Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDN3_LEIMA

TriTrypDb:

LmjF.18.1560 , LMJLV39_180021300 , LMJSD75_180021500

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.631
CLV_NRD_NRD_1	150	152	PF00675	0.591
CLV_NRD_NRD_1	177	179	PF00675	0.605
CLV_NRD_NRD_1	298	300	PF00675	0.613
CLV_NRD_NRD_1	31	33	PF00675	0.536
CLV_NRD_NRD_1	385	387	PF00675	0.435
CLV_NRD_NRD_1	464	466	PF00675	0.467
CLV_NRD_NRD_1	474	476	PF00675	0.515
CLV_NRD_NRD_1	499	501	PF00675	0.577
CLV_NRD_NRD_1	561	563	PF00675	0.738
CLV_PCSK_FUR_1	296	300	PF00082	0.396
CLV_PCSK_FUR_1	559	563	PF00082	0.713
CLV_PCSK_KEX2_1	150	152	PF00082	0.548
CLV_PCSK_KEX2_1	176	178	PF00082	0.617
CLV_PCSK_KEX2_1	23	25	PF00082	0.488
CLV_PCSK_KEX2_1	298	300	PF00082	0.616
CLV_PCSK_KEX2_1	31	33	PF00082	0.581
CLV_PCSK_KEX2_1	385	387	PF00082	0.435
CLV_PCSK_KEX2_1	474	476	PF00082	0.535
CLV_PCSK_KEX2_1	499	501	PF00082	0.577
CLV_PCSK_KEX2_1	561	563	PF00082	0.738
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.488
CLV_PCSK_PC7_1	470	476	PF00082	0.452
CLV_PCSK_SKI1_1	178	182	PF00082	0.610
CLV_PCSK_SKI1_1	209	213	PF00082	0.447
CLV_PCSK_SKI1_1	317	321	PF00082	0.473
CLV_PCSK_SKI1_1	386	390	PF00082	0.596
CLV_PCSK_SKI1_1	39	43	PF00082	0.519
CLV_PCSK_SKI1_1	465	469	PF00082	0.389
CLV_PCSK_SKI1_1	506	510	PF00082	0.528
DEG_APCC_DBOX_1	444	452	PF00400	0.418
DEG_MDM2_SWIB_1	526	533	PF02201	0.351
DOC_ANK_TNKS_1	31	38	PF00023	0.570
DOC_CYCLIN_RxL_1	460	472	PF00134	0.398
DOC_CYCLIN_RxL_1	85	96	PF00134	0.595
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	452	458	PF00134	0.515
DOC_MAPK_gen_1	120	129	PF00069	0.521
DOC_MAPK_gen_1	296	306	PF00069	0.531
DOC_MAPK_gen_1	439	448	PF00069	0.412
DOC_MAPK_HePTP_8	438	450	PF00069	0.489
DOC_MAPK_MEF2A_6	123	131	PF00069	0.509
DOC_MAPK_MEF2A_6	298	306	PF00069	0.548
DOC_MAPK_MEF2A_6	362	370	PF00069	0.491
DOC_MAPK_MEF2A_6	441	450	PF00069	0.454
DOC_MAPK_MEF2A_6	81	89	PF00069	0.436
DOC_MAPK_NFAT4_5	445	453	PF00069	0.488
DOC_USP7_MATH_1	228	232	PF00917	0.639
DOC_USP7_MATH_1	294	298	PF00917	0.550
DOC_USP7_MATH_1	410	414	PF00917	0.396
DOC_USP7_MATH_1	7	11	PF00917	0.503
DOC_USP7_UBL2_3	412	416	PF12436	0.452
DOC_WW_Pin1_4	157	162	PF00397	0.503
DOC_WW_Pin1_4	298	303	PF00397	0.530
DOC_WW_Pin1_4	312	317	PF00397	0.429
DOC_WW_Pin1_4	439	444	PF00397	0.519
DOC_WW_Pin1_4	451	456	PF00397	0.462
DOC_WW_Pin1_4	95	100	PF00397	0.554
LIG_14-3-3_CanoR_1	112	122	PF00244	0.672
LIG_14-3-3_CanoR_1	150	154	PF00244	0.546
LIG_14-3-3_CanoR_1	177	187	PF00244	0.525
LIG_14-3-3_CterR_2	559	563	PF00244	0.681
LIG_APCC_ABBA_1	159	164	PF00400	0.538
LIG_BIR_III_4	105	109	PF00653	0.538
LIG_FHA_1	126	132	PF00498	0.521
LIG_FHA_1	137	143	PF00498	0.454
LIG_FHA_1	198	204	PF00498	0.497
LIG_FHA_1	264	270	PF00498	0.468
LIG_FHA_1	275	281	PF00498	0.331
LIG_FHA_1	542	548	PF00498	0.396
LIG_FHA_1	73	79	PF00498	0.526
LIG_FHA_2	442	448	PF00498	0.464
LIG_FHA_2	65	71	PF00498	0.560
LIG_FHA_2	77	83	PF00498	0.447
LIG_LIR_Gen_1	434	443	PF02991	0.369
LIG_LIR_Gen_1	44	53	PF02991	0.439
LIG_LIR_Gen_1	520	531	PF02991	0.398
LIG_LIR_Nem_3	254	258	PF02991	0.392
LIG_LIR_Nem_3	336	342	PF02991	0.489
LIG_LIR_Nem_3	434	440	PF02991	0.362
LIG_LIR_Nem_3	44	48	PF02991	0.433
LIG_LIR_Nem_3	520	526	PF02991	0.479
LIG_LYPXL_yS_3	255	258	PF13949	0.455
LIG_NBox_RRM_1	543	553	PF00076	0.461
LIG_NRBOX	239	245	PF00104	0.433
LIG_PCNA_yPIPBox_3	377	389	PF02747	0.538
LIG_Pex14_2	526	530	PF04695	0.349
LIG_Rb_pABgroove_1	462	470	PF01858	0.417
LIG_SH2_CRK	22	26	PF00017	0.396
LIG_SH2_CRK	27	31	PF00017	0.418
LIG_SH2_CRK	398	402	PF00017	0.505
LIG_SH2_SRC	52	55	PF00017	0.569
LIG_SH2_STAP1	512	516	PF00017	0.478
LIG_SH2_STAP1	523	527	PF00017	0.347
LIG_SH2_STAT5	214	217	PF00017	0.502
LIG_SH2_STAT5	232	235	PF00017	0.485
LIG_SH2_STAT5	321	324	PF00017	0.447
LIG_SH2_STAT5	341	344	PF00017	0.360
LIG_SH2_STAT5	364	367	PF00017	0.498
LIG_SH2_STAT5	52	55	PF00017	0.452
LIG_SH2_STAT5	528	531	PF00017	0.342
LIG_SH3_2	455	460	PF14604	0.552
LIG_SH3_3	155	161	PF00018	0.517
LIG_SH3_3	27	33	PF00018	0.486
LIG_SH3_3	452	458	PF00018	0.547
LIG_SH3_3	68	74	PF00018	0.544
LIG_SUMO_SIM_anti_2	279	284	PF11976	0.348
LIG_SUMO_SIM_anti_2	444	450	PF11976	0.488
LIG_SUMO_SIM_par_1	126	133	PF11976	0.529
LIG_SUMO_SIM_par_1	163	171	PF11976	0.530
LIG_SUMO_SIM_par_1	264	273	PF11976	0.543
LIG_SUMO_SIM_par_1	277	284	PF11976	0.298
LIG_SUMO_SIM_par_1	428	434	PF11976	0.477
LIG_SUMO_SIM_par_1	447	454	PF11976	0.271
LIG_TRAF2_1	161	164	PF00917	0.532
LIG_TRAF2_1	216	219	PF00917	0.687
LIG_TYR_ITIM	25	30	PF00017	0.487
LIG_UBA3_1	16	23	PF00899	0.426
LIG_WRC_WIRS_1	411	416	PF05994	0.391
LIG_WRC_WIRS_1	42	47	PF05994	0.553
MOD_CDC14_SPxK_1	442	445	PF00782	0.465
MOD_CDK_SPK_2	312	317	PF00069	0.497
MOD_CDK_SPxK_1	439	445	PF00069	0.483
MOD_CK1_1	205	211	PF00069	0.459
MOD_CK1_1	44	50	PF00069	0.462
MOD_CK1_1	76	82	PF00069	0.455
MOD_CK1_1	97	103	PF00069	0.692
MOD_CK2_1	157	163	PF00069	0.555
MOD_CK2_1	201	207	PF00069	0.397
MOD_CK2_1	281	287	PF00069	0.492
MOD_CK2_1	64	70	PF00069	0.511
MOD_CK2_1	76	82	PF00069	0.321
MOD_CK2_1	98	104	PF00069	0.760
MOD_GlcNHglycan	155	158	PF01048	0.597
MOD_GlcNHglycan	398	401	PF01048	0.487
MOD_GlcNHglycan	427	430	PF01048	0.538
MOD_GlcNHglycan	533	536	PF01048	0.361
MOD_GlcNHglycan	9	12	PF01048	0.557
MOD_GSK3_1	136	143	PF00069	0.502
MOD_GSK3_1	145	152	PF00069	0.522
MOD_GSK3_1	153	160	PF00069	0.575
MOD_GSK3_1	197	204	PF00069	0.413
MOD_GSK3_1	294	301	PF00069	0.433
MOD_GSK3_1	321	328	PF00069	0.529
MOD_GSK3_1	364	371	PF00069	0.556
MOD_GSK3_1	72	79	PF00069	0.519
MOD_GSK3_1	94	101	PF00069	0.541
MOD_N-GLC_2	199	201	PF02516	0.501
MOD_NEK2_1	197	202	PF00069	0.452
MOD_NEK2_1	245	250	PF00069	0.449
MOD_PIKK_1	140	146	PF00454	0.534
MOD_PK_1	123	129	PF00069	0.389
MOD_PKA_2	113	119	PF00069	0.722
MOD_PKA_2	149	155	PF00069	0.547
MOD_PKA_2	345	351	PF00069	0.544
MOD_PKB_1	112	120	PF00069	0.721
MOD_PKB_1	176	184	PF00069	0.535
MOD_Plk_1	263	269	PF00069	0.537
MOD_Plk_2-3	345	351	PF00069	0.603
MOD_Plk_4	228	234	PF00069	0.546
MOD_Plk_4	281	287	PF00069	0.523
MOD_Plk_4	368	374	PF00069	0.458
MOD_Plk_4	41	47	PF00069	0.484
MOD_Plk_4	410	416	PF00069	0.417
MOD_Plk_4	500	506	PF00069	0.494
MOD_Plk_4	73	79	PF00069	0.467
MOD_ProDKin_1	157	163	PF00069	0.496
MOD_ProDKin_1	298	304	PF00069	0.528
MOD_ProDKin_1	312	318	PF00069	0.428
MOD_ProDKin_1	439	445	PF00069	0.517
MOD_ProDKin_1	451	457	PF00069	0.463
MOD_ProDKin_1	95	101	PF00069	0.562
TRG_DiLeu_BaEn_1	207	212	PF01217	0.473
TRG_DiLeu_BaEn_1	254	259	PF01217	0.493
TRG_DiLeu_BaEn_1	82	87	PF01217	0.424
TRG_DiLeu_BaEn_2	191	197	PF01217	0.558
TRG_DiLeu_BaEn_4	333	339	PF01217	0.540
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.425
TRG_ENDOCYTIC_2	22	25	PF00928	0.399
TRG_ENDOCYTIC_2	255	258	PF00928	0.446
TRG_ENDOCYTIC_2	27	30	PF00928	0.400
TRG_ENDOCYTIC_2	339	342	PF00928	0.496
TRG_ENDOCYTIC_2	398	401	PF00928	0.456
TRG_ENDOCYTIC_2	523	526	PF00928	0.402
TRG_ER_diArg_1	149	151	PF00400	0.519
TRG_ER_diArg_1	176	178	PF00400	0.619
TRG_ER_diArg_1	296	299	PF00400	0.593
TRG_ER_diArg_1	30	32	PF00400	0.510
TRG_ER_diArg_1	384	386	PF00400	0.412
TRG_ER_diArg_1	474	476	PF00400	0.565
TRG_ER_diArg_1	498	500	PF00400	0.566
TRG_ER_diArg_1	559	562	PF00400	0.708
TRG_NES_CRM1_1	425	436	PF08389	0.522
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRD6	Leptomonas seymouri	55%	100%
A0A1X0P7Z6	Trypanosomatidae	30%	100%
A0A3R7M1T0	Trypanosoma rangeli	30%	100%
A0A3S7WV76	Leishmania donovani	94%	100%
D0A560	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AGQ6	Leishmania infantum	94%	100%
E9AI61	Leishmania braziliensis	78%	100%
E9ARU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BDF3	Trypanosoma cruzi	30%	100%