Putative pumilio protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein 2, putative

Species:

Leishmania major

UniProt:

Q4QDP7_LEIMA

TriTrypDb:

LmjF.18.1420 , LMJLV39_180019600 , LMJSD75_180019900

Length:

890

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDP7

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	443	447	PF00656	0.388
CLV_C14_Caspase3-7	824	828	PF00656	0.669
CLV_NRD_NRD_1	104	106	PF00675	0.719
CLV_NRD_NRD_1	45	47	PF00675	0.655
CLV_NRD_NRD_1	514	516	PF00675	0.528
CLV_NRD_NRD_1	773	775	PF00675	0.733
CLV_PCSK_KEX2_1	103	105	PF00082	0.643
CLV_PCSK_KEX2_1	45	47	PF00082	0.579
CLV_PCSK_KEX2_1	773	775	PF00082	0.733
CLV_PCSK_SKI1_1	258	262	PF00082	0.448
CLV_PCSK_SKI1_1	435	439	PF00082	0.388
CLV_PCSK_SKI1_1	450	454	PF00082	0.234
CLV_PCSK_SKI1_1	511	515	PF00082	0.478
DEG_APCC_DBOX_1	510	518	PF00400	0.486
DEG_SPOP_SBC_1	592	596	PF00917	0.606
DOC_CKS1_1	415	420	PF01111	0.429
DOC_CKS1_1	673	678	PF01111	0.667
DOC_CKS1_1	753	758	PF01111	0.666
DOC_CKS1_1	881	886	PF01111	0.589
DOC_MAPK_gen_1	409	416	PF00069	0.312
DOC_PP1_RVXF_1	307	314	PF00149	0.388
DOC_PP2B_LxvP_1	402	405	PF13499	0.312
DOC_PP2B_LxvP_1	761	764	PF13499	0.587
DOC_PP4_FxxP_1	730	733	PF00568	0.674
DOC_PP4_MxPP_1	97	100	PF00568	0.609
DOC_SPAK_OSR1_1	411	415	PF12202	0.388
DOC_USP7_MATH_1	119	123	PF00917	0.786
DOC_USP7_MATH_1	544	548	PF00917	0.652
DOC_USP7_MATH_1	635	639	PF00917	0.844
DOC_USP7_MATH_1	733	737	PF00917	0.517
DOC_USP7_MATH_1	845	849	PF00917	0.733
DOC_USP7_MATH_1	855	859	PF00917	0.562
DOC_USP7_UBL2_3	450	454	PF12436	0.407
DOC_WW_Pin1_4	414	419	PF00397	0.469
DOC_WW_Pin1_4	483	488	PF00397	0.359
DOC_WW_Pin1_4	672	677	PF00397	0.662
DOC_WW_Pin1_4	752	757	PF00397	0.661
DOC_WW_Pin1_4	776	781	PF00397	0.762
DOC_WW_Pin1_4	797	802	PF00397	0.706
DOC_WW_Pin1_4	880	885	PF00397	0.593
LIG_14-3-3_CanoR_1	746	752	PF00244	0.559
LIG_14-3-3_CanoR_1	78	86	PF00244	0.546
LIG_APCC_ABBA_1	170	175	PF00400	0.481
LIG_APCC_ABBA_1	214	219	PF00400	0.388
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_BIR_III_2	155	159	PF00653	0.530
LIG_BRCT_BRCA1_1	802	806	PF00533	0.726
LIG_CtBP_PxDLS_1	405	409	PF00389	0.312
LIG_FHA_1	159	165	PF00498	0.564
LIG_FHA_1	265	271	PF00498	0.447
LIG_FHA_1	415	421	PF00498	0.481
LIG_FHA_1	524	530	PF00498	0.465
LIG_FHA_2	21	27	PF00498	0.669
LIG_FHA_2	437	443	PF00498	0.388
LIG_FHA_2	486	492	PF00498	0.388
LIG_FHA_2	854	860	PF00498	0.639
LIG_Integrin_isoDGR_2	582	584	PF01839	0.671
LIG_LIR_Apic_2	675	680	PF02991	0.662
LIG_LIR_Apic_2	729	733	PF02991	0.607
LIG_LIR_Gen_1	180	190	PF02991	0.496
LIG_LIR_Gen_1	215	224	PF02991	0.295
LIG_LIR_Gen_1	80	88	PF02991	0.543
LIG_LIR_Nem_3	180	186	PF02991	0.493
LIG_LIR_Nem_3	215	220	PF02991	0.309
LIG_LIR_Nem_3	222	227	PF02991	0.385
LIG_LIR_Nem_3	229	235	PF02991	0.348
LIG_LIR_Nem_3	471	476	PF02991	0.371
LIG_LIR_Nem_3	719	724	PF02991	0.648
LIG_LIR_Nem_3	80	86	PF02991	0.541
LIG_PCNA_yPIPBox_3	234	246	PF02747	0.388
LIG_Pex14_2	177	181	PF04695	0.511
LIG_PTB_Apo_2	782	789	PF02174	0.644
LIG_PTB_Phospho_1	782	788	PF10480	0.646
LIG_Rb_pABgroove_1	235	243	PF01858	0.388
LIG_SH2_CRK	183	187	PF00017	0.468
LIG_SH2_CRK	673	677	PF00017	0.640
LIG_SH2_CRK	83	87	PF00017	0.539
LIG_SH2_GRB2like	473	476	PF00017	0.312
LIG_SH2_GRB2like	576	579	PF00017	0.673
LIG_SH2_GRB2like	783	786	PF00017	0.626
LIG_SH2_PTP2	694	697	PF00017	0.545
LIG_SH2_SRC	694	697	PF00017	0.545
LIG_SH2_SRC	783	786	PF00017	0.702
LIG_SH2_STAP1	473	477	PF00017	0.312
LIG_SH2_STAP1	743	747	PF00017	0.705
LIG_SH2_STAP1	79	83	PF00017	0.578
LIG_SH2_STAT3	235	238	PF00017	0.312
LIG_SH2_STAT3	277	280	PF00017	0.388
LIG_SH2_STAT3	395	398	PF00017	0.312
LIG_SH2_STAT3	476	479	PF00017	0.321
LIG_SH2_STAT3	706	709	PF00017	0.672
LIG_SH2_STAT3	712	715	PF00017	0.607
LIG_SH2_STAT3	878	881	PF00017	0.679
LIG_SH2_STAT5	173	176	PF00017	0.406
LIG_SH2_STAT5	235	238	PF00017	0.312
LIG_SH2_STAT5	395	398	PF00017	0.356
LIG_SH2_STAT5	464	467	PF00017	0.312
LIG_SH2_STAT5	476	479	PF00017	0.312
LIG_SH2_STAT5	694	697	PF00017	0.555
LIG_SH2_STAT5	712	715	PF00017	0.566
LIG_SH2_STAT5	783	786	PF00017	0.626
LIG_SH2_STAT5	79	82	PF00017	0.546
LIG_SH3_3	35	41	PF00018	0.567
LIG_SH3_3	532	538	PF00018	0.543
LIG_SH3_3	646	652	PF00018	0.651
LIG_SH3_3	684	690	PF00018	0.663
LIG_SH3_3	757	763	PF00018	0.600
LIG_SH3_3	89	95	PF00018	0.555
LIG_SH3_5	179	183	PF00018	0.479
LIG_TRAF2_1	253	256	PF00917	0.550
LIG_TRAF2_1	440	443	PF00917	0.312
LIG_TRAF2_1	73	76	PF00917	0.595
LIG_TRAF2_1	884	887	PF00917	0.629
LIG_UBA3_1	262	269	PF00899	0.370
LIG_UBA3_1	302	309	PF00899	0.291
LIG_UBA3_1	448	454	PF00899	0.388
LIG_WRC_WIRS_1	174	179	PF05994	0.516
LIG_WRC_WIRS_1	190	195	PF05994	0.224
MOD_CDK_SPxxK_3	483	490	PF00069	0.340
MOD_CK1_1	127	133	PF00069	0.765
MOD_CK1_1	278	284	PF00069	0.312
MOD_CK1_1	3	9	PF00069	0.593
MOD_CK1_1	621	627	PF00069	0.678
MOD_CK1_1	754	760	PF00069	0.638
MOD_CK1_1	800	806	PF00069	0.766
MOD_CK1_1	848	854	PF00069	0.771
MOD_CK1_1	868	874	PF00069	0.477
MOD_CK2_1	436	442	PF00069	0.388
MOD_CK2_1	485	491	PF00069	0.388
MOD_CK2_1	533	539	PF00069	0.542
MOD_GlcNHglycan	121	124	PF01048	0.761
MOD_GlcNHglycan	331	334	PF01048	0.385
MOD_GlcNHglycan	534	538	PF01048	0.624
MOD_GlcNHglycan	546	549	PF01048	0.654
MOD_GlcNHglycan	550	553	PF01048	0.652
MOD_GlcNHglycan	595	598	PF01048	0.651
MOD_GlcNHglycan	602	605	PF01048	0.779
MOD_GlcNHglycan	718	721	PF01048	0.596
MOD_GlcNHglycan	730	733	PF01048	0.545
MOD_GlcNHglycan	8	11	PF01048	0.604
MOD_GlcNHglycan	837	840	PF01048	0.700
MOD_GlcNHglycan	848	851	PF01048	0.569
MOD_GSK3_1	124	131	PF00069	0.670
MOD_GSK3_1	158	165	PF00069	0.530
MOD_GSK3_1	185	192	PF00069	0.418
MOD_GSK3_1	423	430	PF00069	0.330
MOD_GSK3_1	500	507	PF00069	0.489
MOD_GSK3_1	52	59	PF00069	0.615
MOD_GSK3_1	523	530	PF00069	0.452
MOD_GSK3_1	544	551	PF00069	0.742
MOD_GSK3_1	554	561	PF00069	0.772
MOD_GSK3_1	617	624	PF00069	0.676
MOD_GSK3_1	747	754	PF00069	0.625
MOD_GSK3_1	797	804	PF00069	0.784
MOD_GSK3_1	863	870	PF00069	0.616
MOD_N-GLC_1	3	8	PF02516	0.664
MOD_N-GLC_1	504	509	PF02516	0.498
MOD_N-GLC_1	544	549	PF02516	0.654
MOD_N-GLC_1	558	563	PF02516	0.629
MOD_N-GLC_1	600	605	PF02516	0.604
MOD_N-GLC_1	617	622	PF02516	0.758
MOD_N-GLC_1	741	746	PF02516	0.653
MOD_N-GLC_1	801	806	PF02516	0.647
MOD_N-GLC_1	853	858	PF02516	0.617
MOD_N-GLC_1	866	871	PF02516	0.533
MOD_N-GLC_2	144	146	PF02516	0.527
MOD_NEK2_1	118	123	PF00069	0.642
MOD_NEK2_1	275	280	PF00069	0.388
MOD_NEK2_1	28	33	PF00069	0.674
MOD_NEK2_1	423	428	PF00069	0.314
MOD_NEK2_1	469	474	PF00069	0.388
MOD_NEK2_1	52	57	PF00069	0.668
MOD_NEK2_1	523	528	PF00069	0.442
MOD_NEK2_1	751	756	PF00069	0.625
MOD_NEK2_1	86	91	PF00069	0.590
MOD_NEK2_1	865	870	PF00069	0.609
MOD_NEK2_2	173	178	PF00069	0.500
MOD_NEK2_2	741	746	PF00069	0.653
MOD_NEK2_2	801	806	PF00069	0.647
MOD_PIKK_1	163	169	PF00454	0.524
MOD_PIKK_1	485	491	PF00454	0.388
MOD_PIKK_1	527	533	PF00454	0.461
MOD_PIKK_1	733	739	PF00454	0.516
MOD_PIKK_1	755	761	PF00454	0.667
MOD_PIKK_1	762	768	PF00454	0.635
MOD_PIKK_1	806	812	PF00454	0.654
MOD_PKA_2	264	270	PF00069	0.446
MOD_PKA_2	554	560	PF00069	0.648
MOD_PKA_2	77	83	PF00069	0.554
MOD_Plk_1	275	281	PF00069	0.312
MOD_Plk_1	385	391	PF00069	0.388
MOD_Plk_1	504	510	PF00069	0.491
MOD_Plk_1	741	747	PF00069	0.654
MOD_Plk_1	801	807	PF00069	0.704
MOD_Plk_1	826	832	PF00069	0.685
MOD_Plk_4	212	218	PF00069	0.340
MOD_Plk_4	504	510	PF00069	0.491
MOD_Plk_4	52	58	PF00069	0.627
MOD_Plk_4	523	529	PF00069	0.300
MOD_Plk_4	643	649	PF00069	0.698
MOD_Plk_4	801	807	PF00069	0.642
MOD_ProDKin_1	414	420	PF00069	0.462
MOD_ProDKin_1	483	489	PF00069	0.359
MOD_ProDKin_1	672	678	PF00069	0.665
MOD_ProDKin_1	752	758	PF00069	0.662
MOD_ProDKin_1	776	782	PF00069	0.761
MOD_ProDKin_1	797	803	PF00069	0.708
MOD_ProDKin_1	880	886	PF00069	0.591
MOD_SUMO_for_1	245	248	PF00179	0.472
MOD_SUMO_rev_2	250	260	PF00179	0.464
MOD_SUMO_rev_2	305	311	PF00179	0.340
MOD_SUMO_rev_2	446	455	PF00179	0.395
TRG_DiLeu_BaEn_3	443	449	PF01217	0.312
TRG_DiLeu_BaEn_4	222	228	PF01217	0.388
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.312
TRG_ENDOCYTIC_2	183	186	PF00928	0.385
TRG_ENDOCYTIC_2	664	667	PF00928	0.700
TRG_ENDOCYTIC_2	83	86	PF00928	0.538
TRG_ER_diArg_1	103	105	PF00400	0.709
TRG_ER_diArg_1	408	411	PF00400	0.314
TRG_ER_diArg_1	44	46	PF00400	0.653
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H745	Leishmania donovani	94%	99%
A4H9P5	Leishmania braziliensis	79%	100%
A4HY12	Leishmania infantum	94%	99%
E9ARS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BJ54	Trypanosoma cruzi	27%	100%