Homologous to animal mitochondrial 2-oxoglutarate/malate carriers.. For some reason, these genes duplicated in Leishmaniidae and other pathogenic lineages.. Localization: Mitochondrial (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 19 |
| NetGPI | no | yes: 0, no: 19 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005654 | nucleoplasm | 2 | 5 |
| GO:0005737 | cytoplasm | 2 | 5 |
| GO:0005739 | mitochondrion | 5 | 5 |
| GO:0016020 | membrane | 2 | 20 |
| GO:0020023 | kinetoplast | 2 | 5 |
| GO:0032838 | plasma membrane bounded cell projection cytoplasm | 4 | 5 |
| GO:0043226 | organelle | 2 | 5 |
| GO:0043227 | membrane-bounded organelle | 3 | 5 |
| GO:0043229 | intracellular organelle | 3 | 5 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 5 |
| GO:0097014 | ciliary plasm | 5 | 5 |
| GO:0099568 | cytoplasmic region | 3 | 5 |
| GO:0110165 | cellular anatomical entity | 1 | 20 |
Related structures:
AlphaFold database: Q4QDR6
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006810 | transport | 3 | 5 |
| GO:0006811 | monoatomic ion transport | 4 | 5 |
| GO:0006817 | phosphate ion transport | 7 | 5 |
| GO:0006820 | monoatomic anion transport | 5 | 5 |
| GO:0006835 | dicarboxylic acid transport | 7 | 5 |
| GO:0008272 | sulfate transport | 5 | 5 |
| GO:0009987 | cellular process | 1 | 5 |
| GO:0015698 | inorganic anion transport | 6 | 5 |
| GO:0015709 | thiosulfate transport | 5 | 5 |
| GO:0015711 | organic anion transport | 5 | 5 |
| GO:0015729 | oxaloacetate transport | 6 | 5 |
| GO:0015740 | C4-dicarboxylate transport | 8 | 5 |
| GO:0015743 | malate transport | 6 | 5 |
| GO:0015744 | succinate transport | 6 | 5 |
| GO:0015849 | organic acid transport | 5 | 5 |
| GO:0034220 | monoatomic ion transmembrane transport | 3 | 5 |
| GO:0035435 | phosphate ion transmembrane transport | 6 | 5 |
| GO:0046942 | carboxylic acid transport | 6 | 5 |
| GO:0051179 | localization | 1 | 5 |
| GO:0051234 | establishment of localization | 2 | 5 |
| GO:0055085 | transmembrane transport | 2 | 5 |
| GO:0071422 | succinate transmembrane transport | 5 | 5 |
| GO:0071423 | malate transmembrane transport | 5 | 5 |
| GO:0071702 | organic substance transport | 4 | 5 |
| GO:0072348 | sulfur compound transport | 4 | 5 |
| GO:0098656 | monoatomic anion transmembrane transport | 4 | 5 |
| GO:0098660 | inorganic ion transmembrane transport | 4 | 5 |
| GO:0098661 | inorganic anion transmembrane transport | 5 | 5 |
| GO:1903825 | organic acid transmembrane transport | 3 | 5 |
| GO:1905039 | carboxylic acid transmembrane transport | 4 | 5 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005215 | transporter activity | 1 | 5 |
| GO:0005310 | dicarboxylic acid transmembrane transporter activity | 5 | 5 |
| GO:0005342 | organic acid transmembrane transporter activity | 3 | 5 |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 4 | 5 |
| GO:0008514 | organic anion transmembrane transporter activity | 5 | 5 |
| GO:0015075 | monoatomic ion transmembrane transporter activity | 3 | 5 |
| GO:0015103 | inorganic anion transmembrane transporter activity | 4 | 5 |
| GO:0015116 | sulfate transmembrane transporter activity | 4 | 5 |
| GO:0015117 | thiosulfate transmembrane transporter activity | 4 | 5 |
| GO:0015131 | oxaloacetate transmembrane transporter activity | 6 | 5 |
| GO:0015140 | malate transmembrane transporter activity | 6 | 5 |
| GO:0015141 | succinate transmembrane transporter activity | 6 | 5 |
| GO:0015291 | secondary active transmembrane transporter activity | 4 | 5 |
| GO:0015297 | antiporter activity | 5 | 5 |
| GO:0015318 | inorganic molecular entity transmembrane transporter activity | 3 | 5 |
| GO:0015556 | C4-dicarboxylate transmembrane transporter activity | 6 | 5 |
| GO:0022804 | active transmembrane transporter activity | 3 | 5 |
| GO:0022857 | transmembrane transporter activity | 2 | 5 |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 4 | 5 |
| GO:1901682 | sulfur compound transmembrane transporter activity | 3 | 5 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 58 | 62 | PF00656 | 0.362 |
| CLV_C14_Caspase3-7 | 95 | 99 | PF00656 | 0.337 |
| CLV_NRD_NRD_1 | 204 | 206 | PF00675 | 0.269 |
| CLV_NRD_NRD_1 | 258 | 260 | PF00675 | 0.519 |
| CLV_NRD_NRD_1 | 67 | 69 | PF00675 | 0.559 |
| CLV_PCSK_KEX2_1 | 110 | 112 | PF00082 | 0.559 |
| CLV_PCSK_KEX2_1 | 206 | 208 | PF00082 | 0.268 |
| CLV_PCSK_KEX2_1 | 210 | 212 | PF00082 | 0.397 |
| CLV_PCSK_KEX2_1 | 258 | 260 | PF00082 | 0.532 |
| CLV_PCSK_PC1ET2_1 | 110 | 112 | PF00082 | 0.559 |
| CLV_PCSK_PC1ET2_1 | 206 | 208 | PF00082 | 0.318 |
| CLV_PCSK_PC1ET2_1 | 210 | 212 | PF00082 | 0.438 |
| CLV_PCSK_SKI1_1 | 170 | 174 | PF00082 | 0.319 |
| CLV_PCSK_SKI1_1 | 185 | 189 | PF00082 | 0.193 |
| CLV_PCSK_SKI1_1 | 207 | 211 | PF00082 | 0.434 |
| CLV_PCSK_SKI1_1 | 269 | 273 | PF00082 | 0.526 |
| DEG_APCC_DBOX_1 | 184 | 192 | PF00400 | 0.466 |
| DOC_CYCLIN_yCln2_LP_2 | 137 | 143 | PF00134 | 0.316 |
| DOC_MAPK_MEF2A_6 | 14 | 22 | PF00069 | 0.702 |
| DOC_PP4_FxxP_1 | 39 | 42 | PF00568 | 0.332 |
| DOC_USP7_MATH_1 | 126 | 130 | PF00917 | 0.368 |
| DOC_USP7_MATH_1 | 162 | 166 | PF00917 | 0.571 |
| DOC_USP7_MATH_1 | 181 | 185 | PF00917 | 0.436 |
| DOC_USP7_MATH_1 | 55 | 59 | PF00917 | 0.310 |
| DOC_USP7_UBL2_3 | 206 | 210 | PF12436 | 0.623 |
| DOC_WW_Pin1_4 | 136 | 141 | PF00397 | 0.275 |
| LIG_14-3-3_CanoR_1 | 156 | 160 | PF00244 | 0.546 |
| LIG_14-3-3_CanoR_1 | 243 | 252 | PF00244 | 0.358 |
| LIG_14-3-3_CanoR_1 | 289 | 298 | PF00244 | 0.338 |
| LIG_FHA_1 | 23 | 29 | PF00498 | 0.311 |
| LIG_FHA_1 | 234 | 240 | PF00498 | 0.259 |
| LIG_FHA_1 | 303 | 309 | PF00498 | 0.522 |
| LIG_FHA_1 | 314 | 320 | PF00498 | 0.635 |
| LIG_FHA_1 | 55 | 61 | PF00498 | 0.359 |
| LIG_FHA_1 | 85 | 91 | PF00498 | 0.320 |
| LIG_FHA_2 | 117 | 123 | PF00498 | 0.293 |
| LIG_LIR_Gen_1 | 257 | 267 | PF02991 | 0.346 |
| LIG_LIR_Nem_3 | 173 | 179 | PF02991 | 0.508 |
| LIG_LIR_Nem_3 | 228 | 234 | PF02991 | 0.307 |
| LIG_LIR_Nem_3 | 257 | 263 | PF02991 | 0.313 |
| LIG_LIR_Nem_3 | 281 | 286 | PF02991 | 0.249 |
| LIG_LRP6_Inhibitor_1 | 314 | 320 | PF00058 | 0.414 |
| LIG_Pex14_2 | 31 | 35 | PF04695 | 0.343 |
| LIG_Pex14_2 | 39 | 43 | PF04695 | 0.317 |
| LIG_Rb_pABgroove_1 | 274 | 282 | PF01858 | 0.291 |
| LIG_SH2_CRK | 232 | 236 | PF00017 | 0.298 |
| LIG_SH2_CRK | 260 | 264 | PF00017 | 0.246 |
| LIG_SH2_CRK | 72 | 76 | PF00017 | 0.331 |
| LIG_SH2_GRB2like | 260 | 263 | PF00017 | 0.296 |
| LIG_SH2_NCK_1 | 232 | 236 | PF00017 | 0.298 |
| LIG_SH2_STAP1 | 280 | 284 | PF00017 | 0.273 |
| LIG_SH2_STAT5 | 283 | 286 | PF00017 | 0.341 |
| LIG_SH2_STAT5 | 303 | 306 | PF00017 | 0.403 |
| LIG_SH2_STAT5 | 72 | 75 | PF00017 | 0.382 |
| LIG_SH2_STAT5 | 85 | 88 | PF00017 | 0.313 |
| LIG_SH3_3 | 13 | 19 | PF00018 | 0.676 |
| LIG_SH3_3 | 232 | 238 | PF00018 | 0.405 |
| LIG_TYR_ITIM | 230 | 235 | PF00017 | 0.298 |
| LIG_WRC_WIRS_1 | 133 | 138 | PF05994 | 0.375 |
| LIG_WRC_WIRS_1 | 93 | 98 | PF05994 | 0.337 |
| LIG_WW_2 | 18 | 21 | PF00397 | 0.675 |
| MOD_CK1_1 | 135 | 141 | PF00069 | 0.309 |
| MOD_CK1_1 | 225 | 231 | PF00069 | 0.323 |
| MOD_CK1_1 | 233 | 239 | PF00069 | 0.328 |
| MOD_CK2_1 | 136 | 142 | PF00069 | 0.352 |
| MOD_GlcNHglycan | 111 | 114 | PF01048 | 0.658 |
| MOD_GlcNHglycan | 128 | 131 | PF01048 | 0.208 |
| MOD_GlcNHglycan | 176 | 179 | PF01048 | 0.314 |
| MOD_GlcNHglycan | 246 | 249 | PF01048 | 0.486 |
| MOD_GlcNHglycan | 252 | 255 | PF01048 | 0.475 |
| MOD_GlcNHglycan | 28 | 31 | PF01048 | 0.220 |
| MOD_GlcNHglycan | 76 | 79 | PF01048 | 0.486 |
| MOD_GSK3_1 | 132 | 139 | PF00069 | 0.317 |
| MOD_GSK3_1 | 162 | 169 | PF00069 | 0.501 |
| MOD_GSK3_1 | 170 | 177 | PF00069 | 0.511 |
| MOD_GSK3_1 | 22 | 29 | PF00069 | 0.445 |
| MOD_GSK3_1 | 285 | 292 | PF00069 | 0.391 |
| MOD_GSK3_1 | 55 | 62 | PF00069 | 0.338 |
| MOD_GSK3_1 | 70 | 77 | PF00069 | 0.318 |
| MOD_NEK2_1 | 1 | 6 | PF00069 | 0.579 |
| MOD_NEK2_1 | 10 | 15 | PF00069 | 0.776 |
| MOD_NEK2_1 | 147 | 152 | PF00069 | 0.468 |
| MOD_NEK2_1 | 230 | 235 | PF00069 | 0.375 |
| MOD_NEK2_1 | 26 | 31 | PF00069 | 0.424 |
| MOD_NEK2_1 | 279 | 284 | PF00069 | 0.315 |
| MOD_NEK2_1 | 63 | 68 | PF00069 | 0.336 |
| MOD_NEK2_1 | 83 | 88 | PF00069 | 0.147 |
| MOD_PIKK_1 | 189 | 195 | PF00454 | 0.552 |
| MOD_PIKK_1 | 289 | 295 | PF00454 | 0.433 |
| MOD_PIKK_1 | 55 | 61 | PF00454 | 0.281 |
| MOD_PKA_2 | 155 | 161 | PF00069 | 0.562 |
| MOD_PKA_2 | 244 | 250 | PF00069 | 0.278 |
| MOD_Plk_4 | 132 | 138 | PF00069 | 0.337 |
| MOD_Plk_4 | 155 | 161 | PF00069 | 0.510 |
| MOD_Plk_4 | 162 | 168 | PF00069 | 0.510 |
| MOD_Plk_4 | 199 | 205 | PF00069 | 0.489 |
| MOD_Plk_4 | 222 | 228 | PF00069 | 0.366 |
| MOD_Plk_4 | 230 | 236 | PF00069 | 0.378 |
| MOD_Plk_4 | 279 | 285 | PF00069 | 0.282 |
| MOD_Plk_4 | 291 | 297 | PF00069 | 0.313 |
| MOD_Plk_4 | 46 | 52 | PF00069 | 0.279 |
| MOD_ProDKin_1 | 136 | 142 | PF00069 | 0.275 |
| MOD_SUMO_for_1 | 271 | 274 | PF00179 | 0.358 |
| MOD_SUMO_rev_2 | 247 | 253 | PF00179 | 0.355 |
| TRG_ENDOCYTIC_2 | 232 | 235 | PF00928 | 0.298 |
| TRG_ENDOCYTIC_2 | 260 | 263 | PF00928 | 0.246 |
| TRG_ENDOCYTIC_2 | 72 | 75 | PF00928 | 0.331 |
| TRG_ENDOCYTIC_2 | 93 | 96 | PF00928 | 0.273 |
| TRG_ER_diArg_1 | 204 | 207 | PF00400 | 0.466 |
| TRG_ER_diArg_1 | 243 | 246 | PF00400 | 0.279 |
| TRG_ER_diArg_1 | 258 | 260 | PF00400 | 0.147 |
| TRG_Pf-PMV_PEXEL_1 | 306 | 310 | PF00026 | 0.297 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P8W6 | Leptomonas seymouri | 24% | 94% |
| A0A0N1PCE4 | Leptomonas seymouri | 77% | 100% |
| A0A0S4JNY1 | Bodo saltans | 44% | 89% |
| A0A1X0P7C0 | Trypanosomatidae | 58% | 100% |
| A0A3Q8IB24 | Leishmania donovani | 97% | 100% |
| A0A3Q8IEB7 | Leishmania donovani | 92% | 100% |
| A0A3R7KWT0 | Trypanosoma rangeli | 60% | 100% |
| A0A3S5H742 | Leishmania donovani | 97% | 100% |
| A0A3S5H7M7 | Leishmania donovani | 25% | 95% |
| A0PC02 | Ochotona dauurica | 28% | 100% |
| A2ADF7 | Mus musculus | 22% | 100% |
| A3KPP4 | Danio rerio | 24% | 100% |
| A4H9N5 | Leishmania braziliensis | 85% | 100% |
| A4H9N6 | Leishmania braziliensis | 83% | 100% |
| A4HI60 | Leishmania braziliensis | 24% | 95% |
| A4HXZ9 | Leishmania infantum | 97% | 100% |
| A4HY01 | Leishmania infantum | 93% | 100% |
| A4I5D6 | Leishmania infantum | 25% | 95% |
| B0G143 | Dictyostelium discoideum | 28% | 100% |
| D0A5A6 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 56% | 100% |
| E9ARR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 92% | 100% |
| E9ARR4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 89% | 100% |
| E9B0N4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 25% | 95% |
| F1R4U0 | Danio rerio | 24% | 100% |
| F1RFX9 | Sus scrofa | 26% | 96% |
| F4HT41 | Arabidopsis thaliana | 23% | 93% |
| G5EE96 | Caenorhabditis elegans | 25% | 100% |
| K3VFR5 | Fusarium pseudograminearum (strain CS3096) | 28% | 100% |
| O13844 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 22% | 100% |
| O77792 | Bos taurus | 25% | 100% |
| O81845 | Arabidopsis thaliana | 28% | 100% |
| O89035 | Rattus norvegicus | 24% | 100% |
| O95258 | Homo sapiens | 27% | 98% |
| O95847 | Homo sapiens | 25% | 99% |
| O97562 | Sus scrofa | 26% | 100% |
| O97649 | Sus scrofa | 25% | 100% |
| P04575 | Mesocricetus auratus | 26% | 100% |
| P04633 | Rattus norvegicus | 25% | 100% |
| P0C582 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 25% | 97% |
| P10861 | Bos taurus | 28% | 100% |
| P12242 | Mus musculus | 25% | 100% |
| P14271 | Oryctolagus cuniculus | 28% | 100% |
| P22292 | Bos taurus | 26% | 100% |
| P25874 | Homo sapiens | 28% | 100% |
| P34519 | Caenorhabditis elegans | 25% | 100% |
| P40464 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 25% | 100% |
| P55851 | Homo sapiens | 25% | 100% |
| P55916 | Homo sapiens | 26% | 100% |
| P56499 | Rattus norvegicus | 26% | 100% |
| P56500 | Rattus norvegicus | 26% | 100% |
| P56501 | Mus musculus | 26% | 100% |
| P70406 | Mus musculus | 26% | 100% |
| P79110 | Bos taurus | 24% | 100% |
| P90992 | Caenorhabditis elegans | 28% | 100% |
| P97700 | Rattus norvegicus | 26% | 100% |
| Q02978 | Homo sapiens | 27% | 100% |
| Q06143 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 24% | 100% |
| Q18P97 | Suncus murinus | 25% | 100% |
| Q27257 | Caenorhabditis elegans | 25% | 100% |
| Q3SZI5 | Bos taurus | 25% | 100% |
| Q4Q7J8 | Leishmania major | 25% | 95% |
| Q4QDQ9 | Leishmania major | 95% | 100% |
| Q4QDR2 | Leishmania major | 98% | 100% |
| Q4QDR4 | Leishmania major | 99% | 100% |
| Q54BM3 | Dictyostelium discoideum | 24% | 100% |
| Q54FE6 | Dictyostelium discoideum | 24% | 100% |
| Q54FU9 | Dictyostelium discoideum | 25% | 97% |
| Q54PY7 | Dictyostelium discoideum | 25% | 100% |
| Q55GE2 | Dictyostelium discoideum | 21% | 100% |
| Q5PQM9 | Rattus norvegicus | 24% | 100% |
| Q5R5A8 | Pongo abelii | 25% | 100% |
| Q5RFB7 | Pongo abelii | 21% | 100% |
| Q5SVS4 | Homo sapiens | 23% | 100% |
| Q5SWT3 | Mus musculus | 23% | 100% |
| Q5U3V7 | Danio rerio | 22% | 93% |
| Q5XGI1 | Xenopus tropicalis | 24% | 100% |
| Q5XIF9 | Rattus norvegicus | 23% | 100% |
| Q6FTN2 | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) | 26% | 100% |
| Q6GQ22 | Xenopus laevis | 23% | 100% |
| Q6PGY3 | Danio rerio | 23% | 89% |
| Q6PIV7 | Homo sapiens | 22% | 100% |
| Q7K566 | Drosophila melanogaster | 26% | 100% |
| Q86I81 | Dictyostelium discoideum | 21% | 95% |
| Q8HXE3 | Macaca fascicularis | 24% | 100% |
| Q8K404 | Dicrostonyx groenlandicus | 26% | 100% |
| Q94AG6 | Arabidopsis thaliana | 25% | 98% |
| Q9BQT8 | Homo sapiens | 22% | 100% |
| Q9C5M0 | Arabidopsis thaliana | 24% | 100% |
| Q9CR58 | Mus musculus | 24% | 100% |
| Q9CR62 | Mus musculus | 27% | 100% |
| Q9ER18 | Phodopus sungorus | 26% | 100% |
| Q9FY68 | Arabidopsis thaliana | 24% | 95% |
| Q9GMZ1 | Canis lupus familiaris | 28% | 100% |
| Q9M038 | Arabidopsis thaliana | 22% | 100% |
| Q9N2I9 | Canis lupus familiaris | 25% | 100% |
| Q9N2J1 | Canis lupus familiaris | 25% | 100% |
| Q9QZD8 | Mus musculus | 24% | 100% |
| Q9SB52 | Arabidopsis thaliana | 27% | 100% |
| Q9SJY5 | Arabidopsis thaliana | 27% | 100% |
| Q9UBX3 | Homo sapiens | 26% | 100% |
| Q9UTN1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 22% | 100% |
| Q9VMK1 | Drosophila melanogaster | 24% | 96% |
| Q9W720 | Danio rerio | 26% | 100% |
| Q9W725 | Cyprinus carpio | 25% | 100% |
| Q9XI74 | Arabidopsis thaliana | 25% | 100% |
| Q9Z2B2 | Mus musculus | 27% | 98% |
| Q9ZWG1 | Arabidopsis thaliana | 26% | 100% |
| V5BNM4 | Trypanosoma cruzi | 61% | 98% |
| W5PSH7 | Ovis aries | 28% | 100% |