Putative methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Multisite-specific tRNA:(cytosine-C(5))-methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QDT1_LEIMA

TriTrypDb:

LmjF.18.1110 , LMJLV39_180016600 , LMJSD75_180016800

Length:

849

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDT1

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	13
GO:0006139	nucleobase-containing compound metabolic process	3	13
GO:0006725	cellular aromatic compound metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009451	RNA modification	5	13
GO:0009987	cellular process	1	13
GO:0016070	RNA metabolic process	5	13
GO:0032259	methylation	2	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0043414	macromolecule methylation	3	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0046483	heterocycle metabolic process	3	13
GO:0071704	organic substance metabolic process	2	13
GO:0090304	nucleic acid metabolic process	4	13
GO:1901360	organic cyclic compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0008168	methyltransferase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.626
CLV_NRD_NRD_1	198	200	PF00675	0.732
CLV_NRD_NRD_1	3	5	PF00675	0.653
CLV_NRD_NRD_1	33	35	PF00675	0.380
CLV_NRD_NRD_1	394	396	PF00675	0.294
CLV_NRD_NRD_1	411	413	PF00675	0.261
CLV_NRD_NRD_1	539	541	PF00675	0.280
CLV_NRD_NRD_1	587	589	PF00675	0.429
CLV_NRD_NRD_1	621	623	PF00675	0.423
CLV_NRD_NRD_1	687	689	PF00675	0.373
CLV_NRD_NRD_1	7	9	PF00675	0.618
CLV_NRD_NRD_1	99	101	PF00675	0.514
CLV_PCSK_FUR_1	357	361	PF00082	0.291
CLV_PCSK_KEX2_1	132	134	PF00082	0.626
CLV_PCSK_KEX2_1	2	4	PF00082	0.658
CLV_PCSK_KEX2_1	271	273	PF00082	0.507
CLV_PCSK_KEX2_1	33	35	PF00082	0.554
CLV_PCSK_KEX2_1	359	361	PF00082	0.286
CLV_PCSK_KEX2_1	394	396	PF00082	0.218
CLV_PCSK_KEX2_1	587	589	PF00082	0.536
CLV_PCSK_KEX2_1	621	623	PF00082	0.423
CLV_PCSK_KEX2_1	687	689	PF00082	0.423
CLV_PCSK_KEX2_1	7	9	PF00082	0.597
CLV_PCSK_KEX2_1	99	101	PF00082	0.514
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.678
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.541
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.286
CLV_PCSK_PC7_1	3	9	PF00082	0.672
CLV_PCSK_PC7_1	683	689	PF00082	0.496
CLV_PCSK_SKI1_1	236	240	PF00082	0.500
CLV_PCSK_SKI1_1	248	252	PF00082	0.450
CLV_PCSK_SKI1_1	337	341	PF00082	0.362
CLV_PCSK_SKI1_1	434	438	PF00082	0.300
CLV_PCSK_SKI1_1	540	544	PF00082	0.535
CLV_PCSK_SKI1_1	622	626	PF00082	0.398
CLV_PCSK_SKI1_1	697	701	PF00082	0.447
CLV_PCSK_SKI1_1	716	720	PF00082	0.372
DEG_Nend_UBRbox_1	1	4	PF02207	0.706
DEG_ODPH_VHL_1	680	693	PF01847	0.473
DEG_SIAH_1	731	739	PF03145	0.520
DEG_SPOP_SBC_1	598	602	PF00917	0.581
DOC_CKS1_1	213	218	PF01111	0.512
DOC_CKS1_1	238	243	PF01111	0.560
DOC_CKS1_1	625	630	PF01111	0.492
DOC_CYCLIN_RxL_1	434	446	PF00134	0.504
DOC_CYCLIN_RxL_1	683	694	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	565	571	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	625	631	PF00134	0.493
DOC_MAPK_gen_1	562	571	PF00069	0.569
DOC_MAPK_gen_1	638	647	PF00069	0.447
DOC_MAPK_HePTP_8	635	647	PF00069	0.553
DOC_MAPK_MEF2A_6	638	647	PF00069	0.447
DOC_PP1_RVXF_1	376	382	PF00149	0.508
DOC_PP1_RVXF_1	685	692	PF00149	0.507
DOC_PP2B_LxvP_1	565	568	PF13499	0.498
DOC_PP4_FxxP_1	381	384	PF00568	0.410
DOC_PP4_FxxP_1	679	682	PF00568	0.520
DOC_PP4_FxxP_1	779	782	PF00568	0.371
DOC_USP7_MATH_1	252	256	PF00917	0.519
DOC_USP7_MATH_1	56	60	PF00917	0.784
DOC_USP7_MATH_1	598	602	PF00917	0.629
DOC_USP7_UBL2_3	345	349	PF12436	0.480
DOC_USP7_UBL2_3	733	737	PF12436	0.556
DOC_WW_Pin1_4	166	171	PF00397	0.637
DOC_WW_Pin1_4	212	217	PF00397	0.433
DOC_WW_Pin1_4	237	242	PF00397	0.535
DOC_WW_Pin1_4	498	503	PF00397	0.480
DOC_WW_Pin1_4	624	629	PF00397	0.494
LIG_14-3-3_CanoR_1	100	108	PF00244	0.490
LIG_14-3-3_CanoR_1	222	230	PF00244	0.473
LIG_14-3-3_CanoR_1	236	241	PF00244	0.501
LIG_14-3-3_CanoR_1	347	355	PF00244	0.480
LIG_14-3-3_CanoR_1	622	628	PF00244	0.508
LIG_14-3-3_CanoR_1	683	691	PF00244	0.521
LIG_APCC_ABBA_1	524	529	PF00400	0.480
LIG_BRCT_BRCA1_1	675	679	PF00533	0.494
LIG_deltaCOP1_diTrp_1	203	209	PF00928	0.487
LIG_deltaCOP1_diTrp_1	572	582	PF00928	0.405
LIG_Dynein_DLC8_1	347	353	PF01221	0.520
LIG_FAT_LD_1	75	83	PF03623	0.543
LIG_FHA_1	144	150	PF00498	0.604
LIG_FHA_1	18	24	PF00498	0.564
LIG_FHA_1	218	224	PF00498	0.390
LIG_FHA_1	233	239	PF00498	0.387
LIG_FHA_1	349	355	PF00498	0.490
LIG_FHA_1	444	450	PF00498	0.543
LIG_FHA_1	625	631	PF00498	0.450
LIG_FHA_1	763	769	PF00498	0.423
LIG_FHA_1	96	102	PF00498	0.598
LIG_FHA_2	237	243	PF00498	0.545
LIG_FHA_2	305	311	PF00498	0.539
LIG_FHA_2	367	373	PF00498	0.491
LIG_FHA_2	42	48	PF00498	0.697
LIG_FHA_2	752	758	PF00498	0.635
LIG_LIR_Apic_2	637	643	PF02991	0.449
LIG_LIR_Apic_2	676	682	PF02991	0.466
LIG_LIR_Gen_1	156	162	PF02991	0.559
LIG_LIR_Gen_1	287	296	PF02991	0.409
LIG_LIR_Gen_1	39	48	PF02991	0.608
LIG_LIR_Gen_1	393	404	PF02991	0.471
LIG_LIR_Gen_1	573	583	PF02991	0.429
LIG_LIR_Gen_1	89	97	PF02991	0.589
LIG_LIR_Nem_3	156	161	PF02991	0.550
LIG_LIR_Nem_3	203	209	PF02991	0.499
LIG_LIR_Nem_3	287	291	PF02991	0.417
LIG_LIR_Nem_3	39	43	PF02991	0.543
LIG_LIR_Nem_3	393	399	PF02991	0.471
LIG_LIR_Nem_3	573	579	PF02991	0.396
LIG_LIR_Nem_3	580	585	PF02991	0.391
LIG_LIR_Nem_3	590	596	PF02991	0.426
LIG_LIR_Nem_3	713	718	PF02991	0.451
LIG_LIR_Nem_3	816	820	PF02991	0.487
LIG_LIR_Nem_3	89	95	PF02991	0.584
LIG_MYND_1	510	514	PF01753	0.577
LIG_NRBOX	699	705	PF00104	0.497
LIG_NRBOX	74	80	PF00104	0.538
LIG_NRBOX	741	747	PF00104	0.570
LIG_Pex14_1	376	380	PF04695	0.504
LIG_Pex14_1	421	425	PF04695	0.480
LIG_Pex14_2	535	539	PF04695	0.475
LIG_Rb_pABgroove_1	773	781	PF01858	0.299
LIG_SH2_CRK	361	365	PF00017	0.504
LIG_SH2_CRK	640	644	PF00017	0.498
LIG_SH2_GRB2like	380	383	PF00017	0.410
LIG_SH2_STAT5	275	278	PF00017	0.424
LIG_SH2_STAT5	35	38	PF00017	0.498
LIG_SH2_STAT5	380	383	PF00017	0.562
LIG_SH2_STAT5	425	428	PF00017	0.477
LIG_SH2_STAT5	710	713	PF00017	0.563
LIG_SH3_3	164	170	PF00018	0.624
LIG_SH3_3	243	249	PF00018	0.466
LIG_SH3_3	371	377	PF00018	0.502
LIG_SH3_3	381	387	PF00018	0.508
LIG_SH3_3	507	513	PF00018	0.520
LIG_SUMO_SIM_anti_2	475	481	PF11976	0.480
LIG_SUMO_SIM_anti_2	756	766	PF11976	0.542
LIG_SUMO_SIM_par_1	124	131	PF11976	0.630
LIG_TRAF2_1	287	290	PF00917	0.368
LIG_TRAF2_1	756	759	PF00917	0.596
LIG_TRAF2_1	838	841	PF00917	0.789
LIG_TRFH_1	611	615	PF08558	0.457
LIG_WRC_WIRS_1	579	584	PF05994	0.504
LIG_WRC_WIRS_1	814	819	PF05994	0.442
LIG_WW_1	513	516	PF00397	0.577
MOD_CDK_SPxxK_3	166	173	PF00069	0.672
MOD_CK1_1	104	110	PF00069	0.460
MOD_CK1_1	121	127	PF00069	0.523
MOD_CK1_1	212	218	PF00069	0.485
MOD_CK1_1	284	290	PF00069	0.367
MOD_CK1_1	416	422	PF00069	0.500
MOD_CK1_1	453	459	PF00069	0.468
MOD_CK1_1	600	606	PF00069	0.605
MOD_CK1_1	750	756	PF00069	0.641
MOD_CK2_1	184	190	PF00069	0.698
MOD_CK2_1	284	290	PF00069	0.369
MOD_CK2_1	41	47	PF00069	0.662
MOD_CK2_1	70	76	PF00069	0.554
MOD_CK2_1	737	743	PF00069	0.585
MOD_CK2_1	753	759	PF00069	0.499
MOD_CK2_1	763	769	PF00069	0.423
MOD_GlcNHglycan	123	126	PF01048	0.622
MOD_GlcNHglycan	139	142	PF01048	0.589
MOD_GlcNHglycan	192	195	PF01048	0.676
MOD_GlcNHglycan	255	258	PF01048	0.544
MOD_GlcNHglycan	283	286	PF01048	0.395
MOD_GlcNHglycan	292	295	PF01048	0.364
MOD_GlcNHglycan	327	330	PF01048	0.337
MOD_GlcNHglycan	331	334	PF01048	0.314
MOD_GlcNHglycan	405	408	PF01048	0.262
MOD_GlcNHglycan	421	424	PF01048	0.262
MOD_GlcNHglycan	494	497	PF01048	0.323
MOD_GlcNHglycan	54	57	PF01048	0.759
MOD_GlcNHglycan	58	61	PF01048	0.723
MOD_GlcNHglycan	602	605	PF01048	0.608
MOD_GlcNHglycan	675	678	PF01048	0.375
MOD_GlcNHglycan	72	75	PF01048	0.375
MOD_GlcNHglycan	792	795	PF01048	0.390
MOD_GlcNHglycan	796	799	PF01048	0.406
MOD_GlcNHglycan	834	837	PF01048	0.749
MOD_GSK3_1	132	139	PF00069	0.713
MOD_GSK3_1	232	239	PF00069	0.493
MOD_GSK3_1	248	255	PF00069	0.420
MOD_GSK3_1	258	265	PF00069	0.510
MOD_GSK3_1	325	332	PF00069	0.520
MOD_GSK3_1	382	389	PF00069	0.552
MOD_GSK3_1	403	410	PF00069	0.464
MOD_GSK3_1	413	420	PF00069	0.466
MOD_GSK3_1	421	428	PF00069	0.471
MOD_GSK3_1	52	59	PF00069	0.762
MOD_GSK3_1	596	603	PF00069	0.577
MOD_GSK3_1	744	751	PF00069	0.560
MOD_GSK3_1	790	797	PF00069	0.357
MOD_LATS_1	130	136	PF00433	0.734
MOD_N-GLC_1	184	189	PF02516	0.654
MOD_N-GLC_1	195	200	PF02516	0.531
MOD_N-GLC_1	577	582	PF02516	0.425
MOD_NEK2_1	118	123	PF00069	0.581
MOD_NEK2_1	143	148	PF00069	0.621
MOD_NEK2_1	209	214	PF00069	0.508
MOD_NEK2_1	443	448	PF00069	0.512
MOD_NEK2_1	450	455	PF00069	0.454
MOD_NEK2_1	691	696	PF00069	0.510
MOD_NEK2_1	763	768	PF00069	0.452
MOD_NEK2_1	792	797	PF00069	0.373
MOD_NEK2_2	407	412	PF00069	0.471
MOD_NEK2_2	813	818	PF00069	0.485
MOD_PIKK_1	101	107	PF00454	0.520
MOD_PIKK_1	118	124	PF00454	0.509
MOD_PIKK_1	348	354	PF00454	0.480
MOD_PIKK_1	41	47	PF00454	0.649
MOD_PIKK_1	429	435	PF00454	0.480
MOD_PIKK_1	744	750	PF00454	0.617
MOD_PK_1	413	419	PF00069	0.539
MOD_PK_1	77	83	PF00069	0.532
MOD_PKA_1	132	138	PF00069	0.738
MOD_PKA_2	132	138	PF00069	0.732
MOD_PKA_2	153	159	PF00069	0.639
MOD_PKA_2	682	688	PF00069	0.501
MOD_PKA_2	824	830	PF00069	0.700
MOD_PKA_2	95	101	PF00069	0.579
MOD_Plk_1	143	149	PF00069	0.602
MOD_Plk_1	184	190	PF00069	0.499
MOD_Plk_1	413	419	PF00069	0.539
MOD_Plk_1	577	583	PF00069	0.458
MOD_Plk_1	751	757	PF00069	0.578
MOD_Plk_4	304	310	PF00069	0.486
MOD_Plk_4	322	328	PF00069	0.504
MOD_Plk_4	421	427	PF00069	0.491
MOD_Plk_4	548	554	PF00069	0.618
MOD_Plk_4	578	584	PF00069	0.469
MOD_Plk_4	675	681	PF00069	0.409
MOD_Plk_4	77	83	PF00069	0.524
MOD_Plk_4	813	819	PF00069	0.463
MOD_ProDKin_1	166	172	PF00069	0.633
MOD_ProDKin_1	212	218	PF00069	0.432
MOD_ProDKin_1	237	243	PF00069	0.528
MOD_ProDKin_1	498	504	PF00069	0.480
MOD_ProDKin_1	624	630	PF00069	0.492
TRG_DiLeu_BaEn_1	759	764	PF01217	0.557
TRG_DiLeu_BaEn_2	204	210	PF01217	0.511
TRG_DiLeu_BaEn_2	674	680	PF01217	0.493
TRG_DiLeu_LyEn_5	145	150	PF01217	0.500
TRG_ER_diArg_1	132	134	PF00400	0.628
TRG_ER_diArg_1	33	35	PF00400	0.380
TRG_ER_diArg_1	394	396	PF00400	0.513
TRG_ER_diArg_1	620	622	PF00400	0.448
TRG_ER_diArg_1	635	638	PF00400	0.533
TRG_ER_diArg_1	687	689	PF00400	0.427
TRG_ER_diArg_1	7	10	PF00400	0.629
TRG_ER_diArg_1	99	101	PF00400	0.533
TRG_NES_CRM1_1	13	29	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	697	701	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H1	Leptomonas seymouri	71%	99%
A0A0S4KJ12	Bodo saltans	42%	100%
A0A1X0P6Y3	Trypanosomatidae	54%	100%
A0A3R7M922	Trypanosoma rangeli	53%	100%
A0A3S7WV22	Leishmania donovani	94%	100%
A4H9M1	Leishmania braziliensis	83%	100%
A4HXY5	Leishmania infantum	94%	100%
D0A386	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A5C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ARP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DFH6	Trypanosoma cruzi	50%	100%