Putative chaperone protein DNAj

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania major

UniProt:

Q4QDP0_LEIMA

TriTrypDb:

LmjF.18.1490 , LMJLV39_180020500 , LMJSD75_180020800

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDP0

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	2
GO:0002098	tRNA wobble uridine modification	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006417	regulation of translation	6	10
GO:0006448	regulation of translational elongation	7	10
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009451	RNA modification	5	2
GO:0009889	regulation of biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0010468	regulation of gene expression	5	10
GO:0010556	regulation of macromolecule biosynthetic process	5	10
GO:0010608	post-transcriptional regulation of gene expression	6	10
GO:0016070	RNA metabolic process	5	2
GO:0017182	peptidyl-diphthamide metabolic process	7	10
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	4	10
GO:0018193	peptidyl-amino acid modification	5	10
GO:0018202	peptidyl-histidine modification	6	10
GO:0019222	regulation of metabolic process	3	10
GO:0019538	protein metabolic process	3	10
GO:0031323	regulation of cellular metabolic process	4	10
GO:0031326	regulation of cellular biosynthetic process	5	10
GO:0034248	regulation of amide metabolic process	5	10
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0046483	heterocycle metabolic process	3	2
GO:0050789	regulation of biological process	2	10
GO:0050794	regulation of cellular process	3	10
GO:0051171	regulation of nitrogen compound metabolic process	4	10
GO:0051246	regulation of protein metabolic process	5	10
GO:0060255	regulation of macromolecule metabolic process	4	10
GO:0065007	biological regulation	1	10
GO:0071704	organic substance metabolic process	2	10
GO:0080090	regulation of primary metabolic process	4	10
GO:0090304	nucleic acid metabolic process	4	2
GO:1900247	regulation of cytoplasmic translational elongation	8	10
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	10
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	53	55	PF00675	0.306
CLV_PCSK_KEX2_1	53	55	PF00082	0.424
CLV_PCSK_SKI1_1	31	35	PF00082	0.293
DOC_PP2B_LxvP_1	19	22	PF13499	0.276
DOC_USP7_MATH_1	151	155	PF00917	0.656
DOC_USP7_MATH_1	4	8	PF00917	0.499
DOC_USP7_MATH_1	55	59	PF00917	0.395
DOC_USP7_MATH_1	91	95	PF00917	0.534
DOC_WW_Pin1_4	11	16	PF00397	0.406
LIG_14-3-3_CanoR_1	9	16	PF00244	0.426
LIG_APCC_ABBA_1	144	149	PF00400	0.506
LIG_BIR_II_1	1	5	PF00653	0.644
LIG_FHA_1	105	111	PF00498	0.424
LIG_FHA_1	96	102	PF00498	0.556
LIG_FHA_2	12	18	PF00498	0.393
LIG_FHA_2	39	45	PF00498	0.280
LIG_LIR_Gen_1	105	115	PF02991	0.484
LIG_LIR_Gen_1	14	23	PF02991	0.328
LIG_LIR_Gen_1	69	76	PF02991	0.336
LIG_LIR_LC3C_4	175	180	PF02991	0.442
LIG_LIR_Nem_3	11	16	PF02991	0.424
LIG_LIR_Nem_3	112	117	PF02991	0.442
LIG_LIR_Nem_3	69	73	PF02991	0.327
LIG_PDZ_Class_2	179	184	PF00595	0.461
LIG_Pex14_2	66	70	PF04695	0.340
LIG_PTAP_UEV_1	22	27	PF05743	0.240
LIG_SH2_STAP1	142	146	PF00017	0.482
LIG_SH2_STAT5	84	87	PF00017	0.441
LIG_SH3_3	145	151	PF00018	0.563
LIG_SH3_3	20	26	PF00018	0.240
MOD_CK1_1	165	171	PF00069	0.490
MOD_CK1_1	58	64	PF00069	0.318
MOD_CK2_1	11	17	PF00069	0.514
MOD_CK2_1	59	65	PF00069	0.418
MOD_GlcNHglycan	1	4	PF01048	0.683
MOD_GlcNHglycan	153	156	PF01048	0.662
MOD_GlcNHglycan	164	167	PF01048	0.416
MOD_GlcNHglycan	23	26	PF01048	0.324
MOD_GlcNHglycan	50	53	PF01048	0.371
MOD_GlcNHglycan	55	58	PF01048	0.361
MOD_GSK3_1	102	109	PF00069	0.452
MOD_GSK3_1	4	11	PF00069	0.389
MOD_GSK3_1	44	51	PF00069	0.406
MOD_GSK3_1	55	62	PF00069	0.321
MOD_GSK3_1	91	98	PF00069	0.523
MOD_NEK2_1	162	167	PF00069	0.642
MOD_OFUCOSY	171	176	PF10250	0.440
MOD_PIKK_1	91	97	PF00454	0.475
MOD_PKA_1	53	59	PF00069	0.340
MOD_PKA_2	53	59	PF00069	0.340
MOD_PKA_2	8	14	PF00069	0.435
MOD_Plk_2-3	106	112	PF00069	0.475
MOD_Plk_4	106	112	PF00069	0.475
MOD_Plk_4	174	180	PF00069	0.364
MOD_ProDKin_1	11	17	PF00069	0.410
TRG_ENDOCYTIC_2	108	111	PF00928	0.420
TRG_ENDOCYTIC_2	16	19	PF00928	0.280
TRG_ER_diArg_1	115	118	PF00400	0.503
TRG_ER_diArg_1	126	129	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKZ1	Leptomonas seymouri	55%	100%
A0A0S4JNU9	Bodo saltans	40%	100%
A0A1X0P737	Trypanosomatidae	41%	100%
A0A3S7WV53	Leishmania donovani	92%	100%
A0A422NIQ2	Trypanosoma rangeli	43%	100%
A4H9Q3	Leishmania braziliensis	66%	99%
A4HY19	Leishmania infantum	92%	100%
D0A566	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ART3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q0VBY7	Bos taurus	26%	100%
Q6P3W2	Homo sapiens	27%	100%