Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDS8_LEIMA

TriTrypDb:

LmjF.18.1140 , LMJLV39_180017000 , LMJSD75_180017200

Length:

945

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QDS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.510
CLV_NRD_NRD_1	365	367	PF00675	0.503
CLV_NRD_NRD_1	376	378	PF00675	0.424
CLV_NRD_NRD_1	485	487	PF00675	0.573
CLV_NRD_NRD_1	59	61	PF00675	0.467
CLV_NRD_NRD_1	662	664	PF00675	0.609
CLV_NRD_NRD_1	666	668	PF00675	0.662
CLV_NRD_NRD_1	693	695	PF00675	0.635
CLV_NRD_NRD_1	855	857	PF00675	0.596
CLV_NRD_NRD_1	932	934	PF00675	0.701
CLV_PCSK_FUR_1	374	378	PF00082	0.491
CLV_PCSK_FUR_1	656	660	PF00082	0.625
CLV_PCSK_KEX2_1	228	230	PF00082	0.461
CLV_PCSK_KEX2_1	262	264	PF00082	0.672
CLV_PCSK_KEX2_1	278	280	PF00082	0.449
CLV_PCSK_KEX2_1	358	360	PF00082	0.524
CLV_PCSK_KEX2_1	365	367	PF00082	0.476
CLV_PCSK_KEX2_1	376	378	PF00082	0.417
CLV_PCSK_KEX2_1	485	487	PF00082	0.573
CLV_PCSK_KEX2_1	517	519	PF00082	0.522
CLV_PCSK_KEX2_1	658	660	PF00082	0.583
CLV_PCSK_KEX2_1	661	663	PF00082	0.611
CLV_PCSK_KEX2_1	666	668	PF00082	0.663
CLV_PCSK_KEX2_1	695	697	PF00082	0.683
CLV_PCSK_KEX2_1	854	856	PF00082	0.817
CLV_PCSK_KEX2_1	932	934	PF00082	0.644
CLV_PCSK_KEX2_1	95	97	PF00082	0.411
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.461
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.538
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.413
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.489
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.560
CLV_PCSK_PC1ET2_1	695	697	PF00082	0.760
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.423
CLV_PCSK_PC7_1	656	662	PF00082	0.581
CLV_PCSK_SKI1_1	186	190	PF00082	0.547
CLV_PCSK_SKI1_1	278	282	PF00082	0.598
CLV_PCSK_SKI1_1	328	332	PF00082	0.448
CLV_PCSK_SKI1_1	485	489	PF00082	0.508
CLV_PCSK_SKI1_1	547	551	PF00082	0.467
CLV_PCSK_SKI1_1	843	847	PF00082	0.637
CLV_PCSK_SKI1_1	92	96	PF00082	0.527
CLV_Separin_Metazoa	583	587	PF03568	0.464
CLV_Separin_Metazoa	590	594	PF03568	0.457
CLV_Separin_Metazoa	649	653	PF03568	0.582
DEG_APCC_DBOX_1	185	193	PF00400	0.405
DEG_APCC_DBOX_1	300	308	PF00400	0.491
DEG_APCC_DBOX_1	501	509	PF00400	0.607
DEG_SPOP_SBC_1	345	349	PF00917	0.492
DEG_SPOP_SBC_1	673	677	PF00917	0.720
DOC_CYCLIN_RxL_1	37	51	PF00134	0.526
DOC_CYCLIN_RxL_1	746	759	PF00134	0.542
DOC_CYCLIN_yClb5_NLxxxL_5	260	269	PF00134	0.578
DOC_MAPK_gen_1	438	446	PF00069	0.431
DOC_MAPK_gen_1	578	587	PF00069	0.566
DOC_MAPK_gen_1	746	755	PF00069	0.542
DOC_MAPK_MEF2A_6	440	448	PF00069	0.431
DOC_USP7_MATH_1	181	185	PF00917	0.454
DOC_USP7_MATH_1	188	192	PF00917	0.436
DOC_USP7_MATH_1	241	245	PF00917	0.584
DOC_USP7_MATH_1	346	350	PF00917	0.497
DOC_USP7_MATH_1	665	669	PF00917	0.740
DOC_USP7_MATH_1	671	675	PF00917	0.695
DOC_USP7_MATH_1	705	709	PF00917	0.671
DOC_USP7_MATH_1	807	811	PF00917	0.692
DOC_USP7_MATH_1	884	888	PF00917	0.694
DOC_USP7_MATH_1	914	918	PF00917	0.540
DOC_USP7_UBL2_3	170	174	PF12436	0.480
DOC_WW_Pin1_4	10	15	PF00397	0.563
DOC_WW_Pin1_4	801	806	PF00397	0.614
DOC_WW_Pin1_4	812	817	PF00397	0.575
DOC_WW_Pin1_4	865	870	PF00397	0.610
DOC_WW_Pin1_4	878	883	PF00397	0.681
LIG_14-3-3_CanoR_1	180	190	PF00244	0.550
LIG_14-3-3_CanoR_1	204	212	PF00244	0.554
LIG_14-3-3_CanoR_1	303	308	PF00244	0.576
LIG_14-3-3_CanoR_1	586	594	PF00244	0.491
LIG_14-3-3_CanoR_1	808	816	PF00244	0.483
LIG_14-3-3_CanoR_1	855	865	PF00244	0.657
LIG_14-3-3_CanoR_1	875	880	PF00244	0.622
LIG_14-3-3_CanoR_1	898	903	PF00244	0.653
LIG_14-3-3_CanoR_1	96	104	PF00244	0.434
LIG_Actin_WH2_2	202	219	PF00022	0.544
LIG_Actin_WH2_2	323	340	PF00022	0.347
LIG_Actin_WH2_2	766	784	PF00022	0.414
LIG_CaM_IQ_9	209	225	PF13499	0.553
LIG_Clathr_ClatBox_1	189	193	PF01394	0.423
LIG_FHA_1	13	19	PF00498	0.631
LIG_FHA_1	345	351	PF00498	0.506
LIG_FHA_1	473	479	PF00498	0.499
LIG_FHA_1	587	593	PF00498	0.493
LIG_FHA_1	716	722	PF00498	0.579
LIG_FHA_2	100	106	PF00498	0.484
LIG_FHA_2	284	290	PF00498	0.511
LIG_FHA_2	318	324	PF00498	0.475
LIG_FHA_2	346	352	PF00498	0.488
LIG_FHA_2	355	361	PF00498	0.424
LIG_FHA_2	393	399	PF00498	0.439
LIG_FHA_2	523	529	PF00498	0.535
LIG_FHA_2	597	603	PF00498	0.650
LIG_FHA_2	844	850	PF00498	0.638
LIG_FHA_2	898	904	PF00498	0.534
LIG_LIR_Apic_2	874	880	PF02991	0.608
LIG_LIR_Gen_1	17	24	PF02991	0.480
LIG_LIR_Gen_1	638	647	PF02991	0.526
LIG_LIR_Nem_3	17	23	PF02991	0.505
LIG_NRBOX	772	778	PF00104	0.405
LIG_RPA_C_Fungi	562	574	PF08784	0.457
LIG_SH2_CRK	70	74	PF00017	0.449
LIG_SH2_CRK	877	881	PF00017	0.606
LIG_SH2_NCK_1	70	74	PF00017	0.507
LIG_SH2_NCK_1	877	881	PF00017	0.606
LIG_SH2_PTP2	20	23	PF00017	0.523
LIG_SH2_SRC	20	23	PF00017	0.464
LIG_SH2_STAP1	322	326	PF00017	0.621
LIG_SH2_STAP1	647	651	PF00017	0.578
LIG_SH2_STAT5	140	143	PF00017	0.448
LIG_SH2_STAT5	146	149	PF00017	0.393
LIG_SH2_STAT5	20	23	PF00017	0.523
LIG_SH3_3	708	714	PF00018	0.709
LIG_SUMO_SIM_par_1	392	399	PF11976	0.424
LIG_SUMO_SIM_par_1	769	775	PF11976	0.424
LIG_TRAF2_1	175	178	PF00917	0.471
LIG_TRAF2_1	232	235	PF00917	0.639
LIG_TRAF2_1	287	290	PF00917	0.604
LIG_TRAF2_1	368	371	PF00917	0.482
LIG_TRAF2_1	434	437	PF00917	0.435
LIG_TRAF2_1	646	649	PF00917	0.576
LIG_TRAF2_1	79	82	PF00917	0.431
LIG_TYR_ITIM	18	23	PF00017	0.588
LIG_UBA3_1	507	512	PF00899	0.471
MOD_CDK_SPxxK_3	801	808	PF00069	0.607
MOD_CDK_SPxxK_3	865	872	PF00069	0.576
MOD_CK1_1	13	19	PF00069	0.564
MOD_CK1_1	184	190	PF00069	0.572
MOD_CK1_1	191	197	PF00069	0.508
MOD_CK1_1	600	606	PF00069	0.581
MOD_CK1_1	638	644	PF00069	0.504
MOD_CK1_1	672	678	PF00069	0.651
MOD_CK1_1	681	687	PF00069	0.611
MOD_CK1_1	716	722	PF00069	0.535
MOD_CK1_1	878	884	PF00069	0.676
MOD_CK2_1	283	289	PF00069	0.547
MOD_CK2_1	292	298	PF00069	0.492
MOD_CK2_1	336	342	PF00069	0.561
MOD_CK2_1	345	351	PF00069	0.470
MOD_CK2_1	354	360	PF00069	0.348
MOD_CK2_1	392	398	PF00069	0.461
MOD_CK2_1	430	436	PF00069	0.479
MOD_CK2_1	522	528	PF00069	0.536
MOD_CK2_1	596	602	PF00069	0.545
MOD_CK2_1	643	649	PF00069	0.502
MOD_CK2_1	680	686	PF00069	0.698
MOD_CK2_1	843	849	PF00069	0.713
MOD_CK2_1	897	903	PF00069	0.535
MOD_CK2_1	99	105	PF00069	0.477
MOD_DYRK1A_RPxSP_1	10	14	PF00069	0.638
MOD_GlcNHglycan	10	13	PF01048	0.624
MOD_GlcNHglycan	185	189	PF01048	0.498
MOD_GlcNHglycan	426	429	PF01048	0.494
MOD_GlcNHglycan	431	435	PF01048	0.482
MOD_GlcNHglycan	615	618	PF01048	0.486
MOD_GlcNHglycan	671	674	PF01048	0.711
MOD_GlcNHglycan	81	86	PF01048	0.512
MOD_GlcNHglycan	843	846	PF01048	0.616
MOD_GlcNHglycan	860	865	PF01048	0.658
MOD_GlcNHglycan	877	880	PF01048	0.593
MOD_GlcNHglycan	890	893	PF01048	0.546
MOD_GSK3_1	184	191	PF00069	0.483
MOD_GSK3_1	299	306	PF00069	0.599
MOD_GSK3_1	37	44	PF00069	0.435
MOD_GSK3_1	379	386	PF00069	0.452
MOD_GSK3_1	392	399	PF00069	0.388
MOD_GSK3_1	596	603	PF00069	0.692
MOD_GSK3_1	609	616	PF00069	0.686
MOD_GSK3_1	619	626	PF00069	0.620
MOD_GSK3_1	665	672	PF00069	0.712
MOD_GSK3_1	674	681	PF00069	0.640
MOD_GSK3_1	772	779	PF00069	0.366
MOD_GSK3_1	8	15	PF00069	0.612
MOD_GSK3_1	833	840	PF00069	0.611
MOD_GSK3_1	850	857	PF00069	0.677
MOD_GSK3_1	871	878	PF00069	0.750
MOD_GSK3_1	880	887	PF00069	0.635
MOD_GSK3_1	912	919	PF00069	0.511
MOD_GSK3_1	95	102	PF00069	0.500
MOD_LATS_1	841	847	PF00433	0.516
MOD_N-GLC_1	679	684	PF02516	0.666
MOD_NEK2_1	299	304	PF00069	0.526
MOD_NEK2_1	344	349	PF00069	0.497
MOD_NEK2_1	354	359	PF00069	0.432
MOD_NEK2_1	41	46	PF00069	0.433
MOD_NEK2_1	522	527	PF00069	0.531
MOD_NEK2_1	573	578	PF00069	0.477
MOD_NEK2_1	776	781	PF00069	0.506
MOD_PIKK_1	379	385	PF00454	0.363
MOD_PIKK_1	549	555	PF00454	0.506
MOD_PIKK_1	776	782	PF00454	0.509
MOD_PIKK_1	884	890	PF00454	0.603
MOD_PKA_1	854	860	PF00069	0.595
MOD_PKA_1	95	101	PF00069	0.465
MOD_PKA_2	292	298	PF00069	0.562
MOD_PKA_2	472	478	PF00069	0.442
MOD_PKA_2	643	649	PF00069	0.573
MOD_PKA_2	665	671	PF00069	0.619
MOD_PKA_2	716	722	PF00069	0.535
MOD_PKA_2	799	805	PF00069	0.728
MOD_PKA_2	807	813	PF00069	0.543
MOD_PKA_2	854	860	PF00069	0.620
MOD_PKA_2	871	877	PF00069	0.507
MOD_PKA_2	897	903	PF00069	0.627
MOD_PKA_2	95	101	PF00069	0.465
MOD_PKB_1	301	309	PF00069	0.487
MOD_PKB_1	667	675	PF00069	0.623
MOD_PKB_1	854	862	PF00069	0.554
MOD_Plk_1	184	190	PF00069	0.573
MOD_Plk_1	242	248	PF00069	0.479
MOD_Plk_1	299	305	PF00069	0.523
MOD_Plk_1	370	376	PF00069	0.484
MOD_Plk_1	41	47	PF00069	0.433
MOD_Plk_1	430	436	PF00069	0.499
MOD_Plk_1	638	644	PF00069	0.545
MOD_Plk_1	860	866	PF00069	0.690
MOD_Plk_1	99	105	PF00069	0.533
MOD_Plk_2-3	392	398	PF00069	0.427
MOD_Plk_2-3	766	772	PF00069	0.422
MOD_Plk_4	303	309	PF00069	0.483
MOD_Plk_4	766	772	PF00069	0.422
MOD_ProDKin_1	10	16	PF00069	0.555
MOD_ProDKin_1	801	807	PF00069	0.613
MOD_ProDKin_1	812	818	PF00069	0.571
MOD_ProDKin_1	865	871	PF00069	0.608
MOD_ProDKin_1	878	884	PF00069	0.677
MOD_SUMO_for_1	749	752	PF00179	0.569
MOD_SUMO_rev_2	109	118	PF00179	0.434
MOD_SUMO_rev_2	420	425	PF00179	0.467
TRG_DiLeu_BaEn_1	332	337	PF01217	0.517
TRG_DiLeu_BaEn_1	766	771	PF01217	0.422
TRG_DiLeu_BaEn_4	370	376	PF01217	0.484
TRG_DiLeu_BaEn_4	50	56	PF01217	0.424
TRG_DiLeu_BaEn_4	582	588	PF01217	0.470
TRG_ENDOCYTIC_2	20	23	PF00928	0.464
TRG_ENDOCYTIC_2	640	643	PF00928	0.516
TRG_ENDOCYTIC_2	647	650	PF00928	0.471
TRG_ENDOCYTIC_2	70	73	PF00928	0.391
TRG_ENDOCYTIC_2	91	94	PF00928	0.413
TRG_ER_diArg_1	119	122	PF00400	0.485
TRG_ER_diArg_1	301	304	PF00400	0.550
TRG_ER_diArg_1	365	367	PF00400	0.531
TRG_ER_diArg_1	374	377	PF00400	0.546
TRG_ER_diArg_1	656	659	PF00400	0.593
TRG_ER_diArg_1	660	663	PF00400	0.621
TRG_ER_diArg_1	666	669	PF00400	0.636
TRG_ER_diArg_1	728	731	PF00400	0.468
TRG_ER_diArg_1	785	788	PF00400	0.546
TRG_ER_diArg_1	854	856	PF00400	0.543
TRG_ER_diArg_1	931	933	PF00400	0.699
TRG_NLS_MonoExtC_3	693	699	PF00514	0.630
TRG_NLS_MonoExtN_4	692	698	PF00514	0.629
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	627	632	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	652	657	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBB1	Leptomonas seymouri	62%	80%
A0A3R7MU41	Trypanosoma rangeli	39%	96%
A0A3S5H739	Leishmania donovani	94%	100%
A4H9M4	Leishmania braziliensis	82%	92%
A4HXY8	Leishmania infantum	94%	100%
D0A5B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9ARQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BEK2	Trypanosoma cruzi	36%	95%