LeishMANIAdb
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Putative heat shock protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative heat shock protein
Gene product:
heat shock protein 110, putative
Species:
Leishmania major
UniProt:
Q4QDQ2_LEIMA
TriTrypDb:
LmjF.18.1370 , LMJLV39_180019100 * , LMJSD75_180019400
Length:
823

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. yes yes: 2
Pissara et al. no yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005829 cytosol 2 2
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

Q4QDQ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDQ2

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 2
GO:0009987 cellular process 1 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0044183 protein folding chaperone 1 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140657 ATP-dependent activity 1 12
GO:0140662 ATP-dependent protein folding chaperone 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 525 529 PF00656 0.674
CLV_NRD_NRD_1 159 161 PF00675 0.310
CLV_NRD_NRD_1 586 588 PF00675 0.519
CLV_NRD_NRD_1 664 666 PF00675 0.522
CLV_PCSK_KEX2_1 159 161 PF00082 0.324
CLV_PCSK_KEX2_1 267 269 PF00082 0.317
CLV_PCSK_KEX2_1 32 34 PF00082 0.318
CLV_PCSK_KEX2_1 357 359 PF00082 0.320
CLV_PCSK_KEX2_1 664 666 PF00082 0.468
CLV_PCSK_KEX2_1 68 70 PF00082 0.309
CLV_PCSK_PC1ET2_1 267 269 PF00082 0.317
CLV_PCSK_PC1ET2_1 32 34 PF00082 0.324
CLV_PCSK_PC1ET2_1 357 359 PF00082 0.320
CLV_PCSK_PC1ET2_1 68 70 PF00082 0.309
CLV_PCSK_SKI1_1 281 285 PF00082 0.309
CLV_PCSK_SKI1_1 396 400 PF00082 0.454
CLV_PCSK_SKI1_1 431 435 PF00082 0.409
CLV_PCSK_SKI1_1 552 556 PF00082 0.627
CLV_PCSK_SKI1_1 769 773 PF00082 0.509
CLV_PCSK_SKI1_1 82 86 PF00082 0.314
CLV_PCSK_SKI1_1 98 102 PF00082 0.292
DEG_APCC_DBOX_1 267 275 PF00400 0.324
DEG_APCC_KENBOX_2 540 544 PF00400 0.823
DOC_CDC14_PxL_1 403 411 PF14671 0.496
DOC_CYCLIN_RxL_1 278 285 PF00134 0.309
DOC_CYCLIN_RxL_1 79 88 PF00134 0.308
DOC_MAPK_gen_1 256 263 PF00069 0.311
DOC_MAPK_gen_1 267 273 PF00069 0.305
DOC_MAPK_gen_1 444 450 PF00069 0.537
DOC_MAPK_gen_1 558 567 PF00069 0.446
DOC_MAPK_gen_1 679 688 PF00069 0.497
DOC_MAPK_MEF2A_6 561 569 PF00069 0.435
DOC_PP1_RVXF_1 80 87 PF00149 0.417
DOC_PP1_RVXF_1 96 102 PF00149 0.259
DOC_PP2B_LxvP_1 741 744 PF13499 0.588
DOC_USP7_MATH_1 286 290 PF00917 0.374
DOC_USP7_MATH_1 374 378 PF00917 0.436
DOC_USP7_MATH_1 438 442 PF00917 0.526
DOC_USP7_MATH_1 451 455 PF00917 0.464
DOC_USP7_MATH_1 779 783 PF00917 0.667
DOC_USP7_UBL2_3 555 559 PF12436 0.527
DOC_USP7_UBL2_3 769 773 PF12436 0.574
DOC_USP7_UBL2_3 780 784 PF12436 0.668
DOC_WW_Pin1_4 387 392 PF00397 0.309
DOC_WW_Pin1_4 416 421 PF00397 0.590
DOC_WW_Pin1_4 619 624 PF00397 0.336
LIG_14-3-3_CanoR_1 124 129 PF00244 0.374
LIG_14-3-3_CanoR_1 191 196 PF00244 0.309
LIG_14-3-3_CanoR_1 309 313 PF00244 0.343
LIG_14-3-3_CanoR_1 418 424 PF00244 0.503
LIG_14-3-3_CanoR_1 449 459 PF00244 0.462
LIG_14-3-3_CanoR_1 98 104 PF00244 0.433
LIG_Actin_WH2_2 182 198 PF00022 0.454
LIG_BIR_II_1 1 5 PF00653 0.324
LIG_BIR_III_2 528 532 PF00653 0.609
LIG_BRCT_BRCA1_1 389 393 PF00533 0.309
LIG_BRCT_BRCA1_1 421 425 PF00533 0.512
LIG_Clathr_ClatBox_1 297 301 PF01394 0.368
LIG_deltaCOP1_diTrp_1 644 656 PF00928 0.430
LIG_FHA_1 12 18 PF00498 0.309
LIG_FHA_1 25 31 PF00498 0.309
LIG_FHA_1 33 39 PF00498 0.301
LIG_FHA_1 403 409 PF00498 0.487
LIG_FHA_1 61 67 PF00498 0.290
LIG_FHA_1 86 92 PF00498 0.324
LIG_FHA_2 196 202 PF00498 0.368
LIG_FHA_2 656 662 PF00498 0.511
LIG_FHA_2 680 686 PF00498 0.586
LIG_FHA_2 713 719 PF00498 0.527
LIG_LIR_Apic_2 629 633 PF02991 0.427
LIG_LIR_Gen_1 339 347 PF02991 0.390
LIG_LIR_Gen_1 653 662 PF02991 0.583
LIG_LIR_Gen_1 674 684 PF02991 0.522
LIG_LIR_Nem_3 18 23 PF02991 0.335
LIG_LIR_Nem_3 186 190 PF02991 0.310
LIG_LIR_Nem_3 242 248 PF02991 0.324
LIG_LIR_Nem_3 339 344 PF02991 0.343
LIG_LIR_Nem_3 405 409 PF02991 0.419
LIG_LIR_Nem_3 653 659 PF02991 0.558
LIG_LIR_Nem_3 674 680 PF02991 0.591
LIG_LIR_Nem_3 7 11 PF02991 0.318
LIG_LYPXL_yS_3 406 409 PF13949 0.492
LIG_MYND_1 619 623 PF01753 0.325
LIG_NRBOX 279 285 PF00104 0.324
LIG_PCNA_TLS_4 607 614 PF02747 0.374
LIG_Pex14_2 4 8 PF04695 0.324
LIG_SH2_CRK 677 681 PF00017 0.528
LIG_SH2_GRB2like 128 131 PF00017 0.309
LIG_SH2_GRB2like 464 467 PF00017 0.503
LIG_SH2_NCK_1 630 634 PF00017 0.473
LIG_SH2_SRC 478 481 PF00017 0.534
LIG_SH2_SRC 651 654 PF00017 0.429
LIG_SH2_STAP1 248 252 PF00017 0.402
LIG_SH2_STAP1 662 666 PF00017 0.464
LIG_SH2_STAT3 113 116 PF00017 0.309
LIG_SH2_STAT5 105 108 PF00017 0.324
LIG_SH2_STAT5 128 131 PF00017 0.380
LIG_SH2_STAT5 154 157 PF00017 0.309
LIG_SH2_STAT5 245 248 PF00017 0.420
LIG_SH2_STAT5 282 285 PF00017 0.324
LIG_SH2_STAT5 478 481 PF00017 0.473
LIG_SH2_STAT5 56 59 PF00017 0.324
LIG_SH2_STAT5 613 616 PF00017 0.388
LIG_SH3_1 773 779 PF00018 0.577
LIG_SH3_2 550 555 PF14604 0.751
LIG_SH3_3 299 305 PF00018 0.403
LIG_SH3_3 401 407 PF00018 0.392
LIG_SH3_3 414 420 PF00018 0.430
LIG_SH3_3 421 427 PF00018 0.293
LIG_SH3_3 445 451 PF00018 0.522
LIG_SH3_3 547 553 PF00018 0.663
LIG_SH3_3 771 777 PF00018 0.546
LIG_SH3_3 810 816 PF00018 0.845
LIG_SH3_4 555 562 PF00018 0.639
LIG_SUMO_SIM_par_1 13 18 PF11976 0.324
LIG_SUMO_SIM_par_1 507 513 PF11976 0.423
LIG_TRAF2_1 198 201 PF00917 0.380
LIG_TRAF2_1 658 661 PF00917 0.438
LIG_TRAF2_1 715 718 PF00917 0.527
LIG_TRAF2_1 808 811 PF00917 0.746
LIG_TYR_ITSM 16 23 PF00017 0.436
LIG_WRC_WIRS_1 38 43 PF05994 0.324
LIG_WRC_WIRS_1 656 661 PF05994 0.423
MOD_CDK_SPK_2 387 392 PF00069 0.324
MOD_CK1_1 375 381 PF00069 0.454
MOD_CK1_1 419 425 PF00069 0.487
MOD_CK1_1 579 585 PF00069 0.544
MOD_CK1_1 78 84 PF00069 0.401
MOD_CK2_1 191 197 PF00069 0.309
MOD_CK2_1 28 34 PF00069 0.309
MOD_CK2_1 654 660 PF00069 0.460
MOD_CK2_1 712 718 PF00069 0.545
MOD_CK2_1 758 764 PF00069 0.499
MOD_Cter_Amidation 708 711 PF01082 0.628
MOD_GlcNHglycan 182 185 PF01048 0.527
MOD_GlcNHglycan 284 287 PF01048 0.309
MOD_GlcNHglycan 288 291 PF01048 0.309
MOD_GlcNHglycan 453 456 PF01048 0.575
MOD_GlcNHglycan 578 581 PF01048 0.602
MOD_GlcNHglycan 94 98 PF01048 0.333
MOD_GSK3_1 11 18 PF00069 0.309
MOD_GSK3_1 191 198 PF00069 0.336
MOD_GSK3_1 24 31 PF00069 0.309
MOD_GSK3_1 282 289 PF00069 0.454
MOD_GSK3_1 33 40 PF00069 0.304
MOD_GSK3_1 368 375 PF00069 0.312
MOD_GSK3_1 398 405 PF00069 0.300
MOD_N-GLC_1 11 16 PF02516 0.322
MOD_N-GLC_1 177 182 PF02516 0.309
MOD_N-GLC_1 286 291 PF02516 0.431
MOD_N-GLC_1 372 377 PF02516 0.314
MOD_N-GLC_2 104 106 PF02516 0.324
MOD_NEK2_1 146 151 PF00069 0.431
MOD_NEK2_1 75 80 PF00069 0.242
MOD_NEK2_1 99 104 PF00069 0.454
MOD_NEK2_2 212 217 PF00069 0.320
MOD_NEK2_2 60 65 PF00069 0.343
MOD_PIKK_1 261 267 PF00454 0.511
MOD_PIKK_1 743 749 PF00454 0.640
MOD_PIKK_1 75 81 PF00454 0.261
MOD_PKA_1 32 38 PF00069 0.309
MOD_PKA_1 758 764 PF00069 0.500
MOD_PKA_2 235 241 PF00069 0.330
MOD_PKA_2 308 314 PF00069 0.343
MOD_PKA_2 32 38 PF00069 0.309
MOD_Plk_1 11 17 PF00069 0.318
MOD_Plk_1 300 306 PF00069 0.399
MOD_Plk_1 33 39 PF00069 0.309
MOD_Plk_1 654 660 PF00069 0.476
MOD_Plk_1 75 81 PF00069 0.464
MOD_Plk_2-3 308 314 PF00069 0.454
MOD_Plk_2-3 340 346 PF00069 0.374
MOD_Plk_2-3 655 661 PF00069 0.472
MOD_Plk_2-3 712 718 PF00069 0.541
MOD_Plk_4 172 178 PF00069 0.309
MOD_Plk_4 212 218 PF00069 0.326
MOD_Plk_4 34 40 PF00069 0.311
MOD_Plk_4 579 585 PF00069 0.479
MOD_Plk_4 60 66 PF00069 0.324
MOD_Plk_4 609 615 PF00069 0.380
MOD_Plk_4 746 752 PF00069 0.439
MOD_ProDKin_1 387 393 PF00069 0.309
MOD_ProDKin_1 416 422 PF00069 0.591
MOD_ProDKin_1 619 625 PF00069 0.333
MOD_SUMO_rev_2 102 112 PF00179 0.454
MOD_SUMO_rev_2 249 257 PF00179 0.358
MOD_SUMO_rev_2 712 722 PF00179 0.599
MOD_SUMO_rev_2 752 761 PF00179 0.595
MOD_SUMO_rev_2 77 87 PF00179 0.454
TRG_DiLeu_BaEn_1 157 162 PF01217 0.309
TRG_ENDOCYTIC_2 187 190 PF00928 0.309
TRG_ENDOCYTIC_2 20 23 PF00928 0.436
TRG_ENDOCYTIC_2 248 251 PF00928 0.335
TRG_ENDOCYTIC_2 406 409 PF00928 0.492
TRG_ENDOCYTIC_2 677 680 PF00928 0.482
TRG_ER_diArg_1 159 161 PF00400 0.324
TRG_ER_diArg_1 268 271 PF00400 0.385
TRG_ER_diArg_1 498 501 PF00400 0.414
TRG_ER_diArg_1 601 604 PF00400 0.518
TRG_ER_diArg_1 617 620 PF00400 0.300
TRG_ER_diArg_1 664 666 PF00400 0.507
TRG_ER_diArg_1 680 683 PF00400 0.313
TRG_Pf-PMV_PEXEL_1 159 164 PF00026 0.309
TRG_Pf-PMV_PEXEL_1 357 361 PF00026 0.454
TRG_Pf-PMV_PEXEL_1 46 50 PF00026 0.309
TRG_Pf-PMV_PEXEL_1 670 674 PF00026 0.405

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDD3 Leptomonas seymouri 73% 98%
A0A0S4JJU2 Bodo saltans 24% 100%
A0A0S4JRV7 Bodo saltans 50% 99%
A0A1X0P4V9 Trypanosomatidae 25% 100%
A0A1X0P8H2 Trypanosomatidae 59% 100%
A0A3R7L0X2 Trypanosoma rangeli 56% 99%
A0A3S5H744 Leishmania donovani 96% 100%
A0A3S5H808 Leishmania donovani 24% 100%
A0A3S7X203 Leishmania donovani 25% 100%
A0T0H7 Phaeodactylum tricornutum (strain CCAP 1055/1) 27% 100%
A4H9P0 Leishmania braziliensis 83% 100%
A4HGY5 Leishmania braziliensis 25% 100%
A4HND7 Leishmania braziliensis 26% 100%
A4I417 Leishmania infantum 25% 100%
A4IC10 Leishmania infantum 24% 100%
B3Q972 Rhodopseudomonas palustris (strain TIE-1) 24% 100%
B6JCI3 Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) 25% 100%
C9ZYJ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
D0A590 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9AFU8 Leishmania major 25% 100%
E9AGQ5 Leishmania infantum 96% 100%
E9ARS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B0A4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B700 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
F4HQD4 Arabidopsis thaliana 32% 99%
F4JMJ1 Arabidopsis thaliana 24% 95%
O59838 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
O74225 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 32% 100%
O88600 Rattus norvegicus 29% 98%
O97125 Drosophila melanogaster 26% 100%
P11147 Drosophila melanogaster 26% 100%
P32589 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
P32590 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
P34932 Homo sapiens 28% 98%
P36604 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
P41826 Anopheles albimanus 27% 100%
P41827 Anopheles albimanus 27% 100%
P48722 Mus musculus 28% 98%
Q01233 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 100%
Q05036 Caenorhabditis elegans 31% 100%
Q07US6 Rhodopseudomonas palustris (strain BisA53) 25% 100%
Q0IIM3 Bos taurus 28% 96%
Q2TFN9 Canis lupus familiaris 28% 98%
Q3SW76 Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255) 25% 100%
Q4Q7Y0 Leishmania major 25% 100%
Q4Q7Y4 Leishmania major 25% 100%
Q5B0C0 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 25% 100%
Q5R606 Pongo abelii 30% 96%
Q5RDM4 Pongo abelii 28% 98%
Q61316 Mus musculus 28% 98%
Q61699 Mus musculus 28% 96%
Q6FJI3 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 30% 100%
Q6NCY4 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 24% 100%
Q6TMK3 Dictyostelium discoideum 32% 100%
Q74ZJ0 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 31% 100%
Q875P5 Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651) 29% 100%
Q875V0 Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630) 30% 100%
Q91233 Oncorhynchus tshawytscha 27% 100%
Q92598 Homo sapiens 30% 96%
Q94738 Mesocentrotus franciscanus 33% 93%
Q96VB9 Candida albicans (strain SC5314 / ATCC MYA-2876) 30% 100%
Q9S7C0 Arabidopsis thaliana 32% 99%
Q9SAB1 Arabidopsis thaliana 28% 100%
V5DFF3 Trypanosoma cruzi 57% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS