Putative vacuolar protein sorting complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar protein sorting-associated protein 16 homolog, putative

Species:

Leishmania major

UniProt:

Q4QDT5_LEIMA

TriTrypDb:

LmjF.18.1070 , LMJLV39_180016200 , LMJSD75_180016400

Length:

829

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005768	endosome	7	2
GO:0030897	HOPS complex	3	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0097708	intracellular vesicle	5	2
GO:0098796	membrane protein complex	2	2
GO:0099023	vesicle tethering complex	2	2
GO:0110165	cellular anatomical entity	1	10
GO:0012505	endomembrane system	2	8

Expansion

Sequence features

Q4QDT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDT5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0006996	organelle organization	4	10
GO:0007033	vacuole organization	5	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016043	cellular component organization	3	10
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0033036	macromolecule localization	2	10
GO:0042144	vacuole fusion, non-autophagic	7	2
GO:0045184	establishment of protein localization	3	10
GO:0046907	intracellular transport	3	10
GO:0048284	organelle fusion	5	2
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0097576	vacuole fusion	6	2

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.477
CLV_C14_Caspase3-7	734	738	PF00656	0.460
CLV_NRD_NRD_1	178	180	PF00675	0.420
CLV_PCSK_KEX2_1	100	102	PF00082	0.383
CLV_PCSK_KEX2_1	178	180	PF00082	0.399
CLV_PCSK_KEX2_1	334	336	PF00082	0.320
CLV_PCSK_KEX2_1	360	362	PF00082	0.417
CLV_PCSK_KEX2_1	500	502	PF00082	0.390
CLV_PCSK_KEX2_1	749	751	PF00082	0.420
CLV_PCSK_KEX2_1	785	787	PF00082	0.320
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.383
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.320
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.492
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.390
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.420
CLV_PCSK_PC1ET2_1	785	787	PF00082	0.420
CLV_PCSK_SKI1_1	121	125	PF00082	0.395
CLV_PCSK_SKI1_1	334	338	PF00082	0.420
CLV_PCSK_SKI1_1	446	450	PF00082	0.473
CLV_PCSK_SKI1_1	59	63	PF00082	0.420
CLV_PCSK_SKI1_1	680	684	PF00082	0.469
CLV_PCSK_SKI1_1	695	699	PF00082	0.368
CLV_PCSK_SKI1_1	707	711	PF00082	0.372
CLV_PCSK_SKI1_1	733	737	PF00082	0.396
DEG_APCC_DBOX_1	256	264	PF00400	0.461
DEG_ODPH_VHL_1	265	276	PF01847	0.383
DEG_SPOP_SBC_1	621	625	PF00917	0.632
DOC_MAPK_DCC_7	365	375	PF00069	0.560
DOC_MAPK_gen_1	100	108	PF00069	0.467
DOC_MAPK_gen_1	360	370	PF00069	0.495
DOC_MAPK_MEF2A_6	5	14	PF00069	0.401
DOC_PP1_RVXF_1	151	158	PF00149	0.376
DOC_PP2B_LxvP_1	134	137	PF13499	0.461
DOC_PP2B_LxvP_1	76	79	PF13499	0.369
DOC_PP4_FxxP_1	698	701	PF00568	0.420
DOC_USP7_MATH_1	112	116	PF00917	0.387
DOC_USP7_MATH_1	126	130	PF00917	0.230
DOC_USP7_MATH_1	230	234	PF00917	0.337
DOC_USP7_MATH_1	29	33	PF00917	0.378
DOC_USP7_MATH_1	409	413	PF00917	0.511
DOC_USP7_MATH_1	427	431	PF00917	0.332
DOC_USP7_MATH_1	607	611	PF00917	0.512
DOC_USP7_MATH_1	818	822	PF00917	0.613
DOC_USP7_UBL2_3	442	446	PF12436	0.532
DOC_USP7_UBL2_3	797	801	PF12436	0.320
DOC_WW_Pin1_4	108	113	PF00397	0.466
DOC_WW_Pin1_4	146	151	PF00397	0.320
DOC_WW_Pin1_4	180	185	PF00397	0.454
DOC_WW_Pin1_4	615	620	PF00397	0.631
DOC_WW_Pin1_4	626	631	PF00397	0.696
LIG_14-3-3_CanoR_1	101	110	PF00244	0.356
LIG_14-3-3_CanoR_1	178	184	PF00244	0.384
LIG_14-3-3_CanoR_1	272	277	PF00244	0.268
LIG_14-3-3_CanoR_1	344	350	PF00244	0.420
LIG_14-3-3_CanoR_1	393	397	PF00244	0.526
LIG_14-3-3_CanoR_1	428	432	PF00244	0.550
LIG_14-3-3_CanoR_1	452	459	PF00244	0.483
LIG_14-3-3_CanoR_1	620	630	PF00244	0.733
LIG_14-3-3_CanoR_1	687	691	PF00244	0.434
LIG_Actin_WH2_2	399	417	PF00022	0.418
LIG_Actin_WH2_2	485	502	PF00022	0.420
LIG_BRCT_BRCA1_1	114	118	PF00533	0.461
LIG_BRCT_BRCA1_1	258	262	PF00533	0.322
LIG_BRCT_BRCA1_1	351	355	PF00533	0.345
LIG_BRCT_BRCA1_1	774	778	PF00533	0.461
LIG_Clathr_ClatBox_1	224	228	PF01394	0.345
LIG_Clathr_ClatBox_1	91	95	PF01394	0.461
LIG_FHA_1	101	107	PF00498	0.213
LIG_FHA_1	14	20	PF00498	0.376
LIG_FHA_1	511	517	PF00498	0.346
LIG_FHA_1	623	629	PF00498	0.668
LIG_FHA_1	741	747	PF00498	0.450
LIG_FHA_1	818	824	PF00498	0.581
LIG_FHA_1	86	92	PF00498	0.463
LIG_FHA_2	180	186	PF00498	0.402
LIG_FHA_2	286	292	PF00498	0.418
LIG_FHA_2	376	382	PF00498	0.296
LIG_FHA_2	40	46	PF00498	0.417
LIG_FHA_2	52	58	PF00498	0.355
LIG_FHA_2	732	738	PF00498	0.420
LIG_FHA_2	764	770	PF00498	0.461
LIG_GBD_Chelix_1	406	414	PF00786	0.420
LIG_GBD_Chelix_1	440	448	PF00786	0.501
LIG_LIR_Apic_2	747	751	PF02991	0.420
LIG_LIR_Gen_1	129	138	PF02991	0.430
LIG_LIR_Gen_1	16	24	PF02991	0.461
LIG_LIR_Gen_1	169	177	PF02991	0.324
LIG_LIR_Gen_1	259	270	PF02991	0.323
LIG_LIR_Gen_1	288	297	PF02991	0.377
LIG_LIR_Gen_1	345	351	PF02991	0.313
LIG_LIR_Gen_1	352	362	PF02991	0.307
LIG_LIR_Gen_1	45	55	PF02991	0.461
LIG_LIR_Gen_1	454	463	PF02991	0.418
LIG_LIR_Gen_1	509	519	PF02991	0.345
LIG_LIR_Gen_1	590	598	PF02991	0.476
LIG_LIR_Gen_1	644	655	PF02991	0.353
LIG_LIR_Gen_1	716	725	PF02991	0.376
LIG_LIR_Gen_1	811	818	PF02991	0.514
LIG_LIR_Nem_3	104	110	PF02991	0.355
LIG_LIR_Nem_3	129	134	PF02991	0.430
LIG_LIR_Nem_3	16	21	PF02991	0.384
LIG_LIR_Nem_3	169	174	PF02991	0.324
LIG_LIR_Nem_3	259	265	PF02991	0.323
LIG_LIR_Nem_3	288	292	PF02991	0.377
LIG_LIR_Nem_3	345	349	PF02991	0.399
LIG_LIR_Nem_3	45	51	PF02991	0.461
LIG_LIR_Nem_3	454	459	PF02991	0.330
LIG_LIR_Nem_3	590	596	PF02991	0.485
LIG_LIR_Nem_3	644	650	PF02991	0.366
LIG_LIR_Nem_3	664	668	PF02991	0.131
LIG_LIR_Nem_3	716	722	PF02991	0.346
LIG_LIR_Nem_3	769	773	PF02991	0.320
LIG_LIR_Nem_3	811	817	PF02991	0.510
LIG_LIR_Nem_3	824	828	PF02991	0.645
LIG_MAD2	142	150	PF02301	0.461
LIG_MLH1_MIPbox_1	258	262	PF16413	0.405
LIG_PCNA_PIPBox_1	551	560	PF02747	0.405
LIG_PCNA_yPIPBox_3	551	563	PF02747	0.405
LIG_Pex14_2	342	346	PF04695	0.314
LIG_Pex14_2	825	829	PF04695	0.617
LIG_PTB_Apo_2	12	19	PF02174	0.473
LIG_SH2_CRK	668	672	PF00017	0.461
LIG_SH2_CRK	748	752	PF00017	0.420
LIG_SH2_GRB2like	557	560	PF00017	0.356
LIG_SH2_PTP2	543	546	PF00017	0.376
LIG_SH2_STAP1	218	222	PF00017	0.383
LIG_SH2_STAP1	289	293	PF00017	0.376
LIG_SH2_STAT3	261	264	PF00017	0.405
LIG_SH2_STAT5	200	203	PF00017	0.335
LIG_SH2_STAT5	24	27	PF00017	0.470
LIG_SH2_STAT5	261	264	PF00017	0.358
LIG_SH2_STAT5	543	546	PF00017	0.345
LIG_SH2_STAT5	557	560	PF00017	0.306
LIG_SH2_STAT5	567	570	PF00017	0.303
LIG_SH2_STAT5	573	576	PF00017	0.290
LIG_SH2_STAT5	713	716	PF00017	0.392
LIG_SH2_STAT5	757	760	PF00017	0.331
LIG_SH2_STAT5	771	774	PF00017	0.320
LIG_SH3_3	224	230	PF00018	0.376
LIG_Sin3_3	48	55	PF02671	0.461
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.394
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.345
LIG_SUMO_SIM_anti_2	88	93	PF11976	0.455
LIG_SUMO_SIM_par_1	10	16	PF11976	0.345
LIG_SUMO_SIM_par_1	415	420	PF11976	0.500
LIG_SUMO_SIM_par_1	472	477	PF11976	0.412
LIG_SUMO_SIM_par_1	488	494	PF11976	0.264
LIG_SUMO_SIM_par_1	90	97	PF11976	0.461
LIG_SxIP_EBH_1	754	763	PF03271	0.461
LIG_TRAF2_1	378	381	PF00917	0.297
LIG_TYR_ITIM	541	546	PF00017	0.376
LIG_UBA3_1	792	801	PF00899	0.320
MOD_CDK_SPK_2	615	620	PF00069	0.626
MOD_CDK_SPxxK_3	146	153	PF00069	0.376
MOD_CK1_1	111	117	PF00069	0.446
MOD_CK1_1	127	133	PF00069	0.208
MOD_CK1_1	163	169	PF00069	0.387
MOD_CK1_1	172	178	PF00069	0.318
MOD_CK1_1	256	262	PF00069	0.297
MOD_CK1_1	275	281	PF00069	0.339
MOD_CK1_1	430	436	PF00069	0.464
MOD_CK1_1	521	527	PF00069	0.414
MOD_CK1_1	587	593	PF00069	0.616
MOD_CK1_1	623	629	PF00069	0.656
MOD_CK1_1	726	732	PF00069	0.392
MOD_CK1_1	821	827	PF00069	0.654
MOD_CK2_1	127	133	PF00069	0.461
MOD_CK2_1	179	185	PF00069	0.228
MOD_CK2_1	285	291	PF00069	0.420
MOD_CK2_1	375	381	PF00069	0.298
MOD_CK2_1	430	436	PF00069	0.500
MOD_CK2_1	488	494	PF00069	0.399
MOD_CK2_1	51	57	PF00069	0.417
MOD_CK2_1	69	75	PF00069	0.310
MOD_CK2_1	763	769	PF00069	0.430
MOD_GlcNHglycan	168	171	PF01048	0.427
MOD_GlcNHglycan	207	210	PF01048	0.384
MOD_GlcNHglycan	296	300	PF01048	0.382
MOD_GlcNHglycan	309	312	PF01048	0.261
MOD_GlcNHglycan	523	526	PF01048	0.462
MOD_GlcNHglycan	589	592	PF01048	0.646
MOD_GlcNHglycan	673	676	PF01048	0.420
MOD_GlcNHglycan	710	713	PF01048	0.376
MOD_GlcNHglycan	723	728	PF01048	0.350
MOD_GlcNHglycan	820	823	PF01048	0.565
MOD_GlcNHglycan	95	99	PF01048	0.397
MOD_GSK3_1	108	115	PF00069	0.382
MOD_GSK3_1	160	167	PF00069	0.378
MOD_GSK3_1	179	186	PF00069	0.456
MOD_GSK3_1	230	237	PF00069	0.438
MOD_GSK3_1	25	32	PF00069	0.380
MOD_GSK3_1	291	298	PF00069	0.371
MOD_GSK3_1	345	352	PF00069	0.376
MOD_GSK3_1	529	536	PF00069	0.358
MOD_GSK3_1	622	629	PF00069	0.641
MOD_GSK3_1	671	678	PF00069	0.320
MOD_GSK3_1	723	730	PF00069	0.441
MOD_GSK3_1	74	81	PF00069	0.461
MOD_GSK3_1	740	747	PF00069	0.280
MOD_GSK3_1	813	820	PF00069	0.444
MOD_N-GLC_1	127	132	PF02516	0.435
MOD_N-GLC_2	195	197	PF02516	0.228
MOD_N-GLC_2	23	25	PF02516	0.477
MOD_NEK2_1	124	129	PF00069	0.461
MOD_NEK2_1	160	165	PF00069	0.392
MOD_NEK2_1	306	311	PF00069	0.411
MOD_NEK2_1	342	347	PF00069	0.388
MOD_NEK2_1	349	354	PF00069	0.261
MOD_NEK2_1	356	361	PF00069	0.402
MOD_NEK2_1	488	493	PF00069	0.420
MOD_NEK2_1	51	56	PF00069	0.424
MOD_NEK2_1	510	515	PF00069	0.320
MOD_NEK2_1	518	523	PF00069	0.320
MOD_NEK2_1	650	655	PF00069	0.462
MOD_NEK2_1	671	676	PF00069	0.320
MOD_NEK2_1	714	719	PF00069	0.427
MOD_NEK2_1	85	90	PF00069	0.417
MOD_NEK2_2	218	223	PF00069	0.383
MOD_NEK2_2	427	432	PF00069	0.605
MOD_NEK2_2	675	680	PF00069	0.420
MOD_OFUCOSY	215	220	PF10250	0.228
MOD_PIKK_1	480	486	PF00454	0.424
MOD_PIKK_1	582	588	PF00454	0.622
MOD_PIKK_1	656	662	PF00454	0.415
MOD_PIKK_1	714	720	PF00454	0.405
MOD_PK_1	272	278	PF00069	0.265
MOD_PK_1	69	75	PF00069	0.228
MOD_PKA_1	100	106	PF00069	0.383
MOD_PKA_2	100	106	PF00069	0.417
MOD_PKA_2	177	183	PF00069	0.386
MOD_PKA_2	256	262	PF00069	0.411
MOD_PKA_2	392	398	PF00069	0.538
MOD_PKA_2	427	433	PF00069	0.557
MOD_PKA_2	451	457	PF00069	0.492
MOD_PKA_2	521	527	PF00069	0.376
MOD_PKA_2	686	692	PF00069	0.417
MOD_Plk_1	127	133	PF00069	0.435
MOD_Plk_1	172	178	PF00069	0.320
MOD_Plk_1	295	301	PF00069	0.376
MOD_Plk_1	350	356	PF00069	0.460
MOD_Plk_1	575	581	PF00069	0.405
MOD_Plk_1	656	662	PF00069	0.386
MOD_Plk_1	69	75	PF00069	0.461
MOD_Plk_4	114	120	PF00069	0.349
MOD_Plk_4	127	133	PF00069	0.333
MOD_Plk_4	160	166	PF00069	0.345
MOD_Plk_4	172	178	PF00069	0.345
MOD_Plk_4	183	189	PF00069	0.280
MOD_Plk_4	218	224	PF00069	0.353
MOD_Plk_4	256	262	PF00069	0.393
MOD_Plk_4	351	357	PF00069	0.446
MOD_Plk_4	638	644	PF00069	0.599
MOD_Plk_4	650	656	PF00069	0.420
MOD_Plk_4	731	737	PF00069	0.396
MOD_ProDKin_1	108	114	PF00069	0.466
MOD_ProDKin_1	146	152	PF00069	0.320
MOD_ProDKin_1	180	186	PF00069	0.454
MOD_ProDKin_1	615	621	PF00069	0.641
MOD_ProDKin_1	626	632	PF00069	0.695
MOD_SUMO_for_1	762	765	PF00179	0.461
MOD_SUMO_rev_2	408	417	PF00179	0.500
MOD_SUMO_rev_2	53	61	PF00179	0.450
MOD_SUMO_rev_2	594	602	PF00179	0.469
TRG_DiLeu_BaEn_1	657	662	PF01217	0.320
TRG_DiLeu_BaEn_2	257	263	PF01217	0.461
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.412
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.504
TRG_ENDOCYTIC_2	289	292	PF00928	0.376
TRG_ENDOCYTIC_2	543	546	PF00928	0.345
TRG_ENDOCYTIC_2	567	570	PF00928	0.340
TRG_ENDOCYTIC_2	668	671	PF00928	0.461
TRG_ENDOCYTIC_2	770	773	PF00928	0.345
TRG_ER_diArg_1	177	179	PF00400	0.420
TRG_ER_diArg_1	361	364	PF00400	0.420
TRG_ER_diArg_1	519	522	PF00400	0.415
TRG_NES_CRM1_1	381	392	PF08389	0.309
TRG_NES_CRM1_1	84	96	PF08389	0.461
TRG_Pf-PMV_PEXEL_1	646	651	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	808	812	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I839	Leptomonas seymouri	70%	100%
A0A1X0P6Z7	Trypanosomatidae	40%	90%
A0A3S7WUZ3	Leishmania donovani	96%	100%
A0A422P0I7	Trypanosoma rangeli	39%	90%
A4H9L7	Leishmania braziliensis	88%	90%
A4HXY1	Leishmania infantum	96%	100%
D0A5C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	91%
E9ARP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q55C58	Dictyostelium discoideum	25%	100%
Q5E9L7	Bos taurus	27%	99%
Q93VQ0	Arabidopsis thaliana	26%	97%
Q9H269	Homo sapiens	26%	99%
Q9UT38	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	99%