776 PF00514 0.635
TRG_Pf-PMV_PEXEL_1 373 377 PF00026 0.655

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PG58 Leptomonas seymouri 49% 94%
A0A1X0P7Z9 Trypanosomatidae 38% 100%
A0A3S7WV71 Leishmania donovani 93% 94%
A4H9L0 Leishmania braziliensis 69% 94%
A4HF04 Leishmania braziliensis 24% 100%
A4HXX7 Leishmania infantum 92% 94%
C9ZZS6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9ARP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9AYC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS