EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania major

UniProt:

Q4QDP5_LEIMA

TriTrypDb:

LmjF.18.1440 , LMJLV39_180019900 , LMJSD75_180020200

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QDP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDP5

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.347
CLV_NRD_NRD_1	188	190	PF00675	0.368
CLV_NRD_NRD_1	196	198	PF00675	0.310
CLV_NRD_NRD_1	204	206	PF00675	0.255
CLV_NRD_NRD_1	60	62	PF00675	0.630
CLV_NRD_NRD_1	67	69	PF00675	0.652
CLV_PCSK_KEX2_1	188	190	PF00082	0.314
CLV_PCSK_KEX2_1	196	198	PF00082	0.324
CLV_PCSK_KEX2_1	60	62	PF00082	0.566
CLV_PCSK_KEX2_1	67	69	PF00082	0.625

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC76	Leptomonas seymouri	72%	100%
A0A0S4JR21	Bodo saltans	36%	91%
A0A1X0P714	Trypanosomatidae	53%	100%
A0A3Q8IEC5	Leishmania donovani	93%	100%
A0A422NIP8	Trypanosoma rangeli	55%	100%
A4H9P7	Leishmania braziliensis	83%	99%
A4HY14	Leishmania infantum	93%	100%
D0A578	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ARS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%

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