NADH:ubiquinone oxidoreductase 78 Kd subunit-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I subunit, putative

Species:

Leishmania major

UniProt:

Q4QDP1_LEIMA

TriTrypDb:

LmjF.18.1480 , LMJLV39_180020300 , LMJSD75_180020600

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QDP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDP1

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0022900	electron transport chain	4	12
GO:0022904	respiratory electron transport chain	5	12
GO:0042773	ATP synthesis coupled electron transport	6	12
GO:0044237	cellular metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003954	NADH dehydrogenase activity	4	12
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	5	12
GO:0005215	transporter activity	1	12
GO:0005488	binding	1	12
GO:0008137	NADH dehydrogenase (ubiquinone) activity	4	12
GO:0009055	electron transfer activity	3	12
GO:0015399	primary active transmembrane transporter activity	4	12
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5	12
GO:0016491	oxidoreductase activity	2	12
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	12
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12
GO:0050136	NADH dehydrogenase (quinone) activity	5	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051539	4 iron, 4 sulfur cluster binding	4	12
GO:0051540	metal cluster binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	41	43	PF00082	0.404
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.404
CLV_PCSK_SKI1_1	174	178	PF00082	0.335
DEG_APCC_DBOX_1	203	211	PF00400	0.374
DOC_MAPK_gen_1	114	123	PF00069	0.268
DOC_MAPK_gen_1	32	39	PF00069	0.366
DOC_MAPK_MEF2A_6	117	125	PF00069	0.268
DOC_MAPK_MEF2A_6	66	75	PF00069	0.268
DOC_PP1_RVXF_1	183	190	PF00149	0.315
DOC_PP1_RVXF_1	32	39	PF00149	0.366
DOC_USP7_MATH_1	102	106	PF00917	0.268
DOC_USP7_MATH_1	5	9	PF00917	0.588
LIG_14-3-3_CanoR_1	204	214	PF00244	0.400
LIG_FHA_1	171	177	PF00498	0.347
LIG_FHA_1	182	188	PF00498	0.302
LIG_FHA_1	87	93	PF00498	0.268
LIG_FHA_1	96	102	PF00498	0.268
LIG_FHA_2	137	143	PF00498	0.276
LIG_FHA_2	16	22	PF00498	0.553
LIG_FHA_2	210	216	PF00498	0.418
LIG_LIR_Apic_2	165	171	PF02991	0.393
LIG_SH2_CRK	69	73	PF00017	0.284
LIG_SH2_STAP1	10	14	PF00017	0.410
LIG_SH2_STAT5	168	171	PF00017	0.382
LIG_SH3_3	96	102	PF00018	0.284
LIG_SUMO_SIM_anti_2	122	127	PF11976	0.268
LIG_SUMO_SIM_par_1	50	58	PF11976	0.268
LIG_SxIP_EBH_1	147	158	PF03271	0.268
LIG_TRAF2_1	48	51	PF00917	0.268
LIG_WRC_WIRS_1	210	215	PF05994	0.403
MOD_CK1_1	105	111	PF00069	0.303
MOD_CK1_1	208	214	PF00069	0.387
MOD_CK2_1	15	21	PF00069	0.551
MOD_GSK3_1	205	212	PF00069	0.363
MOD_N-GLC_1	144	149	PF02516	0.285
MOD_N-GLC_2	130	132	PF02516	0.268
MOD_N-GLC_2	178	180	PF02516	0.306
MOD_PIKK_1	225	231	PF00454	0.367
MOD_PIKK_1	86	92	PF00454	0.284
MOD_Plk_1	144	150	PF00069	0.268
MOD_Plk_1	208	214	PF00069	0.394
MOD_Plk_2-3	209	215	PF00069	0.397
MOD_Plk_4	102	108	PF00069	0.268
MOD_Plk_4	209	215	PF00069	0.397
MOD_SUMO_rev_2	153	163	PF00179	0.409
MOD_SUMO_rev_2	215	221	PF00179	0.474
TRG_DiLeu_BaEn_2	208	214	PF01217	0.371
TRG_ENDOCYTIC_2	69	72	PF00928	0.268
TRG_NES_CRM1_1	209	222	PF08389	0.436
TRG_NES_CRM1_1	229	242	PF08389	0.221
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD86	Leptomonas seymouri	95%	82%
A0A0S4JNM7	Bodo saltans	85%	82%
A0A1X0P7Y8	Trypanosomatidae	87%	87%
A0A3S7WV29	Leishmania donovani	99%	100%
A0A422NIN5	Trypanosoma rangeli	83%	87%
A4H9Q2	Leishmania braziliensis	96%	100%
A4HY18	Leishmania infantum	99%	100%
D0A567	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	85%
E9ART2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
P22318	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	29%	100%
V5AZ45	Trypanosoma cruzi	87%	87%