AN1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AN1-like zinc finger, putative

Species:

Leishmania major

UniProt:

Q4QDT0_LEIMA

TriTrypDb:

LmjF.18.1120 , LMJLV39_180016700 , LMJSD75_180016900

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDT0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.740
CLV_C14_Caspase3-7	226	230	PF00656	0.468
CLV_NRD_NRD_1	111	113	PF00675	0.717
CLV_NRD_NRD_1	337	339	PF00675	0.558
CLV_PCSK_FUR_1	109	113	PF00082	0.519
CLV_PCSK_KEX2_1	111	113	PF00082	0.717
CLV_PCSK_KEX2_1	33	35	PF00082	0.413
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.413
CLV_PCSK_SKI1_1	331	335	PF00082	0.514
DEG_Nend_UBRbox_3	1	3	PF02207	0.583
DEG_SPOP_SBC_1	343	347	PF00917	0.531
DOC_MAPK_MEF2A_6	171	179	PF00069	0.755
DOC_PP1_RVXF_1	312	319	PF00149	0.556
DOC_PP4_FxxP_1	219	222	PF00568	0.479
DOC_PP4_FxxP_1	318	321	PF00568	0.502
DOC_USP7_MATH_1	159	163	PF00917	0.665
DOC_USP7_MATH_1	166	170	PF00917	0.665
DOC_USP7_MATH_1	26	30	PF00917	0.393
DOC_USP7_MATH_1	343	347	PF00917	0.609
DOC_USP7_MATH_1	90	94	PF00917	0.668
DOC_USP7_UBL2_3	200	204	PF12436	0.610
DOC_WW_Pin1_4	164	169	PF00397	0.624
DOC_WW_Pin1_4	194	199	PF00397	0.497
DOC_WW_Pin1_4	265	270	PF00397	0.609
DOC_WW_Pin1_4	293	298	PF00397	0.530
DOC_WW_Pin1_4	317	322	PF00397	0.539
LIG_APCC_ABBA_1	284	289	PF00400	0.599
LIG_FHA_1	139	145	PF00498	0.427
LIG_FHA_1	212	218	PF00498	0.363
LIG_FHA_1	281	287	PF00498	0.492
LIG_FHA_1	35	41	PF00498	0.445
LIG_FHA_1	55	61	PF00498	0.325
LIG_FHA_2	17	23	PF00498	0.363
LIG_FHA_2	257	263	PF00498	0.523
LIG_LIR_Apic_2	291	297	PF02991	0.561
LIG_LIR_Apic_2	315	321	PF02991	0.486
LIG_LIR_Nem_3	235	240	PF02991	0.483
LIG_NRBOX	252	258	PF00104	0.571
LIG_PCNA_yPIPBox_3	249	257	PF02747	0.528
LIG_SH2_CRK	295	299	PF00017	0.614
LIG_SH2_CRK	62	66	PF00017	0.503
LIG_SH2_STAT3	69	72	PF00017	0.520
LIG_SH3_3	174	180	PF00018	0.749
LIG_SH3_3	236	242	PF00018	0.459
LIG_SH3_3	279	285	PF00018	0.434
LIG_SUMO_SIM_anti_2	19	25	PF11976	0.413
LIG_SUMO_SIM_par_1	296	302	PF11976	0.374
LIG_TRAF2_2	70	75	PF00917	0.550
LIG_TYR_ITIM	60	65	PF00017	0.490
LIG_UBA3_1	175	183	PF00899	0.638
MOD_CDK_SPxK_1	194	200	PF00069	0.534
MOD_CDK_SPxxK_3	164	171	PF00069	0.680
MOD_CDK_SPxxK_3	265	272	PF00069	0.606
MOD_CK1_1	296	302	PF00069	0.451
MOD_CK1_1	341	347	PF00069	0.687
MOD_CK2_1	164	170	PF00069	0.706
MOD_Cter_Amidation	109	112	PF01082	0.731
MOD_GlcNHglycan	115	118	PF01048	0.556
MOD_GlcNHglycan	161	164	PF01048	0.643
MOD_GlcNHglycan	306	309	PF01048	0.417
MOD_GlcNHglycan	42	45	PF01048	0.401
MOD_GlcNHglycan	99	102	PF01048	0.705
MOD_GSK3_1	203	210	PF00069	0.568
MOD_GSK3_1	338	345	PF00069	0.636
MOD_GSK3_1	34	41	PF00069	0.410
MOD_NEK2_1	113	118	PF00069	0.580
MOD_NEK2_1	175	180	PF00069	0.673
MOD_NEK2_1	256	261	PF00069	0.489
MOD_NEK2_1	280	285	PF00069	0.505
MOD_NEK2_1	298	303	PF00069	0.307
MOD_NEK2_1	40	45	PF00069	0.360
MOD_NEK2_2	90	95	PF00069	0.592
MOD_OFUCOSY	218	224	PF10250	0.301
MOD_PIKK_1	347	353	PF00454	0.761
MOD_PK_1	118	124	PF00069	0.437
MOD_PK_1	183	189	PF00069	0.577
MOD_PKA_1	338	344	PF00069	0.532
MOD_PKA_2	26	32	PF00069	0.430
MOD_Plk_1	312	318	PF00069	0.523
MOD_Plk_2-3	16	22	PF00069	0.449
MOD_Plk_4	299	305	PF00069	0.509
MOD_Plk_4	90	96	PF00069	0.634
MOD_ProDKin_1	164	170	PF00069	0.627
MOD_ProDKin_1	194	200	PF00069	0.507
MOD_ProDKin_1	265	271	PF00069	0.600
MOD_ProDKin_1	293	299	PF00069	0.530
MOD_ProDKin_1	317	323	PF00069	0.552
MOD_SUMO_rev_2	335	341	PF00179	0.619
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.511
TRG_ENDOCYTIC_2	295	298	PF00928	0.580
TRG_ENDOCYTIC_2	62	65	PF00928	0.497
TRG_ER_diArg_1	109	112	PF00400	0.732

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2X2	Leptomonas seymouri	71%	99%
A0A0S4KFT8	Bodo saltans	30%	100%
A0A1X0P6Y8	Trypanosomatidae	30%	100%
A0A3S5ISH4	Trypanosoma rangeli	35%	100%
A0A3S7WV04	Leishmania donovani	94%	100%
A4H9M2	Leishmania braziliensis	79%	100%
A4HXY6	Leishmania infantum	94%	100%
D0A5C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ARP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AZ68	Trypanosoma cruzi	32%	100%