RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q4QDS7_LEIMA

TriTrypDb:

LmjF.18.1150 , LMJLV39_180017100 , LMJSD75_180017300

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDS7

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0061630	ubiquitin protein ligase activity	5	12
GO:0061659	ubiquitin-like protein ligase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.575
CLV_NRD_NRD_1	213	215	PF00675	0.521
CLV_NRD_NRD_1	248	250	PF00675	0.469
CLV_PCSK_KEX2_1	215	217	PF00082	0.573
CLV_PCSK_KEX2_1	247	249	PF00082	0.458
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.573
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.472
CLV_PCSK_SKI1_1	174	178	PF00082	0.496
DEG_APCC_DBOX_1	156	164	PF00400	0.623
DOC_ANK_TNKS_1	48	55	PF00023	0.564
DOC_MAPK_gen_1	174	182	PF00069	0.551
DOC_MAPK_MEF2A_6	174	182	PF00069	0.469
DOC_MAPK_MEF2A_6	198	205	PF00069	0.396
DOC_MAPK_NFAT4_5	175	183	PF00069	0.552
DOC_PP2B_LxvP_1	346	349	PF13499	0.441
DOC_USP7_MATH_1	355	359	PF00917	0.634
DOC_USP7_UBL2_3	175	179	PF12436	0.451
DOC_USP7_UBL2_3	190	194	PF12436	0.507
DOC_WW_Pin1_4	57	62	PF00397	0.688
LIG_14-3-3_CanoR_1	174	179	PF00244	0.476
LIG_14-3-3_CanoR_1	339	349	PF00244	0.286
LIG_14-3-3_CanoR_1	78	84	PF00244	0.567
LIG_FHA_1	118	124	PF00498	0.411
LIG_FHA_1	133	139	PF00498	0.374
LIG_FHA_1	175	181	PF00498	0.469
LIG_FHA_1	208	214	PF00498	0.531
LIG_FHA_2	224	230	PF00498	0.560
LIG_FHA_2	236	242	PF00498	0.339
LIG_FHA_2	289	295	PF00498	0.693
LIG_MYND_1	158	162	PF01753	0.583
LIG_PDZ_Class_1	355	360	PF00595	0.639
LIG_SH2_GRB2like	41	44	PF00017	0.717
LIG_SH2_SRC	116	119	PF00017	0.561
LIG_SH2_SRC	136	139	PF00017	0.387
LIG_SH2_STAT3	196	199	PF00017	0.416
LIG_SH2_STAT5	116	119	PF00017	0.570
LIG_SH2_STAT5	126	129	PF00017	0.557
LIG_SH2_STAT5	262	265	PF00017	0.450
LIG_SH3_1	330	336	PF00018	0.300
LIG_SH3_3	152	158	PF00018	0.422
LIG_SH3_3	330	336	PF00018	0.286
LIG_SH3_3	64	70	PF00018	0.724
LIG_TRAF2_1	184	187	PF00917	0.516
LIG_TRAF2_1	226	229	PF00917	0.526
LIG_WRC_WIRS_1	122	127	PF05994	0.440
MOD_CK1_1	112	118	PF00069	0.493
MOD_CK1_1	350	356	PF00069	0.609
MOD_CK1_1	79	85	PF00069	0.698
MOD_CK2_1	181	187	PF00069	0.529
MOD_CK2_1	223	229	PF00069	0.688
MOD_CK2_1	287	293	PF00069	0.670
MOD_GlcNHglycan	357	360	PF01048	0.637
MOD_GlcNHglycan	78	81	PF01048	0.757
MOD_GSK3_1	105	112	PF00069	0.424
MOD_GSK3_1	117	124	PF00069	0.419
MOD_GSK3_1	126	133	PF00069	0.401
MOD_GSK3_1	228	235	PF00069	0.523
MOD_GSK3_1	249	256	PF00069	0.382
MOD_GSK3_1	272	279	PF00069	0.792
MOD_GSK3_1	79	86	PF00069	0.851
MOD_N-GLC_1	147	152	PF02516	0.445
MOD_N-GLC_1	223	228	PF02516	0.647
MOD_N-GLC_1	4	9	PF02516	0.753
MOD_N-GLC_1	42	47	PF02516	0.742
MOD_N-GLC_1	56	61	PF02516	0.773
MOD_N-GLC_1	76	81	PF02516	0.837
MOD_NEK2_1	125	130	PF00069	0.386
MOD_NEK2_1	287	292	PF00069	0.554
MOD_NMyristoyl	1	7	PF02799	0.608
MOD_PIKK_1	117	123	PF00454	0.529
MOD_PIKK_1	249	255	PF00454	0.391
MOD_PIKK_1	4	10	PF00454	0.714
MOD_PKA_1	174	180	PF00069	0.550
MOD_Plk_1	109	115	PF00069	0.432
MOD_Plk_1	188	194	PF00069	0.424
MOD_Plk_1	228	234	PF00069	0.469
MOD_Plk_1	235	241	PF00069	0.368
MOD_Plk_2-3	181	187	PF00069	0.556
MOD_Plk_2-3	228	234	PF00069	0.547
MOD_Plk_2-3	236	242	PF00069	0.428
MOD_Plk_4	112	118	PF00069	0.535
MOD_Plk_4	121	127	PF00069	0.496
MOD_Plk_4	341	347	PF00069	0.321
MOD_ProDKin_1	57	63	PF00069	0.688
MOD_SUMO_for_1	158	161	PF00179	0.481
MOD_SUMO_for_1	163	166	PF00179	0.466
TRG_ER_diArg_1	213	216	PF00400	0.528
TRG_ER_diArg_1	248	250	PF00400	0.436
TRG_NLS_MonoExtN_4	245	251	PF00514	0.453
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI8	Leptomonas seymouri	73%	98%
A0A0S4JNW6	Bodo saltans	36%	94%
A0A1X0P805	Trypanosomatidae	59%	97%
A0A3S7WV37	Leishmania donovani	93%	99%
A0A422P0Q0	Trypanosoma rangeli	54%	100%
A4H9M5	Leishmania braziliensis	80%	100%
A4HXY9	Leishmania infantum	93%	98%
D0A5B8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ARQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BNN3	Trypanosoma cruzi	54%	100%