Ethanolamine-phosphate cytidylyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cholinephosphate cytidylyltransferase A, putative

Species:

Leishmania major

UniProt:

Q4QDQ6_LEIMA

TriTrypDb:

LmjF.18.1330 , LMJLV39_180018700 , LMJSD75_180019000

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QDQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDQ6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006646	phosphatidylethanolamine biosynthetic process	6	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046337	phosphatidylethanolamine metabolic process	6	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004306	ethanolamine-phosphate cytidylyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12
GO:0070567	cytidylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	587	591	PF00656	0.774
CLV_NRD_NRD_1	202	204	PF00675	0.372
CLV_NRD_NRD_1	391	393	PF00675	0.316
CLV_NRD_NRD_1	545	547	PF00675	0.336
CLV_NRD_NRD_1	580	582	PF00675	0.545
CLV_PCSK_KEX2_1	202	204	PF00082	0.344
CLV_PCSK_KEX2_1	391	393	PF00082	0.317
CLV_PCSK_KEX2_1	482	484	PF00082	0.276
CLV_PCSK_KEX2_1	545	547	PF00082	0.337
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.276
CLV_PCSK_SKI1_1	134	138	PF00082	0.543
CLV_PCSK_SKI1_1	205	209	PF00082	0.339
CLV_PCSK_SKI1_1	306	310	PF00082	0.583
CLV_PCSK_SKI1_1	439	443	PF00082	0.308
CLV_PCSK_SKI1_1	47	51	PF00082	0.336
DEG_APCC_DBOX_1	305	313	PF00400	0.418
DEG_SCF_FBW7_1	553	560	PF00400	0.634
DOC_CKS1_1	434	439	PF01111	0.639
DOC_CKS1_1	533	538	PF01111	0.642
DOC_CKS1_1	554	559	PF01111	0.642
DOC_CYCLIN_RxL_1	44	52	PF00134	0.617
DOC_MAPK_gen_1	335	345	PF00069	0.537
DOC_MAPK_gen_1	391	399	PF00069	0.559
DOC_MAPK_HePTP_8	239	251	PF00069	0.337
DOC_MAPK_MEF2A_6	223	230	PF00069	0.449
DOC_MAPK_MEF2A_6	242	251	PF00069	0.337
DOC_MAPK_MEF2A_6	306	313	PF00069	0.394
DOC_MAPK_MEF2A_6	341	348	PF00069	0.479
DOC_MAPK_MEF2A_6	36	45	PF00069	0.596
DOC_MAPK_MEF2A_6	463	472	PF00069	0.520
DOC_MAPK_MEF2A_6	520	528	PF00069	0.459
DOC_MAPK_NFAT4_5	223	231	PF00069	0.449
DOC_MAPK_NFAT4_5	341	349	PF00069	0.484
DOC_MAPK_RevD_3	376	392	PF00069	0.378
DOC_PP1_RVXF_1	27	34	PF00149	0.652
DOC_PP2B_LxvP_1	159	162	PF13499	0.493
DOC_PP2B_LxvP_1	430	433	PF13499	0.547
DOC_PP2B_LxvP_1	53	56	PF13499	0.631
DOC_USP7_MATH_1	149	153	PF00917	0.464
DOC_USP7_MATH_1	571	575	PF00917	0.656
DOC_USP7_UBL2_3	268	272	PF12436	0.706
DOC_USP7_UBL2_3	337	341	PF12436	0.563
DOC_USP7_UBL2_3	585	589	PF12436	0.633
DOC_WW_Pin1_4	433	438	PF00397	0.637
DOC_WW_Pin1_4	506	511	PF00397	0.476
DOC_WW_Pin1_4	532	537	PF00397	0.644
DOC_WW_Pin1_4	553	558	PF00397	0.639
LIG_14-3-3_CanoR_1	174	184	PF00244	0.356
LIG_14-3-3_CanoR_1	202	210	PF00244	0.539
LIG_14-3-3_CanoR_1	216	222	PF00244	0.487
LIG_14-3-3_CanoR_1	260	266	PF00244	0.547
LIG_14-3-3_CanoR_1	569	576	PF00244	0.626
LIG_14-3-3_CanoR_1	581	588	PF00244	0.662
LIG_Actin_WH2_2	91	106	PF00022	0.720
LIG_BRCT_BRCA1_1	7	11	PF00533	0.560
LIG_Clathr_ClatBox_1	378	382	PF01394	0.344
LIG_EH1_1	288	296	PF00400	0.449
LIG_EH1_1	417	425	PF00400	0.523
LIG_eIF4E_1	340	346	PF01652	0.581
LIG_eIF4E_1	418	424	PF01652	0.550
LIG_FHA_1	162	168	PF00498	0.481
LIG_FHA_1	176	182	PF00498	0.242
LIG_FHA_1	26	32	PF00498	0.614
LIG_FHA_1	320	326	PF00498	0.395
LIG_FHA_1	554	560	PF00498	0.547
LIG_FHA_2	10	16	PF00498	0.542
LIG_FHA_2	227	233	PF00498	0.363
LIG_FHA_2	486	492	PF00498	0.476
LIG_FHA_2	533	539	PF00498	0.612
LIG_FHA_2	585	591	PF00498	0.750
LIG_IRF3_LxIS_1	184	190	PF10401	0.451
LIG_LIR_Apic_2	480	484	PF02991	0.562
LIG_LIR_Apic_2	531	536	PF02991	0.477
LIG_LIR_Apic_2	538	544	PF02991	0.532
LIG_LIR_Gen_1	163	170	PF02991	0.497
LIG_LIR_Gen_1	212	222	PF02991	0.484
LIG_LIR_Gen_1	286	297	PF02991	0.358
LIG_LIR_Gen_1	327	336	PF02991	0.359
LIG_LIR_Gen_1	362	370	PF02991	0.330
LIG_LIR_LC3C_4	322	325	PF02991	0.449
LIG_LIR_Nem_3	163	169	PF02991	0.482
LIG_LIR_Nem_3	212	217	PF02991	0.492
LIG_LIR_Nem_3	241	247	PF02991	0.284
LIG_LIR_Nem_3	286	292	PF02991	0.348
LIG_LIR_Nem_3	327	331	PF02991	0.393
LIG_LIR_Nem_3	35	41	PF02991	0.572
LIG_LIR_Nem_3	362	367	PF02991	0.405
LIG_LIR_Nem_3	537	543	PF02991	0.545
LIG_LIR_Nem_3	76	80	PF02991	0.600
LIG_NRBOX	181	187	PF00104	0.363
LIG_NRBOX	289	295	PF00104	0.475
LIG_NRBOX	401	407	PF00104	0.637
LIG_NRBOX	60	66	PF00104	0.595
LIG_PDZ_Class_3	587	592	PF00595	0.708
LIG_Pex14_2	38	42	PF04695	0.570
LIG_PTB_Apo_2	270	277	PF02174	0.691
LIG_PTB_Apo_2	72	79	PF02174	0.648
LIG_PTB_Phospho_1	270	276	PF10480	0.693
LIG_PTB_Phospho_1	72	78	PF10480	0.641
LIG_SH2_CRK	320	324	PF00017	0.343
LIG_SH2_CRK	340	344	PF00017	0.577
LIG_SH2_CRK	364	368	PF00017	0.324
LIG_SH2_CRK	481	485	PF00017	0.562
LIG_SH2_CRK	533	537	PF00017	0.578
LIG_SH2_CRK	541	545	PF00017	0.495
LIG_SH2_CRK	71	75	PF00017	0.531
LIG_SH2_GRB2like	521	524	PF00017	0.562
LIG_SH2_NCK_1	533	537	PF00017	0.561
LIG_SH2_SRC	418	421	PF00017	0.536
LIG_SH2_STAP1	428	432	PF00017	0.537
LIG_SH2_STAT5	166	169	PF00017	0.474
LIG_SH2_STAT5	244	247	PF00017	0.363
LIG_SH2_STAT5	276	279	PF00017	0.608
LIG_SH2_STAT5	280	283	PF00017	0.569
LIG_SH2_STAT5	357	360	PF00017	0.617
LIG_SH2_STAT5	384	387	PF00017	0.544
LIG_SH2_STAT5	418	421	PF00017	0.511
LIG_SH2_STAT5	501	504	PF00017	0.562
LIG_SH3_3	504	510	PF00018	0.501
LIG_SH3_3	551	557	PF00018	0.607
LIG_SH3_4	585	592	PF00018	0.616
LIG_SH3_5	162	166	PF00018	0.521
LIG_SUMO_SIM_anti_2	180	186	PF11976	0.453
LIG_SUMO_SIM_anti_2	288	294	PF11976	0.420
LIG_SUMO_SIM_anti_2	330	335	PF11976	0.459
LIG_SUMO_SIM_anti_2	365	372	PF11976	0.355
LIG_SUMO_SIM_par_1	184	190	PF11976	0.393
LIG_SUMO_SIM_par_1	250	256	PF11976	0.449
LIG_SUMO_SIM_par_1	321	327	PF11976	0.364
LIG_SUMO_SIM_par_1	377	382	PF11976	0.418
LIG_SUMO_SIM_par_1	422	427	PF11976	0.515
LIG_SUMO_SIM_par_1	90	97	PF11976	0.556
LIG_TRAF2_1	12	15	PF00917	0.652
LIG_TRAF2_1	474	477	PF00917	0.517
LIG_TRAF2_1	488	491	PF00917	0.473
LIG_TRFH_1	356	360	PF08558	0.413
LIG_TYR_ITIM	318	323	PF00017	0.475
LIG_TYR_ITIM	519	524	PF00017	0.547
LIG_UBA3_1	308	315	PF00899	0.441
LIG_UBA3_1	333	341	PF00899	0.567
LIG_WRC_WIRS_1	325	330	PF05994	0.344
MOD_CDK_SPxK_1	433	439	PF00069	0.638
MOD_CK1_1	152	158	PF00069	0.635
MOD_CK1_1	206	212	PF00069	0.573
MOD_CK1_1	285	291	PF00069	0.321
MOD_CK1_1	362	368	PF00069	0.275
MOD_CK1_1	509	515	PF00069	0.487
MOD_CK1_1	572	578	PF00069	0.677
MOD_CK2_1	226	232	PF00069	0.363
MOD_CK2_1	471	477	PF00069	0.507
MOD_CK2_1	485	491	PF00069	0.461
MOD_CK2_1	571	577	PF00069	0.634
MOD_CK2_1	9	15	PF00069	0.543
MOD_GlcNHglycan	122	125	PF01048	0.561
MOD_GlcNHglycan	151	154	PF01048	0.464
MOD_GlcNHglycan	205	208	PF01048	0.330
MOD_GlcNHglycan	261	264	PF01048	0.384
MOD_GSK3_1	148	155	PF00069	0.466
MOD_GSK3_1	21	28	PF00069	0.573
MOD_GSK3_1	212	219	PF00069	0.528
MOD_GSK3_1	408	415	PF00069	0.516
MOD_GSK3_1	5	12	PF00069	0.568
MOD_GSK3_1	532	539	PF00069	0.611
MOD_GSK3_1	549	556	PF00069	0.442
MOD_GSK3_1	559	566	PF00069	0.541
MOD_GSK3_1	580	587	PF00069	0.709
MOD_NEK2_1	187	192	PF00069	0.395
MOD_NEK2_1	226	231	PF00069	0.336
MOD_NEK2_1	426	431	PF00069	0.518
MOD_NEK2_1	5	10	PF00069	0.649
MOD_NEK2_1	64	69	PF00069	0.521
MOD_NEK2_1	73	78	PF00069	0.545
MOD_PIKK_1	359	365	PF00454	0.469
MOD_PKA_2	259	265	PF00069	0.588
MOD_PKA_2	282	288	PF00069	0.467
MOD_PKA_2	580	586	PF00069	0.725
MOD_PKB_1	203	211	PF00069	0.607
MOD_PKB_1	567	575	PF00069	0.606
MOD_Plk_1	113	119	PF00069	0.765
MOD_Plk_1	172	178	PF00069	0.438
MOD_Plk_1	285	291	PF00069	0.343
MOD_Plk_1	424	430	PF00069	0.520
MOD_Plk_1	5	11	PF00069	0.578
MOD_Plk_1	572	578	PF00069	0.709
MOD_Plk_2-3	584	590	PF00069	0.722
MOD_Plk_4	113	119	PF00069	0.772
MOD_Plk_4	177	183	PF00069	0.349
MOD_Plk_4	226	232	PF00069	0.335
MOD_Plk_4	253	259	PF00069	0.328
MOD_Plk_4	285	291	PF00069	0.354
MOD_Plk_4	319	325	PF00069	0.348
MOD_Plk_4	362	368	PF00069	0.286
MOD_Plk_4	401	407	PF00069	0.529
MOD_Plk_4	412	418	PF00069	0.491
MOD_Plk_4	5	11	PF00069	0.578
MOD_Plk_4	536	542	PF00069	0.565
MOD_Plk_4	559	565	PF00069	0.540
MOD_Plk_4	73	79	PF00069	0.630
MOD_ProDKin_1	433	439	PF00069	0.638
MOD_ProDKin_1	506	512	PF00069	0.476
MOD_ProDKin_1	532	538	PF00069	0.640
MOD_ProDKin_1	553	559	PF00069	0.636
MOD_SUMO_rev_2	574	583	PF00179	0.728
TRG_DiLeu_BaEn_1	14	19	PF01217	0.637
TRG_DiLeu_BaEn_1	286	291	PF01217	0.363
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.470
TRG_ENDOCYTIC_2	166	169	PF00928	0.455
TRG_ENDOCYTIC_2	244	247	PF00928	0.344
TRG_ENDOCYTIC_2	320	323	PF00928	0.364
TRG_ENDOCYTIC_2	340	343	PF00928	0.626
TRG_ENDOCYTIC_2	364	367	PF00928	0.313
TRG_ENDOCYTIC_2	521	524	PF00928	0.544
TRG_ENDOCYTIC_2	540	543	PF00928	0.433
TRG_ENDOCYTIC_2	71	74	PF00928	0.514
TRG_ENDOCYTIC_2	77	80	PF00928	0.579
TRG_ER_diArg_1	202	205	PF00400	0.575
TRG_ER_diArg_1	391	393	PF00400	0.517
TRG_ER_diArg_1	544	546	PF00400	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I259	Leptomonas seymouri	78%	100%
A0A0S4JNN5	Bodo saltans	47%	100%
A0A1X0P717	Trypanosomatidae	62%	100%
A0A3Q8IA23	Leishmania donovani	96%	100%
A0A422P0J5	Trypanosoma rangeli	60%	100%
A4H9L4	Leishmania braziliensis	89%	100%
A4HY04	Leishmania infantum	96%	100%
D0A5A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ARR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BEI8	Trypanosoma cruzi	59%	100%