EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania major

UniProt:

Q4QDP5_LEIMA

TriTrypDb:

LmjF.18.1440 , LMJLV39_180019900 , LMJSD75_180020200

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDP5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.347
CLV_NRD_NRD_1	188	190	PF00675	0.368
CLV_NRD_NRD_1	196	198	PF00675	0.310
CLV_NRD_NRD_1	204	206	PF00675	0.255
CLV_NRD_NRD_1	60	62	PF00675	0.630
CLV_NRD_NRD_1	67	69	PF00675	0.652
CLV_PCSK_KEX2_1	188	190	PF00082	0.314
CLV_PCSK_KEX2_1	196	198	PF00082	0.324
CLV_PCSK_KEX2_1	60	62	PF00082	0.566
CLV_PCSK_KEX2_1	67	69	PF00082	0.625
CLV_PCSK_PC7_1	63	69	PF00082	0.445
CLV_PCSK_SKI1_1	129	133	PF00082	0.451
CLV_PCSK_SKI1_1	216	220	PF00082	0.335
CLV_PCSK_SKI1_1	32	36	PF00082	0.483
DOC_CKS1_1	41	46	PF01111	0.426
DOC_MAPK_gen_1	196	204	PF00069	0.342
DOC_USP7_MATH_1	36	40	PF00917	0.542
DOC_WW_Pin1_4	40	45	PF00397	0.401
LIG_14-3-3_CanoR_1	20	28	PF00244	0.427
LIG_14-3-3_CanoR_1	216	225	PF00244	0.390
LIG_eIF4E_1	140	146	PF01652	0.375
LIG_FHA_1	140	146	PF00498	0.375
LIG_FHA_1	172	178	PF00498	0.297
LIG_FHA_1	41	47	PF00498	0.507
LIG_LIR_Gen_1	144	153	PF02991	0.301
LIG_LIR_Gen_1	158	168	PF02991	0.329
LIG_LIR_Nem_3	109	114	PF02991	0.400
LIG_LIR_Nem_3	12	16	PF02991	0.471
LIG_LIR_Nem_3	127	131	PF02991	0.501
LIG_LIR_Nem_3	143	149	PF02991	0.298
LIG_LIR_Nem_3	158	163	PF02991	0.350
LIG_LIR_Nem_3	219	225	PF02991	0.525
LIG_LYPXL_yS_3	222	225	PF13949	0.522
LIG_Pex14_2	146	150	PF04695	0.297
LIG_SH2_SRC	50	53	PF00017	0.380
LIG_SH2_STAT5	147	150	PF00017	0.389
LIG_SH2_STAT5	176	179	PF00017	0.372
LIG_SH2_STAT5	209	212	PF00017	0.378
LIG_SH2_STAT5	50	53	PF00017	0.398
LIG_SH3_3	38	44	PF00018	0.519
LIG_TRAF2_1	102	105	PF00917	0.611
LIG_UBA3_1	198	206	PF00899	0.297
LIG_WRC_WIRS_1	125	130	PF05994	0.343
MOD_GlcNHglycan	38	41	PF01048	0.554
MOD_GSK3_1	36	43	PF00069	0.568
MOD_NEK2_1	28	33	PF00069	0.523
MOD_NEK2_1	78	83	PF00069	0.724
MOD_NEK2_2	124	129	PF00069	0.372
MOD_NMyristoyl	1	7	PF02799	0.632
MOD_PIKK_1	216	222	PF00454	0.389
MOD_PKA_2	19	25	PF00069	0.461
MOD_PKA_2	3	9	PF00069	0.622
MOD_Plk_2-3	19	25	PF00069	0.496
MOD_ProDKin_1	40	46	PF00069	0.399
MOD_SUMO_rev_2	162	169	PF00179	0.414
TRG_DiLeu_BaEn_1	194	199	PF01217	0.297
TRG_DiLeu_BaEn_1	213	218	PF01217	0.297
TRG_DiLeu_BaEn_3	23	29	PF01217	0.436
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.514
TRG_DiLeu_LyEn_5	213	218	PF01217	0.357
TRG_ENDOCYTIC_2	111	114	PF00928	0.378
TRG_ENDOCYTIC_2	13	16	PF00928	0.462
TRG_ENDOCYTIC_2	147	150	PF00928	0.393
TRG_ENDOCYTIC_2	209	212	PF00928	0.410
TRG_ENDOCYTIC_2	222	225	PF00928	0.522
TRG_ER_diArg_1	187	189	PF00400	0.403
TRG_ER_diArg_1	196	198	PF00400	0.340
TRG_ER_diArg_1	60	63	PF00400	0.615
TRG_ER_diArg_1	67	69	PF00400	0.634
TRG_ER_diLys_1	228	233	PF00400	0.392
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC76	Leptomonas seymouri	72%	100%
A0A0S4JR21	Bodo saltans	36%	91%
A0A1X0P714	Trypanosomatidae	53%	100%
A0A3Q8IEC5	Leishmania donovani	93%	100%
A0A422NIP8	Trypanosoma rangeli	55%	100%
A4H9P7	Leishmania braziliensis	83%	99%
A4HY14	Leishmania infantum	93%	100%
D0A578	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ARS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%