LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QDQ3_LEIMA
TriTrypDb:
LmjF.18.1360 , LMJLV39_180019000 * , LMJSD75_180019300
Length:
960

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDQ3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDQ3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 287 291 PF00656 0.578
CLV_C14_Caspase3-7 3 7 PF00656 0.497
CLV_C14_Caspase3-7 309 313 PF00656 0.598
CLV_C14_Caspase3-7 756 760 PF00656 0.405
CLV_NRD_NRD_1 104 106 PF00675 0.643
CLV_NRD_NRD_1 207 209 PF00675 0.500
CLV_NRD_NRD_1 240 242 PF00675 0.634
CLV_NRD_NRD_1 649 651 PF00675 0.628
CLV_NRD_NRD_1 771 773 PF00675 0.610
CLV_NRD_NRD_1 787 789 PF00675 0.437
CLV_NRD_NRD_1 801 803 PF00675 0.535
CLV_NRD_NRD_1 823 825 PF00675 0.677
CLV_NRD_NRD_1 898 900 PF00675 0.732
CLV_PCSK_FUR_1 292 296 PF00082 0.613
CLV_PCSK_KEX2_1 104 106 PF00082 0.635
CLV_PCSK_KEX2_1 207 209 PF00082 0.502
CLV_PCSK_KEX2_1 240 242 PF00082 0.613
CLV_PCSK_KEX2_1 294 296 PF00082 0.613
CLV_PCSK_KEX2_1 649 651 PF00082 0.522
CLV_PCSK_KEX2_1 771 773 PF00082 0.585
CLV_PCSK_KEX2_1 787 789 PF00082 0.459
CLV_PCSK_KEX2_1 801 803 PF00082 0.535
CLV_PCSK_KEX2_1 823 825 PF00082 0.652
CLV_PCSK_KEX2_1 898 900 PF00082 0.732
CLV_PCSK_PC1ET2_1 294 296 PF00082 0.613
CLV_PCSK_SKI1_1 104 108 PF00082 0.581
CLV_PCSK_SKI1_1 192 196 PF00082 0.530
CLV_PCSK_SKI1_1 256 260 PF00082 0.553
CLV_PCSK_SKI1_1 5 9 PF00082 0.675
CLV_PCSK_SKI1_1 600 604 PF00082 0.659
CLV_PCSK_SKI1_1 675 679 PF00082 0.562
CLV_PCSK_SKI1_1 750 754 PF00082 0.635
CLV_PCSK_SKI1_1 788 792 PF00082 0.631
CLV_PCSK_SKI1_1 899 903 PF00082 0.641
CLV_Separin_Metazoa 798 802 PF03568 0.587
DEG_APCC_DBOX_1 545 553 PF00400 0.666
DEG_APCC_KENBOX_2 849 853 PF00400 0.759
DEG_SPOP_SBC_1 883 887 PF00917 0.794
DOC_CDC14_PxL_1 773 781 PF14671 0.517
DOC_MAPK_DCC_7 230 239 PF00069 0.662
DOC_MAPK_gen_1 186 195 PF00069 0.599
DOC_MAPK_HePTP_8 227 239 PF00069 0.659
DOC_MAPK_MEF2A_6 230 239 PF00069 0.652
DOC_MIT_MIM_1 203 212 PF04212 0.621
DOC_MIT_MIM_1 767 776 PF04212 0.560
DOC_PP4_FxxP_1 20 23 PF00568 0.718
DOC_PP4_FxxP_1 8 11 PF00568 0.672
DOC_USP7_MATH_1 145 149 PF00917 0.634
DOC_USP7_MATH_1 15 19 PF00917 0.726
DOC_USP7_MATH_1 24 28 PF00917 0.729
DOC_USP7_MATH_1 278 282 PF00917 0.626
DOC_USP7_MATH_1 324 328 PF00917 0.575
DOC_USP7_MATH_1 536 540 PF00917 0.475
DOC_USP7_MATH_1 586 590 PF00917 0.641
DOC_USP7_MATH_1 69 73 PF00917 0.591
DOC_USP7_MATH_1 869 873 PF00917 0.694
DOC_USP7_MATH_1 883 887 PF00917 0.740
DOC_USP7_MATH_1 906 910 PF00917 0.790
DOC_USP7_MATH_1 93 97 PF00917 0.682
DOC_USP7_MATH_1 950 954 PF00917 0.703
DOC_USP7_UBL2_3 684 688 PF12436 0.570
DOC_WW_Pin1_4 19 24 PF00397 0.651
DOC_WW_Pin1_4 39 44 PF00397 0.703
DOC_WW_Pin1_4 889 894 PF00397 0.747
DOC_WW_Pin1_4 910 915 PF00397 0.768
DOC_WW_Pin1_4 918 923 PF00397 0.689
DOC_WW_Pin1_4 951 956 PF00397 0.698
LIG_14-3-3_CanoR_1 152 158 PF00244 0.528
LIG_14-3-3_CanoR_1 256 262 PF00244 0.510
LIG_14-3-3_CanoR_1 26 30 PF00244 0.776
LIG_14-3-3_CanoR_1 279 283 PF00244 0.570
LIG_14-3-3_CanoR_1 353 361 PF00244 0.670
LIG_14-3-3_CanoR_1 419 427 PF00244 0.561
LIG_14-3-3_CanoR_1 675 680 PF00244 0.578
LIG_14-3-3_CanoR_1 716 724 PF00244 0.614
LIG_14-3-3_CanoR_1 867 876 PF00244 0.789
LIG_14-3-3_CanoR_1 949 955 PF00244 0.758
LIG_Actin_WH2_2 766 782 PF00022 0.523
LIG_BIR_III_2 14 18 PF00653 0.732
LIG_BRCT_BRCA1_1 952 956 PF00533 0.722
LIG_BRCT_BRCA1_1 98 102 PF00533 0.639
LIG_FAT_LD_1 254 262 PF03623 0.619
LIG_FHA_1 116 122 PF00498 0.654
LIG_FHA_1 213 219 PF00498 0.543
LIG_FHA_1 234 240 PF00498 0.548
LIG_FHA_1 374 380 PF00498 0.531
LIG_FHA_1 399 405 PF00498 0.575
LIG_FHA_1 430 436 PF00498 0.589
LIG_FHA_1 78 84 PF00498 0.762
LIG_FHA_1 795 801 PF00498 0.522
LIG_FHA_2 159 165 PF00498 0.479
LIG_FHA_2 167 173 PF00498 0.475
LIG_FHA_2 257 263 PF00498 0.567
LIG_FHA_2 264 270 PF00498 0.591
LIG_FHA_2 285 291 PF00498 0.474
LIG_FHA_2 372 378 PF00498 0.632
LIG_FHA_2 420 426 PF00498 0.607
LIG_FHA_2 474 480 PF00498 0.559
LIG_FHA_2 532 538 PF00498 0.705
LIG_FHA_2 703 709 PF00498 0.532
LIG_FHA_2 754 760 PF00498 0.558
LIG_FHA_2 868 874 PF00498 0.737
LIG_GBD_Chelix_1 253 261 PF00786 0.593
LIG_HCF-1_HBM_1 364 367 PF13415 0.625
LIG_LIR_Apic_2 18 23 PF02991 0.699
LIG_LIR_Apic_2 6 11 PF02991 0.672
LIG_LIR_Apic_2 66 71 PF02991 0.703
LIG_LIR_Gen_1 331 339 PF02991 0.472
LIG_LIR_Gen_1 673 681 PF02991 0.586
LIG_LIR_Gen_1 733 741 PF02991 0.486
LIG_LIR_Gen_1 825 835 PF02991 0.642
LIG_LIR_Gen_1 853 864 PF02991 0.742
LIG_LIR_Nem_3 304 310 PF02991 0.585
LIG_LIR_Nem_3 331 336 PF02991 0.457
LIG_LIR_Nem_3 673 679 PF02991 0.589
LIG_LIR_Nem_3 733 738 PF02991 0.484
LIG_LIR_Nem_3 825 831 PF02991 0.600
LIG_LIR_Nem_3 853 859 PF02991 0.738
LIG_REV1ctd_RIR_1 273 283 PF16727 0.600
LIG_RPA_C_Fungi 274 286 PF08784 0.515
LIG_SH2_CRK 146 150 PF00017 0.608
LIG_SH2_CRK 676 680 PF00017 0.597
LIG_SH2_CRK 735 739 PF00017 0.569
LIG_SH2_NCK_1 68 72 PF00017 0.537
LIG_SH2_SRC 68 71 PF00017 0.765
LIG_SH2_STAP1 153 157 PF00017 0.550
LIG_SH2_STAP1 481 485 PF00017 0.495
LIG_SH2_STAT5 146 149 PF00017 0.619
LIG_SH2_STAT5 367 370 PF00017 0.616
LIG_SH2_STAT5 94 97 PF00017 0.671
LIG_SH3_3 887 893 PF00018 0.787
LIG_SH3_3 952 958 PF00018 0.645
LIG_SH3_CIN85_PxpxPR_1 893 898 PF14604 0.718
LIG_Sin3_3 463 470 PF02671 0.562
LIG_SUMO_SIM_par_1 320 328 PF11976 0.528
LIG_TRAF2_1 169 172 PF00917 0.608
LIG_TRAF2_1 267 270 PF00917 0.531
LIG_TRAF2_1 361 364 PF00917 0.647
LIG_TRAF2_1 670 673 PF00917 0.573
LIG_TRAF2_1 793 796 PF00917 0.533
LIG_TRAF2_2 11 16 PF00917 0.668
LIG_UBA3_1 322 330 PF00899 0.442
LIG_WRPW_1 956 960 PF00400 0.708
LIG_WRPW_2 956 959 PF00400 0.703
MOD_CDC14_SPxK_1 42 45 PF00782 0.720
MOD_CDC14_SPxK_1 954 957 PF00782 0.709
MOD_CDK_SPxK_1 39 45 PF00069 0.730
MOD_CDK_SPxK_1 951 957 PF00069 0.718
MOD_CDK_SPxxK_3 19 26 PF00069 0.681
MOD_CK1_1 162 168 PF00069 0.568
MOD_CK1_1 260 266 PF00069 0.603
MOD_CK1_1 268 274 PF00069 0.619
MOD_CK1_1 281 287 PF00069 0.476
MOD_CK1_1 429 435 PF00069 0.589
MOD_CK1_1 581 587 PF00069 0.700
MOD_CK1_1 702 708 PF00069 0.613
MOD_CK1_1 79 85 PF00069 0.616
MOD_CK1_1 909 915 PF00069 0.763
MOD_CK1_1 930 936 PF00069 0.752
MOD_CK1_1 951 957 PF00069 0.726
MOD_CK1_1 96 102 PF00069 0.624
MOD_CK2_1 158 164 PF00069 0.453
MOD_CK2_1 166 172 PF00069 0.434
MOD_CK2_1 256 262 PF00069 0.572
MOD_CK2_1 263 269 PF00069 0.596
MOD_CK2_1 371 377 PF00069 0.630
MOD_CK2_1 419 425 PF00069 0.589
MOD_CK2_1 452 458 PF00069 0.556
MOD_CK2_1 531 537 PF00069 0.615
MOD_CK2_1 667 673 PF00069 0.551
MOD_CK2_1 702 708 PF00069 0.489
MOD_CK2_1 845 851 PF00069 0.727
MOD_CK2_1 867 873 PF00069 0.767
MOD_GlcNHglycan 153 156 PF01048 0.410
MOD_GlcNHglycan 2 5 PF01048 0.598
MOD_GlcNHglycan 283 286 PF01048 0.482
MOD_GlcNHglycan 537 541 PF01048 0.641
MOD_GlcNHglycan 588 591 PF01048 0.667
MOD_GlcNHglycan 636 639 PF01048 0.668
MOD_GlcNHglycan 70 74 PF01048 0.606
MOD_GlcNHglycan 834 838 PF01048 0.629
MOD_GlcNHglycan 847 850 PF01048 0.594
MOD_GlcNHglycan 851 855 PF01048 0.538
MOD_GlcNHglycan 886 889 PF01048 0.809
MOD_GlcNHglycan 904 907 PF01048 0.729
MOD_GlcNHglycan 929 932 PF01048 0.715
MOD_GlcNHglycan 950 953 PF01048 0.682
MOD_GSK3_1 147 154 PF00069 0.540
MOD_GSK3_1 15 22 PF00069 0.715
MOD_GSK3_1 158 165 PF00069 0.481
MOD_GSK3_1 256 263 PF00069 0.563
MOD_GSK3_1 264 271 PF00069 0.532
MOD_GSK3_1 277 284 PF00069 0.330
MOD_GSK3_1 35 42 PF00069 0.778
MOD_GSK3_1 352 359 PF00069 0.637
MOD_GSK3_1 425 432 PF00069 0.621
MOD_GSK3_1 634 641 PF00069 0.686
MOD_GSK3_1 77 84 PF00069 0.697
MOD_GSK3_1 867 874 PF00069 0.689
MOD_GSK3_1 902 909 PF00069 0.788
MOD_GSK3_1 918 925 PF00069 0.766
MOD_N-GLC_1 927 932 PF02516 0.769
MOD_NEK2_1 132 137 PF00069 0.511
MOD_NEK2_1 212 217 PF00069 0.694
MOD_NEK2_1 246 251 PF00069 0.581
MOD_NEK2_1 352 357 PF00069 0.651
MOD_NEK2_1 385 390 PF00069 0.601
MOD_NEK2_1 452 457 PF00069 0.590
MOD_NEK2_1 470 475 PF00069 0.547
MOD_NEK2_1 506 511 PF00069 0.536
MOD_NEK2_1 56 61 PF00069 0.755
MOD_NEK2_1 83 88 PF00069 0.721
MOD_NEK2_1 859 864 PF00069 0.740
MOD_NEK2_1 876 881 PF00069 0.736
MOD_PIKK_1 268 274 PF00454 0.644
MOD_PIKK_1 33 39 PF00454 0.790
MOD_PIKK_1 352 358 PF00454 0.629
MOD_PIKK_1 385 391 PF00454 0.601
MOD_PIKK_1 419 425 PF00454 0.589
MOD_PIKK_1 426 432 PF00454 0.559
MOD_PIKK_1 444 450 PF00454 0.458
MOD_PIKK_1 470 476 PF00454 0.601
MOD_PIKK_1 56 62 PF00454 0.704
MOD_PIKK_1 715 721 PF00454 0.622
MOD_PIKK_1 77 83 PF00454 0.704
MOD_PKA_2 115 121 PF00069 0.571
MOD_PKA_2 151 157 PF00069 0.591
MOD_PKA_2 25 31 PF00069 0.788
MOD_PKA_2 278 284 PF00069 0.595
MOD_PKA_2 315 321 PF00069 0.617
MOD_PKA_2 352 358 PF00069 0.679
MOD_PKA_2 578 584 PF00069 0.685
MOD_PKA_2 586 592 PF00069 0.691
MOD_PKA_2 702 708 PF00069 0.491
MOD_PKA_2 715 721 PF00069 0.545
MOD_PKA_2 859 865 PF00069 0.741
MOD_PKA_2 948 954 PF00069 0.765
MOD_Plk_1 228 234 PF00069 0.565
MOD_Plk_1 24 30 PF00069 0.751
MOD_Plk_1 495 501 PF00069 0.604
MOD_Plk_1 506 512 PF00069 0.508
MOD_Plk_1 600 606 PF00069 0.603
MOD_Plk_1 707 713 PF00069 0.654
MOD_Plk_1 96 102 PF00069 0.630
MOD_Plk_2-3 166 172 PF00069 0.568
MOD_Plk_4 15 21 PF00069 0.676
MOD_Plk_4 278 284 PF00069 0.532
MOD_Plk_4 334 340 PF00069 0.577
MOD_Plk_4 387 393 PF00069 0.603
MOD_Plk_4 871 877 PF00069 0.733
MOD_ProDKin_1 19 25 PF00069 0.655
MOD_ProDKin_1 39 45 PF00069 0.703
MOD_ProDKin_1 889 895 PF00069 0.747
MOD_ProDKin_1 910 916 PF00069 0.768
MOD_ProDKin_1 918 924 PF00069 0.692
MOD_ProDKin_1 951 957 PF00069 0.697
MOD_SUMO_for_1 121 124 PF00179 0.616
MOD_SUMO_for_1 793 796 PF00179 0.593
MOD_SUMO_rev_2 162 170 PF00179 0.573
MOD_SUMO_rev_2 213 223 PF00179 0.633
MOD_SUMO_rev_2 327 332 PF00179 0.545
MOD_SUMO_rev_2 348 352 PF00179 0.622
MOD_SUMO_rev_2 464 473 PF00179 0.600
MOD_SUMO_rev_2 524 529 PF00179 0.449
MOD_SUMO_rev_2 695 700 PF00179 0.543
MOD_SUMO_rev_2 747 752 PF00179 0.569
MOD_SUMO_rev_2 812 820 PF00179 0.563
TRG_DiLeu_BaEn_1 399 404 PF01217 0.597
TRG_DiLeu_BaEn_1 588 593 PF01217 0.496
TRG_DiLeu_BaEn_1 733 738 PF01217 0.546
TRG_DiLeu_BaEn_1 795 800 PF01217 0.627
TRG_DiLeu_BaEn_2 316 322 PF01217 0.593
TRG_DiLeu_BaEn_4 558 564 PF01217 0.675
TRG_DiLeu_BaEn_4 607 613 PF01217 0.641
TRG_DiLeu_BaEn_4 695 701 PF01217 0.517
TRG_DiLeu_BaEn_4 747 753 PF01217 0.594
TRG_DiLeu_BaEn_4 795 801 PF01217 0.540
TRG_DiLeu_BaLyEn_6 102 107 PF01217 0.645
TRG_DiLeu_BaLyEn_6 253 258 PF01217 0.618
TRG_ENDOCYTIC_2 146 149 PF00928 0.608
TRG_ENDOCYTIC_2 676 679 PF00928 0.600
TRG_ENDOCYTIC_2 735 738 PF00928 0.464
TRG_ENDOCYTIC_2 856 859 PF00928 0.739
TRG_ER_diArg_1 104 106 PF00400 0.643
TRG_ER_diArg_1 207 209 PF00400 0.526
TRG_ER_diArg_1 239 241 PF00400 0.601
TRG_ER_diArg_1 700 703 PF00400 0.488
TRG_ER_diArg_1 771 774 PF00400 0.631
TRG_ER_diArg_1 800 802 PF00400 0.622
TRG_ER_diArg_1 897 899 PF00400 0.715
TRG_Pf-PMV_PEXEL_1 104 108 PF00026 0.553
TRG_Pf-PMV_PEXEL_1 168 172 PF00026 0.487
TRG_Pf-PMV_PEXEL_1 207 211 PF00026 0.528
TRG_Pf-PMV_PEXEL_1 412 416 PF00026 0.501
TRG_Pf-PMV_PEXEL_1 486 491 PF00026 0.520
TRG_Pf-PMV_PEXEL_1 518 523 PF00026 0.549
TRG_Pf-PMV_PEXEL_1 690 694 PF00026 0.626
TRG_Pf-PMV_PEXEL_1 771 775 PF00026 0.597

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKJ3 Leptomonas seymouri 62% 98%
A0A0S4JNT6 Bodo saltans 30% 100%
A0A1X0P823 Trypanosomatidae 36% 100%
A0A3Q8IJT0 Leishmania donovani 93% 100%
A0A422NIX4 Trypanosoma rangeli 35% 100%
A4H9N9 Leishmania braziliensis 81% 100%
A4HY07 Leishmania infantum 93% 100%
D0A592 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9ARS0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5BJ58 Trypanosoma cruzi 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS