SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QDR9_LEIMA

TriTrypDb:

LmjF.18.1230 , LMJLV39_180017900 , LMJSD75_180018200

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.617
CLV_C14_Caspase3-7	332	336	PF00656	0.478
CLV_C14_Caspase3-7	438	442	PF00656	0.521
CLV_C14_Caspase3-7	46	50	PF00656	0.568
CLV_C14_Caspase3-7	477	481	PF00656	0.575
CLV_NRD_NRD_1	2	4	PF00675	0.560
CLV_NRD_NRD_1	499	501	PF00675	0.633
CLV_NRD_NRD_1	506	508	PF00675	0.562
CLV_NRD_NRD_1	558	560	PF00675	0.590
CLV_NRD_NRD_1	606	608	PF00675	0.415
CLV_NRD_NRD_1	95	97	PF00675	0.489
CLV_PCSK_KEX2_1	2	4	PF00082	0.625
CLV_PCSK_KEX2_1	501	503	PF00082	0.675
CLV_PCSK_KEX2_1	506	508	PF00082	0.642
CLV_PCSK_KEX2_1	558	560	PF00082	0.590
CLV_PCSK_KEX2_1	606	608	PF00082	0.415
CLV_PCSK_KEX2_1	97	99	PF00082	0.471
CLV_PCSK_PC1ET2_1	501	503	PF00082	0.621
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.365
CLV_PCSK_PC7_1	502	508	PF00082	0.658
CLV_PCSK_SKI1_1	524	528	PF00082	0.624
CLV_PCSK_SKI1_1	54	58	PF00082	0.505
CLV_Separin_Metazoa	521	525	PF03568	0.611
DEG_APCC_DBOX_1	179	187	PF00400	0.432
DEG_Nend_UBRbox_1	1	4	PF02207	0.658
DEG_SPOP_SBC_1	115	119	PF00917	0.531
DEG_SPOP_SBC_1	171	175	PF00917	0.575
DEG_SPOP_SBC_1	404	408	PF00917	0.474
DOC_CKS1_1	568	573	PF01111	0.499
DOC_CYCLIN_RxL_1	313	323	PF00134	0.521
DOC_CYCLIN_RxL_1	521	531	PF00134	0.608
DOC_CYCLIN_yCln2_LP_2	452	458	PF00134	0.454
DOC_MAPK_DCC_7	197	205	PF00069	0.345
DOC_MAPK_gen_1	180	188	PF00069	0.449
DOC_MAPK_MEF2A_6	197	206	PF00069	0.264
DOC_PP1_RVXF_1	70	77	PF00149	0.459
DOC_PP4_FxxP_1	266	269	PF00568	0.454
DOC_PP4_FxxP_1	583	586	PF00568	0.454
DOC_USP7_MATH_1	116	120	PF00917	0.606
DOC_USP7_MATH_1	132	136	PF00917	0.563
DOC_USP7_MATH_1	159	163	PF00917	0.772
DOC_USP7_MATH_1	167	171	PF00917	0.681
DOC_USP7_MATH_1	192	196	PF00917	0.466
DOC_USP7_MATH_1	222	226	PF00917	0.664
DOC_USP7_MATH_1	476	480	PF00917	0.589
DOC_USP7_MATH_1	491	495	PF00917	0.547
DOC_USP7_MATH_1	552	556	PF00917	0.511
DOC_WW_Pin1_4	155	160	PF00397	0.693
DOC_WW_Pin1_4	198	203	PF00397	0.329
DOC_WW_Pin1_4	212	217	PF00397	0.517
DOC_WW_Pin1_4	218	223	PF00397	0.520
DOC_WW_Pin1_4	358	363	PF00397	0.481
DOC_WW_Pin1_4	416	421	PF00397	0.507
DOC_WW_Pin1_4	489	494	PF00397	0.785
DOC_WW_Pin1_4	509	514	PF00397	0.688
DOC_WW_Pin1_4	567	572	PF00397	0.513
LIG_14-3-3_CanoR_1	234	239	PF00244	0.450
LIG_14-3-3_CanoR_1	331	340	PF00244	0.471
LIG_14-3-3_CanoR_1	403	413	PF00244	0.538
LIG_14-3-3_CanoR_1	54	64	PF00244	0.489
LIG_14-3-3_CanoR_1	611	615	PF00244	0.503
LIG_14-3-3_CanoR_1	96	106	PF00244	0.485
LIG_BIR_III_4	354	358	PF00653	0.474
LIG_BRCT_BRCA1_1	172	176	PF00533	0.545
LIG_BRCT_BRCA1_1	194	198	PF00533	0.284
LIG_BRCT_BRCA1_1	611	615	PF00533	0.503
LIG_EVH1_1	112	116	PF00568	0.603
LIG_FHA_1	115	121	PF00498	0.666
LIG_FHA_1	245	251	PF00498	0.470
LIG_FHA_1	259	265	PF00498	0.466
LIG_FHA_1	271	277	PF00498	0.482
LIG_FHA_1	321	327	PF00498	0.515
LIG_FHA_1	404	410	PF00498	0.509
LIG_FHA_1	552	558	PF00498	0.671
LIG_FHA_2	234	240	PF00498	0.496
LIG_FHA_2	320	326	PF00498	0.555
LIG_FHA_2	330	336	PF00498	0.456
LIG_FHA_2	64	70	PF00498	0.487
LIG_LIR_Apic_2	100	106	PF02991	0.563
LIG_LIR_Apic_2	175	181	PF02991	0.500
LIG_LIR_Gen_1	138	149	PF02991	0.539
LIG_LIR_Gen_1	173	183	PF02991	0.470
LIG_LIR_Gen_1	278	287	PF02991	0.509
LIG_LIR_Nem_3	138	144	PF02991	0.498
LIG_LIR_Nem_3	173	179	PF02991	0.490
LIG_LIR_Nem_3	278	283	PF02991	0.509
LIG_LIR_Nem_3	450	456	PF02991	0.544
LIG_LIR_Nem_3	612	618	PF02991	0.522
LIG_MYND_1	109	113	PF01753	0.525
LIG_NRBOX	439	445	PF00104	0.509
LIG_PTB_Apo_2	420	427	PF02174	0.521
LIG_PTB_Phospho_1	420	426	PF10480	0.521
LIG_REV1ctd_RIR_1	367	375	PF16727	0.405
LIG_REV1ctd_RIR_1	74	83	PF16727	0.388
LIG_SH2_NCK_1	27	31	PF00017	0.503
LIG_SH2_NCK_1	426	430	PF00017	0.454
LIG_SH2_NCK_1	475	479	PF00017	0.402
LIG_SH2_PTP2	456	459	PF00017	0.521
LIG_SH2_SRC	456	459	PF00017	0.509
LIG_SH2_STAP1	304	308	PF00017	0.521
LIG_SH2_STAP1	392	396	PF00017	0.454
LIG_SH2_STAT3	591	594	PF00017	0.481
LIG_SH2_STAT5	307	310	PF00017	0.460
LIG_SH2_STAT5	382	385	PF00017	0.504
LIG_SH2_STAT5	426	429	PF00017	0.454
LIG_SH2_STAT5	456	459	PF00017	0.479
LIG_SH3_3	103	109	PF00018	0.604
LIG_SH3_3	110	116	PF00018	0.601
LIG_SH3_3	210	216	PF00018	0.464
LIG_SH3_3	294	300	PF00018	0.513
LIG_SH3_3	339	345	PF00018	0.566
LIG_SH3_3	565	571	PF00018	0.533
LIG_SH3_3	58	64	PF00018	0.471
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.443
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.415
LIG_SUMO_SIM_par_1	201	207	PF11976	0.393
LIG_SUMO_SIM_par_1	209	215	PF11976	0.491
LIG_TRAF2_1	237	240	PF00917	0.518
LIG_TRAF2_1	66	69	PF00917	0.556
LIG_TYR_ITSM	276	283	PF00017	0.509
LIG_UBA3_1	409	415	PF00899	0.479
LIG_WRC_WIRS_1	276	281	PF05994	0.479
LIG_WRC_WIRS_1	366	371	PF05994	0.521
LIG_WW_3	215	219	PF00397	0.501
MOD_CDC14_SPxK_1	215	218	PF00782	0.416
MOD_CDK_SPxK_1	212	218	PF00069	0.405
MOD_CDK_SPxxK_3	567	574	PF00069	0.503
MOD_CK1_1	118	124	PF00069	0.800
MOD_CK1_1	135	141	PF00069	0.476
MOD_CK1_1	170	176	PF00069	0.522
MOD_CK1_1	258	264	PF00069	0.486
MOD_CK1_1	365	371	PF00069	0.511
MOD_CK1_1	492	498	PF00069	0.789
MOD_CK2_1	233	239	PF00069	0.526
MOD_CK2_1	385	391	PF00069	0.454
MOD_CK2_1	63	69	PF00069	0.554
MOD_DYRK1A_RPxSP_1	218	222	PF00069	0.461
MOD_GlcNHglycan	134	137	PF01048	0.592
MOD_GlcNHglycan	152	155	PF01048	0.560
MOD_GlcNHglycan	162	165	PF01048	0.688
MOD_GlcNHglycan	169	172	PF01048	0.521
MOD_GlcNHglycan	190	193	PF01048	0.436
MOD_GlcNHglycan	224	227	PF01048	0.679
MOD_GlcNHglycan	291	294	PF01048	0.331
MOD_GlcNHglycan	3	6	PF01048	0.547
MOD_GlcNHglycan	335	339	PF01048	0.379
MOD_GlcNHglycan	353	358	PF01048	0.372
MOD_GlcNHglycan	379	382	PF01048	0.223
MOD_GlcNHglycan	476	479	PF01048	0.505
MOD_GlcNHglycan	509	512	PF01048	0.682
MOD_GlcNHglycan	543	546	PF01048	0.607
MOD_GlcNHglycan	591	594	PF01048	0.449
MOD_GSK3_1	114	121	PF00069	0.652
MOD_GSK3_1	135	142	PF00069	0.551
MOD_GSK3_1	155	162	PF00069	0.751
MOD_GSK3_1	167	174	PF00069	0.533
MOD_GSK3_1	188	195	PF00069	0.342
MOD_GSK3_1	218	225	PF00069	0.707
MOD_GSK3_1	229	236	PF00069	0.546
MOD_GSK3_1	308	315	PF00069	0.486
MOD_GSK3_1	330	337	PF00069	0.544
MOD_GSK3_1	358	365	PF00069	0.565
MOD_GSK3_1	394	401	PF00069	0.454
MOD_GSK3_1	489	496	PF00069	0.565
MOD_N-GLC_1	416	421	PF02516	0.279
MOD_NEK2_1	1	6	PF00069	0.576
MOD_NEK2_1	120	125	PF00069	0.656
MOD_NEK2_1	204	209	PF00069	0.458
MOD_NEK2_1	255	260	PF00069	0.482
MOD_NEK2_1	308	313	PF00069	0.458
MOD_NEK2_1	329	334	PF00069	0.474
MOD_NEK2_1	398	403	PF00069	0.454
MOD_NEK2_1	610	615	PF00069	0.506
MOD_NEK2_1	7	12	PF00069	0.450
MOD_NEK2_2	192	197	PF00069	0.497
MOD_NEK2_2	275	280	PF00069	0.479
MOD_PIKK_1	120	126	PF00454	0.675
MOD_PIKK_1	29	35	PF00454	0.391
MOD_PIKK_1	552	558	PF00454	0.573
MOD_PIKK_1	97	103	PF00454	0.568
MOD_PKA_1	96	102	PF00069	0.373
MOD_PKA_2	1	7	PF00069	0.610
MOD_PKA_2	233	239	PF00069	0.461
MOD_PKA_2	330	336	PF00069	0.500
MOD_PKA_2	385	391	PF00069	0.467
MOD_PKA_2	610	616	PF00069	0.506
MOD_PKA_2	97	103	PF00069	0.452
MOD_Plk_1	239	245	PF00069	0.467
MOD_Plk_1	430	436	PF00069	0.479
MOD_Plk_1	469	475	PF00069	0.454
MOD_Plk_4	107	113	PF00069	0.592
MOD_Plk_4	172	178	PF00069	0.483
MOD_Plk_4	275	281	PF00069	0.462
MOD_Plk_4	303	309	PF00069	0.487
MOD_Plk_4	362	368	PF00069	0.519
MOD_Plk_4	394	400	PF00069	0.474
MOD_Plk_4	405	411	PF00069	0.454
MOD_Plk_4	573	579	PF00069	0.423
MOD_Plk_4	610	616	PF00069	0.585
MOD_Plk_4	7	13	PF00069	0.454
MOD_ProDKin_1	155	161	PF00069	0.692
MOD_ProDKin_1	198	204	PF00069	0.326
MOD_ProDKin_1	212	218	PF00069	0.527
MOD_ProDKin_1	358	364	PF00069	0.481
MOD_ProDKin_1	416	422	PF00069	0.507
MOD_ProDKin_1	489	495	PF00069	0.785
MOD_ProDKin_1	509	515	PF00069	0.685
MOD_ProDKin_1	567	573	PF00069	0.506
MOD_SUMO_rev_2	567	576	PF00179	0.491
TRG_DiLeu_BaEn_1	107	112	PF01217	0.521
TRG_DiLeu_BaEn_1	598	603	PF01217	0.510
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.383
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.483
TRG_ENDOCYTIC_2	280	283	PF00928	0.509
TRG_ENDOCYTIC_2	425	428	PF00928	0.483
TRG_ENDOCYTIC_2	456	459	PF00928	0.484
TRG_ER_diArg_1	1	3	PF00400	0.579
TRG_ER_diArg_1	179	182	PF00400	0.455
TRG_ER_diArg_1	383	386	PF00400	0.479
TRG_ER_diArg_1	557	559	PF00400	0.583
TRG_ER_diArg_1	606	608	PF00400	0.440
TRG_ER_diArg_1	95	98	PF00400	0.413
TRG_NLS_MonoExtN_4	498	504	PF00514	0.620
TRG_NLS_MonoExtN_4	94	100	PF00514	0.428
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJT8	Leptomonas seymouri	55%	97%
A0A3S5H741	Leishmania donovani	91%	100%
A4H9N2	Leishmania braziliensis	78%	99%
A4HXZ6	Leishmania infantum	91%	100%
D0A5B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ARR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BNM7	Trypanosoma cruzi	38%	100%