Dynein assembly factor 2, axonemal homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-RNA processing PIH1/Nop17, putative

Species:

Leishmania major

UniProt:

Q4QDR8_LEIMA

TriTrypDb:

LmjF.18.1240 , LMJLV39_180018000 , LMJSD75_180018300

Length:

771

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.470
CLV_C14_Caspase3-7	309	313	PF00656	0.506
CLV_C14_Caspase3-7	375	379	PF00656	0.461
CLV_C14_Caspase3-7	486	490	PF00656	0.733
CLV_NRD_NRD_1	180	182	PF00675	0.334
CLV_NRD_NRD_1	263	265	PF00675	0.235
CLV_NRD_NRD_1	405	407	PF00675	0.303
CLV_NRD_NRD_1	479	481	PF00675	0.576
CLV_NRD_NRD_1	737	739	PF00675	0.480
CLV_NRD_NRD_1	75	77	PF00675	0.458
CLV_PCSK_KEX2_1	180	182	PF00082	0.334
CLV_PCSK_KEX2_1	263	265	PF00082	0.231
CLV_PCSK_KEX2_1	387	389	PF00082	0.217
CLV_PCSK_KEX2_1	405	407	PF00082	0.221
CLV_PCSK_KEX2_1	737	739	PF00082	0.486
CLV_PCSK_KEX2_1	75	77	PF00082	0.458
CLV_PCSK_KEX2_1	756	758	PF00082	0.432
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.284
CLV_PCSK_PC1ET2_1	756	758	PF00082	0.529
CLV_PCSK_PC7_1	383	389	PF00082	0.275
CLV_PCSK_SKI1_1	103	107	PF00082	0.486
CLV_PCSK_SKI1_1	144	148	PF00082	0.311
CLV_PCSK_SKI1_1	156	160	PF00082	0.319
CLV_PCSK_SKI1_1	455	459	PF00082	0.243
CLV_PCSK_SKI1_1	765	769	PF00082	0.470
DEG_SCF_TRCP1_1	629	635	PF00400	0.576
DEG_SPOP_SBC_1	323	327	PF00917	0.692
DEG_SPOP_SBC_1	331	335	PF00917	0.788
DEG_SPOP_SBC_1	358	362	PF00917	0.504
DOC_CKS1_1	272	277	PF01111	0.428
DOC_CYCLIN_yCln2_LP_2	436	442	PF00134	0.507
DOC_MAPK_FxFP_2	99	102	PF00069	0.299
DOC_MAPK_gen_1	405	412	PF00069	0.515
DOC_MAPK_gen_1	754	762	PF00069	0.492
DOC_MAPK_MEF2A_6	405	414	PF00069	0.481
DOC_MAPK_MEF2A_6	431	440	PF00069	0.519
DOC_MAPK_MEF2A_6	455	464	PF00069	0.423
DOC_MAPK_NFAT4_5	455	463	PF00069	0.417
DOC_PP1_RVXF_1	218	225	PF00149	0.563
DOC_PP1_RVXF_1	396	402	PF00149	0.445
DOC_PP2B_LxvP_1	436	439	PF13499	0.507
DOC_PP2B_LxvP_1	624	627	PF13499	0.592
DOC_PP4_FxxP_1	99	102	PF00568	0.299
DOC_USP7_MATH_1	166	170	PF00917	0.505
DOC_USP7_MATH_1	17	21	PF00917	0.755
DOC_USP7_MATH_1	187	191	PF00917	0.651
DOC_USP7_MATH_1	192	196	PF00917	0.671
DOC_USP7_MATH_1	202	206	PF00917	0.644
DOC_USP7_MATH_1	207	211	PF00917	0.431
DOC_USP7_MATH_1	232	236	PF00917	0.412
DOC_USP7_MATH_1	332	336	PF00917	0.765
DOC_USP7_MATH_1	351	355	PF00917	0.636
DOC_USP7_MATH_1	358	362	PF00917	0.549
DOC_USP7_MATH_1	502	506	PF00917	0.650
DOC_USP7_MATH_1	561	565	PF00917	0.706
DOC_USP7_MATH_1	609	613	PF00917	0.729
DOC_USP7_MATH_1	627	631	PF00917	0.688
DOC_USP7_MATH_1	642	646	PF00917	0.666
DOC_USP7_MATH_1	647	651	PF00917	0.740
DOC_USP7_MATH_1	683	687	PF00917	0.485
DOC_USP7_MATH_2	425	431	PF00917	0.439
DOC_USP7_UBL2_3	634	638	PF12436	0.534
DOC_USP7_UBL2_3	671	675	PF12436	0.530
DOC_USP7_UBL2_3	735	739	PF12436	0.553
DOC_WW_Pin1_4	188	193	PF00397	0.661
DOC_WW_Pin1_4	210	215	PF00397	0.552
DOC_WW_Pin1_4	271	276	PF00397	0.451
DOC_WW_Pin1_4	286	291	PF00397	0.522
DOC_WW_Pin1_4	318	323	PF00397	0.692
DOC_WW_Pin1_4	354	359	PF00397	0.630
DOC_WW_Pin1_4	39	44	PF00397	0.455
DOC_WW_Pin1_4	412	417	PF00397	0.475
DOC_WW_Pin1_4	509	514	PF00397	0.804
DOC_WW_Pin1_4	515	520	PF00397	0.613
DOC_WW_Pin1_4	533	538	PF00397	0.682
DOC_WW_Pin1_4	542	547	PF00397	0.609
LIG_14-3-3_CanoR_1	359	364	PF00244	0.615
LIG_14-3-3_CanoR_1	383	391	PF00244	0.527
LIG_14-3-3_CanoR_1	455	461	PF00244	0.464
LIG_14-3-3_CanoR_1	480	484	PF00244	0.620
LIG_Actin_WH2_2	466	482	PF00022	0.526
LIG_APCC_ABBAyCdc20_2	54	60	PF00400	0.530
LIG_BIR_III_4	165	169	PF00653	0.439
LIG_BRCT_BRCA1_1	234	238	PF00533	0.417
LIG_BRCT_BRCA1_1	256	260	PF00533	0.484
LIG_BRCT_BRCA1_1	95	99	PF00533	0.394
LIG_CtBP_PxDLS_1	43	47	PF00389	0.444
LIG_deltaCOP1_diTrp_1	378	382	PF00928	0.417
LIG_EH1_1	574	582	PF00400	0.471
LIG_FHA_1	191	197	PF00498	0.528
LIG_FHA_1	226	232	PF00498	0.425
LIG_FHA_1	358	364	PF00498	0.526
LIG_FHA_1	457	463	PF00498	0.432
LIG_FHA_1	674	680	PF00498	0.623
LIG_FHA_2	160	166	PF00498	0.454
LIG_FHA_2	307	313	PF00498	0.653
LIG_FHA_2	40	46	PF00498	0.437
LIG_FHA_2	439	445	PF00498	0.473
LIG_FHA_2	539	545	PF00498	0.629
LIG_FHA_2	597	603	PF00498	0.589
LIG_FHA_2	659	665	PF00498	0.563
LIG_FHA_2	703	709	PF00498	0.464
LIG_FHA_2	72	78	PF00498	0.427
LIG_LIR_Apic_2	169	174	PF02991	0.418
LIG_LIR_Apic_2	96	102	PF02991	0.328
LIG_LIR_Gen_1	235	246	PF02991	0.426
LIG_LIR_Gen_1	55	66	PF02991	0.396
LIG_LIR_Gen_1	94	105	PF02991	0.342
LIG_LIR_Nem_3	183	188	PF02991	0.507
LIG_LIR_Nem_3	235	241	PF02991	0.426
LIG_LIR_Nem_3	304	310	PF02991	0.541
LIG_LIR_Nem_3	400	404	PF02991	0.421
LIG_LIR_Nem_3	430	435	PF02991	0.489
LIG_LIR_Nem_3	55	61	PF02991	0.418
LIG_LIR_Nem_3	94	100	PF02991	0.357
LIG_PCNA_yPIPBox_3	574	588	PF02747	0.508
LIG_Pex14_2	95	99	PF04695	0.370
LIG_RPA_C_Fungi	586	598	PF08784	0.558
LIG_RPA_C_Fungi	712	724	PF08784	0.490
LIG_SH2_CRK	185	189	PF00017	0.593
LIG_SH2_SRC	185	188	PF00017	0.516
LIG_SH2_STAT3	81	84	PF00017	0.431
LIG_SH2_STAT5	366	369	PF00017	0.349
LIG_SH2_STAT5	766	769	PF00017	0.567
LIG_SH2_STAT5	81	84	PF00017	0.443
LIG_SH3_3	220	226	PF00018	0.262
LIG_SH3_3	292	298	PF00018	0.591
LIG_SH3_3	386	392	PF00018	0.315
LIG_SH3_3	461	467	PF00018	0.255
LIG_SH3_3	504	510	PF00018	0.654
LIG_SH3_3	511	517	PF00018	0.632
LIG_SH3_3	547	553	PF00018	0.655
LIG_SUMO_SIM_anti_2	433	439	PF11976	0.335
LIG_SUMO_SIM_par_1	106	112	PF11976	0.335
LIG_SUMO_SIM_par_1	172	178	PF11976	0.258
LIG_SUMO_SIM_par_1	227	233	PF11976	0.373
LIG_SUMO_SIM_par_1	267	274	PF11976	0.400
LIG_SUMO_SIM_par_1	408	413	PF11976	0.185
LIG_SUMO_SIM_par_1	456	461	PF11976	0.349
LIG_SUMO_SIM_par_1	650	656	PF11976	0.482
LIG_TRAF2_1	42	45	PF00917	0.429
LIG_TRAF2_1	441	444	PF00917	0.356
LIG_TRAF2_1	657	660	PF00917	0.633
LIG_TRAF2_1	661	664	PF00917	0.645
LIG_TRAF2_1	686	689	PF00917	0.573
LIG_TRAF2_1	716	719	PF00917	0.501
LIG_TRAF2_1	725	728	PF00917	0.438
LIG_WW_2	467	470	PF00397	0.608
MOD_CDK_SPK_2	354	359	PF00069	0.577
MOD_CK1_1	131	137	PF00069	0.634
MOD_CK1_1	190	196	PF00069	0.622
MOD_CK1_1	205	211	PF00069	0.601
MOD_CK1_1	212	218	PF00069	0.385
MOD_CK1_1	268	274	PF00069	0.332
MOD_CK1_1	313	319	PF00069	0.662
MOD_CK1_1	325	331	PF00069	0.665
MOD_CK1_1	334	340	PF00069	0.699
MOD_CK1_1	354	360	PF00069	0.658
MOD_CK1_1	536	542	PF00069	0.681
MOD_CK1_1	632	638	PF00069	0.717
MOD_CK2_1	116	122	PF00069	0.534
MOD_CK2_1	166	172	PF00069	0.358
MOD_CK2_1	39	45	PF00069	0.449
MOD_CK2_1	427	433	PF00069	0.377
MOD_CK2_1	438	444	PF00069	0.257
MOD_CK2_1	538	544	PF00069	0.695
MOD_CK2_1	561	567	PF00069	0.662
MOD_CK2_1	627	633	PF00069	0.716
MOD_CK2_1	658	664	PF00069	0.576
MOD_CK2_1	683	689	PF00069	0.589
MOD_CK2_1	702	708	PF00069	0.278
MOD_CK2_1	71	77	PF00069	0.439
MOD_DYRK1A_RPxSP_1	542	546	PF00069	0.736
MOD_GlcNHglycan	118	121	PF01048	0.557
MOD_GlcNHglycan	129	133	PF01048	0.647
MOD_GlcNHglycan	14	17	PF01048	0.727
MOD_GlcNHglycan	140	143	PF01048	0.379
MOD_GlcNHglycan	20	23	PF01048	0.726
MOD_GlcNHglycan	207	210	PF01048	0.609
MOD_GlcNHglycan	26	29	PF01048	0.701
MOD_GlcNHglycan	317	320	PF01048	0.658
MOD_GlcNHglycan	327	330	PF01048	0.600
MOD_GlcNHglycan	334	337	PF01048	0.642
MOD_GlcNHglycan	353	356	PF01048	0.769
MOD_GlcNHglycan	474	477	PF01048	0.573
MOD_GlcNHglycan	563	566	PF01048	0.716
MOD_GlcNHglycan	610	614	PF01048	0.606
MOD_GlcNHglycan	617	620	PF01048	0.533
MOD_GlcNHglycan	629	632	PF01048	0.680
MOD_GlcNHglycan	633	637	PF01048	0.636
MOD_GlcNHglycan	649	652	PF01048	0.707
MOD_GSK3_1	156	163	PF00069	0.322
MOD_GSK3_1	188	195	PF00069	0.629
MOD_GSK3_1	205	212	PF00069	0.470
MOD_GSK3_1	264	271	PF00069	0.315
MOD_GSK3_1	276	283	PF00069	0.301
MOD_GSK3_1	306	313	PF00069	0.631
MOD_GSK3_1	318	325	PF00069	0.679
MOD_GSK3_1	330	337	PF00069	0.650
MOD_GSK3_1	354	361	PF00069	0.608
MOD_GSK3_1	366	373	PF00069	0.412
MOD_GSK3_1	423	430	PF00069	0.329
MOD_GSK3_1	496	503	PF00069	0.674
MOD_GSK3_1	538	545	PF00069	0.685
MOD_GSK3_1	555	562	PF00069	0.655
MOD_GSK3_1	625	632	PF00069	0.730
MOD_GSK3_1	643	650	PF00069	0.594
MOD_GSK3_1	673	680	PF00069	0.599
MOD_GSK3_1	702	709	PF00069	0.315
MOD_GSK3_1	756	763	PF00069	0.573
MOD_N-GLC_1	276	281	PF02516	0.255
MOD_N-GLC_1	313	318	PF02516	0.539
MOD_N-GLC_2	148	150	PF02516	0.255
MOD_NEK2_1	128	133	PF00069	0.541
MOD_NEK2_1	410	415	PF00069	0.225
MOD_NEK2_1	451	456	PF00069	0.407
MOD_NEK2_1	458	463	PF00069	0.316
MOD_NEK2_1	479	484	PF00069	0.571
MOD_NEK2_1	653	658	PF00069	0.724
MOD_PIKK_1	175	181	PF00454	0.349
MOD_PIKK_1	334	340	PF00454	0.614
MOD_PIKK_1	496	502	PF00454	0.759
MOD_PIKK_1	659	665	PF00454	0.719
MOD_PKA_1	756	762	PF00069	0.553
MOD_PKA_2	166	172	PF00069	0.396
MOD_PKA_2	233	239	PF00069	0.285
MOD_PKA_2	280	286	PF00069	0.430
MOD_PKA_2	301	307	PF00069	0.633
MOD_PKA_2	358	364	PF00069	0.604
MOD_PKA_2	370	376	PF00069	0.354
MOD_PKA_2	382	388	PF00069	0.432
MOD_PKA_2	479	485	PF00069	0.591
MOD_PKA_2	747	753	PF00069	0.517
MOD_PKA_2	756	762	PF00069	0.491
MOD_PKB_1	10	18	PF00069	0.583
MOD_Plk_1	276	282	PF00069	0.255
MOD_Plk_1	410	416	PF00069	0.242
MOD_Plk_1	93	99	PF00069	0.376
MOD_Plk_4	265	271	PF00069	0.335
MOD_Plk_4	702	708	PF00069	0.314
MOD_ProDKin_1	188	194	PF00069	0.660
MOD_ProDKin_1	210	216	PF00069	0.536
MOD_ProDKin_1	271	277	PF00069	0.303
MOD_ProDKin_1	286	292	PF00069	0.515
MOD_ProDKin_1	318	324	PF00069	0.692
MOD_ProDKin_1	354	360	PF00069	0.627
MOD_ProDKin_1	39	45	PF00069	0.449
MOD_ProDKin_1	412	418	PF00069	0.335
MOD_ProDKin_1	509	515	PF00069	0.805
MOD_ProDKin_1	533	539	PF00069	0.682
MOD_ProDKin_1	542	548	PF00069	0.612
MOD_SUMO_rev_2	119	126	PF00179	0.594
TRG_DiLeu_BaEn_2	663	669	PF01217	0.621
TRG_DiLeu_BaEn_4	77	83	PF01217	0.432
TRG_ENDOCYTIC_2	185	188	PF00928	0.578
TRG_ENDOCYTIC_2	432	435	PF00928	0.349
TRG_ER_diArg_1	180	182	PF00400	0.400
TRG_ER_diArg_1	262	264	PF00400	0.270
TRG_ER_diArg_1	404	406	PF00400	0.366
TRG_ER_diArg_1	696	699	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3H0	Leptomonas seymouri	52%	96%
A0A0S4JRA4	Bodo saltans	34%	100%
A0A1X0P812	Trypanosomatidae	35%	100%
A0A3Q8IB73	Leishmania donovani	89%	100%
A0A3R7N1E2	Trypanosoma rangeli	37%	100%
A4H9N3	Leishmania braziliensis	77%	100%
A4HXZ7	Leishmania infantum	90%	100%
B4HR78	Drosophila sechellia	23%	92%
D0A5A8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ARR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q0E9G3	Drosophila melanogaster	22%	92%
V5AZ63	Trypanosoma cruzi	37%	100%