Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDN9_LEIMA

TriTrypDb:

LmjF.18.1500 , LMJLV39_180020600 , LMJSD75_180020900

Length:

1046

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDN9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.727
CLV_C14_Caspase3-7	650	654	PF00656	0.828
CLV_NRD_NRD_1	1039	1041	PF00675	0.513
CLV_NRD_NRD_1	155	157	PF00675	0.546
CLV_NRD_NRD_1	234	236	PF00675	0.762
CLV_NRD_NRD_1	456	458	PF00675	0.579
CLV_NRD_NRD_1	682	684	PF00675	0.673
CLV_NRD_NRD_1	898	900	PF00675	0.606
CLV_NRD_NRD_1	932	934	PF00675	0.467
CLV_PCSK_FUR_1	231	235	PF00082	0.756
CLV_PCSK_FUR_1	680	684	PF00082	0.743
CLV_PCSK_KEX2_1	1038	1040	PF00082	0.539
CLV_PCSK_KEX2_1	155	157	PF00082	0.473
CLV_PCSK_KEX2_1	230	232	PF00082	0.785
CLV_PCSK_KEX2_1	233	235	PF00082	0.760
CLV_PCSK_KEX2_1	456	458	PF00082	0.579
CLV_PCSK_KEX2_1	682	684	PF00082	0.642
CLV_PCSK_KEX2_1	898	900	PF00082	0.606
CLV_PCSK_KEX2_1	932	934	PF00082	0.534
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.785
CLV_PCSK_SKI1_1	1007	1011	PF00082	0.601
CLV_PCSK_SKI1_1	1040	1044	PF00082	0.584
CLV_PCSK_SKI1_1	308	312	PF00082	0.574
CLV_PCSK_SKI1_1	457	461	PF00082	0.745
CLV_PCSK_SKI1_1	683	687	PF00082	0.690
CLV_PCSK_SKI1_1	692	696	PF00082	0.708
CLV_PCSK_SKI1_1	975	979	PF00082	0.595
DEG_APCC_DBOX_1	232	240	PF00400	0.675
DEG_SPOP_SBC_1	817	821	PF00917	0.711
DOC_CKS1_1	260	265	PF01111	0.642
DOC_CKS1_1	513	518	PF01111	0.615
DOC_CKS1_1	532	537	PF01111	0.539
DOC_CYCLIN_RxL_1	680	693	PF00134	0.757
DOC_CYCLIN_RxL_1	969	981	PF00134	0.606
DOC_CYCLIN_yCln2_LP_2	498	504	PF00134	0.813
DOC_MAPK_DCC_7	231	241	PF00069	0.613
DOC_MAPK_gen_1	1038	1046	PF00069	0.613
DOC_MAPK_gen_1	230	241	PF00069	0.607
DOC_MAPK_gen_1	682	691	PF00069	0.703
DOC_MAPK_gen_1	868	877	PF00069	0.534
DOC_MAPK_JIP1_4	871	877	PF00069	0.612
DOC_MAPK_MEF2A_6	188	196	PF00069	0.709
DOC_MAPK_MEF2A_6	233	241	PF00069	0.571
DOC_MAPK_MEF2A_6	586	595	PF00069	0.595
DOC_MAPK_MEF2A_6	868	877	PF00069	0.543
DOC_MAPK_MEF2A_6	889	897	PF00069	0.565
DOC_PP2B_LxvP_1	833	836	PF13499	0.565
DOC_PP4_FxxP_1	549	552	PF00568	0.456
DOC_PP4_FxxP_1	80	83	PF00568	0.685
DOC_USP7_MATH_1	103	107	PF00917	0.568
DOC_USP7_MATH_1	1042	1046	PF00917	0.628
DOC_USP7_MATH_1	224	228	PF00917	0.778
DOC_USP7_MATH_1	315	319	PF00917	0.665
DOC_USP7_MATH_1	342	346	PF00917	0.779
DOC_USP7_MATH_1	369	373	PF00917	0.772
DOC_USP7_MATH_1	568	572	PF00917	0.597
DOC_USP7_MATH_1	629	633	PF00917	0.826
DOC_USP7_MATH_1	684	688	PF00917	0.697
DOC_USP7_MATH_1	723	727	PF00917	0.761
DOC_USP7_MATH_1	746	750	PF00917	0.707
DOC_USP7_MATH_1	811	815	PF00917	0.657
DOC_USP7_MATH_1	817	821	PF00917	0.685
DOC_USP7_MATH_1	836	840	PF00917	0.539
DOC_USP7_MATH_1	935	939	PF00917	0.705
DOC_WW_Pin1_4	158	163	PF00397	0.730
DOC_WW_Pin1_4	243	248	PF00397	0.670
DOC_WW_Pin1_4	259	264	PF00397	0.745
DOC_WW_Pin1_4	277	282	PF00397	0.490
DOC_WW_Pin1_4	347	352	PF00397	0.783
DOC_WW_Pin1_4	381	386	PF00397	0.728
DOC_WW_Pin1_4	512	517	PF00397	0.574
DOC_WW_Pin1_4	531	536	PF00397	0.497
DOC_WW_Pin1_4	703	708	PF00397	0.719
DOC_WW_Pin1_4	715	720	PF00397	0.729
DOC_WW_Pin1_4	731	736	PF00397	0.711
DOC_WW_Pin1_4	79	84	PF00397	0.723
DOC_WW_Pin1_4	823	828	PF00397	0.655
DOC_WW_Pin1_4	847	852	PF00397	0.585
DOC_WW_Pin1_4	882	887	PF00397	0.628
DOC_WW_Pin1_4	985	990	PF00397	0.651
LIG_14-3-3_CanoR_1	10	15	PF00244	0.724
LIG_14-3-3_CanoR_1	155	163	PF00244	0.760
LIG_14-3-3_CanoR_1	288	292	PF00244	0.609
LIG_14-3-3_CanoR_1	337	346	PF00244	0.708
LIG_14-3-3_CanoR_1	569	573	PF00244	0.622
LIG_14-3-3_CanoR_1	683	689	PF00244	0.657
LIG_14-3-3_CanoR_1	715	719	PF00244	0.787
LIG_14-3-3_CanoR_1	969	977	PF00244	0.616
LIG_Actin_WH2_2	549	566	PF00022	0.553
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_BIR_III_2	394	398	PF00653	0.787
LIG_BIR_III_2	49	53	PF00653	0.716
LIG_BIR_III_2	628	632	PF00653	0.812
LIG_BRCT_BRCA1_1	122	126	PF00533	0.564
LIG_CSL_BTD_1	266	269	PF09270	0.581
LIG_CSL_BTD_1	348	351	PF09270	0.702
LIG_CSL_BTD_1	873	876	PF09270	0.522
LIG_DLG_GKlike_1	889	897	PF00625	0.627
LIG_FHA_1	105	111	PF00498	0.570
LIG_FHA_1	158	164	PF00498	0.702
LIG_FHA_1	326	332	PF00498	0.653
LIG_FHA_1	399	405	PF00498	0.748
LIG_FHA_1	483	489	PF00498	0.803
LIG_FHA_1	546	552	PF00498	0.448
LIG_FHA_1	732	738	PF00498	0.679
LIG_FHA_1	750	756	PF00498	0.692
LIG_FHA_1	762	768	PF00498	0.472
LIG_FHA_1	852	858	PF00498	0.554
LIG_FHA_1	989	995	PF00498	0.595
LIG_FHA_2	1025	1031	PF00498	0.636
LIG_FHA_2	259	265	PF00498	0.744
LIG_FHA_2	513	519	PF00498	0.592
LIG_FHA_2	55	61	PF00498	0.724
LIG_FHA_2	618	624	PF00498	0.696
LIG_FHA_2	817	823	PF00498	0.742
LIG_FHA_2	883	889	PF00498	0.560
LIG_LIR_Apic_2	11	15	PF02991	0.586
LIG_LIR_Apic_2	379	385	PF02991	0.783
LIG_LIR_Apic_2	475	481	PF02991	0.758
LIG_LIR_Apic_2	548	552	PF02991	0.459
LIG_LIR_Gen_1	131	140	PF02991	0.534
LIG_LIR_Gen_1	518	527	PF02991	0.543
LIG_LIR_Gen_1	577	584	PF02991	0.370
LIG_LIR_Nem_3	123	129	PF02991	0.528
LIG_LIR_Nem_3	131	135	PF02991	0.439
LIG_LIR_Nem_3	445	451	PF02991	0.721
LIG_LIR_Nem_3	518	522	PF02991	0.561
LIG_LIR_Nem_3	548	553	PF02991	0.458
LIG_LIR_Nem_3	577	583	PF02991	0.444
LIG_LIR_Nem_3	74	80	PF02991	0.734
LIG_LIR_Nem_3	754	760	PF02991	0.586
LIG_LIR_Nem_3	783	788	PF02991	0.515
LIG_LYPXL_yS_3	757	760	PF13949	0.595
LIG_MYND_1	797	801	PF01753	0.622
LIG_NRBOX	910	916	PF00104	0.494
LIG_PDZ_Class_2	1041	1046	PF00595	0.721
LIG_Rb_pABgroove_1	472	480	PF01858	0.760
LIG_RPA_C_Fungi	928	940	PF08784	0.552
LIG_SH2_CRK	12	16	PF00017	0.590
LIG_SH2_CRK	448	452	PF00017	0.737
LIG_SH2_CRK	478	482	PF00017	0.755
LIG_SH2_NCK_1	12	16	PF00017	0.590
LIG_SH2_NCK_1	314	318	PF00017	0.644
LIG_SH2_NCK_1	478	482	PF00017	0.755
LIG_SH2_PTP2	382	385	PF00017	0.746
LIG_SH2_PTP2	785	788	PF00017	0.517
LIG_SH2_STAP1	34	38	PF00017	0.542
LIG_SH2_STAT5	30	33	PF00017	0.678
LIG_SH2_STAT5	382	385	PF00017	0.734
LIG_SH2_STAT5	541	544	PF00017	0.499
LIG_SH2_STAT5	582	585	PF00017	0.427
LIG_SH2_STAT5	785	788	PF00017	0.463
LIG_SH2_STAT5	79	82	PF00017	0.569
LIG_SH2_STAT5	795	798	PF00017	0.497
LIG_SH3_1	478	484	PF00018	0.656
LIG_SH3_3	236	242	PF00018	0.776
LIG_SH3_3	380	386	PF00018	0.710
LIG_SH3_3	478	484	PF00018	0.668
LIG_SH3_3	507	513	PF00018	0.719
LIG_SH3_3	678	684	PF00018	0.594
LIG_SH3_3	83	89	PF00018	0.686
LIG_SH3_3	870	876	PF00018	0.550
LIG_SH3_5	385	389	PF00018	0.795
LIG_SUMO_SIM_anti_2	947	952	PF11976	0.579
LIG_SUMO_SIM_par_1	106	112	PF11976	0.575
LIG_SUMO_SIM_par_1	398	403	PF11976	0.805
LIG_SUMO_SIM_par_1	687	693	PF11976	0.670
LIG_SxIP_EBH_1	823	834	PF03271	0.607
LIG_TRAF2_1	33	36	PF00917	0.593
LIG_TRAF2_1	552	555	PF00917	0.611
LIG_TRAF2_1	885	888	PF00917	0.618
LIG_TRAF2_2	535	540	PF00917	0.587
LIG_TRFH_1	847	851	PF08558	0.541
LIG_TYR_ITIM	446	451	PF00017	0.723
LIG_TYR_ITIM	755	760	PF00017	0.600
LIG_WRC_WIRS_1	129	134	PF05994	0.460
LIG_WRC_WIRS_1	546	551	PF05994	0.446
LIG_WRC_WIRS_1	691	696	PF05994	0.675
MOD_CDC14_SPxK_1	350	353	PF00782	0.581
MOD_CDK_SPxK_1	259	265	PF00069	0.518
MOD_CDK_SPxK_1	347	353	PF00069	0.590
MOD_CDK_SPxxK_3	882	889	PF00069	0.624
MOD_CK1_1	128	134	PF00069	0.464
MOD_CK1_1	158	164	PF00069	0.710
MOD_CK1_1	2	8	PF00069	0.600
MOD_CK1_1	211	217	PF00069	0.777
MOD_CK1_1	246	252	PF00069	0.744
MOD_CK1_1	259	265	PF00069	0.663
MOD_CK1_1	381	387	PF00069	0.755
MOD_CK1_1	452	458	PF00069	0.737
MOD_CK1_1	490	496	PF00069	0.753
MOD_CK1_1	571	577	PF00069	0.470
MOD_CK1_1	662	668	PF00069	0.767
MOD_CK1_1	670	676	PF00069	0.678
MOD_CK1_1	687	693	PF00069	0.688
MOD_CK1_1	726	732	PF00069	0.704
MOD_CK1_1	733	739	PF00069	0.646
MOD_CK1_1	749	755	PF00069	0.594
MOD_CK1_1	82	88	PF00069	0.656
MOD_CK1_1	882	888	PF00069	0.561
MOD_CK1_1	988	994	PF00069	0.613
MOD_CK2_1	1024	1030	PF00069	0.693
MOD_CK2_1	258	264	PF00069	0.697
MOD_CK2_1	512	518	PF00069	0.612
MOD_CK2_1	54	60	PF00069	0.748
MOD_CK2_1	617	623	PF00069	0.623
MOD_CK2_1	852	858	PF00069	0.544
MOD_CK2_1	882	888	PF00069	0.561
MOD_CK2_1	903	909	PF00069	0.574
MOD_CMANNOS	770	773	PF00535	0.516
MOD_DYRK1A_RPxSP_1	512	516	PF00069	0.629
MOD_GlcNHglycan	1	4	PF01048	0.722
MOD_GlcNHglycan	12	15	PF01048	0.565
MOD_GlcNHglycan	176	179	PF01048	0.789
MOD_GlcNHglycan	226	229	PF01048	0.752
MOD_GlcNHglycan	418	421	PF01048	0.822
MOD_GlcNHglycan	429	432	PF01048	0.641
MOD_GlcNHglycan	451	454	PF01048	0.748
MOD_GlcNHglycan	657	660	PF01048	0.768
MOD_GlcNHglycan	661	664	PF01048	0.727
MOD_GlcNHglycan	728	731	PF01048	0.624
MOD_GlcNHglycan	739	742	PF01048	0.459
MOD_GlcNHglycan	900	903	PF01048	0.615
MOD_GlcNHglycan	937	940	PF01048	0.625
MOD_GlcNHglycan	955	958	PF01048	0.269
MOD_GSK3_1	104	111	PF00069	0.547
MOD_GSK3_1	208	215	PF00069	0.722
MOD_GSK3_1	321	328	PF00069	0.599
MOD_GSK3_1	487	494	PF00069	0.753
MOD_GSK3_1	504	511	PF00069	0.679
MOD_GSK3_1	567	574	PF00069	0.584
MOD_GSK3_1	651	658	PF00069	0.680
MOD_GSK3_1	662	669	PF00069	0.635
MOD_GSK3_1	724	731	PF00069	0.658
MOD_GSK3_1	733	740	PF00069	0.674
MOD_GSK3_1	745	752	PF00069	0.632
MOD_GSK3_1	811	818	PF00069	0.597
MOD_GSK3_1	834	841	PF00069	0.538
MOD_GSK3_1	847	854	PF00069	0.571
MOD_GSK3_1	875	882	PF00069	0.545
MOD_N-GLC_2	339	341	PF02516	0.711
MOD_NEK2_1	125	130	PF00069	0.644
MOD_NEK2_1	208	213	PF00069	0.699
MOD_NEK2_1	287	292	PF00069	0.617
MOD_NEK2_1	310	315	PF00069	0.619
MOD_NEK2_1	641	646	PF00069	0.576
MOD_NEK2_1	857	862	PF00069	0.613
MOD_NEK2_1	944	949	PF00069	0.514
MOD_NEK2_1	978	983	PF00069	0.675
MOD_NEK2_2	568	573	PF00069	0.535
MOD_NEK2_2	838	843	PF00069	0.403
MOD_PIKK_1	140	146	PF00454	0.581
MOD_PIKK_1	389	395	PF00454	0.732
MOD_PIKK_1	457	463	PF00454	0.809
MOD_PIKK_1	493	499	PF00454	0.744
MOD_PIKK_1	761	767	PF00454	0.528
MOD_PIKK_1	978	984	PF00454	0.719
MOD_PK_1	363	369	PF00069	0.767
MOD_PK_1	651	657	PF00069	0.641
MOD_PKA_1	155	161	PF00069	0.510
MOD_PKA_1	898	904	PF00069	0.629
MOD_PKA_2	1024	1030	PF00069	0.701
MOD_PKA_2	155	161	PF00069	0.627
MOD_PKA_2	211	217	PF00069	0.704
MOD_PKA_2	287	293	PF00069	0.625
MOD_PKA_2	508	514	PF00069	0.683
MOD_PKA_2	556	562	PF00069	0.552
MOD_PKA_2	568	574	PF00069	0.581
MOD_PKA_2	714	720	PF00069	0.777
MOD_PKA_2	898	904	PF00069	0.629
MOD_PKA_2	968	974	PF00069	0.548
MOD_Plk_1	325	331	PF00069	0.667
MOD_Plk_1	363	369	PF00069	0.767
MOD_Plk_1	811	817	PF00069	0.702
MOD_Plk_1	857	863	PF00069	0.653
MOD_Plk_1	889	895	PF00069	0.583
MOD_Plk_1	94	100	PF00069	0.582
MOD_Plk_4	104	110	PF00069	0.592
MOD_Plk_4	270	276	PF00069	0.532
MOD_Plk_4	342	348	PF00069	0.755
MOD_Plk_4	378	384	PF00069	0.791
MOD_Plk_4	545	551	PF00069	0.443
MOD_Plk_4	662	668	PF00069	0.727
MOD_Plk_4	684	690	PF00069	0.669
MOD_Plk_4	733	739	PF00069	0.550
MOD_Plk_4	781	787	PF00069	0.529
MOD_Plk_4	811	817	PF00069	0.702
MOD_Plk_4	857	863	PF00069	0.653
MOD_Plk_4	946	952	PF00069	0.512
MOD_ProDKin_1	158	164	PF00069	0.733
MOD_ProDKin_1	243	249	PF00069	0.670
MOD_ProDKin_1	259	265	PF00069	0.739
MOD_ProDKin_1	277	283	PF00069	0.489
MOD_ProDKin_1	347	353	PF00069	0.783
MOD_ProDKin_1	381	387	PF00069	0.729
MOD_ProDKin_1	512	518	PF00069	0.570
MOD_ProDKin_1	531	537	PF00069	0.497
MOD_ProDKin_1	703	709	PF00069	0.719
MOD_ProDKin_1	715	721	PF00069	0.730
MOD_ProDKin_1	731	737	PF00069	0.719
MOD_ProDKin_1	79	85	PF00069	0.721
MOD_ProDKin_1	823	829	PF00069	0.650
MOD_ProDKin_1	847	853	PF00069	0.580
MOD_ProDKin_1	882	888	PF00069	0.623
MOD_ProDKin_1	985	991	PF00069	0.647
MOD_SUMO_rev_2	183	190	PF00179	0.701
MOD_SUMO_rev_2	585	591	PF00179	0.645
TRG_DiLeu_BaEn_2	1004	1010	PF01217	0.544
TRG_DiLeu_BaEn_4	890	896	PF01217	0.622
TRG_DiLeu_BaLyEn_6	1031	1036	PF01217	0.595
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.573
TRG_DiLeu_BaLyEn_6	772	777	PF01217	0.478
TRG_DiLeu_BaLyEn_6	876	881	PF01217	0.531
TRG_ENDOCYTIC_2	34	37	PF00928	0.551
TRG_ENDOCYTIC_2	448	451	PF00928	0.726
TRG_ENDOCYTIC_2	580	583	PF00928	0.534
TRG_ENDOCYTIC_2	757	760	PF00928	0.595
TRG_ENDOCYTIC_2	785	788	PF00928	0.517
TRG_ER_diArg_1	1037	1040	PF00400	0.525
TRG_ER_diArg_1	231	234	PF00400	0.795
TRG_ER_diArg_1	299	302	PF00400	0.606
TRG_ER_diArg_1	679	682	PF00400	0.637
TRG_ER_diArg_1	842	845	PF00400	0.478
TRG_ER_diArg_1	897	899	PF00400	0.586
TRG_ER_diArg_1	931	933	PF00400	0.522
TRG_NLS_MonoExtC_3	229	234	PF00514	0.756
TRG_Pf-PMV_PEXEL_1	115	120	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U0	Leptomonas seymouri	43%	94%
A0A3S7WV44	Leishmania donovani	92%	100%
A4H9Q4	Leishmania braziliensis	76%	100%
A4HY20	Leishmania infantum	92%	100%
D0A565	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ART4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	92%