Noc2-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Noc2p family, putative

Species:

Leishmania major

UniProt:

Q4QDM8_LEIMA

TriTrypDb:

LmjF.18.1610 , LMJLV39_180021800 , LMJSD75_180022000

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0030689	Noc complex	3	2
GO:0030690	Noc1p-Noc2p complex	4	2
GO:0030691	Noc2p-Noc3p complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	2
GO:0005634	nucleus	5	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10

Expansion

Sequence features

Q4QDM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDM8

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0022613	ribonucleoprotein complex biogenesis	4	2
GO:0042273	ribosomal large subunit biogenesis	5	2
GO:0044085	cellular component biogenesis	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.622
CLV_C14_Caspase3-7	128	132	PF00656	0.550
CLV_C14_Caspase3-7	446	450	PF00656	0.300
CLV_C14_Caspase3-7	97	101	PF00656	0.509
CLV_NRD_NRD_1	136	138	PF00675	0.661
CLV_NRD_NRD_1	182	184	PF00675	0.472
CLV_NRD_NRD_1	25	27	PF00675	0.430
CLV_NRD_NRD_1	40	42	PF00675	0.433
CLV_NRD_NRD_1	538	540	PF00675	0.365
CLV_NRD_NRD_1	651	653	PF00675	0.651
CLV_PCSK_KEX2_1	136	138	PF00082	0.628
CLV_PCSK_KEX2_1	226	228	PF00082	0.341
CLV_PCSK_KEX2_1	25	27	PF00082	0.430
CLV_PCSK_KEX2_1	571	573	PF00082	0.244
CLV_PCSK_KEX2_1	644	646	PF00082	0.596
CLV_PCSK_KEX2_1	651	653	PF00082	0.600
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.435
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.303
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.608
CLV_PCSK_PC7_1	222	228	PF00082	0.355
CLV_PCSK_PC7_1	647	653	PF00082	0.712
CLV_PCSK_SKI1_1	192	196	PF00082	0.435
CLV_PCSK_SKI1_1	226	230	PF00082	0.378
CLV_PCSK_SKI1_1	264	268	PF00082	0.338
CLV_PCSK_SKI1_1	27	31	PF00082	0.419
CLV_PCSK_SKI1_1	313	317	PF00082	0.244
CLV_PCSK_SKI1_1	368	372	PF00082	0.258
CLV_PCSK_SKI1_1	45	49	PF00082	0.463
CLV_PCSK_SKI1_1	461	465	PF00082	0.259
CLV_PCSK_SKI1_1	8	12	PF00082	0.457
DEG_APCC_DBOX_1	141	149	PF00400	0.458
DEG_APCC_DBOX_1	624	632	PF00400	0.573
DOC_CDC14_PxL_1	453	461	PF14671	0.259
DOC_CYCLIN_RxL_1	220	233	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	451	457	PF00134	0.389
DOC_MAPK_gen_1	217	225	PF00069	0.427
DOC_MAPK_gen_1	226	232	PF00069	0.293
DOC_MAPK_gen_1	539	547	PF00069	0.243
DOC_MAPK_MEF2A_6	429	437	PF00069	0.244
DOC_MAPK_MEF2A_6	447	455	PF00069	0.244
DOC_MAPK_MEF2A_6	461	470	PF00069	0.241
DOC_PP2B_LxvP_1	451	454	PF13499	0.389
DOC_PP4_FxxP_1	185	188	PF00568	0.445
DOC_PP4_FxxP_1	425	428	PF00568	0.244
DOC_USP7_MATH_1	194	198	PF00917	0.507
DOC_USP7_MATH_1	231	235	PF00917	0.525
DOC_USP7_MATH_1	281	285	PF00917	0.437
DOC_USP7_MATH_1	396	400	PF00917	0.278
DOC_USP7_MATH_1	533	537	PF00917	0.260
DOC_USP7_MATH_1	598	602	PF00917	0.327
DOC_USP7_UBL2_3	12	16	PF12436	0.441
DOC_USP7_UBL2_3	213	217	PF12436	0.406
DOC_USP7_UBL2_3	268	272	PF12436	0.323
DOC_USP7_UBL2_3	567	571	PF12436	0.303
DOC_USP7_UBL2_3	636	640	PF12436	0.524
DOC_USP7_UBL2_3	7	11	PF12436	0.458
DOC_WW_Pin1_4	424	429	PF00397	0.244
DOC_WW_Pin1_4	462	467	PF00397	0.259
LIG_14-3-3_CanoR_1	178	185	PF00244	0.564
LIG_14-3-3_CanoR_1	461	466	PF00244	0.244
LIG_14-3-3_CanoR_1	491	501	PF00244	0.233
LIG_14-3-3_CanoR_1	539	548	PF00244	0.276
LIG_14-3-3_CanoR_1	625	629	PF00244	0.526
LIG_Actin_WH2_2	256	274	PF00022	0.323
LIG_Actin_WH2_2	353	370	PF00022	0.259
LIG_BIR_II_1	1	5	PF00653	0.512
LIG_BIR_III_4	620	624	PF00653	0.603
LIG_BRCT_BRCA1_1	308	312	PF00533	0.244
LIG_FHA_1	219	225	PF00498	0.382
LIG_FHA_1	265	271	PF00498	0.351
LIG_FHA_1	487	493	PF00498	0.259
LIG_FHA_1	513	519	PF00498	0.295
LIG_FHA_2	101	107	PF00498	0.559
LIG_FHA_2	139	145	PF00498	0.435
LIG_FHA_2	345	351	PF00498	0.244
LIG_FHA_2	398	404	PF00498	0.338
LIG_FHA_2	65	71	PF00498	0.457
LIG_FHA_2	79	85	PF00498	0.435
LIG_GBD_Chelix_1	224	232	PF00786	0.426
LIG_GBD_Chelix_1	363	371	PF00786	0.244
LIG_LIR_Apic_2	182	188	PF02991	0.515
LIG_LIR_Apic_2	399	404	PF02991	0.303
LIG_LIR_Apic_2	423	428	PF02991	0.244
LIG_LIR_Gen_1	601	611	PF02991	0.423
LIG_LIR_Gen_1	70	80	PF02991	0.410
LIG_LIR_Nem_3	309	315	PF02991	0.284
LIG_LIR_Nem_3	393	397	PF02991	0.278
LIG_LIR_Nem_3	449	455	PF02991	0.244
LIG_LIR_Nem_3	529	534	PF02991	0.244
LIG_LIR_Nem_3	68	74	PF02991	0.408
LIG_LIR_Nem_3	9	13	PF02991	0.453
LIG_LYPXL_SIV_4	352	360	PF13949	0.321
LIG_PCNA_PIPBox_1	338	347	PF02747	0.303
LIG_Pex14_2	312	316	PF04695	0.244
LIG_Pex14_2	527	531	PF04695	0.244
LIG_PTB_Apo_2	381	388	PF02174	0.244
LIG_PTB_Phospho_1	381	387	PF10480	0.244
LIG_SH2_CRK	290	294	PF00017	0.447
LIG_SH2_GRB2like	387	390	PF00017	0.244
LIG_SH2_NCK_1	401	405	PF00017	0.244
LIG_SH2_PTP2	452	455	PF00017	0.338
LIG_SH2_SRC	353	356	PF00017	0.262
LIG_SH2_SRC	387	390	PF00017	0.244
LIG_SH2_SRC	452	455	PF00017	0.338
LIG_SH2_STAT3	359	362	PF00017	0.244
LIG_SH2_STAT5	262	265	PF00017	0.392
LIG_SH2_STAT5	359	362	PF00017	0.244
LIG_SH2_STAT5	366	369	PF00017	0.244
LIG_SH2_STAT5	387	390	PF00017	0.244
LIG_SH2_STAT5	452	455	PF00017	0.263
LIG_SH2_STAT5	458	461	PF00017	0.225
LIG_SH2_STAT5	512	515	PF00017	0.244
LIG_SH2_STAT5	74	77	PF00017	0.413
LIG_SH3_3	252	258	PF00018	0.333
LIG_SH3_3	451	457	PF00018	0.255
LIG_SH3_3	522	528	PF00018	0.338
LIG_SH3_3	542	548	PF00018	0.123
LIG_SUMO_SIM_anti_2	482	489	PF11976	0.265
LIG_SUMO_SIM_anti_2	88	95	PF11976	0.641
LIG_TRAF2_1	141	144	PF00917	0.490
LIG_TRAF2_1	280	283	PF00917	0.363
LIG_TRAF2_1	51	54	PF00917	0.614
LIG_UBA3_1	486	494	PF00899	0.389
LIG_WRC_WIRS_1	206	211	PF05994	0.470
MOD_CDK_SPK_2	424	429	PF00069	0.244
MOD_CK1_1	150	156	PF00069	0.528
MOD_CK1_1	215	221	PF00069	0.471
MOD_CK1_1	295	301	PF00069	0.430
MOD_CK1_1	399	405	PF00069	0.237
MOD_CK1_1	519	525	PF00069	0.252
MOD_CK2_1	138	144	PF00069	0.469
MOD_CK2_1	150	156	PF00069	0.449
MOD_CK2_1	28	34	PF00069	0.472
MOD_CK2_1	344	350	PF00069	0.244
MOD_CK2_1	397	403	PF00069	0.338
MOD_CK2_1	64	70	PF00069	0.445
MOD_CK2_1	78	84	PF00069	0.403
MOD_CK2_1	96	102	PF00069	0.458
MOD_Cter_Amidation	642	645	PF01082	0.703
MOD_GlcNHglycan	149	152	PF01048	0.519
MOD_GlcNHglycan	163	166	PF01048	0.267
MOD_GlcNHglycan	245	248	PF01048	0.449
MOD_GlcNHglycan	308	311	PF01048	0.292
MOD_GlcNHglycan	479	482	PF01048	0.288
MOD_GlcNHglycan	596	599	PF01048	0.319
MOD_GlcNHglycan	620	624	PF01048	0.606
MOD_GlcNHglycan	637	640	PF01048	0.670
MOD_GSK3_1	143	150	PF00069	0.546
MOD_GSK3_1	204	211	PF00069	0.424
MOD_GSK3_1	21	28	PF00069	0.554
MOD_GSK3_1	302	309	PF00069	0.394
MOD_GSK3_1	315	322	PF00069	0.301
MOD_GSK3_1	464	471	PF00069	0.309
MOD_GSK3_1	512	519	PF00069	0.351
MOD_GSK3_1	594	601	PF00069	0.305
MOD_GSK3_1	96	103	PF00069	0.523
MOD_LATS_1	176	182	PF00433	0.640
MOD_N-GLC_1	329	334	PF02516	0.280
MOD_N-GLC_2	276	278	PF02516	0.379
MOD_N-GLC_2	96	98	PF02516	0.449
MOD_NEK2_1	230	235	PF00069	0.344
MOD_NEK2_1	245	250	PF00069	0.269
MOD_NEK2_1	271	276	PF00069	0.368
MOD_NEK2_1	306	311	PF00069	0.249
MOD_NEK2_1	319	324	PF00069	0.303
MOD_NEK2_1	486	491	PF00069	0.244
MOD_NEK2_2	212	217	PF00069	0.465
MOD_NEK2_2	281	286	PF00069	0.426
MOD_NEK2_2	302	307	PF00069	0.381
MOD_NEK2_2	602	607	PF00069	0.303
MOD_PIKK_1	143	149	PF00454	0.454
MOD_PIKK_1	372	378	PF00454	0.244
MOD_PIKK_1	468	474	PF00454	0.306
MOD_PIKK_1	492	498	PF00454	0.255
MOD_PIKK_1	540	546	PF00454	0.314
MOD_PIKK_1	562	568	PF00454	0.302
MOD_PKA_1	25	31	PF00069	0.483
MOD_PKA_2	138	144	PF00069	0.449
MOD_PKA_2	25	31	PF00069	0.483
MOD_PKA_2	624	630	PF00069	0.523
MOD_Plk_1	143	149	PF00069	0.612
MOD_Plk_1	281	287	PF00069	0.347
MOD_Plk_1	329	335	PF00069	0.280
MOD_Plk_1	534	540	PF00069	0.244
MOD_Plk_2-3	100	106	PF00069	0.557
MOD_Plk_2-3	624	630	PF00069	0.538
MOD_Plk_2-3	70	76	PF00069	0.404
MOD_Plk_2-3	78	84	PF00069	0.414
MOD_Plk_4	205	211	PF00069	0.559
MOD_Plk_4	231	237	PF00069	0.362
MOD_Plk_4	245	251	PF00069	0.306
MOD_Plk_4	266	272	PF00069	0.328
MOD_Plk_4	315	321	PF00069	0.284
MOD_Plk_4	598	604	PF00069	0.381
MOD_Plk_4	70	76	PF00069	0.404
MOD_Plk_4	78	84	PF00069	0.414
MOD_ProDKin_1	424	430	PF00069	0.244
MOD_ProDKin_1	462	468	PF00069	0.259
MOD_SUMO_rev_2	34	44	PF00179	0.445
TRG_DiLeu_BaEn_1	186	191	PF01217	0.480
TRG_DiLeu_BaEn_1	509	514	PF01217	0.259
TRG_DiLeu_BaEn_1	78	83	PF01217	0.406
TRG_DiLeu_BaEn_4	143	149	PF01217	0.475
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.369
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.467
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.259
TRG_ENDOCYTIC_2	290	293	PF00928	0.296
TRG_ENDOCYTIC_2	452	455	PF00928	0.338
TRG_ENDOCYTIC_2	603	606	PF00928	0.280
TRG_ENDOCYTIC_2	72	75	PF00928	0.392
TRG_ER_diArg_1	135	137	PF00400	0.682
TRG_ER_diArg_1	645	648	PF00400	0.694
TRG_ER_diArg_1	650	652	PF00400	0.669
TRG_NLS_MonoExtC_3	643	648	PF00514	0.664
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.178
TRG_Pf-PMV_PEXEL_1	539	544	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P383	Leptomonas seymouri	86%	100%
A0A0S4IWR5	Bodo saltans	60%	99%
A0A1X0P734	Trypanosomatidae	68%	100%
A0A3R7MKH6	Trypanosoma rangeli	67%	100%
A0A3S7WV72	Leishmania donovani	97%	100%
A4H9R2	Leishmania braziliensis	88%	100%
A4HY31	Leishmania infantum	97%	100%
A8WTM7	Caenorhabditis briggsae	22%	91%
D0A554	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9ARU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P39744	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	92%
Q0WVH0	Arabidopsis thaliana	22%	100%
Q9P7G0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	93%
Q9WV70	Mus musculus	26%	88%
V5B4B0	Trypanosoma cruzi	66%	100%