Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acetyltransferase (GNAT) family, putative

Species:

Leishmania major

UniProt:

Q4QDQ8_LEIMA

TriTrypDb:

LmjF.18.1310 , LMJLV39_180018500 , LMJSD75_180018800

Length:

805

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0016020	membrane	2	7
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QDQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDQ8

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	2
GO:0006474	N-terminal protein amino acid acetylation	5	2
GO:0006475	internal protein amino acid acetylation	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0007059	chromosome segregation	2	6
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	6
GO:0016570	histone modification	5	2
GO:0016573	histone acetylation	6	2
GO:0017196	N-terminal peptidyl-methionine acetylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0018206	peptidyl-methionine modification	6	2
GO:0018393	internal peptidyl-lysine acetylation	8	2
GO:0018394	peptidyl-lysine acetylation	7	2
GO:0019538	protein metabolic process	3	2
GO:0031365	N-terminal protein amino acid modification	5	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0043966	histone H3 acetylation	7	2
GO:0043967	histone H4 acetylation	7	2
GO:0044238	primary metabolic process	2	2
GO:0051604	protein maturation	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004402	histone acetyltransferase activity	4	2
GO:0004596	peptide alpha-N-acetyltransferase activity	8	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0034212	peptide N-acetyltransferase activity	7	7
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.698
CLV_C14_Caspase3-7	437	441	PF00656	0.680
CLV_C14_Caspase3-7	508	512	PF00656	0.543
CLV_C14_Caspase3-7	66	70	PF00656	0.625
CLV_C14_Caspase3-7	706	710	PF00656	0.720
CLV_C14_Caspase3-7	78	82	PF00656	0.620
CLV_NRD_NRD_1	123	125	PF00675	0.348
CLV_NRD_NRD_1	191	193	PF00675	0.331
CLV_NRD_NRD_1	304	306	PF00675	0.357
CLV_NRD_NRD_1	400	402	PF00675	0.387
CLV_NRD_NRD_1	414	416	PF00675	0.383
CLV_NRD_NRD_1	513	515	PF00675	0.441
CLV_NRD_NRD_1	533	535	PF00675	0.338
CLV_NRD_NRD_1	669	671	PF00675	0.510
CLV_NRD_NRD_1	754	756	PF00675	0.455
CLV_NRD_NRD_1	85	87	PF00675	0.443
CLV_PCSK_FUR_1	443	447	PF00082	0.460
CLV_PCSK_FUR_1	667	671	PF00082	0.559
CLV_PCSK_KEX2_1	123	125	PF00082	0.348
CLV_PCSK_KEX2_1	191	193	PF00082	0.331
CLV_PCSK_KEX2_1	400	402	PF00082	0.443
CLV_PCSK_KEX2_1	414	416	PF00082	0.321
CLV_PCSK_KEX2_1	445	447	PF00082	0.476
CLV_PCSK_KEX2_1	513	515	PF00082	0.441
CLV_PCSK_KEX2_1	533	535	PF00082	0.338
CLV_PCSK_KEX2_1	667	669	PF00082	0.508
CLV_PCSK_KEX2_1	753	755	PF00082	0.449
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.443
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.321
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.476
CLV_PCSK_SKI1_1	14	18	PF00082	0.382
CLV_PCSK_SKI1_1	247	251	PF00082	0.462
CLV_PCSK_SKI1_1	379	383	PF00082	0.326
CLV_PCSK_SKI1_1	572	576	PF00082	0.345
DEG_APCC_DBOX_1	13	21	PF00400	0.577
DEG_SPOP_SBC_1	139	143	PF00917	0.631
DEG_SPOP_SBC_1	154	158	PF00917	0.676
DEG_SPOP_SBC_1	256	260	PF00917	0.688
DOC_CDC14_PxL_1	481	489	PF14671	0.591
DOC_CKS1_1	696	701	PF01111	0.761
DOC_MAPK_gen_1	400	406	PF00069	0.561
DOC_MAPK_MEF2A_6	14	21	PF00069	0.575
DOC_MAPK_NFAT4_5	14	22	PF00069	0.574
DOC_MAPK_RevD_3	290	306	PF00069	0.528
DOC_PP1_RVXF_1	178	184	PF00149	0.572
DOC_PP1_RVXF_1	766	772	PF00149	0.657
DOC_PP1_RVXF_1	774	781	PF00149	0.557
DOC_PP2B_LxvP_1	656	659	PF13499	0.688
DOC_USP7_MATH_1	148	152	PF00917	0.756
DOC_USP7_MATH_1	154	158	PF00917	0.650
DOC_USP7_MATH_1	256	260	PF00917	0.671
DOC_USP7_MATH_1	311	315	PF00917	0.622
DOC_USP7_MATH_1	461	465	PF00917	0.688
DOC_USP7_MATH_1	472	476	PF00917	0.573
DOC_USP7_MATH_1	603	607	PF00917	0.804
DOC_USP7_MATH_1	651	655	PF00917	0.742
DOC_USP7_MATH_1	758	762	PF00917	0.719
DOC_WW_Pin1_4	150	155	PF00397	0.783
DOC_WW_Pin1_4	242	247	PF00397	0.653
DOC_WW_Pin1_4	259	264	PF00397	0.690
DOC_WW_Pin1_4	456	461	PF00397	0.666
DOC_WW_Pin1_4	465	470	PF00397	0.619
DOC_WW_Pin1_4	53	58	PF00397	0.603
DOC_WW_Pin1_4	614	619	PF00397	0.665
DOC_WW_Pin1_4	695	700	PF00397	0.788
DOC_WW_Pin1_4	713	718	PF00397	0.684
DOC_WW_Pin1_4	727	732	PF00397	0.573
DOC_WW_Pin1_4	80	85	PF00397	0.642
DOC_WW_Pin1_4	87	92	PF00397	0.627
DOC_WW_Pin1_4	99	104	PF00397	0.778
LIG_14-3-3_CanoR_1	255	263	PF00244	0.638
LIG_14-3-3_CanoR_1	33	41	PF00244	0.640
LIG_14-3-3_CanoR_1	379	384	PF00244	0.526
LIG_14-3-3_CanoR_1	74	84	PF00244	0.629
LIG_14-3-3_CanoR_1	753	758	PF00244	0.671
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_BIR_III_2	199	203	PF00653	0.532
LIG_BIR_III_3	1	5	PF00653	0.608
LIG_BRCT_BRCA1_1	473	477	PF00533	0.644
LIG_deltaCOP1_diTrp_1	233	238	PF00928	0.577
LIG_eIF4E_1	398	404	PF01652	0.574
LIG_EVH1_1	656	660	PF00568	0.656
LIG_FHA_1	128	134	PF00498	0.682
LIG_FHA_1	145	151	PF00498	0.581
LIG_FHA_1	172	178	PF00498	0.622
LIG_FHA_1	313	319	PF00498	0.648
LIG_FHA_1	328	334	PF00498	0.474
LIG_FHA_1	353	359	PF00498	0.474
LIG_FHA_1	367	373	PF00498	0.474
LIG_FHA_1	619	625	PF00498	0.746
LIG_FHA_2	228	234	PF00498	0.561
LIG_FHA_2	26	32	PF00498	0.596
LIG_FHA_2	432	438	PF00498	0.686
LIG_FHA_2	504	510	PF00498	0.660
LIG_FHA_2	523	529	PF00498	0.513
LIG_FHA_2	610	616	PF00498	0.696
LIG_FHA_2	64	70	PF00498	0.630
LIG_FHA_2	687	693	PF00498	0.714
LIG_FHA_2	704	710	PF00498	0.625
LIG_HOMEOBOX	210	213	PF00046	0.472
LIG_LIR_Apic_2	725	731	PF02991	0.635
LIG_LIR_Gen_1	208	218	PF02991	0.523
LIG_LIR_Gen_1	474	485	PF02991	0.602
LIG_LIR_Nem_3	35	41	PF02991	0.637
LIG_LIR_Nem_3	394	398	PF02991	0.562
LIG_LIR_Nem_3	474	480	PF02991	0.644
LIG_LIR_Nem_3	733	737	PF02991	0.590
LIG_LIR_Nem_3	782	788	PF02991	0.300
LIG_LYPXL_yS_3	734	737	PF13949	0.591
LIG_NRBOX	402	408	PF00104	0.617
LIG_PCNA_yPIPBox_3	537	549	PF02747	0.539
LIG_Pex14_2	38	42	PF04695	0.590
LIG_RPA_C_Fungi	339	351	PF08784	0.383
LIG_RPA_C_Fungi	561	573	PF08784	0.410
LIG_SH2_CRK	585	589	PF00017	0.390
LIG_SH2_CRK	796	800	PF00017	0.383
LIG_SH2_SRC	578	581	PF00017	0.363
LIG_SH2_STAP1	205	209	PF00017	0.407
LIG_SH2_STAP1	210	214	PF00017	0.338
LIG_SH2_STAP1	391	395	PF00017	0.415
LIG_SH2_STAP1	585	589	PF00017	0.378
LIG_SH2_STAT3	383	386	PF00017	0.383
LIG_SH2_STAT5	205	208	PF00017	0.410
LIG_SH2_STAT5	357	360	PF00017	0.321
LIG_SH2_STAT5	383	386	PF00017	0.351
LIG_SH2_STAT5	395	398	PF00017	0.501
LIG_SH2_STAT5	483	486	PF00017	0.468
LIG_SH2_STAT5	592	595	PF00017	0.463
LIG_SH3_3	128	134	PF00018	0.471
LIG_SH3_3	267	273	PF00018	0.556
LIG_SH3_3	360	366	PF00018	0.314
LIG_SH3_3	450	456	PF00018	0.584
LIG_SH3_3	457	463	PF00018	0.628
LIG_SH3_3	654	660	PF00018	0.590
LIG_SH3_3	675	681	PF00018	0.595
LIG_SH3_3	698	704	PF00018	0.607
LIG_SUMO_SIM_anti_2	739	744	PF11976	0.443
LIG_SUMO_SIM_par_1	739	744	PF11976	0.443
LIG_TRAF2_1	285	288	PF00917	0.498
LIG_TRAF2_1	297	300	PF00917	0.353
LIG_TRAF2_1	506	509	PF00917	0.414
LIG_TRAF2_1	525	528	PF00917	0.628
LIG_TRAF2_1	633	636	PF00917	0.621
LIG_TYR_ITIM	794	799	PF00017	0.383
LIG_UBA3_1	740	747	PF00899	0.440
LIG_WRC_WIRS_1	358	363	PF05994	0.310
MOD_CDK_SPK_2	242	247	PF00069	0.561
MOD_CDK_SPK_2	727	732	PF00069	0.514
MOD_CDK_SPxK_1	713	719	PF00069	0.621
MOD_CDK_SPxK_1	80	86	PF00069	0.548
MOD_CDK_SPxxK_3	80	87	PF00069	0.537
MOD_CK1_1	115	121	PF00069	0.569
MOD_CK1_1	153	159	PF00069	0.601
MOD_CK1_1	258	264	PF00069	0.587
MOD_CK1_1	265	271	PF00069	0.551
MOD_CK1_1	277	283	PF00069	0.586
MOD_CK1_1	314	320	PF00069	0.624
MOD_CK1_1	321	327	PF00069	0.559
MOD_CK1_1	352	358	PF00069	0.383
MOD_CK1_1	464	470	PF00069	0.588
MOD_CK1_1	661	667	PF00069	0.642
MOD_CK1_1	679	685	PF00069	0.596
MOD_CK1_1	722	728	PF00069	0.612
MOD_CK1_1	730	736	PF00069	0.508
MOD_CK1_1	90	96	PF00069	0.570
MOD_CK2_1	159	165	PF00069	0.751
MOD_CK2_1	205	211	PF00069	0.452
MOD_CK2_1	227	233	PF00069	0.432
MOD_CK2_1	25	31	PF00069	0.478
MOD_CK2_1	486	492	PF00069	0.420
MOD_CK2_1	503	509	PF00069	0.508
MOD_CK2_1	522	528	PF00069	0.499
MOD_CK2_1	614	620	PF00069	0.615
MOD_CK2_1	73	79	PF00069	0.528
MOD_CK2_1	758	764	PF00069	0.605
MOD_GlcNHglycan	161	164	PF01048	0.633
MOD_GlcNHglycan	264	267	PF01048	0.579
MOD_GlcNHglycan	325	328	PF01048	0.498
MOD_GlcNHglycan	428	431	PF01048	0.583
MOD_GlcNHglycan	449	452	PF01048	0.589
MOD_GlcNHglycan	48	51	PF01048	0.469
MOD_GlcNHglycan	605	608	PF01048	0.643
MOD_GlcNHglycan	677	681	PF01048	0.665
MOD_GlcNHglycan	760	763	PF01048	0.597
MOD_GSK3_1	108	115	PF00069	0.608
MOD_GSK3_1	138	145	PF00069	0.731
MOD_GSK3_1	149	156	PF00069	0.585
MOD_GSK3_1	171	178	PF00069	0.516
MOD_GSK3_1	201	208	PF00069	0.371
MOD_GSK3_1	21	28	PF00069	0.565
MOD_GSK3_1	238	245	PF00069	0.527
MOD_GSK3_1	255	262	PF00069	0.602
MOD_GSK3_1	314	321	PF00069	0.587
MOD_GSK3_1	323	330	PF00069	0.471
MOD_GSK3_1	461	468	PF00069	0.730
MOD_GSK3_1	59	66	PF00069	0.527
MOD_GSK3_1	603	610	PF00069	0.641
MOD_GSK3_1	614	621	PF00069	0.526
MOD_GSK3_1	758	765	PF00069	0.546
MOD_GSK3_1	93	100	PF00069	0.534
MOD_NEK2_1	140	145	PF00069	0.550
MOD_NEK2_1	155	160	PF00069	0.594
MOD_NEK2_1	41	46	PF00069	0.459
MOD_NEK2_1	423	428	PF00069	0.635
MOD_NEK2_1	557	562	PF00069	0.490
MOD_NEK2_1	609	614	PF00069	0.694
MOD_NEK2_1	85	90	PF00069	0.627
MOD_NEK2_2	472	477	PF00069	0.555
MOD_PIKK_1	248	254	PF00454	0.627
MOD_PIKK_1	274	280	PF00454	0.504
MOD_PIKK_1	382	388	PF00454	0.383
MOD_PIKK_1	461	467	PF00454	0.686
MOD_PIKK_1	762	768	PF00454	0.637
MOD_PKA_1	753	759	PF00069	0.642
MOD_PKA_2	238	244	PF00069	0.509
MOD_PKA_2	32	38	PF00069	0.553
MOD_PKA_2	46	52	PF00069	0.438
MOD_PKA_2	73	79	PF00069	0.541
MOD_PKA_2	753	759	PF00069	0.671
MOD_PKA_2	85	91	PF00069	0.523
MOD_PKB_1	668	676	PF00069	0.567
MOD_Plk_1	164	170	PF00069	0.542
MOD_Plk_2-3	25	31	PF00069	0.478
MOD_Plk_2-3	486	492	PF00069	0.416
MOD_Plk_2-3	522	528	PF00069	0.499
MOD_Plk_4	205	211	PF00069	0.452
MOD_Plk_4	25	31	PF00069	0.523
MOD_Plk_4	291	297	PF00069	0.398
MOD_Plk_4	327	333	PF00069	0.502
MOD_Plk_4	379	385	PF00069	0.338
MOD_Plk_4	418	424	PF00069	0.425
MOD_Plk_4	472	478	PF00069	0.545
MOD_Plk_4	479	485	PF00069	0.427
MOD_Plk_4	486	492	PF00069	0.374
MOD_ProDKin_1	150	156	PF00069	0.742
MOD_ProDKin_1	242	248	PF00069	0.569
MOD_ProDKin_1	259	265	PF00069	0.616
MOD_ProDKin_1	456	462	PF00069	0.580
MOD_ProDKin_1	465	471	PF00069	0.509
MOD_ProDKin_1	53	59	PF00069	0.495
MOD_ProDKin_1	614	620	PF00069	0.574
MOD_ProDKin_1	695	701	PF00069	0.749
MOD_ProDKin_1	713	719	PF00069	0.604
MOD_ProDKin_1	727	733	PF00069	0.441
MOD_ProDKin_1	80	86	PF00069	0.548
MOD_ProDKin_1	87	93	PF00069	0.521
MOD_ProDKin_1	99	105	PF00069	0.734
MOD_SUMO_rev_2	751	761	PF00179	0.585
TRG_DiLeu_BaEn_2	534	540	PF01217	0.471
TRG_ENDOCYTIC_2	210	213	PF00928	0.360
TRG_ENDOCYTIC_2	577	580	PF00928	0.399
TRG_ENDOCYTIC_2	585	588	PF00928	0.401
TRG_ENDOCYTIC_2	734	737	PF00928	0.474
TRG_ENDOCYTIC_2	796	799	PF00928	0.383
TRG_ER_diArg_1	122	124	PF00400	0.451
TRG_ER_diArg_1	179	182	PF00400	0.440
TRG_ER_diArg_1	190	192	PF00400	0.334
TRG_ER_diArg_1	497	500	PF00400	0.487
TRG_ER_diArg_1	513	515	PF00400	0.563
TRG_ER_diArg_1	532	534	PF00400	0.387
TRG_ER_diArg_1	666	669	PF00400	0.639
TRG_ER_diArg_1	752	755	PF00400	0.557
TRG_NLS_Bipartite_1	400	418	PF00514	0.432
TRG_NLS_MonoCore_2	412	417	PF00514	0.485
TRG_NLS_MonoExtN_4	413	418	PF00514	0.438
TRG_NLS_MonoExtN_4	84	90	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4M7	Leptomonas seymouri	43%	97%
A0A3S7WV24	Leishmania donovani	89%	100%
A4H9N7	Leishmania braziliensis	69%	100%
A4HY02	Leishmania infantum	86%	100%
E9ARR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%