Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDP2_LEIMA

TriTrypDb:

LmjF.18.1470 , LMJLV39_180020200 , LMJSD75_180020500

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QDP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDP2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	312	314	PF00675	0.387
CLV_NRD_NRD_1	317	319	PF00675	0.292
CLV_NRD_NRD_1	32	34	PF00675	0.479
CLV_PCSK_FUR_1	315	319	PF00082	0.405
CLV_PCSK_KEX2_1	314	316	PF00082	0.398
CLV_PCSK_KEX2_1	317	319	PF00082	0.283
CLV_PCSK_KEX2_1	32	34	PF00082	0.479
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.375
CLV_PCSK_PC7_1	313	319	PF00082	0.374
CLV_PCSK_SKI1_1	95	99	PF00082	0.403
DOC_CDC14_PxL_1	80	88	PF14671	0.667
DOC_MAPK_MEF2A_6	104	111	PF00069	0.607
DOC_PP4_FxxP_1	132	135	PF00568	0.611
DOC_PP4_FxxP_1	196	199	PF00568	0.657
DOC_PP4_FxxP_1	232	235	PF00568	0.587
DOC_PP4_FxxP_1	261	264	PF00568	0.528
DOC_USP7_MATH_1	62	66	PF00917	0.797
DOC_USP7_MATH_1	71	75	PF00917	0.778
DOC_USP7_MATH_1	91	95	PF00917	0.459
DOC_USP7_MATH_2	190	196	PF00917	0.755
DOC_WW_Pin1_4	154	159	PF00397	0.668
DOC_WW_Pin1_4	204	209	PF00397	0.633
LIG_14-3-3_CanoR_1	64	73	PF00244	0.779
LIG_14-3-3_CanoR_1	85	91	PF00244	0.620
LIG_APCC_ABBA_1	270	275	PF00400	0.540
LIG_BRCT_BRCA1_1	228	232	PF00533	0.600
LIG_FHA_1	121	127	PF00498	0.588
LIG_FHA_1	294	300	PF00498	0.677
LIG_FHA_1	96	102	PF00498	0.569
LIG_LIR_Apic_2	194	199	PF02991	0.651
LIG_LIR_Apic_2	229	235	PF02991	0.595
LIG_LIR_Apic_2	260	264	PF02991	0.530
LIG_LIR_Gen_1	220	225	PF02991	0.668
LIG_LIR_Gen_1	279	290	PF02991	0.554
LIG_LIR_Nem_3	114	118	PF02991	0.629
LIG_LIR_Nem_3	136	141	PF02991	0.665
LIG_LIR_Nem_3	194	200	PF02991	0.651
LIG_LIR_Nem_3	220	224	PF02991	0.669
LIG_LIR_Nem_3	255	261	PF02991	0.614
LIG_LIR_Nem_3	279	285	PF02991	0.545
LIG_LIR_Nem_3	329	334	PF02991	0.414
LIG_PCNA_yPIPBox_3	284	295	PF02747	0.556
LIG_Pex14_1	331	335	PF04695	0.480
LIG_Pex14_2	196	200	PF04695	0.652
LIG_Pex14_2	261	265	PF04695	0.531
LIG_REV1ctd_RIR_1	135	143	PF16727	0.668
LIG_SH2_CRK	164	168	PF00017	0.708
LIG_SH2_SRC	321	324	PF00017	0.447
LIG_SH2_STAP1	164	168	PF00017	0.699
LIG_SH2_STAT5	321	324	PF00017	0.447
LIG_SH2_STAT5	88	91	PF00017	0.647
LIG_SH3_3	13	19	PF00018	0.713
LIG_SH3_3	164	170	PF00018	0.763
LIG_SH3_3	23	29	PF00018	0.594
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.561
LIG_SUMO_SIM_anti_2	289	294	PF11976	0.579
LIG_TYR_ITIM	333	338	PF00017	0.480
LIG_WRC_WIRS_1	193	198	PF05994	0.749
LIG_WRC_WIRS_1	237	242	PF05994	0.613
LIG_WRC_WIRS_1	258	263	PF05994	0.544
LIG_WW_3	168	172	PF00397	0.691
MOD_CK1_1	24	30	PF00069	0.736
MOD_CK1_1	65	71	PF00069	0.728
MOD_CK2_1	298	304	PF00069	0.591
MOD_GlcNHglycan	159	162	PF01048	0.554
MOD_GlcNHglycan	23	26	PF01048	0.523
MOD_GlcNHglycan	343	346	PF01048	0.714
MOD_GlcNHglycan	54	57	PF01048	0.571
MOD_GlcNHglycan	67	70	PF01048	0.580
MOD_GSK3_1	107	114	PF00069	0.524
MOD_GSK3_1	204	211	PF00069	0.642
MOD_GSK3_1	60	67	PF00069	0.754
MOD_GSK3_1	91	98	PF00069	0.599
MOD_N-GLC_1	208	213	PF02516	0.473
MOD_N-GLC_1	293	298	PF02516	0.472
MOD_NEK2_1	257	262	PF00069	0.664
MOD_NEK2_1	86	91	PF00069	0.631
MOD_NEK2_2	226	231	PF00069	0.626
MOD_NMyristoyl	1	7	PF02799	0.590
MOD_PKA_2	63	69	PF00069	0.758
MOD_PKA_2	86	92	PF00069	0.639
MOD_Plk_1	120	126	PF00069	0.611
MOD_Plk_1	208	214	PF00069	0.674
MOD_Plk_4	147	153	PF00069	0.603
MOD_Plk_4	163	169	PF00069	0.678
MOD_Plk_4	192	198	PF00069	0.741
MOD_Plk_4	208	214	PF00069	0.571
MOD_Plk_4	286	292	PF00069	0.558
MOD_Plk_4	326	332	PF00069	0.407
MOD_ProDKin_1	154	160	PF00069	0.673
MOD_ProDKin_1	204	210	PF00069	0.635
TRG_ENDOCYTIC_2	115	118	PF00928	0.522
TRG_ENDOCYTIC_2	164	167	PF00928	0.714
TRG_ENDOCYTIC_2	221	224	PF00928	0.644
TRG_ENDOCYTIC_2	258	261	PF00928	0.562
TRG_ENDOCYTIC_2	335	338	PF00928	0.560
TRG_ER_diArg_1	315	318	PF00400	0.634
TRG_ER_diArg_1	32	34	PF00400	0.766
TRG_ER_diArg_1	84	87	PF00400	0.594
TRG_NLS_MonoExtC_3	312	317	PF00514	0.600
TRG_NLS_MonoExtN_4	313	318	PF00514	0.601
TRG_Pf-PMV_PEXEL_1	116	121	PF00026	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX40	Leptomonas seymouri	75%	97%
A0A0S4JJX8	Bodo saltans	52%	100%
A0A1X0P7D7	Trypanosomatidae	63%	100%
A0A3S7WV34	Leishmania donovani	94%	100%
A4H9Q0	Leishmania braziliensis	78%	100%
A4HY17	Leishmania infantum	94%	100%
D0A568	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9ART1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BJ52	Trypanosoma cruzi	60%	100%