Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDP3_LEIMA

TriTrypDb:

LmjF.18.1460 , LMJLV39_180020100 , LMJSD75_180020400

Length:

908

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	2
GO:0005858	axonemal dynein complex	4	2
GO:0005875	microtubule associated complex	2	3
GO:0005929	cilium	4	3
GO:0030286	dynein complex	3	3
GO:0030990	intraciliary transport particle	2	2
GO:0032991	protein-containing complex	1	3
GO:0036064	ciliary basal body	3	2
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3
GO:1902494	catalytic complex	2	3
GO:0005840	ribosome	5	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

Q4QDP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDP3

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	2
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3
GO:0006810	transport	3	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0045503	dynein light chain binding	3	3
GO:0045504	dynein heavy chain binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.506
CLV_C14_Caspase3-7	225	229	PF00656	0.708
CLV_C14_Caspase3-7	311	315	PF00656	0.645
CLV_C14_Caspase3-7	378	382	PF00656	0.675
CLV_C14_Caspase3-7	437	441	PF00656	0.639
CLV_C14_Caspase3-7	691	695	PF00656	0.634
CLV_NRD_NRD_1	124	126	PF00675	0.615
CLV_NRD_NRD_1	127	129	PF00675	0.633
CLV_NRD_NRD_1	15	17	PF00675	0.478
CLV_NRD_NRD_1	180	182	PF00675	0.541
CLV_NRD_NRD_1	19	21	PF00675	0.483
CLV_NRD_NRD_1	192	194	PF00675	0.452
CLV_NRD_NRD_1	201	203	PF00675	0.462
CLV_NRD_NRD_1	205	207	PF00675	0.485
CLV_NRD_NRD_1	266	268	PF00675	0.467
CLV_NRD_NRD_1	351	353	PF00675	0.610
CLV_NRD_NRD_1	607	609	PF00675	0.532
CLV_NRD_NRD_1	64	66	PF00675	0.598
CLV_NRD_NRD_1	72	74	PF00675	0.505
CLV_NRD_NRD_1	8	10	PF00675	0.482
CLV_NRD_NRD_1	842	844	PF00675	0.443
CLV_PCSK_KEX2_1	124	126	PF00082	0.642
CLV_PCSK_KEX2_1	14	16	PF00082	0.503
CLV_PCSK_KEX2_1	173	175	PF00082	0.516
CLV_PCSK_KEX2_1	182	184	PF00082	0.516
CLV_PCSK_KEX2_1	194	196	PF00082	0.491
CLV_PCSK_KEX2_1	201	203	PF00082	0.356
CLV_PCSK_KEX2_1	205	207	PF00082	0.466
CLV_PCSK_KEX2_1	266	268	PF00082	0.467
CLV_PCSK_KEX2_1	351	353	PF00082	0.610
CLV_PCSK_KEX2_1	633	635	PF00082	0.601
CLV_PCSK_KEX2_1	72	74	PF00082	0.540
CLV_PCSK_KEX2_1	79	81	PF00082	0.578
CLV_PCSK_KEX2_1	8	10	PF00082	0.497
CLV_PCSK_KEX2_1	842	844	PF00082	0.443
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.574
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.496
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.553
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.446
CLV_PCSK_PC1ET2_1	633	635	PF00082	0.512
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.591
CLV_PCSK_PC7_1	11	17	PF00082	0.603
CLV_PCSK_PC7_1	190	196	PF00082	0.467
CLV_PCSK_PC7_1	201	207	PF00082	0.446
CLV_PCSK_PC7_1	75	81	PF00082	0.633
CLV_PCSK_SKI1_1	201	205	PF00082	0.567
CLV_PCSK_SKI1_1	232	236	PF00082	0.661
CLV_PCSK_SKI1_1	345	349	PF00082	0.599
CLV_PCSK_SKI1_1	352	356	PF00082	0.613
CLV_PCSK_SKI1_1	412	416	PF00082	0.466
CLV_PCSK_SKI1_1	571	575	PF00082	0.359
CLV_PCSK_SKI1_1	670	674	PF00082	0.417
DEG_APCC_DBOX_1	231	239	PF00400	0.561
DEG_SPOP_SBC_1	454	458	PF00917	0.498
DOC_CKS1_1	516	521	PF01111	0.295
DOC_MAPK_gen_1	465	475	PF00069	0.420
DOC_MAPK_MEF2A_6	468	477	PF00069	0.364
DOC_PP1_RVXF_1	265	272	PF00149	0.548
DOC_PP2B_LxvP_1	719	722	PF13499	0.448
DOC_PP4_FxxP_1	574	577	PF00568	0.300
DOC_USP7_MATH_1	117	121	PF00917	0.659
DOC_USP7_MATH_1	151	155	PF00917	0.528
DOC_USP7_MATH_1	30	34	PF00917	0.626
DOC_USP7_MATH_1	389	393	PF00917	0.754
DOC_USP7_MATH_1	454	458	PF00917	0.429
DOC_USP7_MATH_1	48	52	PF00917	0.778
DOC_USP7_MATH_1	680	684	PF00917	0.632
DOC_USP7_MATH_1	711	715	PF00917	0.464
DOC_USP7_MATH_1	735	739	PF00917	0.396
DOC_USP7_MATH_1	752	756	PF00917	0.514
DOC_USP7_MATH_1	94	98	PF00917	0.653
DOC_USP7_MATH_2	636	642	PF00917	0.560
DOC_WW_Pin1_4	111	116	PF00397	0.682
DOC_WW_Pin1_4	233	238	PF00397	0.670
DOC_WW_Pin1_4	35	40	PF00397	0.615
DOC_WW_Pin1_4	495	500	PF00397	0.580
DOC_WW_Pin1_4	515	520	PF00397	0.363
DOC_WW_Pin1_4	532	537	PF00397	0.355
DOC_WW_Pin1_4	640	645	PF00397	0.576
DOC_WW_Pin1_4	733	738	PF00397	0.553
DOC_WW_Pin1_4	796	801	PF00397	0.481
LIG_14-3-3_CanoR_1	261	269	PF00244	0.460
LIG_14-3-3_CanoR_1	521	529	PF00244	0.448
LIG_14-3-3_CanoR_1	561	569	PF00244	0.373
LIG_14-3-3_CanoR_1	847	855	PF00244	0.504
LIG_14-3-3_CanoR_1	897	907	PF00244	0.459
LIG_Actin_WH2_2	343	359	PF00022	0.549
LIG_Actin_WH2_2	881	899	PF00022	0.412
LIG_AP2alpha_2	635	637	PF02296	0.442
LIG_BIR_III_4	228	232	PF00653	0.581
LIG_BRCT_BRCA1_1	163	167	PF00533	0.584
LIG_Clathr_ClatBox_1	616	620	PF01394	0.303
LIG_FHA_1	167	173	PF00498	0.462
LIG_FHA_1	397	403	PF00498	0.610
LIG_FHA_1	413	419	PF00498	0.427
LIG_FHA_1	587	593	PF00498	0.509
LIG_FHA_1	600	606	PF00498	0.609
LIG_FHA_1	713	719	PF00498	0.447
LIG_FHA_1	762	768	PF00498	0.427
LIG_FHA_1	787	793	PF00498	0.426
LIG_FHA_1	797	803	PF00498	0.360
LIG_FHA_2	237	243	PF00498	0.619
LIG_FHA_2	315	321	PF00498	0.624
LIG_FHA_2	366	372	PF00498	0.782
LIG_FHA_2	435	441	PF00498	0.743
LIG_FHA_2	515	521	PF00498	0.395
LIG_FHA_2	605	611	PF00498	0.587
LIG_FHA_2	66	72	PF00498	0.532
LIG_FHA_2	859	865	PF00498	0.335
LIG_Integrin_isoDGR_2	358	360	PF01839	0.501
LIG_LIR_Gen_1	502	510	PF02991	0.337
LIG_LIR_Gen_1	610	619	PF02991	0.581
LIG_LIR_Nem_3	285	290	PF02991	0.426
LIG_LIR_Nem_3	344	350	PF02991	0.601
LIG_LIR_Nem_3	502	507	PF02991	0.351
LIG_LIR_Nem_3	610	616	PF02991	0.583
LIG_LIR_Nem_3	777	783	PF02991	0.395
LIG_NRBOX	504	510	PF00104	0.366
LIG_PDZ_Wminus1_1	906	908	PF00595	0.378
LIG_REV1ctd_RIR_1	345	356	PF16727	0.602
LIG_SH2_NCK_1	751	755	PF00017	0.640
LIG_SH2_SRC	785	788	PF00017	0.342
LIG_SH2_STAP1	287	291	PF00017	0.435
LIG_SH2_STAP1	569	573	PF00017	0.474
LIG_SH2_STAP1	613	617	PF00017	0.434
LIG_SH2_STAT3	251	254	PF00017	0.438
LIG_SH2_STAT5	290	293	PF00017	0.462
LIG_SH2_STAT5	793	796	PF00017	0.392
LIG_SH3_3	301	307	PF00018	0.530
LIG_SH3_3	326	332	PF00018	0.411
LIG_SH3_3	446	452	PF00018	0.526
LIG_SH3_3	476	482	PF00018	0.436
LIG_SH3_3	513	519	PF00018	0.297
LIG_SH3_3	533	539	PF00018	0.320
LIG_SH3_3	762	768	PF00018	0.438
LIG_SUMO_SIM_anti_2	417	422	PF11976	0.421
LIG_SUMO_SIM_anti_2	502	509	PF11976	0.323
LIG_SUMO_SIM_anti_2	861	867	PF11976	0.451
LIG_SUMO_SIM_par_1	506	512	PF11976	0.435
LIG_SUMO_SIM_par_1	889	894	PF11976	0.342
LIG_TRAF2_1	120	123	PF00917	0.692
LIG_TRAF2_1	175	178	PF00917	0.510
LIG_TRAF2_1	186	189	PF00917	0.495
LIG_TRAF2_1	307	310	PF00917	0.534
LIG_TRAF2_1	339	342	PF00917	0.613
LIG_TRAF2_1	4	7	PF00917	0.445
LIG_TRAF2_1	68	71	PF00917	0.543
LIG_TRFH_1	659	663	PF08558	0.472
LIG_TYR_ITAM	610	630	PF00017	0.432
LIG_TYR_ITIM	771	776	PF00017	0.310
LIG_WRC_WIRS_1	501	506	PF05994	0.508
MOD_CDC14_SPxK_1	38	41	PF00782	0.609
MOD_CDC14_SPxK_1	535	538	PF00782	0.369
MOD_CDK_SPxK_1	35	41	PF00069	0.613
MOD_CDK_SPxK_1	515	521	PF00069	0.358
MOD_CDK_SPxK_1	532	538	PF00069	0.351
MOD_CDK_SPxxK_3	111	118	PF00069	0.580
MOD_CK1_1	236	242	PF00069	0.701
MOD_CK1_1	37	43	PF00069	0.605
MOD_CK1_1	430	436	PF00069	0.516
MOD_CK1_1	44	50	PF00069	0.468
MOD_CK1_1	443	449	PF00069	0.598
MOD_CK1_1	457	463	PF00069	0.342
MOD_CK1_1	51	57	PF00069	0.546
MOD_CK1_1	527	533	PF00069	0.353
MOD_CK1_1	578	584	PF00069	0.346
MOD_CK1_1	604	610	PF00069	0.529
MOD_CK1_1	640	646	PF00069	0.452
MOD_CK1_1	665	671	PF00069	0.521
MOD_CK1_1	712	718	PF00069	0.548
MOD_CK2_1	1	7	PF00069	0.511
MOD_CK2_1	117	123	PF00069	0.705
MOD_CK2_1	172	178	PF00069	0.580
MOD_CK2_1	183	189	PF00069	0.573
MOD_CK2_1	294	300	PF00069	0.597
MOD_CK2_1	314	320	PF00069	0.628
MOD_CK2_1	365	371	PF00069	0.528
MOD_CK2_1	514	520	PF00069	0.368
MOD_CK2_1	604	610	PF00069	0.637
MOD_CK2_1	65	71	PF00069	0.540
MOD_CK2_1	864	870	PF00069	0.509
MOD_CMANNOS	822	825	PF00535	0.299
MOD_GlcNHglycan	152	156	PF01048	0.474
MOD_GlcNHglycan	16	19	PF01048	0.544
MOD_GlcNHglycan	185	188	PF01048	0.633
MOD_GlcNHglycan	224	227	PF01048	0.730
MOD_GlcNHglycan	272	276	PF01048	0.568
MOD_GlcNHglycan	284	287	PF01048	0.517
MOD_GlcNHglycan	296	299	PF01048	0.573
MOD_GlcNHglycan	32	35	PF01048	0.502
MOD_GlcNHglycan	360	363	PF01048	0.683
MOD_GlcNHglycan	391	394	PF01048	0.681
MOD_GlcNHglycan	432	435	PF01048	0.693
MOD_GlcNHglycan	50	53	PF01048	0.636
MOD_GlcNHglycan	526	529	PF01048	0.400
MOD_GlcNHglycan	564	567	PF01048	0.458
MOD_GlcNHglycan	57	60	PF01048	0.725
MOD_GlcNHglycan	640	643	PF01048	0.679
MOD_GlcNHglycan	674	677	PF01048	0.572
MOD_GlcNHglycan	682	685	PF01048	0.648
MOD_GlcNHglycan	699	702	PF01048	0.647
MOD_GlcNHglycan	754	757	PF01048	0.671
MOD_GlcNHglycan	816	819	PF01048	0.342
MOD_GlcNHglycan	96	99	PF01048	0.554
MOD_GSK3_1	157	164	PF00069	0.577
MOD_GSK3_1	30	37	PF00069	0.603
MOD_GSK3_1	412	419	PF00069	0.544
MOD_GSK3_1	430	437	PF00069	0.657
MOD_GSK3_1	44	51	PF00069	0.632
MOD_GSK3_1	440	447	PF00069	0.609
MOD_GSK3_1	450	457	PF00069	0.315
MOD_GSK3_1	600	607	PF00069	0.599
MOD_GSK3_1	615	622	PF00069	0.238
MOD_GSK3_1	672	679	PF00069	0.504
MOD_GSK3_1	697	704	PF00069	0.617
MOD_GSK3_1	740	747	PF00069	0.560
MOD_GSK3_1	752	759	PF00069	0.704
MOD_GSK3_1	771	778	PF00069	0.344
MOD_GSK3_1	796	803	PF00069	0.385
MOD_GSK3_1	846	853	PF00069	0.447
MOD_GSK3_1	854	861	PF00069	0.328
MOD_N-GLC_1	427	432	PF02516	0.530
MOD_N-GLC_1	600	605	PF02516	0.492
MOD_N-GLC_2	550	552	PF02516	0.420
MOD_NEK2_1	271	276	PF00069	0.620
MOD_NEK2_1	294	299	PF00069	0.498
MOD_NEK2_1	414	419	PF00069	0.440
MOD_NEK2_1	455	460	PF00069	0.377
MOD_NEK2_1	509	514	PF00069	0.465
MOD_NEK2_1	562	567	PF00069	0.529
MOD_NEK2_1	619	624	PF00069	0.412
MOD_NEK2_1	637	642	PF00069	0.589
MOD_OFUCOSY	526	531	PF10250	0.389
MOD_PIKK_1	314	320	PF00454	0.603
MOD_PIKK_1	41	47	PF00454	0.622
MOD_PIKK_1	712	718	PF00454	0.474
MOD_PIKK_1	850	856	PF00454	0.459
MOD_PKA_1	14	20	PF00069	0.582
MOD_PKA_1	173	179	PF00069	0.482
MOD_PKA_1	65	71	PF00069	0.535
MOD_PKA_2	132	138	PF00069	0.689
MOD_PKA_2	14	20	PF00069	0.582
MOD_PKA_2	161	167	PF00069	0.591
MOD_PKA_2	173	179	PF00069	0.557
MOD_PKA_2	260	266	PF00069	0.447
MOD_PKA_2	464	470	PF00069	0.410
MOD_PKA_2	726	732	PF00069	0.531
MOD_PKA_2	814	820	PF00069	0.321
MOD_PKA_2	846	852	PF00069	0.485
MOD_PKB_1	181	189	PF00069	0.545
MOD_Plk_1	151	157	PF00069	0.475
MOD_Plk_1	427	433	PF00069	0.579
MOD_Plk_1	600	606	PF00069	0.455
MOD_Plk_2-3	401	407	PF00069	0.427
MOD_Plk_2-3	440	446	PF00069	0.553
MOD_Plk_4	416	422	PF00069	0.459
MOD_Plk_4	500	506	PF00069	0.430
MOD_Plk_4	735	741	PF00069	0.381
MOD_Plk_4	771	777	PF00069	0.426
MOD_ProDKin_1	111	117	PF00069	0.682
MOD_ProDKin_1	233	239	PF00069	0.668
MOD_ProDKin_1	35	41	PF00069	0.617
MOD_ProDKin_1	495	501	PF00069	0.569
MOD_ProDKin_1	515	521	PF00069	0.358
MOD_ProDKin_1	532	538	PF00069	0.359
MOD_ProDKin_1	640	646	PF00069	0.573
MOD_ProDKin_1	733	739	PF00069	0.545
MOD_ProDKin_1	796	802	PF00069	0.474
MOD_SUMO_rev_2	175	184	PF00179	0.488
MOD_SUMO_rev_2	186	196	PF00179	0.531
MOD_SUMO_rev_2	23	30	PF00179	0.593
MOD_SUMO_rev_2	58	68	PF00179	0.736
MOD_SUMO_rev_2	71	81	PF00179	0.533
TRG_DiLeu_BaEn_1	199	204	PF01217	0.565
TRG_DiLeu_BaEn_4	199	205	PF01217	0.585
TRG_DiLeu_BaEn_4	5	11	PF01217	0.558
TRG_DiLeu_LyEn_5	199	204	PF01217	0.480
TRG_ENDOCYTIC_2	613	616	PF00928	0.514
TRG_ENDOCYTIC_2	627	630	PF00928	0.382
TRG_ENDOCYTIC_2	773	776	PF00928	0.358
TRG_ER_diArg_1	181	184	PF00400	0.595
TRG_ER_diArg_1	193	196	PF00400	0.450
TRG_ER_diArg_1	201	203	PF00400	0.323
TRG_ER_diArg_1	204	206	PF00400	0.461
TRG_ER_diArg_1	265	267	PF00400	0.456
TRG_ER_diArg_1	324	327	PF00400	0.503
TRG_ER_diArg_1	350	352	PF00400	0.614
TRG_ER_diArg_1	468	471	PF00400	0.420
TRG_ER_diArg_1	72	75	PF00400	0.536
TRG_ER_diArg_1	8	11	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	8	13	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED2	Leptomonas seymouri	55%	100%
A0A0S4JR75	Bodo saltans	32%	100%
A0A1X0P8I2	Trypanosomatidae	40%	100%
A0A3Q8ID60	Leishmania donovani	94%	100%
A0A3R7KCG9	Trypanosoma rangeli	40%	100%
A4H9P9	Leishmania braziliensis	76%	100%
A4HY16	Leishmania infantum	93%	100%
E9ART0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q8C761	Mus musculus	23%	91%
Q8WVS4	Homo sapiens	23%	85%
V5BNK6	Trypanosoma cruzi	41%	100%