Putative calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C2, putative

Species:

Leishmania major

UniProt:

Q4QDT6_LEIMA

TriTrypDb:

LmjF.18.1060 , LMJSD75_180016300

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

Q4QDT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDT6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0019538	protein metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004175	endopeptidase activity	4	10
GO:0004197	cysteine-type endopeptidase activity	5	10
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	10
GO:0008233	peptidase activity	3	10
GO:0008234	cysteine-type peptidase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.374
CLV_C14_Caspase3-7	626	630	PF00656	0.468
CLV_C14_Caspase3-7	700	704	PF00656	0.539
CLV_NRD_NRD_1	198	200	PF00675	0.510
CLV_NRD_NRD_1	54	56	PF00675	0.548
CLV_NRD_NRD_1	573	575	PF00675	0.397
CLV_PCSK_KEX2_1	4	6	PF00082	0.651
CLV_PCSK_KEX2_1	573	575	PF00082	0.397
CLV_PCSK_KEX2_1	653	655	PF00082	0.472
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.516
CLV_PCSK_PC1ET2_1	653	655	PF00082	0.516
CLV_PCSK_SKI1_1	175	179	PF00082	0.511
CLV_PCSK_SKI1_1	199	203	PF00082	0.419
CLV_PCSK_SKI1_1	453	457	PF00082	0.337
CLV_PCSK_SKI1_1	488	492	PF00082	0.417
CLV_PCSK_SKI1_1	557	561	PF00082	0.409
CLV_PCSK_SKI1_1	59	63	PF00082	0.499
CLV_PCSK_SKI1_1	87	91	PF00082	0.509
DEG_APCC_DBOX_1	58	66	PF00400	0.531
DEG_MDM2_SWIB_1	642	649	PF02201	0.527
DOC_CYCLIN_yClb1_LxF_4	271	277	PF00134	0.539
DOC_MAPK_gen_1	4	14	PF00069	0.596
DOC_MAPK_gen_1	533	542	PF00069	0.460
DOC_MAPK_gen_1	55	64	PF00069	0.561
DOC_MAPK_MEF2A_6	535	544	PF00069	0.470
DOC_PIKK_1	66	74	PF02985	0.504
DOC_PP1_RVXF_1	471	477	PF00149	0.547
DOC_PP4_FxxP_1	223	226	PF00568	0.573
DOC_PP4_FxxP_1	734	737	PF00568	0.463
DOC_USP7_MATH_1	240	244	PF00917	0.636
DOC_USP7_MATH_1	405	409	PF00917	0.552
DOC_USP7_MATH_1	447	451	PF00917	0.589
DOC_USP7_MATH_1	680	684	PF00917	0.389
DOC_USP7_MATH_1	729	733	PF00917	0.476
DOC_USP7_UBL2_3	342	346	PF12436	0.490
DOC_WW_Pin1_4	254	259	PF00397	0.571
DOC_WW_Pin1_4	301	306	PF00397	0.518
DOC_WW_Pin1_4	330	335	PF00397	0.588
DOC_WW_Pin1_4	535	540	PF00397	0.441
DOC_WW_Pin1_4	681	686	PF00397	0.623
LIG_14-3-3_CanoR_1	199	206	PF00244	0.452
LIG_14-3-3_CanoR_1	379	389	PF00244	0.523
LIG_14-3-3_CanoR_1	390	399	PF00244	0.552
LIG_14-3-3_CanoR_1	605	611	PF00244	0.479
LIG_14-3-3_CanoR_1	619	628	PF00244	0.537
LIG_14-3-3_CanoR_1	654	662	PF00244	0.449
LIG_14-3-3_CanoR_1	715	719	PF00244	0.519
LIG_14-3-3_CanoR_1	762	769	PF00244	0.550
LIG_14-3-3_CterR_2	770	774	PF00244	0.657
LIG_APCC_ABBA_1	306	311	PF00400	0.576
LIG_APCC_ABBA_1	493	498	PF00400	0.462
LIG_BRCT_BRCA1_1	331	335	PF00533	0.495
LIG_BRCT_BRCA1_1	382	386	PF00533	0.536
LIG_BRCT_BRCA1_1	518	522	PF00533	0.408
LIG_BRCT_BRCA1_1	594	598	PF00533	0.496
LIG_BRCT_BRCA1_1	638	642	PF00533	0.500
LIG_BRCT_BRCA1_1	683	687	PF00533	0.592
LIG_BRCT_BRCA1_2	518	524	PF00533	0.402
LIG_CaM_IQ_9	32	47	PF13499	0.534
LIG_EH1_1	138	146	PF00400	0.551
LIG_FHA_1	188	194	PF00498	0.596
LIG_FHA_1	196	202	PF00498	0.541
LIG_FHA_1	320	326	PF00498	0.576
LIG_FHA_1	464	470	PF00498	0.549
LIG_FHA_1	601	607	PF00498	0.494
LIG_FHA_1	668	674	PF00498	0.494
LIG_FHA_1	715	721	PF00498	0.495
LIG_FHA_1	763	769	PF00498	0.610
LIG_FHA_2	205	211	PF00498	0.594
LIG_FHA_2	368	374	PF00498	0.590
LIG_FHA_2	382	388	PF00498	0.602
LIG_FHA_2	405	411	PF00498	0.589
LIG_FHA_2	42	48	PF00498	0.469
LIG_FHA_2	476	482	PF00498	0.500
LIG_FHA_2	503	509	PF00498	0.541
LIG_FHA_2	695	701	PF00498	0.583
LIG_FHA_2	709	715	PF00498	0.487
LIG_KLC1_Yacidic_2	307	311	PF13176	0.543
LIG_LIR_Apic_2	221	226	PF02991	0.599
LIG_LIR_Apic_2	731	737	PF02991	0.473
LIG_LIR_Gen_1	17	27	PF02991	0.519
LIG_LIR_Gen_1	207	216	PF02991	0.557
LIG_LIR_Gen_1	275	285	PF02991	0.543
LIG_LIR_Gen_1	333	344	PF02991	0.512
LIG_LIR_Gen_1	383	392	PF02991	0.546
LIG_LIR_Gen_1	438	448	PF02991	0.531
LIG_LIR_Gen_1	478	486	PF02991	0.523
LIG_LIR_Gen_1	487	496	PF02991	0.502
LIG_LIR_Gen_1	595	606	PF02991	0.488
LIG_LIR_Gen_1	643	652	PF02991	0.592
LIG_LIR_LC3C_4	283	286	PF02991	0.543
LIG_LIR_Nem_3	17	23	PF02991	0.425
LIG_LIR_Nem_3	207	212	PF02991	0.580
LIG_LIR_Nem_3	232	238	PF02991	0.440
LIG_LIR_Nem_3	275	280	PF02991	0.592
LIG_LIR_Nem_3	333	339	PF02991	0.492
LIG_LIR_Nem_3	383	389	PF02991	0.479
LIG_LIR_Nem_3	438	443	PF02991	0.491
LIG_LIR_Nem_3	460	464	PF02991	0.551
LIG_LIR_Nem_3	478	482	PF02991	0.397
LIG_LIR_Nem_3	485	489	PF02991	0.479
LIG_LIR_Nem_3	595	601	PF02991	0.478
LIG_LIR_Nem_3	643	649	PF02991	0.553
LIG_LIR_Nem_3	731	736	PF02991	0.384
LIG_LRP6_Inhibitor_1	111	117	PF00058	0.488
LIG_MLH1_MIPbox_1	594	598	PF16413	0.475
LIG_PCNA_yPIPBox_3	117	130	PF02747	0.543
LIG_Pex14_1	235	239	PF04695	0.321
LIG_Pex14_1	646	650	PF04695	0.577
LIG_Pex14_2	382	386	PF04695	0.584
LIG_Pex14_2	482	486	PF04695	0.558
LIG_Pex14_2	490	494	PF04695	0.467
LIG_Pex14_2	642	646	PF04695	0.504
LIG_PTB_Apo_2	522	529	PF02174	0.395
LIG_SH2_CRK	209	213	PF00017	0.599
LIG_SH2_CRK	277	281	PF00017	0.561
LIG_SH2_CRK	336	340	PF00017	0.518
LIG_SH2_CRK	351	355	PF00017	0.410
LIG_SH2_CRK	440	444	PF00017	0.509
LIG_SH2_NCK_1	209	213	PF00017	0.534
LIG_SH2_PTP2	20	23	PF00017	0.493
LIG_SH2_STAP1	209	213	PF00017	0.534
LIG_SH2_STAP1	277	281	PF00017	0.418
LIG_SH2_STAP1	336	340	PF00017	0.595
LIG_SH2_STAP1	440	444	PF00017	0.486
LIG_SH2_STAP1	457	461	PF00017	0.561
LIG_SH2_STAP1	748	752	PF00017	0.513
LIG_SH2_STAT3	262	265	PF00017	0.559
LIG_SH2_STAT5	139	142	PF00017	0.517
LIG_SH2_STAT5	20	23	PF00017	0.451
LIG_SH2_STAT5	295	298	PF00017	0.538
LIG_SH2_STAT5	309	312	PF00017	0.485
LIG_SH2_STAT5	353	356	PF00017	0.589
LIG_SH2_STAT5	52	55	PF00017	0.469
LIG_SH2_STAT5	738	741	PF00017	0.493
LIG_SH3_3	252	258	PF00018	0.568
LIG_SH3_3	443	449	PF00018	0.543
LIG_SH3_3	682	688	PF00018	0.562
LIG_SUMO_SIM_anti_2	142	149	PF11976	0.543
LIG_SUMO_SIM_anti_2	360	367	PF11976	0.562
LIG_SUMO_SIM_anti_2	670	675	PF11976	0.538
LIG_SUMO_SIM_anti_2	697	703	PF11976	0.595
LIG_SUMO_SIM_par_1	142	149	PF11976	0.537
LIG_SUMO_SIM_par_1	536	543	PF11976	0.523
LIG_SUMO_SIM_par_1	672	678	PF11976	0.414
LIG_TRAF2_1	243	246	PF00917	0.601
LIG_TRAF2_1	408	411	PF00917	0.543
LIG_TRAF2_1	413	416	PF00917	0.496
LIG_TRAF2_1	711	714	PF00917	0.588
LIG_TRFH_1	598	602	PF08558	0.515
LIG_TRFH_1	733	737	PF08558	0.441
LIG_TYR_ITIM	279	284	PF00017	0.418
LIG_TYR_ITIM	423	428	PF00017	0.552
LIG_TYR_ITSM	205	212	PF00017	0.602
LIG_WRC_WIRS_1	241	246	PF05994	0.577
LIG_WRC_WIRS_1	273	278	PF05994	0.449
LIG_WRC_WIRS_1	720	725	PF05994	0.538
MOD_CK1_1	157	163	PF00069	0.637
MOD_CK1_1	19	25	PF00069	0.497
MOD_CK1_1	195	201	PF00069	0.510
MOD_CK1_1	208	214	PF00069	0.531
MOD_CK1_1	330	336	PF00069	0.561
MOD_CK1_1	378	384	PF00069	0.582
MOD_CK1_1	517	523	PF00069	0.428
MOD_CK1_1	543	549	PF00069	0.557
MOD_CK1_1	640	646	PF00069	0.505
MOD_CK1_1	678	684	PF00069	0.600
MOD_CK1_1	96	102	PF00069	0.448
MOD_CK2_1	240	246	PF00069	0.557
MOD_CK2_1	301	307	PF00069	0.552
MOD_CK2_1	367	373	PF00069	0.590
MOD_CK2_1	404	410	PF00069	0.523
MOD_CK2_1	502	508	PF00069	0.554
MOD_CK2_1	620	626	PF00069	0.444
MOD_CK2_1	708	714	PF00069	0.531
MOD_GlcNHglycan	109	112	PF01048	0.419
MOD_GlcNHglycan	170	173	PF01048	0.629
MOD_GlcNHglycan	195	198	PF01048	0.430
MOD_GlcNHglycan	415	419	PF01048	0.363
MOD_GlcNHglycan	450	453	PF01048	0.324
MOD_GlcNHglycan	47	51	PF01048	0.545
MOD_GlcNHglycan	547	550	PF01048	0.613
MOD_GlcNHglycan	642	645	PF01048	0.376
MOD_GlcNHglycan	665	668	PF01048	0.434
MOD_GSK3_1	12	19	PF00069	0.621
MOD_GSK3_1	121	128	PF00069	0.515
MOD_GSK3_1	131	138	PF00069	0.421
MOD_GSK3_1	154	161	PF00069	0.620
MOD_GSK3_1	187	194	PF00069	0.540
MOD_GSK3_1	195	202	PF00069	0.456
MOD_GSK3_1	204	211	PF00069	0.554
MOD_GSK3_1	377	384	PF00069	0.587
MOD_GSK3_1	410	417	PF00069	0.530
MOD_GSK3_1	498	505	PF00069	0.553
MOD_GSK3_1	510	517	PF00069	0.391
MOD_GSK3_1	540	547	PF00069	0.499
MOD_GSK3_1	609	616	PF00069	0.450
MOD_GSK3_1	636	643	PF00069	0.533
MOD_GSK3_1	663	670	PF00069	0.573
MOD_GSK3_1	719	726	PF00069	0.511
MOD_GSK3_1	754	761	PF00069	0.554
MOD_GSK3_1	89	96	PF00069	0.457
MOD_N-GLC_1	435	440	PF02516	0.357
MOD_N-GLC_1	580	585	PF02516	0.367
MOD_N-GLC_2	266	268	PF02516	0.487
MOD_N-GLC_2	329	331	PF02516	0.352
MOD_N-GLC_2	576	578	PF02516	0.457
MOD_NEK2_1	131	136	PF00069	0.414
MOD_NEK2_1	158	163	PF00069	0.628
MOD_NEK2_1	187	192	PF00069	0.690
MOD_NEK2_1	193	198	PF00069	0.546
MOD_NEK2_1	249	254	PF00069	0.604
MOD_NEK2_1	280	285	PF00069	0.556
MOD_NEK2_1	319	324	PF00069	0.595
MOD_NEK2_1	35	40	PF00069	0.515
MOD_NEK2_1	377	382	PF00069	0.535
MOD_NEK2_1	414	419	PF00069	0.600
MOD_NEK2_1	46	51	PF00069	0.466
MOD_NEK2_1	515	520	PF00069	0.410
MOD_NEK2_1	544	549	PF00069	0.575
MOD_NEK2_1	606	611	PF00069	0.386
MOD_NEK2_1	637	642	PF00069	0.483
MOD_NEK2_1	675	680	PF00069	0.536
MOD_NEK2_1	723	728	PF00069	0.464
MOD_NEK2_1	758	763	PF00069	0.488
MOD_NEK2_1	769	774	PF00069	0.663
MOD_NEK2_1	89	94	PF00069	0.461
MOD_NEK2_2	229	234	PF00069	0.536
MOD_NEK2_2	729	734	PF00069	0.538
MOD_NEK2_2	748	753	PF00069	0.200
MOD_OFUCOSY	316	323	PF10250	0.249
MOD_PIKK_1	517	523	PF00454	0.531
MOD_PIKK_1	675	681	PF00454	0.418
MOD_PIKK_1	708	714	PF00454	0.583
MOD_PIKK_1	756	762	PF00454	0.508
MOD_PK_1	621	627	PF00069	0.455
MOD_PK_1	695	701	PF00069	0.533
MOD_PK_1	764	770	PF00069	0.550
MOD_PKA_1	199	205	PF00069	0.321
MOD_PKA_1	653	659	PF00069	0.435
MOD_PKA_2	131	137	PF00069	0.491
MOD_PKA_2	378	384	PF00069	0.510
MOD_PKA_2	620	626	PF00069	0.503
MOD_PKA_2	653	659	PF00069	0.456
MOD_PKA_2	663	669	PF00069	0.521
MOD_PKA_2	714	720	PF00069	0.482
MOD_PKB_1	619	627	PF00069	0.453
MOD_Plk_1	16	22	PF00069	0.507
MOD_Plk_1	214	220	PF00069	0.487
MOD_Plk_1	355	361	PF00069	0.552
MOD_Plk_1	410	416	PF00069	0.576
MOD_Plk_1	550	556	PF00069	0.527
MOD_Plk_1	580	586	PF00069	0.318
MOD_Plk_1	713	719	PF00069	0.448
MOD_Plk_1	748	754	PF00069	0.470
MOD_Plk_2-3	410	416	PF00069	0.552
MOD_Plk_4	125	131	PF00069	0.473
MOD_Plk_4	135	141	PF00069	0.431
MOD_Plk_4	16	22	PF00069	0.518
MOD_Plk_4	208	214	PF00069	0.477
MOD_Plk_4	272	278	PF00069	0.542
MOD_Plk_4	280	286	PF00069	0.503
MOD_Plk_4	321	327	PF00069	0.584
MOD_Plk_4	524	530	PF00069	0.386
MOD_Plk_4	592	598	PF00069	0.485
MOD_Plk_4	645	651	PF00069	0.504
MOD_Plk_4	669	675	PF00069	0.514
MOD_Plk_4	719	725	PF00069	0.477
MOD_Plk_4	729	735	PF00069	0.422
MOD_Plk_4	748	754	PF00069	0.209
MOD_Plk_4	764	770	PF00069	0.476
MOD_Plk_4	89	95	PF00069	0.473
MOD_ProDKin_1	254	260	PF00069	0.576
MOD_ProDKin_1	301	307	PF00069	0.518
MOD_ProDKin_1	330	336	PF00069	0.588
MOD_ProDKin_1	535	541	PF00069	0.438
MOD_ProDKin_1	681	687	PF00069	0.613
MOD_SUMO_rev_2	497	506	PF00179	0.543
MOD_SUMO_rev_2	84	89	PF00179	0.530
TRG_DiLeu_BaEn_1	122	127	PF01217	0.511
TRG_DiLeu_BaEn_1	487	492	PF01217	0.563
TRG_DiLeu_BaEn_1	731	736	PF01217	0.467
TRG_DiLeu_BaEn_1	84	89	PF01217	0.491
TRG_DiLeu_BaEn_2	566	572	PF01217	0.400
TRG_DiLeu_BaEn_4	84	90	PF01217	0.474
TRG_ENDOCYTIC_2	20	23	PF00928	0.419
TRG_ENDOCYTIC_2	209	212	PF00928	0.618
TRG_ENDOCYTIC_2	238	241	PF00928	0.541
TRG_ENDOCYTIC_2	277	280	PF00928	0.538
TRG_ENDOCYTIC_2	281	284	PF00928	0.527
TRG_ENDOCYTIC_2	336	339	PF00928	0.518
TRG_ENDOCYTIC_2	351	354	PF00928	0.410
TRG_ENDOCYTIC_2	425	428	PF00928	0.518
TRG_ENDOCYTIC_2	440	443	PF00928	0.532
TRG_ER_diArg_1	572	574	PF00400	0.421
TRG_ER_diArg_1	618	621	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.314
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF13	Leptomonas seymouri	48%	100%
A0A1X0P7A0	Trypanosomatidae	26%	100%
A0A3Q8IB60	Leishmania donovani	92%	100%
A0A3R7KWU1	Trypanosoma rangeli	26%	100%
A4H9L6	Leishmania braziliensis	72%	100%
A4HXY0	Leishmania infantum	92%	100%
D0A5C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ARP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%