RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q4QDN2_LEIMA

TriTrypDb:

LmjF.18.1570 , LMJLV39_180021400 , LMJSD75_180021600

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QDN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDN2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	41	45	PF00082	0.537
CLV_PCSK_SKI1_1	83	87	PF00082	0.497
DEG_APCC_DBOX_1	57	65	PF00400	0.453
DOC_USP7_UBL2_3	18	22	PF12436	0.524
DOC_WW_Pin1_4	93	98	PF00397	0.438
LIG_BIR_II_1	1	5	PF00653	0.589
LIG_FHA_1	113	119	PF00498	0.341
LIG_FHA_1	65	71	PF00498	0.601
LIG_SH3_3	113	119	PF00018	0.393
LIG_SH3_3	84	90	PF00018	0.437
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.471
LIG_WW_1	90	93	PF00397	0.480
MOD_CK1_1	128	134	PF00069	0.375
MOD_CK2_1	36	42	PF00069	0.481
MOD_GlcNHglycan	1	4	PF01048	0.569
MOD_GlcNHglycan	135	138	PF01048	0.411
MOD_GSK3_1	133	140	PF00069	0.344
MOD_GSK3_1	75	82	PF00069	0.492
MOD_NEK2_1	43	48	PF00069	0.552
MOD_NEK2_1	70	75	PF00069	0.515
MOD_NEK2_1	81	86	PF00069	0.485
MOD_NEK2_2	112	117	PF00069	0.342
MOD_OFUCOSY	120	126	PF10250	0.433
MOD_PIKK_1	36	42	PF00454	0.436
MOD_Plk_1	33	39	PF00069	0.492
MOD_Plk_4	112	118	PF00069	0.298
MOD_Plk_4	25	31	PF00069	0.457
MOD_Plk_4	43	49	PF00069	0.594
MOD_Plk_4	64	70	PF00069	0.482
MOD_ProDKin_1	93	99	PF00069	0.439
TRG_DiLeu_BaEn_1	5	10	PF01217	0.452
TRG_DiLeu_BaEn_2	145	151	PF01217	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D9	Leptomonas seymouri	60%	100%
A0A1X0P747	Trypanosomatidae	37%	100%
A0A3S7WV41	Leishmania donovani	98%	100%
A0A422NPM7	Trypanosoma rangeli	34%	100%
A4H9Q8	Leishmania braziliensis	88%	99%
A4HY27	Leishmania infantum	98%	100%
D0A558	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ARU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%