Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex 1 protein (LYR family), putative

Species:

Leishmania major

UniProt:

Q4QDS2_LEIMA

TriTrypDb:

LmjF.18.1200 , LMJLV39_180017600 , LMJSD75_180017800

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QDS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDS2

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0022607	cellular component assembly	4	5
GO:0033108	mitochondrial respiratory chain complex assembly	6	5
GO:0034552	respiratory chain complex II assembly	6	5
GO:0034553	mitochondrial respiratory chain complex II assembly	7	5
GO:0043933	protein-containing complex organization	4	5
GO:0065003	protein-containing complex assembly	5	5
GO:0071840	cellular component organization or biogenesis	2	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.572
CLV_NRD_NRD_1	159	161	PF00675	0.706
CLV_NRD_NRD_1	191	193	PF00675	0.635
CLV_NRD_NRD_1	219	221	PF00675	0.411
CLV_NRD_NRD_1	237	239	PF00675	0.183
CLV_NRD_NRD_1	252	254	PF00675	0.411
CLV_NRD_NRD_1	46	48	PF00675	0.737
CLV_PCSK_FUR_1	12	16	PF00082	0.793
CLV_PCSK_KEX2_1	128	130	PF00082	0.572
CLV_PCSK_KEX2_1	14	16	PF00082	0.681
CLV_PCSK_KEX2_1	158	160	PF00082	0.712
CLV_PCSK_KEX2_1	191	193	PF00082	0.635
CLV_PCSK_KEX2_1	219	221	PF00082	0.411
CLV_PCSK_KEX2_1	252	254	PF00082	0.411
CLV_PCSK_KEX2_1	46	48	PF00082	0.737
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.789
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.411
CLV_PCSK_SKI1_1	204	208	PF00082	0.411
DEG_APCC_DBOX_1	203	211	PF00400	0.411
DEG_Nend_UBRbox_1	1	4	PF02207	0.636
DEG_SCF_FBW7_1	175	181	PF00400	0.688
DEG_SPOP_SBC_1	131	135	PF00917	0.733
DEG_SPOP_SBC_1	67	71	PF00917	0.682
DOC_CKS1_1	175	180	PF01111	0.658
DOC_MAPK_gen_1	238	244	PF00069	0.372
DOC_MAPK_gen_1	32	40	PF00069	0.715
DOC_PP1_RVXF_1	241	247	PF00149	0.411
DOC_PP2B_LxvP_1	65	68	PF13499	0.755
DOC_USP7_MATH_1	118	122	PF00917	0.794
DOC_USP7_MATH_1	127	131	PF00917	0.715
DOC_USP7_MATH_1	138	142	PF00917	0.699
DOC_USP7_MATH_1	184	188	PF00917	0.696
DOC_USP7_MATH_1	190	194	PF00917	0.550
DOC_USP7_MATH_1	68	72	PF00917	0.591
DOC_USP7_UBL2_3	14	18	PF12436	0.789
DOC_USP7_UBL2_3	239	243	PF12436	0.411
DOC_WW_Pin1_4	121	126	PF00397	0.645
DOC_WW_Pin1_4	132	137	PF00397	0.706
DOC_WW_Pin1_4	174	179	PF00397	0.686
DOC_WW_Pin1_4	186	191	PF00397	0.641
DOC_WW_Pin1_4	52	57	PF00397	0.649
LIG_14-3-3_CanoR_1	128	132	PF00244	0.684
LIG_14-3-3_CanoR_1	219	223	PF00244	0.409
LIG_Actin_WH2_2	195	210	PF00022	0.422
LIG_APCC_ABBAyCdc20_2	162	168	PF00400	0.520
LIG_APCC_ABBAyCdc20_2	47	53	PF00400	0.699
LIG_FHA_1	73	79	PF00498	0.648
LIG_FHA_2	144	150	PF00498	0.697
LIG_GBD_Chelix_1	87	95	PF00786	0.718
LIG_PCNA_yPIPBox_3	191	203	PF02747	0.534
LIG_Pex14_1	246	250	PF04695	0.411
LIG_RPA_C_Fungi	215	227	PF08784	0.512
LIG_SH2_STAT3	225	228	PF00017	0.494
LIG_SH2_STAT3	230	233	PF00017	0.432
LIG_SH2_STAT3	39	42	PF00017	0.637
LIG_SH2_STAT5	225	228	PF00017	0.407
LIG_SH2_STAT5	39	42	PF00017	0.663
LIG_SH3_1	169	175	PF00018	0.685
LIG_SH3_1	176	182	PF00018	0.536
LIG_SH3_3	169	175	PF00018	0.699
LIG_SH3_3	176	182	PF00018	0.578
LIG_SH3_3	35	41	PF00018	0.664
LIG_SH3_3	53	59	PF00018	0.607
MOD_CDC14_SPxK_1	189	192	PF00782	0.703
MOD_CDK_SPK_2	186	191	PF00069	0.741
MOD_CDK_SPxK_1	186	192	PF00069	0.731
MOD_CDK_SPxxK_3	121	128	PF00069	0.659
MOD_CK1_1	121	127	PF00069	0.781
MOD_CK1_1	130	136	PF00069	0.646
MOD_CK1_1	262	268	PF00069	0.650
MOD_CK1_1	69	75	PF00069	0.693
MOD_CK1_1	86	92	PF00069	0.527
MOD_CK2_1	143	149	PF00069	0.807
MOD_Cter_Amidation	250	253	PF01082	0.394
MOD_GlcNHglycan	116	119	PF01048	0.673
MOD_GlcNHglycan	140	143	PF01048	0.734
MOD_GlcNHglycan	186	189	PF01048	0.668
MOD_GlcNHglycan	192	195	PF01048	0.577
MOD_GlcNHglycan	222	225	PF01048	0.512
MOD_GSK3_1	100	107	PF00069	0.725
MOD_GSK3_1	110	117	PF00069	0.644
MOD_GSK3_1	127	134	PF00069	0.712
MOD_GSK3_1	143	150	PF00069	0.742
MOD_GSK3_1	174	181	PF00069	0.738
MOD_GSK3_1	182	189	PF00069	0.777
MOD_GSK3_1	198	205	PF00069	0.367
MOD_GSK3_1	68	75	PF00069	0.703
MOD_GSK3_1	82	89	PF00069	0.708
MOD_NEK2_1	5	10	PF00069	0.660
MOD_PIKK_1	58	64	PF00454	0.701
MOD_PKA_2	127	133	PF00069	0.608
MOD_PKA_2	190	196	PF00069	0.618
MOD_PKA_2	218	224	PF00069	0.409
MOD_Plk_1	147	153	PF00069	0.781
MOD_Plk_1	208	214	PF00069	0.515
MOD_Plk_4	198	204	PF00069	0.411
MOD_ProDKin_1	121	127	PF00069	0.646
MOD_ProDKin_1	132	138	PF00069	0.705
MOD_ProDKin_1	174	180	PF00069	0.686
MOD_ProDKin_1	186	192	PF00069	0.630
MOD_ProDKin_1	52	58	PF00069	0.651
MOD_SUMO_for_1	242	245	PF00179	0.372
TRG_ENDOCYTIC_2	203	206	PF00928	0.404
TRG_ER_diArg_1	157	160	PF00400	0.708
TRG_ER_diArg_1	190	192	PF00400	0.662
TRG_ER_diArg_1	45	47	PF00400	0.730
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U5	Leptomonas seymouri	50%	99%
A0A3Q8IJR9	Leishmania donovani	89%	100%
A4H9N0	Leishmania braziliensis	70%	70%
A4HXZ4	Leishmania infantum	89%	100%
E9ARQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%