BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QDN4_LEIMA

TriTrypDb:

LmjF.18.1550 , LMJLV39_180021200 , LMJSD75_180021400

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.527
CLV_NRD_NRD_1	175	177	PF00675	0.529
CLV_NRD_NRD_1	201	203	PF00675	0.570
CLV_NRD_NRD_1	204	206	PF00675	0.540
CLV_NRD_NRD_1	247	249	PF00675	0.658
CLV_NRD_NRD_1	388	390	PF00675	0.655
CLV_PCSK_FUR_1	202	206	PF00082	0.546
CLV_PCSK_KEX2_1	175	177	PF00082	0.529
CLV_PCSK_KEX2_1	201	203	PF00082	0.570
CLV_PCSK_KEX2_1	204	206	PF00082	0.540
CLV_PCSK_KEX2_1	247	249	PF00082	0.658
CLV_PCSK_KEX2_1	40	42	PF00082	0.608
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.608
CLV_PCSK_PC7_1	197	203	PF00082	0.466
CLV_PCSK_SKI1_1	122	126	PF00082	0.402
CLV_PCSK_SKI1_1	165	169	PF00082	0.590
CLV_PCSK_SKI1_1	247	251	PF00082	0.795
CLV_PCSK_SKI1_1	376	380	PF00082	0.654
CLV_PCSK_SKI1_1	40	44	PF00082	0.522
CLV_PCSK_SKI1_1	77	81	PF00082	0.530
DEG_SPOP_SBC_1	361	365	PF00917	0.630
DOC_CDC14_PxL_1	207	215	PF14671	0.622
DOC_MAPK_gen_1	175	182	PF00069	0.461
DOC_MAPK_MEF2A_6	175	184	PF00069	0.452
DOC_MAPK_MEF2A_6	329	338	PF00069	0.413
DOC_PP1_RVXF_1	33	39	PF00149	0.486
DOC_PP2B_LxvP_1	251	254	PF13499	0.558
DOC_PP4_FxxP_1	250	253	PF00568	0.560
DOC_USP7_MATH_1	218	222	PF00917	0.532
DOC_USP7_MATH_1	225	229	PF00917	0.552
DOC_USP7_MATH_1	260	264	PF00917	0.737
DOC_USP7_MATH_1	360	364	PF00917	0.703
DOC_USP7_MATH_1	4	8	PF00917	0.740
DOC_USP7_MATH_1	94	98	PF00917	0.598
DOC_WW_Pin1_4	223	228	PF00397	0.508
DOC_WW_Pin1_4	239	244	PF00397	0.739
DOC_WW_Pin1_4	249	254	PF00397	0.635
LIG_14-3-3_CanoR_1	122	128	PF00244	0.375
LIG_14-3-3_CanoR_1	165	171	PF00244	0.508
LIG_14-3-3_CanoR_1	283	290	PF00244	0.574
LIG_14-3-3_CanoR_1	295	300	PF00244	0.602
LIG_Actin_WH2_2	400	417	PF00022	0.569
LIG_BIR_II_1	1	5	PF00653	0.811
LIG_BIR_III_1	1	5	PF00653	0.733
LIG_BIR_III_3	1	5	PF00653	0.733
LIG_Clathr_ClatBox_1	396	400	PF01394	0.539
LIG_FHA_1	166	172	PF00498	0.452
LIG_FHA_1	283	289	PF00498	0.579
LIG_FHA_1	70	76	PF00498	0.574
LIG_FHA_2	153	159	PF00498	0.432
LIG_FHA_2	369	375	PF00498	0.683
LIG_LIR_Gen_1	155	164	PF02991	0.576
LIG_LIR_Nem_3	155	160	PF02991	0.570
LIG_LIR_Nem_3	200	206	PF02991	0.553
LIG_LIR_Nem_3	208	213	PF02991	0.458
LIG_LIR_Nem_3	99	105	PF02991	0.489
LIG_LYPXL_yS_3	210	213	PF13949	0.603
LIG_NRBOX	179	185	PF00104	0.555
LIG_PDZ_Class_2	414	419	PF00595	0.686
LIG_Pex14_1	203	207	PF04695	0.635
LIG_Pex14_2	50	54	PF04695	0.507
LIG_REV1ctd_RIR_1	47	55	PF16727	0.511
LIG_SH2_CRK	157	161	PF00017	0.584
LIG_SH2_CRK	188	192	PF00017	0.458
LIG_SH2_STAP1	128	132	PF00017	0.444
LIG_SH2_STAP1	166	170	PF00017	0.498
LIG_SH2_STAT3	377	380	PF00017	0.632
LIG_SH2_STAT5	330	333	PF00017	0.532
LIG_SH2_STAT5	337	340	PF00017	0.472
LIG_SH2_STAT5	37	40	PF00017	0.500
LIG_SH2_STAT5	53	56	PF00017	0.519
LIG_SH3_3	251	257	PF00018	0.591
LIG_SUMO_SIM_par_1	394	400	PF11976	0.489
MOD_CDC14_SPxK_1	244	247	PF00782	0.720
MOD_CDC14_SPxK_1	252	255	PF00782	0.659
MOD_CDK_SPxK_1	241	247	PF00069	0.720
MOD_CDK_SPxK_1	249	255	PF00069	0.662
MOD_CDK_SPxxK_3	241	248	PF00069	0.784
MOD_CK1_1	221	227	PF00069	0.606
MOD_CK1_1	262	268	PF00069	0.695
MOD_CK1_1	364	370	PF00069	0.560
MOD_CK1_1	69	75	PF00069	0.606
MOD_CK2_1	368	374	PF00069	0.653
MOD_GlcNHglycan	143	146	PF01048	0.511
MOD_GlcNHglycan	15	18	PF01048	0.633
MOD_GlcNHglycan	194	197	PF01048	0.608
MOD_GlcNHglycan	220	223	PF01048	0.648
MOD_GlcNHglycan	227	230	PF01048	0.615
MOD_GlcNHglycan	232	236	PF01048	0.524
MOD_GlcNHglycan	262	265	PF01048	0.746
MOD_GlcNHglycan	269	272	PF01048	0.672
MOD_GlcNHglycan	299	302	PF01048	0.652
MOD_GlcNHglycan	364	367	PF01048	0.704
MOD_GlcNHglycan	382	385	PF01048	0.535
MOD_GlcNHglycan	64	67	PF01048	0.767
MOD_GlcNHglycan	68	71	PF01048	0.675
MOD_GlcNHglycan	82	85	PF01048	0.292
MOD_GlcNHglycan	92	95	PF01048	0.503
MOD_GSK3_1	221	228	PF00069	0.643
MOD_GSK3_1	256	263	PF00069	0.745
MOD_GSK3_1	297	304	PF00069	0.531
MOD_GSK3_1	360	367	PF00069	0.563
MOD_GSK3_1	4	11	PF00069	0.644
MOD_GSK3_1	62	69	PF00069	0.767
MOD_GSK3_1	90	97	PF00069	0.520
MOD_LATS_1	139	145	PF00433	0.553
MOD_LATS_1	78	84	PF00433	0.570
MOD_NEK2_1	101	106	PF00069	0.394
MOD_NEK2_1	190	195	PF00069	0.645
MOD_NEK2_1	306	311	PF00069	0.654
MOD_NEK2_1	313	318	PF00069	0.562
MOD_NEK2_1	36	41	PF00069	0.503
MOD_NEK2_1	90	95	PF00069	0.486
MOD_NEK2_2	123	128	PF00069	0.543
MOD_NEK2_2	368	373	PF00069	0.557
MOD_PKA_2	282	288	PF00069	0.657
MOD_PKA_2	306	312	PF00069	0.626
MOD_PKA_2	380	386	PF00069	0.639
MOD_PKB_1	295	303	PF00069	0.652
MOD_Plk_1	301	307	PF00069	0.536
MOD_Plk_1	4	10	PF00069	0.793
MOD_Plk_4	123	129	PF00069	0.443
MOD_Plk_4	152	158	PF00069	0.418
MOD_Plk_4	166	172	PF00069	0.570
MOD_Plk_4	262	268	PF00069	0.676
MOD_Plk_4	70	76	PF00069	0.571
MOD_ProDKin_1	223	229	PF00069	0.515
MOD_ProDKin_1	239	245	PF00069	0.739
MOD_ProDKin_1	249	255	PF00069	0.635
MOD_SUMO_for_1	132	135	PF00179	0.483
MOD_SUMO_rev_2	383	392	PF00179	0.652
TRG_ENDOCYTIC_2	157	160	PF00928	0.573
TRG_ENDOCYTIC_2	188	191	PF00928	0.535
TRG_ENDOCYTIC_2	210	213	PF00928	0.603
TRG_ER_diArg_1	174	176	PF00400	0.376
TRG_ER_diArg_1	201	203	PF00400	0.570
TRG_ER_diArg_1	204	206	PF00400	0.540
TRG_ER_diArg_1	246	248	PF00400	0.676
TRG_ER_diArg_1	294	297	PF00400	0.557
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZP2	Leptomonas seymouri	45%	99%
A0A3S7WV66	Leishmania donovani	91%	100%
A4H9Q7	Leishmania braziliensis	70%	100%
A4HY26	Leishmania infantum	92%	100%
E9ART9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%