Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania major

UniProt:

Q4QDM9_LEIMA

TriTrypDb:

LmjF.18.1600 , LMJLV39_180021700 , LMJSD75_180021900

Length:

796

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	2
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDM9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003774	cytoskeletal motor activity	1	12
GO:0003777	microtubule motor activity	2	12
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.390
CLV_C14_Caspase3-7	607	611	PF00656	0.579
CLV_C14_Caspase3-7	674	678	PF00656	0.590
CLV_NRD_NRD_1	151	153	PF00675	0.289
CLV_NRD_NRD_1	187	189	PF00675	0.270
CLV_NRD_NRD_1	367	369	PF00675	0.475
CLV_NRD_NRD_1	4	6	PF00675	0.341
CLV_NRD_NRD_1	403	405	PF00675	0.558
CLV_NRD_NRD_1	409	411	PF00675	0.485
CLV_NRD_NRD_1	47	49	PF00675	0.344
CLV_NRD_NRD_1	566	568	PF00675	0.475
CLV_NRD_NRD_1	654	656	PF00675	0.499
CLV_NRD_NRD_1	774	776	PF00675	0.699
CLV_PCSK_FUR_1	313	317	PF00082	0.299
CLV_PCSK_KEX2_1	150	152	PF00082	0.284
CLV_PCSK_KEX2_1	187	189	PF00082	0.252
CLV_PCSK_KEX2_1	315	317	PF00082	0.299
CLV_PCSK_KEX2_1	366	368	PF00082	0.542
CLV_PCSK_KEX2_1	4	6	PF00082	0.341
CLV_PCSK_KEX2_1	403	405	PF00082	0.523
CLV_PCSK_KEX2_1	409	411	PF00082	0.452
CLV_PCSK_KEX2_1	47	49	PF00082	0.406
CLV_PCSK_KEX2_1	566	568	PF00082	0.475
CLV_PCSK_KEX2_1	654	656	PF00082	0.544
CLV_PCSK_KEX2_1	773	775	PF00082	0.675
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.299
CLV_PCSK_PC1ET2_1	773	775	PF00082	0.675
CLV_PCSK_PC7_1	147	153	PF00082	0.228
CLV_PCSK_PC7_1	770	776	PF00082	0.568
CLV_PCSK_SKI1_1	280	284	PF00082	0.394
CLV_PCSK_SKI1_1	566	570	PF00082	0.475
CLV_PCSK_SKI1_1	63	67	PF00082	0.337
CLV_PCSK_SKI1_1	75	79	PF00082	0.332
CLV_Separin_Metazoa	117	121	PF03568	0.358
DEG_SCF_FBW7_2	663	669	PF00400	0.565
DEG_SPOP_SBC_1	561	565	PF00917	0.461
DOC_ANK_TNKS_1	776	783	PF00023	0.553
DOC_CDC14_PxL_1	420	428	PF14671	0.411
DOC_CKS1_1	663	668	PF01111	0.762
DOC_MAPK_DCC_7	418	428	PF00069	0.415
DOC_MAPK_gen_1	208	216	PF00069	0.235
DOC_MAPK_gen_1	346	353	PF00069	0.392
DOC_MAPK_gen_1	4	12	PF00069	0.325
DOC_MAPK_MEF2A_6	120	129	PF00069	0.343
DOC_MAPK_MEF2A_6	208	216	PF00069	0.250
DOC_MAPK_MEF2A_6	270	278	PF00069	0.231
DOC_MAPK_MEF2A_6	4	12	PF00069	0.351
DOC_PP1_RVXF_1	211	217	PF00149	0.358
DOC_PP2B_LxvP_1	394	397	PF13499	0.470
DOC_PP2B_PxIxI_1	157	163	PF00149	0.358
DOC_USP7_MATH_1	196	200	PF00917	0.254
DOC_USP7_MATH_1	387	391	PF00917	0.557
DOC_USP7_MATH_1	450	454	PF00917	0.546
DOC_USP7_MATH_1	636	640	PF00917	0.688
DOC_USP7_MATH_1	658	662	PF00917	0.601
DOC_USP7_MATH_1	732	736	PF00917	0.664
DOC_USP7_MATH_1	769	773	PF00917	0.500
DOC_USP7_MATH_2	701	707	PF00917	0.498
DOC_WW_Pin1_4	226	231	PF00397	0.225
DOC_WW_Pin1_4	523	528	PF00397	0.609
DOC_WW_Pin1_4	594	599	PF00397	0.584
DOC_WW_Pin1_4	662	667	PF00397	0.584
DOC_WW_Pin1_4	733	738	PF00397	0.610
DOC_WW_Pin1_4	75	80	PF00397	0.358
LIG_14-3-3_CanoR_1	187	191	PF00244	0.271
LIG_14-3-3_CanoR_1	19	26	PF00244	0.443
LIG_14-3-3_CanoR_1	194	204	PF00244	0.257
LIG_14-3-3_CanoR_1	224	228	PF00244	0.247
LIG_14-3-3_CanoR_1	245	250	PF00244	0.260
LIG_14-3-3_CanoR_1	309	317	PF00244	0.226
LIG_14-3-3_CanoR_1	333	341	PF00244	0.411
LIG_14-3-3_CanoR_1	488	494	PF00244	0.530
LIG_14-3-3_CanoR_1	654	663	PF00244	0.641
LIG_Actin_WH2_2	301	317	PF00022	0.225
LIG_APCC_ABBA_1	130	135	PF00400	0.263
LIG_APCC_ABBA_1	664	669	PF00400	0.618
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_BIR_III_4	531	535	PF00653	0.477
LIG_Clathr_ClatBox_1	648	652	PF01394	0.481
LIG_DLG_GKlike_1	596	604	PF00625	0.495
LIG_eIF4E_1	50	56	PF01652	0.358
LIG_FHA_1	165	171	PF00498	0.243
LIG_FHA_1	271	277	PF00498	0.329
LIG_FHA_1	28	34	PF00498	0.364
LIG_FHA_1	286	292	PF00498	0.293
LIG_FHA_1	309	315	PF00498	0.248
LIG_FHA_1	355	361	PF00498	0.525
LIG_FHA_1	406	412	PF00498	0.467
LIG_FHA_1	563	569	PF00498	0.435
LIG_FHA_1	595	601	PF00498	0.642
LIG_FHA_1	658	664	PF00498	0.670
LIG_FHA_1	96	102	PF00498	0.263
LIG_FHA_2	169	175	PF00498	0.278
LIG_FHA_2	246	252	PF00498	0.225
LIG_FHA_2	320	326	PF00498	0.454
LIG_FHA_2	33	39	PF00498	0.221
LIG_FHA_2	456	462	PF00498	0.364
LIG_KLC1_Yacidic_2	131	135	PF13176	0.261
LIG_LIR_Apic_2	435	440	PF02991	0.411
LIG_LIR_Gen_1	174	184	PF02991	0.223
LIG_LIR_Gen_1	263	274	PF02991	0.252
LIG_LIR_Nem_3	174	179	PF02991	0.209
LIG_LIR_Nem_3	263	269	PF02991	0.261
LIG_LIR_Nem_3	431	437	PF02991	0.386
LIG_LIR_Nem_3	746	750	PF02991	0.514
LIG_LIR_Nem_3	84	90	PF02991	0.230
LIG_MYND_1	737	741	PF01753	0.482
LIG_NRBOX	273	279	PF00104	0.263
LIG_OCRL_FandH_1	485	497	PF00620	0.322
LIG_Pex14_2	434	438	PF04695	0.360
LIG_SH2_GRB2like	266	269	PF00017	0.225
LIG_SH2_NCK_1	99	103	PF00017	0.336
LIG_SH2_SRC	133	136	PF00017	0.412
LIG_SH2_STAP1	310	314	PF00017	0.263
LIG_SH2_STAP1	430	434	PF00017	0.490
LIG_SH2_STAT5	133	136	PF00017	0.426
LIG_SH2_STAT5	266	269	PF00017	0.225
LIG_SH2_STAT5	281	284	PF00017	0.269
LIG_SH2_STAT5	310	313	PF00017	0.232
LIG_SH2_STAT5	433	436	PF00017	0.340
LIG_SH2_STAT5	437	440	PF00017	0.326
LIG_SH2_STAT5	447	450	PF00017	0.346
LIG_SH2_STAT5	513	516	PF00017	0.402
LIG_SH2_STAT5	545	548	PF00017	0.504
LIG_SH2_STAT5	99	102	PF00017	0.261
LIG_SH3_3	224	230	PF00018	0.358
LIG_SH3_3	547	553	PF00018	0.403
LIG_SH3_3	707	713	PF00018	0.682
LIG_SH3_3	731	737	PF00018	0.724
LIG_SH3_3	756	762	PF00018	0.638
LIG_SH3_3	76	82	PF00018	0.267
LIG_SH3_5	296	300	PF00018	0.261
LIG_SUMO_SIM_anti_2	271	278	PF11976	0.225
LIG_SUMO_SIM_par_1	157	163	PF11976	0.269
LIG_SUMO_SIM_par_1	647	652	PF11976	0.482
LIG_TRAF2_1	104	107	PF00917	0.276
LIG_TRAF2_1	666	669	PF00917	0.612
LIG_UBA3_1	204	208	PF00899	0.225
LIG_WRC_WIRS_1	287	292	PF05994	0.358
LIG_WW_3	713	717	PF00397	0.581
MOD_CK1_1	169	175	PF00069	0.261
MOD_CK1_1	186	192	PF00069	0.282
MOD_CK1_1	198	204	PF00069	0.260
MOD_CK1_1	22	28	PF00069	0.257
MOD_CK1_1	244	250	PF00069	0.225
MOD_CK1_1	286	292	PF00069	0.255
MOD_CK1_1	354	360	PF00069	0.360
MOD_CK1_1	492	498	PF00069	0.386
MOD_CK1_1	599	605	PF00069	0.581
MOD_CK1_1	614	620	PF00069	0.683
MOD_CK1_1	637	643	PF00069	0.595
MOD_CK1_1	680	686	PF00069	0.665
MOD_CK1_1	708	714	PF00069	0.591
MOD_CK1_1	743	749	PF00069	0.747
MOD_CK1_1	753	759	PF00069	0.710
MOD_CK1_1	95	101	PF00069	0.263
MOD_CK2_1	101	107	PF00069	0.241
MOD_CK2_1	168	174	PF00069	0.209
MOD_CK2_1	245	251	PF00069	0.235
MOD_CK2_1	495	501	PF00069	0.438
MOD_CK2_1	625	631	PF00069	0.749
MOD_Cter_Amidation	45	48	PF01082	0.261
MOD_DYRK1A_RPxSP_1	594	598	PF00069	0.439
MOD_DYRK1A_RPxSP_1	75	79	PF00069	0.230
MOD_GlcNHglycan	296	299	PF01048	0.366
MOD_GlcNHglycan	328	332	PF01048	0.496
MOD_GlcNHglycan	389	392	PF01048	0.566
MOD_GlcNHglycan	394	397	PF01048	0.552
MOD_GlcNHglycan	399	403	PF01048	0.545
MOD_GlcNHglycan	448	451	PF01048	0.368
MOD_GlcNHglycan	547	550	PF01048	0.574
MOD_GlcNHglycan	634	639	PF01048	0.591
MOD_GlcNHglycan	643	646	PF01048	0.483
MOD_GlcNHglycan	670	676	PF01048	0.624
MOD_GlcNHglycan	692	695	PF01048	0.785
MOD_GlcNHglycan	729	732	PF01048	0.611
MOD_GlcNHglycan	747	750	PF01048	0.643
MOD_GlcNHglycan	752	755	PF01048	0.682
MOD_GlcNHglycan	756	759	PF01048	0.610
MOD_GlcNHglycan	94	97	PF01048	0.301
MOD_GSK3_1	15	22	PF00069	0.242
MOD_GSK3_1	164	171	PF00069	0.235
MOD_GSK3_1	219	226	PF00069	0.257
MOD_GSK3_1	235	242	PF00069	0.254
MOD_GSK3_1	27	34	PF00069	0.343
MOD_GSK3_1	304	311	PF00069	0.238
MOD_GSK3_1	351	358	PF00069	0.494
MOD_GSK3_1	446	453	PF00069	0.518
MOD_GSK3_1	492	499	PF00069	0.486
MOD_GSK3_1	590	597	PF00069	0.555
MOD_GSK3_1	600	607	PF00069	0.685
MOD_GSK3_1	614	621	PF00069	0.618
MOD_GSK3_1	625	632	PF00069	0.642
MOD_GSK3_1	636	643	PF00069	0.490
MOD_GSK3_1	654	661	PF00069	0.554
MOD_GSK3_1	673	680	PF00069	0.720
MOD_GSK3_1	745	752	PF00069	0.634
MOD_GSK3_1	91	98	PF00069	0.247
MOD_N-GLC_1	239	244	PF02516	0.263
MOD_N-GLC_1	355	360	PF02516	0.566
MOD_N-GLC_1	625	630	PF02516	0.790
MOD_N-GLC_2	21	23	PF02516	0.261
MOD_NEK2_1	269	274	PF00069	0.294
MOD_NEK2_1	308	313	PF00069	0.240
MOD_NEK2_1	372	377	PF00069	0.507
MOD_NEK2_1	474	479	PF00069	0.388
MOD_NEK2_1	489	494	PF00069	0.376
MOD_NEK2_1	600	605	PF00069	0.639
MOD_NEK2_1	750	755	PF00069	0.641
MOD_NEK2_2	203	208	PF00069	0.241
MOD_PIKK_1	308	314	PF00454	0.225
MOD_PIKK_1	32	38	PF00454	0.168
MOD_PIKK_1	721	727	PF00454	0.486
MOD_PKA_1	654	660	PF00069	0.438
MOD_PKA_2	186	192	PF00069	0.292
MOD_PKA_2	196	202	PF00069	0.302
MOD_PKA_2	223	229	PF00069	0.257
MOD_PKA_2	244	250	PF00069	0.233
MOD_PKA_2	269	275	PF00069	0.267
MOD_PKA_2	308	314	PF00069	0.226
MOD_PKA_2	319	325	PF00069	0.395
MOD_PKA_2	332	338	PF00069	0.494
MOD_PKA_2	405	411	PF00069	0.570
MOD_PKA_2	654	660	PF00069	0.438
MOD_PKA_2	708	714	PF00069	0.576
MOD_PKA_2	750	756	PF00069	0.633
MOD_PKA_2	769	775	PF00069	0.521
MOD_PKB_1	11	19	PF00069	0.261
MOD_PKB_1	594	602	PF00069	0.448
MOD_Plk_1	239	245	PF00069	0.263
MOD_Plk_1	270	276	PF00069	0.241
MOD_Plk_1	342	348	PF00069	0.524
MOD_Plk_1	372	378	PF00069	0.451
MOD_Plk_1	614	620	PF00069	0.562
MOD_Plk_1	658	664	PF00069	0.530
MOD_Plk_1	702	708	PF00069	0.617
MOD_Plk_2-3	496	502	PF00069	0.434
MOD_Plk_4	223	229	PF00069	0.377
MOD_Plk_4	245	251	PF00069	0.276
MOD_Plk_4	272	278	PF00069	0.267
MOD_Plk_4	286	292	PF00069	0.291
MOD_Plk_4	450	456	PF00069	0.552
MOD_Plk_4	474	480	PF00069	0.372
MOD_Plk_4	553	559	PF00069	0.476
MOD_Plk_4	600	606	PF00069	0.754
MOD_Plk_4	614	620	PF00069	0.676
MOD_ProDKin_1	226	232	PF00069	0.225
MOD_ProDKin_1	523	529	PF00069	0.621
MOD_ProDKin_1	594	600	PF00069	0.587
MOD_ProDKin_1	662	668	PF00069	0.585
MOD_ProDKin_1	733	739	PF00069	0.613
MOD_ProDKin_1	75	81	PF00069	0.358
MOD_SUMO_for_1	568	571	PF00179	0.409
TRG_DiLeu_BaEn_1	336	341	PF01217	0.463
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.515
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.429
TRG_ENDOCYTIC_2	266	269	PF00928	0.225
TRG_ER_diArg_1	10	13	PF00400	0.263
TRG_ER_diArg_1	149	152	PF00400	0.264
TRG_ER_diArg_1	317	320	PF00400	0.423
TRG_ER_diArg_1	366	368	PF00400	0.542
TRG_ER_diArg_1	4	6	PF00400	0.370
TRG_ER_diArg_1	403	406	PF00400	0.470
TRG_ER_diArg_1	409	411	PF00400	0.448
TRG_ER_diArg_1	47	49	PF00400	0.458
TRG_ER_diArg_1	566	568	PF00400	0.478
TRG_ER_diArg_1	653	655	PF00400	0.549
TRG_ER_diArg_1	774	777	PF00400	0.693
TRG_NES_CRM1_1	342	355	PF08389	0.396
TRG_NLS_MonoExtC_3	772	777	PF00514	0.664
TRG_NLS_MonoExtN_4	313	319	PF00514	0.358
TRG_NLS_MonoExtN_4	770	777	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	698	703	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F8	Leptomonas seymouri	58%	95%
A0A1X0P728	Trypanosomatidae	50%	90%
A0A3R7KGY3	Trypanosoma rangeli	49%	91%
A0A3S5H747	Leishmania donovani	92%	100%
A4H9R1	Leishmania braziliensis	79%	100%
A4HY30	Leishmania infantum	92%	100%
D0A556	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	92%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ARU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q9FZ06	Arabidopsis thaliana	25%	87%
V5D4P5	Trypanosoma cruzi	53%	100%