Zinc_finger_protein_family_member_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDQ4_LEIMA

TriTrypDb:

LmjF.18.1350 , LMJLV39_180018900 , LMJSD75_180019200

Length:

632

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDQ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.578
CLV_NRD_NRD_1	273	275	PF00675	0.648
CLV_NRD_NRD_1	453	455	PF00675	0.504
CLV_PCSK_KEX2_1	273	275	PF00082	0.648
CLV_PCSK_KEX2_1	450	452	PF00082	0.477
CLV_PCSK_KEX2_1	455	457	PF00082	0.535
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.477
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.535
CLV_PCSK_PC7_1	451	457	PF00082	0.506
CLV_PCSK_SKI1_1	320	324	PF00082	0.373
CLV_PCSK_SKI1_1	397	401	PF00082	0.517
CLV_PCSK_SKI1_1	611	615	PF00082	0.394
DEG_Nend_Nbox_1	1	3	PF02207	0.569
DEG_SCF_FBW7_1	581	586	PF00400	0.640
DEG_SPOP_SBC_1	173	177	PF00917	0.610
DOC_CKS1_1	43	48	PF01111	0.657
DOC_MAPK_gen_1	499	509	PF00069	0.630
DOC_PP2B_LxvP_1	607	610	PF13499	0.438
DOC_PP4_FxxP_1	13	16	PF00568	0.564
DOC_USP7_MATH_1	173	177	PF00917	0.611
DOC_USP7_MATH_1	31	35	PF00917	0.539
DOC_USP7_MATH_1	336	340	PF00917	0.492
DOC_USP7_MATH_1	392	396	PF00917	0.419
DOC_USP7_MATH_1	500	504	PF00917	0.649
DOC_USP7_MATH_1	572	576	PF00917	0.639
DOC_USP7_MATH_1	577	581	PF00917	0.620
DOC_USP7_MATH_1	82	86	PF00917	0.583
DOC_WW_Pin1_4	174	179	PF00397	0.682
DOC_WW_Pin1_4	224	229	PF00397	0.611
DOC_WW_Pin1_4	236	241	PF00397	0.797
DOC_WW_Pin1_4	246	251	PF00397	0.576
DOC_WW_Pin1_4	42	47	PF00397	0.681
DOC_WW_Pin1_4	517	522	PF00397	0.623
DOC_WW_Pin1_4	543	548	PF00397	0.633
DOC_WW_Pin1_4	579	584	PF00397	0.683
DOC_WW_Pin1_4	587	592	PF00397	0.629
LIG_14-3-3_CanoR_1	502	508	PF00244	0.648
LIG_14-3-3_CanoR_1	57	61	PF00244	0.579
LIG_BIR_III_4	65	69	PF00653	0.569
LIG_BRCT_BRCA1_1	339	343	PF00533	0.467
LIG_BRCT_BRCA1_1	84	88	PF00533	0.588
LIG_BRCT_BRCA1_1	9	13	PF00533	0.568
LIG_FHA_1	169	175	PF00498	0.712
LIG_FHA_1	204	210	PF00498	0.611
LIG_FHA_1	287	293	PF00498	0.493
LIG_FHA_1	303	309	PF00498	0.347
LIG_FHA_1	317	323	PF00498	0.323
LIG_FHA_1	436	442	PF00498	0.301
LIG_FHA_2	270	276	PF00498	0.605
LIG_FHA_2	277	283	PF00498	0.476
LIG_FHA_2	349	355	PF00498	0.385
LIG_FHA_2	414	420	PF00498	0.474
LIG_FHA_2	546	552	PF00498	0.615
LIG_LIR_Apic_2	10	16	PF02991	0.557
LIG_LIR_Gen_1	3	13	PF02991	0.551
LIG_LIR_Gen_1	347	358	PF02991	0.376
LIG_LIR_Gen_1	59	69	PF02991	0.558
LIG_LIR_Nem_3	196	202	PF02991	0.545
LIG_LIR_Nem_3	294	300	PF02991	0.406
LIG_LIR_Nem_3	3	9	PF02991	0.555
LIG_LIR_Nem_3	347	353	PF02991	0.383
LIG_LIR_Nem_3	59	64	PF02991	0.563
LIG_LIR_Nem_3	85	91	PF02991	0.578
LIG_LYPXL_yS_3	372	375	PF13949	0.384
LIG_NRBOX	602	608	PF00104	0.520
LIG_PCNA_yPIPBox_3	273	284	PF02747	0.545
LIG_Pex14_2	293	297	PF04695	0.368
LIG_SH2_CRK	301	305	PF00017	0.357
LIG_SH2_GRB2like	421	424	PF00017	0.355
LIG_SH2_NCK_1	202	206	PF00017	0.602
LIG_SH2_NCK_1	301	305	PF00017	0.357
LIG_SH2_NCK_1	6	10	PF00017	0.552
LIG_SH2_NCK_1	61	65	PF00017	0.633
LIG_SH2_SRC	421	424	PF00017	0.355
LIG_SH2_SRC	6	9	PF00017	0.560
LIG_SH2_STAP1	99	103	PF00017	0.791
LIG_SH2_STAT3	229	232	PF00017	0.609
LIG_SH2_STAT5	129	132	PF00017	0.592
LIG_SH2_STAT5	163	166	PF00017	0.620
LIG_SH2_STAT5	350	353	PF00017	0.388
LIG_SH2_STAT5	362	365	PF00017	0.381
LIG_SH2_STAT5	608	611	PF00017	0.499
LIG_SH3_3	289	295	PF00018	0.375
LIG_SH3_3	306	312	PF00018	0.463
LIG_SH3_3	326	332	PF00018	0.397
LIG_SH3_3	370	376	PF00018	0.394
LIG_SH3_3	380	386	PF00018	0.424
LIG_SH3_3	40	46	PF00018	0.706
LIG_SH3_3	615	621	PF00018	0.450
LIG_SH3_CIN85_PxpxPR_1	236	241	PF14604	0.607
LIG_SUMO_SIM_anti_2	379	385	PF11976	0.498
LIG_SUMO_SIM_par_1	288	294	PF11976	0.531
LIG_TRAF2_1	279	282	PF00917	0.502
LIG_TYR_ITSM	57	64	PF00017	0.647
MOD_CDK_SPK_2	236	241	PF00069	0.632
MOD_CDK_SPxxK_3	236	243	PF00069	0.794
MOD_CK1_1	131	137	PF00069	0.581
MOD_CK1_1	167	173	PF00069	0.686
MOD_CK1_1	268	274	PF00069	0.694
MOD_CK1_1	34	40	PF00069	0.557
MOD_CK1_1	473	479	PF00069	0.710
MOD_CK1_1	489	495	PF00069	0.540
MOD_CK1_1	503	509	PF00069	0.584
MOD_CK1_1	520	526	PF00069	0.601
MOD_CK1_1	529	535	PF00069	0.650
MOD_CK1_1	599	605	PF00069	0.471
MOD_CK2_1	269	275	PF00069	0.611
MOD_CK2_1	276	282	PF00069	0.483
MOD_CK2_1	348	354	PF00069	0.379
MOD_CK2_1	545	551	PF00069	0.618
MOD_GlcNHglycan	140	143	PF01048	0.657
MOD_GlcNHglycan	184	187	PF01048	0.604
MOD_GlcNHglycan	19	22	PF01048	0.604
MOD_GlcNHglycan	195	198	PF01048	0.560
MOD_GlcNHglycan	210	213	PF01048	0.584
MOD_GlcNHglycan	222	225	PF01048	0.531
MOD_GlcNHglycan	236	239	PF01048	0.723
MOD_GlcNHglycan	262	265	PF01048	0.667
MOD_GlcNHglycan	268	271	PF01048	0.591
MOD_GlcNHglycan	422	426	PF01048	0.433
MOD_GlcNHglycan	488	491	PF01048	0.621
MOD_GlcNHglycan	496	499	PF01048	0.665
MOD_GlcNHglycan	502	505	PF01048	0.567
MOD_GlcNHglycan	537	540	PF01048	0.737
MOD_GlcNHglycan	558	561	PF01048	0.578
MOD_GlcNHglycan	65	69	PF01048	0.627
MOD_GlcNHglycan	7	12	PF01048	0.573
MOD_GSK3_1	164	171	PF00069	0.671
MOD_GSK3_1	203	210	PF00069	0.615
MOD_GSK3_1	220	227	PF00069	0.621
MOD_GSK3_1	246	253	PF00069	0.611
MOD_GSK3_1	260	267	PF00069	0.640
MOD_GSK3_1	282	289	PF00069	0.537
MOD_GSK3_1	30	37	PF00069	0.613
MOD_GSK3_1	413	420	PF00069	0.495
MOD_GSK3_1	457	464	PF00069	0.703
MOD_GSK3_1	469	476	PF00069	0.645
MOD_GSK3_1	525	532	PF00069	0.648
MOD_GSK3_1	577	584	PF00069	0.670
MOD_GSK3_1	593	600	PF00069	0.448
MOD_N-GLC_1	167	172	PF02516	0.687
MOD_N-GLC_1	246	251	PF02516	0.738
MOD_N-GLC_1	264	269	PF02516	0.532
MOD_N-GLC_1	316	321	PF02516	0.413
MOD_N-GLC_1	348	353	PF02516	0.438
MOD_N-GLC_1	469	474	PF02516	0.653
MOD_N-GLC_1	476	481	PF02516	0.620
MOD_N-GLC_1	526	531	PF02516	0.642
MOD_N-GLC_1	532	537	PF02516	0.612
MOD_N-GLC_1	554	559	PF02516	0.634
MOD_NEK2_1	130	135	PF00069	0.657
MOD_NEK2_1	208	213	PF00069	0.658
MOD_NEK2_1	316	321	PF00069	0.420
MOD_NEK2_1	337	342	PF00069	0.472
MOD_NEK2_1	36	41	PF00069	0.610
MOD_NEK2_1	435	440	PF00069	0.373
MOD_NEK2_1	554	559	PF00069	0.746
MOD_NEK2_1	585	590	PF00069	0.487
MOD_NEK2_1	597	602	PF00069	0.459
MOD_NEK2_1	614	619	PF00069	0.404
MOD_NEK2_1	627	632	PF00069	0.588
MOD_NEK2_2	56	61	PF00069	0.658
MOD_OFUCOSY	335	341	PF10250	0.495
MOD_PIKK_1	145	151	PF00454	0.677
MOD_PIKK_1	44	50	PF00454	0.642
MOD_PIKK_1	597	603	PF00454	0.540
MOD_PIKK_1	625	631	PF00454	0.627
MOD_PKA_2	515	521	PF00069	0.630
MOD_PKA_2	56	62	PF00069	0.665
MOD_Plk_1	316	322	PF00069	0.407
MOD_Plk_1	348	354	PF00069	0.320
MOD_Plk_1	476	482	PF00069	0.637
MOD_Plk_1	532	538	PF00069	0.646
MOD_Plk_1	554	560	PF00069	0.514
MOD_Plk_1	614	620	PF00069	0.521
MOD_Plk_4	158	164	PF00069	0.681
MOD_Plk_4	31	37	PF00069	0.543
MOD_Plk_4	348	354	PF00069	0.320
MOD_Plk_4	532	538	PF00069	0.781
MOD_Plk_4	56	62	PF00069	0.709
MOD_Plk_4	602	608	PF00069	0.453
MOD_Plk_4	614	620	PF00069	0.445
MOD_Plk_4	92	98	PF00069	0.572
MOD_ProDKin_1	174	180	PF00069	0.680
MOD_ProDKin_1	224	230	PF00069	0.611
MOD_ProDKin_1	236	242	PF00069	0.799
MOD_ProDKin_1	246	252	PF00069	0.577
MOD_ProDKin_1	42	48	PF00069	0.682
MOD_ProDKin_1	517	523	PF00069	0.622
MOD_ProDKin_1	543	549	PF00069	0.630
MOD_ProDKin_1	579	585	PF00069	0.677
MOD_ProDKin_1	587	593	PF00069	0.619
MOD_SUMO_rev_2	291	300	PF00179	0.370
MOD_SUMO_rev_2	442	452	PF00179	0.481
TRG_DiLeu_BaEn_2	430	436	PF01217	0.410
TRG_ENDOCYTIC_2	350	353	PF00928	0.394
TRG_ENDOCYTIC_2	372	375	PF00928	0.384
TRG_ENDOCYTIC_2	6	9	PF00928	0.560
TRG_ENDOCYTIC_2	61	64	PF00928	0.639
TRG_ENDOCYTIC_2	99	102	PF00928	0.672
TRG_ER_diArg_1	240	243	PF00400	0.640
TRG_ER_diArg_1	453	456	PF00400	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV5	Leptomonas seymouri	41%	100%
A0A3S5H743	Leishmania donovani	94%	100%
A4H9L2	Leishmania braziliensis	76%	100%
A4HY06	Leishmania infantum	94%	100%
E9ARR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%