Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDQ5_LEIMA

TriTrypDb:

LmjF.18.1340 , LMJLV39_180018800 , LMJSD75_180019100

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDQ5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.567
CLV_C14_Caspase3-7	186	190	PF00656	0.618
CLV_NRD_NRD_1	372	374	PF00675	0.637
CLV_NRD_NRD_1	441	443	PF00675	0.482
CLV_NRD_NRD_1	465	467	PF00675	0.486
CLV_PCSK_FUR_1	545	549	PF00082	0.459
CLV_PCSK_KEX2_1	372	374	PF00082	0.637
CLV_PCSK_KEX2_1	547	549	PF00082	0.512
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.473
CLV_PCSK_SKI1_1	437	441	PF00082	0.455
CLV_PCSK_SKI1_1	6	10	PF00082	0.652
DEG_Nend_Nbox_1	1	3	PF02207	0.615
DEG_SPOP_SBC_1	246	250	PF00917	0.653
DEG_SPOP_SBC_1	667	671	PF00917	0.654
DEG_SPOP_SBC_1	83	87	PF00917	0.532
DOC_CDC14_PxL_1	484	492	PF14671	0.603
DOC_CKS1_1	322	327	PF01111	0.677
DOC_CKS1_1	53	58	PF01111	0.630
DOC_CKS1_1	711	716	PF01111	0.658
DOC_CKS1_1	94	99	PF01111	0.619
DOC_CYCLIN_RxL_1	474	486	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	624	627	PF00134	0.590
DOC_MAPK_gen_1	466	475	PF00069	0.447
DOC_MAPK_MEF2A_6	428	435	PF00069	0.465
DOC_PP2B_LxvP_1	170	173	PF13499	0.498
DOC_PP2B_LxvP_1	418	421	PF13499	0.457
DOC_PP2B_LxvP_1	624	627	PF13499	0.590
DOC_PP2B_LxvP_1	725	728	PF13499	0.599
DOC_PP2B_PxIxI_1	44	50	PF00149	0.704
DOC_PP4_FxxP_1	304	307	PF00568	0.655
DOC_PP4_FxxP_1	652	655	PF00568	0.626
DOC_USP7_MATH_1	122	126	PF00917	0.610
DOC_USP7_MATH_1	134	138	PF00917	0.528
DOC_USP7_MATH_1	198	202	PF00917	0.607
DOC_USP7_MATH_1	209	213	PF00917	0.551
DOC_USP7_MATH_1	330	334	PF00917	0.650
DOC_USP7_MATH_1	357	361	PF00917	0.676
DOC_USP7_MATH_1	478	482	PF00917	0.366
DOC_USP7_MATH_1	576	580	PF00917	0.609
DOC_USP7_MATH_1	581	585	PF00917	0.578
DOC_USP7_MATH_1	667	671	PF00917	0.639
DOC_USP7_MATH_1	730	734	PF00917	0.651
DOC_WW_Pin1_4	129	134	PF00397	0.659
DOC_WW_Pin1_4	155	160	PF00397	0.642
DOC_WW_Pin1_4	162	167	PF00397	0.588
DOC_WW_Pin1_4	181	186	PF00397	0.488
DOC_WW_Pin1_4	240	245	PF00397	0.650
DOC_WW_Pin1_4	248	253	PF00397	0.580
DOC_WW_Pin1_4	259	264	PF00397	0.520
DOC_WW_Pin1_4	276	281	PF00397	0.515
DOC_WW_Pin1_4	303	308	PF00397	0.665
DOC_WW_Pin1_4	318	323	PF00397	0.621
DOC_WW_Pin1_4	348	353	PF00397	0.678
DOC_WW_Pin1_4	396	401	PF00397	0.602
DOC_WW_Pin1_4	41	46	PF00397	0.696
DOC_WW_Pin1_4	502	507	PF00397	0.499
DOC_WW_Pin1_4	52	57	PF00397	0.573
DOC_WW_Pin1_4	676	681	PF00397	0.686
DOC_WW_Pin1_4	710	715	PF00397	0.776
DOC_WW_Pin1_4	743	748	PF00397	0.678
DOC_WW_Pin1_4	749	754	PF00397	0.670
DOC_WW_Pin1_4	93	98	PF00397	0.619
LIG_14-3-3_CanoR_1	113	117	PF00244	0.776
LIG_14-3-3_CanoR_1	373	383	PF00244	0.550
LIG_14-3-3_CanoR_1	6	11	PF00244	0.566
LIG_BIR_III_4	294	298	PF00653	0.638
LIG_BRCT_BRCA1_1	131	135	PF00533	0.616
LIG_BRCT_BRCA1_1	151	155	PF00533	0.487
LIG_BRCT_BRCA1_1	267	271	PF00533	0.612
LIG_eIF4E_1	704	710	PF01652	0.675
LIG_FHA_1	159	165	PF00498	0.691
LIG_FHA_1	256	262	PF00498	0.661
LIG_FHA_1	264	270	PF00498	0.530
LIG_FHA_1	526	532	PF00498	0.508
LIG_FHA_1	613	619	PF00498	0.535
LIG_FHA_1	85	91	PF00498	0.608
LIG_HP1_1	688	692	PF01393	0.651
LIG_LIR_Apic_2	303	307	PF02991	0.656
LIG_LIR_Apic_2	650	655	PF02991	0.631
LIG_LIR_Gen_1	405	414	PF02991	0.383
LIG_LIR_Gen_1	757	766	PF02991	0.601
LIG_LIR_Nem_3	405	409	PF02991	0.387
LIG_LIR_Nem_3	411	417	PF02991	0.497
LIG_LIR_Nem_3	486	490	PF02991	0.461
LIG_LIR_Nem_3	757	761	PF02991	0.630
LIG_LYPXL_yS_3	487	490	PF13949	0.453
LIG_LYPXL_yS_3	662	665	PF13949	0.674
LIG_MYND_1	622	626	PF01753	0.589
LIG_MYND_1	663	667	PF01753	0.610
LIG_REV1ctd_RIR_1	61	67	PF16727	0.740
LIG_SH2_GRB2like	538	541	PF00017	0.466
LIG_SH2_NCK_1	91	95	PF00017	0.539
LIG_SH2_PTP2	689	692	PF00017	0.661
LIG_SH2_SRC	704	707	PF00017	0.648
LIG_SH2_STAP1	106	110	PF00017	0.539
LIG_SH2_STAP1	410	414	PF00017	0.476
LIG_SH2_STAT5	538	541	PF00017	0.466
LIG_SH2_STAT5	689	692	PF00017	0.661
LIG_SH2_STAT5	704	707	PF00017	0.527
LIG_SH3_1	91	97	PF00018	0.533
LIG_SH3_2	322	327	PF14604	0.654
LIG_SH3_3	176	182	PF00018	0.615
LIG_SH3_3	201	207	PF00018	0.650
LIG_SH3_3	219	225	PF00018	0.595
LIG_SH3_3	319	325	PF00018	0.724
LIG_SH3_3	39	45	PF00018	0.640
LIG_SH3_3	485	491	PF00018	0.461
LIG_SH3_3	495	501	PF00018	0.392
LIG_SH3_3	50	56	PF00018	0.629
LIG_SH3_3	674	680	PF00018	0.789
LIG_SH3_3	708	714	PF00018	0.623
LIG_SH3_3	744	750	PF00018	0.643
LIG_SH3_3	91	97	PF00018	0.624
LIG_SUMO_SIM_anti_2	494	500	PF11976	0.488
LIG_SUMO_SIM_par_1	160	165	PF11976	0.621
LIG_TRFH_1	652	656	PF08558	0.585
MOD_CDC14_SPxK_1	351	354	PF00782	0.564
MOD_CDK_SPK_2	318	323	PF00069	0.731
MOD_CDK_SPxK_1	321	327	PF00069	0.671
MOD_CDK_SPxK_1	348	354	PF00069	0.598
MOD_CDK_SPxxK_3	162	169	PF00069	0.608
MOD_CDK_SPxxK_3	93	100	PF00069	0.624
MOD_CK1_1	104	110	PF00069	0.656
MOD_CK1_1	112	118	PF00069	0.608
MOD_CK1_1	12	18	PF00069	0.671
MOD_CK1_1	123	129	PF00069	0.494
MOD_CK1_1	150	156	PF00069	0.637
MOD_CK1_1	158	164	PF00069	0.593
MOD_CK1_1	231	237	PF00069	0.676
MOD_CK1_1	240	246	PF00069	0.569
MOD_CK1_1	259	265	PF00069	0.639
MOD_CK1_1	321	327	PF00069	0.686
MOD_CK1_1	333	339	PF00069	0.622
MOD_CK1_1	379	385	PF00069	0.645
MOD_CK1_1	399	405	PF00069	0.541
MOD_CK1_1	43	49	PF00069	0.798
MOD_CK1_1	469	475	PF00069	0.436
MOD_CK1_1	579	585	PF00069	0.553
MOD_CK1_1	669	675	PF00069	0.663
MOD_CK1_1	70	76	PF00069	0.686
MOD_CK1_1	733	739	PF00069	0.724
MOD_CK1_1	757	763	PF00069	0.743
MOD_CK2_1	303	309	PF00069	0.790
MOD_CK2_1	399	405	PF00069	0.576
MOD_CK2_1	409	415	PF00069	0.546
MOD_CK2_1	450	456	PF00069	0.382
MOD_CK2_1	502	508	PF00069	0.497
MOD_Cter_Amidation	545	548	PF01082	0.468
MOD_GlcNHglycan	103	106	PF01048	0.560
MOD_GlcNHglycan	116	119	PF01048	0.544
MOD_GlcNHglycan	122	125	PF01048	0.483
MOD_GlcNHglycan	136	139	PF01048	0.469
MOD_GlcNHglycan	18	21	PF01048	0.647
MOD_GlcNHglycan	185	188	PF01048	0.633
MOD_GlcNHglycan	239	242	PF01048	0.665
MOD_GlcNHglycan	263	266	PF01048	0.600
MOD_GlcNHglycan	285	288	PF01048	0.675
MOD_GlcNHglycan	30	33	PF01048	0.596
MOD_GlcNHglycan	335	338	PF01048	0.698
MOD_GlcNHglycan	376	379	PF01048	0.707
MOD_GlcNHglycan	583	586	PF01048	0.698
MOD_GlcNHglycan	590	593	PF01048	0.672
MOD_GlcNHglycan	604	607	PF01048	0.557
MOD_GlcNHglycan	631	634	PF01048	0.564
MOD_GlcNHglycan	694	697	PF01048	0.700
MOD_GlcNHglycan	732	735	PF01048	0.739
MOD_GlcNHglycan	739	742	PF01048	0.694
MOD_GlcNHglycan	77	80	PF01048	0.631
MOD_GlcNHglycan	91	94	PF01048	0.545
MOD_GSK3_1	112	119	PF00069	0.747
MOD_GSK3_1	123	130	PF00069	0.642
MOD_GSK3_1	147	154	PF00069	0.641
MOD_GSK3_1	158	165	PF00069	0.566
MOD_GSK3_1	228	235	PF00069	0.675
MOD_GSK3_1	236	243	PF00069	0.612
MOD_GSK3_1	255	262	PF00069	0.666
MOD_GSK3_1	296	303	PF00069	0.657
MOD_GSK3_1	353	360	PF00069	0.641
MOD_GSK3_1	395	402	PF00069	0.666
MOD_GSK3_1	405	412	PF00069	0.367
MOD_GSK3_1	41	48	PF00069	0.789
MOD_GSK3_1	416	423	PF00069	0.473
MOD_GSK3_1	51	58	PF00069	0.664
MOD_GSK3_1	515	522	PF00069	0.453
MOD_GSK3_1	525	532	PF00069	0.416
MOD_GSK3_1	584	591	PF00069	0.595
MOD_GSK3_1	66	73	PF00069	0.568
MOD_GSK3_1	665	672	PF00069	0.665
MOD_GSK3_1	705	712	PF00069	0.630
MOD_GSK3_1	726	733	PF00069	0.714
MOD_GSK3_1	89	96	PF00069	0.630
MOD_GSK3_1	9	16	PF00069	0.678
MOD_N-GLC_1	150	155	PF02516	0.678
MOD_N-GLC_1	256	261	PF02516	0.618
MOD_N-GLC_1	275	280	PF02516	0.670
MOD_N-GLC_1	374	379	PF02516	0.605
MOD_N-GLC_1	730	735	PF02516	0.729
MOD_NEK2_1	116	121	PF00069	0.799
MOD_NEK2_1	210	215	PF00069	0.538
MOD_NEK2_1	245	250	PF00069	0.657
MOD_NEK2_1	28	33	PF00069	0.679
MOD_NEK2_1	296	301	PF00069	0.680
MOD_NEK2_1	433	438	PF00069	0.502
MOD_NEK2_1	692	697	PF00069	0.649
MOD_NEK2_1	717	722	PF00069	0.648
MOD_NEK2_1	737	742	PF00069	0.520
MOD_NEK2_1	75	80	PF00069	0.670
MOD_NEK2_1	754	759	PF00069	0.518
MOD_OFUCOSY	254	260	PF10250	0.601
MOD_PIKK_1	399	405	PF00454	0.556
MOD_PIKK_1	420	426	PF00454	0.490
MOD_PKA_1	466	472	PF00069	0.462
MOD_PKA_2	112	118	PF00069	0.775
MOD_PKA_2	469	475	PF00069	0.436
MOD_PKA_2	518	524	PF00069	0.487
MOD_Plk_1	150	156	PF00069	0.649
MOD_Plk_1	256	262	PF00069	0.634
MOD_Plk_1	379	385	PF00069	0.622
MOD_Plk_1	4	10	PF00069	0.546
MOD_Plk_1	494	500	PF00069	0.443
MOD_Plk_2-3	405	411	PF00069	0.429
MOD_Plk_4	265	271	PF00069	0.644
MOD_Plk_4	300	306	PF00069	0.702
MOD_Plk_4	405	411	PF00069	0.497
MOD_Plk_4	413	419	PF00069	0.432
MOD_Plk_4	494	500	PF00069	0.465
MOD_Plk_4	647	653	PF00069	0.665
MOD_Plk_4	700	706	PF00069	0.663
MOD_ProDKin_1	129	135	PF00069	0.660
MOD_ProDKin_1	155	161	PF00069	0.642
MOD_ProDKin_1	162	168	PF00069	0.585
MOD_ProDKin_1	181	187	PF00069	0.489
MOD_ProDKin_1	240	246	PF00069	0.649
MOD_ProDKin_1	248	254	PF00069	0.579
MOD_ProDKin_1	259	265	PF00069	0.520
MOD_ProDKin_1	276	282	PF00069	0.519
MOD_ProDKin_1	303	309	PF00069	0.666
MOD_ProDKin_1	318	324	PF00069	0.619
MOD_ProDKin_1	348	354	PF00069	0.680
MOD_ProDKin_1	396	402	PF00069	0.595
MOD_ProDKin_1	41	47	PF00069	0.700
MOD_ProDKin_1	502	508	PF00069	0.497
MOD_ProDKin_1	52	58	PF00069	0.572
MOD_ProDKin_1	676	682	PF00069	0.683
MOD_ProDKin_1	710	716	PF00069	0.778
MOD_ProDKin_1	743	749	PF00069	0.679
MOD_ProDKin_1	93	99	PF00069	0.621
MOD_SUMO_rev_2	558	568	PF00179	0.522
TRG_DiLeu_BaEn_2	455	461	PF01217	0.363
TRG_DiLeu_BaLyEn_6	660	665	PF01217	0.670
TRG_ENDOCYTIC_2	487	490	PF00928	0.453
TRG_ENDOCYTIC_2	662	665	PF00928	0.674
TRG_ENDOCYTIC_2	689	692	PF00928	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID50	Leishmania donovani	92%	100%
A4H9L3	Leishmania braziliensis	64%	100%
A4HY05	Leishmania infantum	92%	100%
E9ARR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%