Plasma membrane ATPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

P-type H+-ATPase, putative

Species:

Leishmania major

UniProt:

Q4QDN8_LEIMA

TriTrypDb:

LmjF.18.1510 , LMJLV39_180020800 , LMJSD75_180021000

Length:

974

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	19
GO:0016020	membrane	2	20
GO:0110165	cellular anatomical entity	1	20

Expansion

Sequence features

Q4QDN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDN8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	19
GO:0006811	monoatomic ion transport	4	19
GO:0006812	monoatomic cation transport	5	19
GO:0006873	intracellular monoatomic ion homeostasis	4	3
GO:0006885	regulation of pH	8	3
GO:0009987	cellular process	1	19
GO:0019725	cellular homeostasis	2	3
GO:0030003	intracellular monoatomic cation homeostasis	5	3
GO:0030004	obsolete cellular monovalent inorganic cation homeostasis	6	3
GO:0030641	regulation of cellular pH	7	3
GO:0034220	monoatomic ion transmembrane transport	3	19
GO:0042592	homeostatic process	3	3
GO:0048878	chemical homeostasis	4	3
GO:0050801	monoatomic ion homeostasis	5	3
GO:0051179	localization	1	19
GO:0051234	establishment of localization	2	19
GO:0051453	regulation of intracellular pH	8	3
GO:0055067	obsolete monovalent inorganic cation homeostasis	7	3
GO:0055080	monoatomic cation homeostasis	6	3
GO:0055082	intracellular chemical homeostasis	3	3
GO:0055085	transmembrane transport	2	19
GO:0065007	biological regulation	1	3
GO:0065008	regulation of biological quality	2	3
GO:0098655	monoatomic cation transmembrane transport	4	19
GO:0098660	inorganic ion transmembrane transport	4	19
GO:0098662	inorganic cation transmembrane transport	5	19
GO:0098771	inorganic ion homeostasis	6	3
GO:0120029	proton export across plasma membrane	4	19
GO:0140115	export across plasma membrane	3	19
GO:0140352	export from cell	2	19
GO:1902600	proton transmembrane transport	6	19

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	20
GO:0003824	catalytic activity	1	20
GO:0005215	transporter activity	1	19
GO:0005488	binding	1	20
GO:0005524	ATP binding	5	20
GO:0008324	monoatomic cation transmembrane transporter activity	4	19
GO:0008553	P-type proton-exporting transporter activity	4	19
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	19
GO:0015075	monoatomic ion transmembrane transporter activity	3	19
GO:0015078	proton transmembrane transporter activity	5	19
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	19
GO:0015399	primary active transmembrane transporter activity	4	19
GO:0015662	P-type ion transporter activity	4	19
GO:0016462	pyrophosphatase activity	5	20
GO:0016787	hydrolase activity	2	20
GO:0016817	hydrolase activity, acting on acid anhydrides	3	20
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	20
GO:0016887	ATP hydrolysis activity	7	20
GO:0017076	purine nucleotide binding	4	20
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	20
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	19
GO:0022804	active transmembrane transporter activity	3	19
GO:0022853	active monoatomic ion transmembrane transporter activity	4	19
GO:0022857	transmembrane transporter activity	2	19
GO:0022890	inorganic cation transmembrane transporter activity	4	19
GO:0030554	adenyl nucleotide binding	5	20
GO:0032553	ribonucleotide binding	3	20
GO:0032555	purine ribonucleotide binding	4	20
GO:0032559	adenyl ribonucleotide binding	5	20
GO:0035639	purine ribonucleoside triphosphate binding	4	20
GO:0036094	small molecule binding	2	20
GO:0042626	ATPase-coupled transmembrane transporter activity	2	19
GO:0043167	ion binding	2	20
GO:0043168	anion binding	3	20
GO:0097159	organic cyclic compound binding	2	20
GO:0097367	carbohydrate derivative binding	2	20
GO:0140358	P-type transmembrane transporter activity	3	19
GO:0140657	ATP-dependent activity	1	19
GO:1901265	nucleoside phosphate binding	3	20
GO:1901363	heterocyclic compound binding	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	467	471	PF00656	0.568
CLV_C14_Caspase3-7	844	848	PF00656	0.420
CLV_NRD_NRD_1	263	265	PF00675	0.386
CLV_NRD_NRD_1	32	34	PF00675	0.603
CLV_NRD_NRD_1	435	437	PF00675	0.425
CLV_NRD_NRD_1	512	514	PF00675	0.314
CLV_PCSK_KEX2_1	263	265	PF00082	0.386
CLV_PCSK_KEX2_1	32	34	PF00082	0.577
CLV_PCSK_KEX2_1	426	428	PF00082	0.314
CLV_PCSK_KEX2_1	435	437	PF00082	0.314
CLV_PCSK_KEX2_1	512	514	PF00082	0.314
CLV_PCSK_KEX2_1	614	616	PF00082	0.314
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.321
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.314
CLV_PCSK_SKI1_1	264	268	PF00082	0.333
CLV_PCSK_SKI1_1	293	297	PF00082	0.569
CLV_PCSK_SKI1_1	394	398	PF00082	0.349
CLV_PCSK_SKI1_1	522	526	PF00082	0.314
CLV_PCSK_SKI1_1	60	64	PF00082	0.345
CLV_PCSK_SKI1_1	653	657	PF00082	0.336
CLV_PCSK_SKI1_1	787	791	PF00082	0.545
CLV_Separin_Metazoa	391	395	PF03568	0.514
DEG_APCC_DBOX_1	393	401	PF00400	0.514
DEG_SCF_SKP2-CKS1_1	22	29	PF00560	0.832
DEG_SPOP_SBC_1	314	318	PF00917	0.521
DOC_ANK_TNKS_1	224	231	PF00023	0.528
DOC_CDC14_PxL_1	698	706	PF14671	0.321
DOC_CYCLIN_RxL_1	533	542	PF00134	0.567
DOC_CYCLIN_RxL_1	653	664	PF00134	0.542
DOC_CYCLIN_RxL_1	931	942	PF00134	0.721
DOC_CYCLIN_yCln2_LP_2	55	58	PF00134	0.663
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.356
DOC_MAPK_DCC_7	733	741	PF00069	0.659
DOC_MAPK_gen_1	512	521	PF00069	0.508
DOC_MAPK_gen_1	614	622	PF00069	0.560
DOC_MAPK_gen_1	730	740	PF00069	0.601
DOC_MAPK_MEF2A_6	445	454	PF00069	0.512
DOC_MAPK_MEF2A_6	515	523	PF00069	0.508
DOC_MAPK_MEF2A_6	567	575	PF00069	0.568
DOC_MAPK_MEF2A_6	614	622	PF00069	0.560
DOC_MAPK_MEF2A_6	733	741	PF00069	0.551
DOC_MAPK_MEF2A_6	787	796	PF00069	0.345
DOC_MAPK_MEF2A_6	863	871	PF00069	0.397
DOC_PP1_RVXF_1	261	268	PF00149	0.554
DOC_PP1_RVXF_1	656	663	PF00149	0.535
DOC_PP2B_LxvP_1	500	503	PF13499	0.514
DOC_PP2B_LxvP_1	55	58	PF13499	0.656
DOC_PP4_FxxP_1	499	502	PF00568	0.514
DOC_PP4_FxxP_1	699	702	PF00568	0.405
DOC_USP7_MATH_1	179	183	PF00917	0.523
DOC_USP7_MATH_1	186	190	PF00917	0.517
DOC_USP7_MATH_1	320	324	PF00917	0.521
DOC_USP7_MATH_1	688	692	PF00917	0.451
DOC_USP7_MATH_1	750	754	PF00917	0.371
DOC_USP7_MATH_1	903	907	PF00917	0.752
DOC_USP7_MATH_1	928	932	PF00917	0.809
DOC_USP7_UBL2_3	147	151	PF12436	0.674
DOC_USP7_UBL2_3	324	328	PF12436	0.536
DOC_WW_Pin1_4	23	28	PF00397	0.856
DOC_WW_Pin1_4	682	687	PF00397	0.391
DOC_WW_Pin1_4	81	86	PF00397	0.521
DOC_WW_Pin1_4	817	822	PF00397	0.668
DOC_WW_Pin1_4	954	959	PF00397	0.799
DOC_WW_Pin1_4	960	965	PF00397	0.796
LIG_14-3-3_CanoR_1	264	270	PF00244	0.543
LIG_14-3-3_CanoR_1	32	37	PF00244	0.770
LIG_14-3-3_CanoR_1	427	433	PF00244	0.528
LIG_14-3-3_CanoR_1	478	483	PF00244	0.528
LIG_14-3-3_CanoR_1	658	663	PF00244	0.514
LIG_14-3-3_CanoR_1	666	672	PF00244	0.364
LIG_Actin_WH2_2	248	265	PF00022	0.586
LIG_APCC_ABBA_1	909	914	PF00400	0.830
LIG_BIR_II_1	1	5	PF00653	0.789
LIG_BRCT_BRCA1_1	236	240	PF00533	0.562
LIG_CtBP_PxDLS_1	561	565	PF00389	0.586
LIG_EH1_1	297	305	PF00400	0.384
LIG_EH1_1	448	456	PF00400	0.555
LIG_FHA_1	233	239	PF00498	0.562
LIG_FHA_1	242	248	PF00498	0.489
LIG_FHA_1	314	320	PF00498	0.531
LIG_FHA_1	351	357	PF00498	0.509
LIG_FHA_1	377	383	PF00498	0.636
LIG_FHA_1	397	403	PF00498	0.527
LIG_FHA_1	51	57	PF00498	0.721
LIG_FHA_1	662	668	PF00498	0.359
LIG_FHA_1	849	855	PF00498	0.400
LIG_FHA_2	367	373	PF00498	0.549
LIG_FHA_2	429	435	PF00498	0.593
LIG_FHA_2	496	502	PF00498	0.553
LIG_FHA_2	61	67	PF00498	0.536
LIG_FHA_2	857	863	PF00498	0.472
LIG_FHA_2	928	934	PF00498	0.650
LIG_GBD_Chelix_1	104	112	PF00786	0.374
LIG_LIR_Apic_2	498	502	PF02991	0.514
LIG_LIR_Gen_1	159	170	PF02991	0.508
LIG_LIR_Gen_1	411	421	PF02991	0.536
LIG_LIR_Gen_1	584	593	PF02991	0.513
LIG_LIR_Gen_1	654	663	PF02991	0.648
LIG_LIR_Gen_1	693	704	PF02991	0.375
LIG_LIR_Gen_1	719	727	PF02991	0.430
LIG_LIR_Gen_1	790	801	PF02991	0.303
LIG_LIR_Nem_3	159	165	PF02991	0.514
LIG_LIR_Nem_3	411	416	PF02991	0.515
LIG_LIR_Nem_3	584	590	PF02991	0.514
LIG_LIR_Nem_3	661	665	PF02991	0.357
LIG_LIR_Nem_3	693	699	PF02991	0.362
LIG_LIR_Nem_3	719	725	PF02991	0.422
LIG_LIR_Nem_3	773	778	PF02991	0.380
LIG_LIR_Nem_3	790	796	PF02991	0.188
LIG_LIR_Nem_3	799	804	PF02991	0.364
LIG_LIR_Nem_3	84	90	PF02991	0.521
LIG_LIR_Nem_3	895	900	PF02991	0.620
LIG_NBox_RRM_1	292	302	PF00076	0.397
LIG_NRBOX	707	713	PF00104	0.367
LIG_PALB2_WD40_1	770	778	PF16756	0.399
LIG_PAM2_1	265	277	PF00658	0.345
LIG_PCNA_PIPBox_1	493	502	PF02747	0.567
LIG_PCNA_yPIPBox_3	785	795	PF02747	0.347
LIG_Pex14_1	868	872	PF04695	0.396
LIG_Pex14_2	288	292	PF04695	0.347
LIG_Pex14_2	578	582	PF04695	0.545
LIG_Pex14_2	678	682	PF04695	0.364
LIG_Pex14_2	801	805	PF04695	0.364
LIG_PTB_Apo_2	769	776	PF02174	0.433
LIG_REV1ctd_RIR_1	238	247	PF16727	0.528
LIG_SH2_CRK	413	417	PF00017	0.586
LIG_SH2_GRB2like	770	773	PF00017	0.451
LIG_SH2_SRC	722	725	PF00017	0.604
LIG_SH2_SRC	770	773	PF00017	0.451
LIG_SH2_STAP1	598	602	PF00017	0.526
LIG_SH2_STAP1	722	726	PF00017	0.569
LIG_SH2_STAP1	765	769	PF00017	0.484
LIG_SH2_STAP1	770	774	PF00017	0.468
LIG_SH2_STAT3	765	768	PF00017	0.448
LIG_SH2_STAT5	234	237	PF00017	0.581
LIG_SH2_STAT5	283	286	PF00017	0.356
LIG_SH2_STAT5	598	601	PF00017	0.538
LIG_SH2_STAT5	793	796	PF00017	0.364
LIG_SH2_STAT5	872	875	PF00017	0.396
LIG_SH2_STAT5	90	93	PF00017	0.514
LIG_SH2_STAT5	968	971	PF00017	0.734
LIG_SH3_2	27	32	PF14604	0.802
LIG_SH3_3	166	172	PF00018	0.569
LIG_SH3_3	24	30	PF00018	0.809
LIG_SH3_3	302	308	PF00018	0.374
LIG_SH3_3	417	423	PF00018	0.514
LIG_SH3_3	499	505	PF00018	0.521
LIG_SH3_3	905	911	PF00018	0.803
LIG_SH3_4	16	23	PF00018	0.703
LIG_SUMO_SIM_anti_2	463	471	PF11976	0.577
LIG_SUMO_SIM_anti_2	753	759	PF11976	0.370
LIG_SUMO_SIM_par_1	192	199	PF11976	0.521
LIG_SUMO_SIM_par_1	300	306	PF11976	0.365
LIG_SUMO_SIM_par_1	307	312	PF11976	0.351
LIG_SUMO_SIM_par_1	316	323	PF11976	0.496
LIG_SUMO_SIM_par_1	463	471	PF11976	0.546
LIG_SUMO_SIM_par_1	537	542	PF11976	0.610
LIG_TRAF2_1	21	24	PF00917	0.843
LIG_TRAF2_1	369	372	PF00917	0.555
LIG_TRAF2_1	63	66	PF00917	0.615
LIG_TRAF2_1	958	961	PF00917	0.681
LIG_TRFH_1	682	686	PF08558	0.386
LIG_TYR_ITIM	720	725	PF00017	0.422
LIG_UBA3_1	791	795	PF00899	0.374
LIG_WRC_WIRS_1	289	294	PF05994	0.430
LIG_WRC_WIRS_1	496	501	PF05994	0.514
LIG_WRC_WIRS_1	659	664	PF05994	0.514
LIG_WW_3	391	395	PF00397	0.514
LIG_WW_3	501	505	PF00397	0.508
MOD_CDK_SPK_2	682	687	PF00069	0.427
MOD_CDK_SPxK_1	23	29	PF00069	0.833
MOD_CK1_1	250	256	PF00069	0.575
MOD_CK1_1	35	41	PF00069	0.739
MOD_CK1_1	350	356	PF00069	0.525
MOD_CK1_1	661	667	PF00069	0.384
MOD_CK1_1	806	812	PF00069	0.553
MOD_CK1_1	901	907	PF00069	0.705
MOD_CK1_1	913	919	PF00069	0.714
MOD_CK1_1	927	933	PF00069	0.748
MOD_CK1_1	939	945	PF00069	0.815
MOD_CK2_1	18	24	PF00069	0.839
MOD_CK2_1	186	192	PF00069	0.521
MOD_CK2_1	334	340	PF00069	0.572
MOD_CK2_1	366	372	PF00069	0.549
MOD_CK2_1	60	66	PF00069	0.521
MOD_CK2_1	856	862	PF00069	0.479
MOD_CK2_1	927	933	PF00069	0.807
MOD_CK2_1	954	960	PF00069	0.701
MOD_GlcNHglycan	179	182	PF01048	0.322
MOD_GlcNHglycan	336	339	PF01048	0.390
MOD_GlcNHglycan	342	345	PF01048	0.344
MOD_GlcNHglycan	436	439	PF01048	0.372
MOD_GlcNHglycan	667	670	PF01048	0.364
MOD_GlcNHglycan	741	744	PF01048	0.397
MOD_GlcNHglycan	902	906	PF01048	0.525
MOD_GlcNHglycan	926	929	PF01048	0.622
MOD_GlcNHglycan	930	933	PF01048	0.487
MOD_GlcNHglycan	941	944	PF01048	0.513
MOD_GSK3_1	203	210	PF00069	0.514
MOD_GSK3_1	228	235	PF00069	0.508
MOD_GSK3_1	320	327	PF00069	0.512
MOD_GSK3_1	35	42	PF00069	0.737
MOD_GSK3_1	350	357	PF00069	0.528
MOD_GSK3_1	421	428	PF00069	0.555
MOD_GSK3_1	46	53	PF00069	0.714
MOD_GSK3_1	478	485	PF00069	0.514
MOD_GSK3_1	507	514	PF00069	0.514
MOD_GSK3_1	56	63	PF00069	0.482
MOD_GSK3_1	596	603	PF00069	0.514
MOD_GSK3_1	661	668	PF00069	0.364
MOD_GSK3_1	796	803	PF00069	0.364
MOD_GSK3_1	813	820	PF00069	0.546
MOD_GSK3_1	827	834	PF00069	0.371
MOD_GSK3_1	924	931	PF00069	0.744
MOD_N-GLC_1	127	132	PF02516	0.384
MOD_N-GLC_1	936	941	PF02516	0.568
MOD_NEK2_1	146	151	PF00069	0.617
MOD_NEK2_1	241	246	PF00069	0.515
MOD_NEK2_1	288	293	PF00069	0.338
MOD_NEK2_1	303	308	PF00069	0.305
MOD_NEK2_1	376	381	PF00069	0.619
MOD_NEK2_1	441	446	PF00069	0.508
MOD_NEK2_1	571	576	PF00069	0.557
MOD_NEK2_1	707	712	PF00069	0.370
MOD_NEK2_1	794	799	PF00069	0.364
MOD_NEK2_1	804	809	PF00069	0.391
MOD_NEK2_1	813	818	PF00069	0.563
MOD_NEK2_1	831	836	PF00069	0.360
MOD_NEK2_1	936	941	PF00069	0.768
MOD_NEK2_2	133	138	PF00069	0.531
MOD_NEK2_2	152	157	PF00069	0.460
MOD_NEK2_2	236	241	PF00069	0.514
MOD_PIKK_1	16	22	PF00454	0.830
MOD_PIKK_1	764	770	PF00454	0.613
MOD_PK_1	32	38	PF00069	0.755
MOD_PK_1	478	484	PF00069	0.567
MOD_PKA_1	32	38	PF00069	0.755
MOD_PKA_2	157	163	PF00069	0.600
MOD_PKA_2	32	38	PF00069	0.755
MOD_PKA_2	434	440	PF00069	0.592
MOD_PKA_2	46	52	PF00069	0.767
MOD_PKA_2	511	517	PF00069	0.517
MOD_PKA_2	665	671	PF00069	0.364
MOD_PKB_1	594	602	PF00069	0.514
MOD_Plk_1	127	133	PF00069	0.401
MOD_Plk_1	186	192	PF00069	0.508
MOD_Plk_1	770	776	PF00069	0.404
MOD_Plk_1	936	942	PF00069	0.768
MOD_Plk_2-3	18	24	PF00069	0.830
MOD_Plk_4	152	158	PF00069	0.556
MOD_Plk_4	236	242	PF00069	0.539
MOD_Plk_4	32	38	PF00069	0.754
MOD_Plk_4	376	382	PF00069	0.557
MOD_Plk_4	396	402	PF00069	0.536
MOD_Plk_4	428	434	PF00069	0.549
MOD_Plk_4	495	501	PF00069	0.514
MOD_Plk_4	640	646	PF00069	0.546
MOD_Plk_4	658	664	PF00069	0.487
MOD_Plk_4	741	747	PF00069	0.540
MOD_Plk_4	751	757	PF00069	0.312
MOD_Plk_4	770	776	PF00069	0.381
MOD_Plk_4	787	793	PF00069	0.188
MOD_Plk_4	800	806	PF00069	0.356
MOD_Plk_4	83	89	PF00069	0.592
MOD_Plk_4	836	842	PF00069	0.456
MOD_ProDKin_1	23	29	PF00069	0.855
MOD_ProDKin_1	682	688	PF00069	0.395
MOD_ProDKin_1	81	87	PF00069	0.521
MOD_ProDKin_1	817	823	PF00069	0.663
MOD_ProDKin_1	954	960	PF00069	0.809
MOD_SUMO_rev_2	371	379	PF00179	0.586
MOD_SUMO_rev_2	501	510	PF00179	0.520
MOD_SUMO_rev_2	514	524	PF00179	0.483
MOD_SUMO_rev_2	78	85	PF00179	0.559
MOD_SUMO_rev_2	9	17	PF00179	0.804
TRG_DiLeu_BaEn_1	66	71	PF01217	0.536
TRG_DiLeu_BaEn_4	371	377	PF01217	0.555
TRG_ENDOCYTIC_2	134	137	PF00928	0.519
TRG_ENDOCYTIC_2	289	292	PF00928	0.390
TRG_ENDOCYTIC_2	413	416	PF00928	0.548
TRG_ENDOCYTIC_2	568	571	PF00928	0.543
TRG_ENDOCYTIC_2	689	692	PF00928	0.403
TRG_ENDOCYTIC_2	722	725	PF00928	0.557
TRG_ENDOCYTIC_2	793	796	PF00928	0.364
TRG_ENDOCYTIC_2	872	875	PF00928	0.391
TRG_ER_diArg_1	262	264	PF00400	0.586
TRG_ER_diArg_1	511	513	PF00400	0.514
TRG_ER_diArg_1	593	596	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	537	542	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFH3	Leptomonas seymouri	25%	80%
A0A0S4INU6	Bodo saltans	23%	80%
A0A0S4IVK7	Bodo saltans	70%	100%
A0A0S4J1M1	Bodo saltans	26%	89%
A0A0S4JA92	Bodo saltans	23%	96%
A0A0S4JRV4	Bodo saltans	27%	96%
A0A0S4JT33	Bodo saltans	41%	100%
A0A1X0NL00	Trypanosomatidae	69%	100%
A0A1X0NNY6	Trypanosomatidae	28%	97%
A0A1X0NPD9	Trypanosomatidae	24%	88%
A0A1X0P689	Trypanosomatidae	27%	93%
A0A1X0P720	Trypanosomatidae	83%	100%
A0A1X0P724	Trypanosomatidae	72%	100%
A0A1X0P7A1	Trypanosomatidae	83%	100%
A0A1X0P842	Trypanosomatidae	67%	97%
A0A381MFJ0	Leishmania infantum	97%	100%
A0A3R7KM63	Trypanosoma rangeli	26%	94%
A0A3R7MRX8	Trypanosoma rangeli	27%	94%
A0A3S5H5E7	Leishmania donovani	26%	100%
A0A3S5H5Y9	Leishmania donovani	23%	88%
A0A3S5IRL5	Trypanosoma rangeli	80%	100%
A0A3S5ISK9	Trypanosoma rangeli	23%	91%
A0A3S7WPW0	Leishmania donovani	24%	87%
A0A3S7WV61	Leishmania donovani	97%	100%
A0A3S7WV68	Leishmania donovani	96%	100%
A0A3S7X978	Leishmania donovani	26%	88%
A0A422NP08	Trypanosoma rangeli	68%	100%
A0R3Y2	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	27%	100%
A2VDL6	Bos taurus	26%	95%
A4H514	Leishmania braziliensis	24%	87%
A4H9Q5	Leishmania braziliensis	94%	100%
A4HMM8	Leishmania braziliensis	25%	88%
A4HSA9	Leishmania infantum	25%	100%
A4HTF0	Leishmania infantum	24%	100%
A4HY23	Leishmania infantum	96%	100%
A4IBA6	Leishmania infantum	26%	88%
A7L9Z8	Mus musculus	27%	100%
C9ZUN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	90%
C9ZZN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	94%
D0A564	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
D0ZTB2	Salmonella typhimurium (strain 14028s / SGSC 2262)	30%	100%
D2WKD8	Sus scrofa	26%	95%
E9AF31	Leishmania major	26%	88%
E9AL76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	88%
E9AL78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	87%
E9ART6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B686	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	80%
O22218	Arabidopsis thaliana	25%	95%
O34431	Bacillus subtilis (strain 168)	28%	100%
O43108	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	100%
O59868	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O64806	Arabidopsis thaliana	26%	96%
O75185	Homo sapiens	27%	100%
O81108	Arabidopsis thaliana	26%	96%
O97198	Leishmania major	29%	100%
P04074	Ovis aries	27%	95%
P05023	Homo sapiens	26%	95%
P05024	Sus scrofa	26%	95%
P05025	Tetronarce californica	25%	95%
P05030	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P06685	Rattus norvegicus	26%	95%
P06686	Rattus norvegicus	26%	95%
P06687	Rattus norvegicus	25%	96%
P07038	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	34%	100%
P09572	Gallus gallus	26%	95%
P09626	Rattus norvegicus	26%	94%
P09627	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
P0A505	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	26%	100%
P0ABB8	Escherichia coli (strain K12)	31%	100%
P0ABB9	Escherichia coli O157:H7	31%	100%
P11718	Leishmania donovani	97%	100%
P12522	Leishmania donovani	96%	100%
P13586	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P13607	Drosophila melanogaster	25%	94%
P13637	Homo sapiens	25%	96%
P17326	Artemia franciscana	26%	98%
P18907	Equus caballus	27%	95%
P19156	Sus scrofa	26%	94%
P19456	Arabidopsis thaliana	37%	100%
P19657	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P20431	Arabidopsis thaliana	36%	100%
P20648	Homo sapiens	28%	94%
P20649	Arabidopsis thaliana	37%	100%
P22036	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	27%	100%
P22180	Solanum lycopersicum	37%	100%
P24545	Zygosaccharomyces rouxii	34%	100%
P24797	Gallus gallus	26%	96%
P24798	Gallus gallus	25%	96%
P25489	Catostomus commersonii	26%	95%
P27112	Oryctolagus cuniculus	27%	94%
P28774	Artemia franciscana	25%	97%
P28876	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	96%
P28877	Candida albicans	33%	100%
P30714	Rhinella marina	26%	95%
P35317	Hydra vulgaris	26%	94%
P36640	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	30%	100%
P37278	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	29%	100%
P47317	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	28%	100%
P49380	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	34%	100%
P50993	Homo sapiens	26%	95%
P50996	Canis lupus familiaris	27%	94%
P50997	Canis lupus familiaris	27%	95%
P54210	Dunaliella acidophila	37%	88%
P54211	Dunaliella bioculata	37%	86%
P54678	Dictyostelium discoideum	26%	87%
P54679	Dictyostelium discoideum	35%	92%
P54707	Homo sapiens	25%	94%
P54708	Rattus norvegicus	26%	94%
P58312	Oreochromis mossambicus	26%	96%
P63688	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	28%	100%
P78036	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	28%	100%
P83970	Triticum aestivum	35%	100%
P98194	Homo sapiens	26%	100%
P9WPS8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WPS9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
P9WPT0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	100%
P9WPT1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
Q03194	Nicotiana plumbaginifolia	36%	100%
Q07421	Ajellomyces capsulatus	34%	100%
Q08435	Nicotiana plumbaginifolia	37%	100%
Q08436	Nicotiana plumbaginifolia	36%	100%
Q08DA1	Bos taurus	27%	95%
Q13733	Homo sapiens	25%	95%
Q21286	Caenorhabditis elegans	21%	81%
Q2QMX9	Oryza sativa subsp. japonica	28%	95%
Q2QY12	Oryza sativa subsp. japonica	26%	94%
Q2RAS0	Oryza sativa subsp. japonica	26%	96%
Q37145	Arabidopsis thaliana	26%	95%
Q42556	Arabidopsis thaliana	35%	100%
Q43128	Arabidopsis thaliana	35%	100%
Q4QDN7	Leishmania major	100%	100%
Q4QIM6	Leishmania major	23%	87%
Q4QIM8	Leishmania major	24%	88%
Q4VNC0	Homo sapiens	22%	80%
Q4VNC1	Homo sapiens	21%	81%
Q58623	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	36%	100%
Q5R5K5	Pongo abelii	25%	100%
Q5RCD8	Pongo abelii	26%	95%
Q5RDR3	Pongo abelii	26%	95%
Q5XF90	Mus musculus	22%	82%
Q5ZKB7	Gallus gallus	21%	81%
Q64436	Mus musculus	26%	94%
Q64541	Rattus norvegicus	24%	95%
Q64566	Rattus norvegicus	25%	100%
Q65X71	Oryza sativa subsp. japonica	27%	95%
Q6ATV4	Oryza sativa subsp. japonica	27%	94%
Q6PIC6	Mus musculus	25%	96%
Q6PIE5	Mus musculus	26%	95%
Q6RWA9	Taenia solium	25%	96%
Q73E41	Bacillus cereus (strain ATCC 10987 / NRS 248)	30%	100%
Q7X8B5	Oryza sativa subsp. japonica	25%	90%
Q7XEK4	Oryza sativa subsp. japonica	25%	94%
Q7XPY2	Oryza sativa subsp. japonica	35%	100%
Q80XR2	Mus musculus	25%	100%
Q8RUN1	Oryza sativa subsp. japonica	25%	93%
Q8VDN2	Mus musculus	26%	95%
Q8Y8Q5	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	28%	100%
Q92030	Anguilla anguilla	26%	95%
Q92123	Xenopus laevis	26%	95%
Q92126	Xenopus laevis	26%	94%
Q9CFU9	Lactococcus lactis subsp. lactis (strain IL1403)	25%	100%
Q9HDW7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	75%
Q9LF79	Arabidopsis thaliana	24%	91%
Q9LU41	Arabidopsis thaliana	25%	90%
Q9LV11	Arabidopsis thaliana	37%	100%
Q9LY32	Arabidopsis thaliana	36%	100%
Q9M2A0	Arabidopsis thaliana	35%	100%
Q9M2L4	Arabidopsis thaliana	26%	95%
Q9N0Z6	Oryctolagus cuniculus	26%	95%
Q9SH76	Arabidopsis thaliana	35%	100%
Q9SJB3	Arabidopsis thaliana	36%	100%
Q9SU58	Arabidopsis thaliana	37%	100%
Q9SZR1	Arabidopsis thaliana	25%	91%
Q9WV27	Mus musculus	25%	94%
Q9YH26	Oreochromis mossambicus	25%	95%
Q9Z1W8	Mus musculus	26%	94%
V5BDL7	Trypanosoma cruzi	67%	100%
V5BHZ2	Trypanosoma cruzi	27%	94%