Putative 5-oxoprolinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5-oxoprolinase, putative

Species:

Leishmania major

UniProt:

Q4QDT8_LEIMA

TriTrypDb:

LmjF.18.1040 , LMJLV39_180016000 , LMJSD75_180015900

Length:

1344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006518	peptide metabolic process	4	2
GO:0006575	cellular modified amino acid metabolic process	3	2
GO:0006749	glutathione metabolic process	4	2
GO:0006790	sulfur compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0043603	amide metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	6
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	4	6
GO:0017168	5-oxoprolinase (ATP-hydrolyzing) activity	5	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.450
CLV_C14_Caspase3-7	412	416	PF00656	0.400
CLV_NRD_NRD_1	1008	1010	PF00675	0.344
CLV_NRD_NRD_1	1215	1217	PF00675	0.265
CLV_NRD_NRD_1	1248	1250	PF00675	0.246
CLV_NRD_NRD_1	588	590	PF00675	0.290
CLV_NRD_NRD_1	63	65	PF00675	0.200
CLV_NRD_NRD_1	66	68	PF00675	0.201
CLV_PCSK_FUR_1	1213	1217	PF00082	0.325
CLV_PCSK_KEX2_1	1008	1010	PF00082	0.284

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB9	Leptomonas seymouri	81%	100%
A0A0S4KJR3	Bodo saltans	53%	100%
A0A3S7WV18	Leishmania donovani	96%	100%
A4HXX8	Leishmania infantum	96%	100%
E9AI59	Leishmania braziliensis	90%	100%
E9ARP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O14841	Homo sapiens	48%	100%
P28273	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P97608	Rattus norvegicus	48%	100%
Q10093	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%

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