ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania major

UniProt:

Q4QDT2_LEIMA

TriTrypDb:

LmjF.18.1100 , LMJLV39_180016500 , LMJSD75_180016700

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0000502	proteasome complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905368	peptidase complex	3	2
GO:1905369	endopeptidase complex	4	2

Expansion

Sequence features

Q4QDT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.401
CLV_PCSK_KEX2_1	145	147	PF00082	0.325
CLV_PCSK_SKI1_1	131	135	PF00082	0.349
CLV_PCSK_SKI1_1	208	212	PF00082	0.423
CLV_PCSK_SKI1_1	34	38	PF00082	0.531
DEG_APCC_DBOX_1	123	131	PF00400	0.325
DEG_Nend_UBRbox_3	1	3	PF02207	0.639
DOC_CKS1_1	16	21	PF01111	0.549
DOC_CYCLIN_RxL_1	126	135	PF00134	0.450
DOC_USP7_MATH_1	73	77	PF00917	0.711
DOC_USP7_MATH_2	72	78	PF00917	0.542
DOC_WW_Pin1_4	113	118	PF00397	0.415
DOC_WW_Pin1_4	15	20	PF00397	0.412
DOC_WW_Pin1_4	4	9	PF00397	0.627
DOC_WW_Pin1_4	95	100	PF00397	0.641
LIG_14-3-3_CanoR_1	145	155	PF00244	0.345
LIG_BIR_III_4	111	115	PF00653	0.527
LIG_BRCT_BRCA1_1	16	20	PF00533	0.573
LIG_BRCT_BRCA1_1	192	196	PF00533	0.466
LIG_deltaCOP1_diTrp_1	12	20	PF00928	0.599
LIG_FHA_1	114	120	PF00498	0.302
LIG_FHA_1	80	86	PF00498	0.659
LIG_FHA_2	56	62	PF00498	0.737
LIG_FHA_2	9	15	PF00498	0.634
LIG_LIR_Apic_2	13	19	PF02991	0.629
LIG_PCNA_APIM_2	206	212	PF02747	0.408
LIG_PCNA_yPIPBox_3	153	166	PF02747	0.379
LIG_PCNA_yPIPBox_3	203	217	PF02747	0.393
LIG_Pex14_1	16	20	PF04695	0.545
LIG_SH2_CRK	5	9	PF00017	0.634
LIG_SH2_STAT5	209	212	PF00017	0.399
LIG_SH3_3	23	29	PF00018	0.414
LIG_SH3_3	66	72	PF00018	0.644
LIG_TRAF2_1	58	61	PF00917	0.739
MOD_CK2_1	165	171	PF00069	0.471
MOD_CK2_1	37	43	PF00069	0.578
MOD_CK2_1	55	61	PF00069	0.525
MOD_CK2_1	8	14	PF00069	0.651
MOD_GlcNHglycan	102	105	PF01048	0.559
MOD_GlcNHglycan	192	195	PF01048	0.465
MOD_GlcNHglycan	65	68	PF01048	0.781
MOD_GSK3_1	15	22	PF00069	0.408
MOD_GSK3_1	4	11	PF00069	0.604
MOD_GSK3_1	63	70	PF00069	0.744
MOD_GSK3_1	79	86	PF00069	0.665
MOD_N-GLC_1	62	67	PF02516	0.755
MOD_NEK2_1	165	170	PF00069	0.436
MOD_NEK2_1	37	42	PF00069	0.481
MOD_PIKK_1	50	56	PF00454	0.637
MOD_Plk_1	37	43	PF00069	0.578
MOD_Plk_4	125	131	PF00069	0.354
MOD_ProDKin_1	113	119	PF00069	0.325
MOD_ProDKin_1	15	21	PF00069	0.405
MOD_ProDKin_1	4	10	PF00069	0.616
MOD_ProDKin_1	95	101	PF00069	0.634
MOD_SUMO_rev_2	218	227	PF00179	0.415
MOD_SUMO_rev_2	74	82	PF00179	0.741
TRG_DiLeu_BaEn_2	160	166	PF01217	0.450
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.325
TRG_ENDOCYTIC_2	197	200	PF00928	0.379
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U8	Leptomonas seymouri	58%	74%
A0A1X0P783	Trypanosomatidae	45%	72%
A0A3S7WV17	Leishmania donovani	94%	100%
A0A422P0K3	Trypanosoma rangeli	46%	78%
A4H9M0	Leishmania braziliensis	82%	74%
A4HXY4	Leishmania infantum	94%	100%
D0A5C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	78%
E9ARP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q9WV06	Mus musculus	29%	70%
V5BJ76	Trypanosoma cruzi	47%	77%