Putative vacuolar protein sorting complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar protein sorting-associated protein 16 homolog, putative

Species:

Leishmania major

UniProt:

Q4QDT5_LEIMA

TriTrypDb:

LmjF.18.1070 , LMJLV39_180016200 , LMJSD75_180016400

Length:

829

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005768	endosome	7	2
GO:0012505	endomembrane system	2	8
GO:0030897	HOPS complex	3	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10

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Expansion

Sequence features

Q4QDT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDT5

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0006996	organelle organization	4	10
GO:0007033	vacuole organization	5	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016043	cellular component organization	3	10
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2

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Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.477
CLV_C14_Caspase3-7	734	738	PF00656	0.460
CLV_NRD_NRD_1	178	180	PF00675	0.420
CLV_PCSK_KEX2_1	100	102	PF00082	0.383
CLV_PCSK_KEX2_1	178	180	PF00082	0.399
CLV_PCSK_KEX2_1	334	336	PF00082	0.320
CLV_PCSK_KEX2_1	360	362	PF00082	0.417
CLV_PCSK_KEX2_1	500	502	PF00082	0.390
CLV_PCSK_KEX2_1	749	751	PF00082	0.420
CLV_PCSK_KEX2_1	785	787	PF00082	0.320

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I839	Leptomonas seymouri	70%	100%
A0A1X0P6Z7	Trypanosomatidae	40%	90%
A0A3S7WUZ3	Leishmania donovani	96%	100%
A0A422P0I7	Trypanosoma rangeli	39%	90%
A4H9L7	Leishmania braziliensis	88%	90%
A4HXY1	Leishmania infantum	96%	100%
D0A5C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	91%
E9ARP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q55C58	Dictyostelium discoideum	25%	100%
Q5E9L7	Bos taurus	27%	99%

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