IMP_cyclohyd domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDM6_LEIMA

TriTrypDb:

LmjF.18.1625 , LMJLV39_180022000 , LMJSD75_180022200

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.498
CLV_NRD_NRD_1	56	58	PF00675	0.454
CLV_PCSK_KEX2_1	56	58	PF00082	0.454
CLV_PCSK_SKI1_1	107	111	PF00082	0.424
CLV_PCSK_SKI1_1	176	180	PF00082	0.543
CLV_PCSK_SKI1_1	197	201	PF00082	0.528
CLV_PCSK_SKI1_1	204	208	PF00082	0.403
CLV_PCSK_SKI1_1	8	12	PF00082	0.453
DEG_APCC_DBOX_1	196	204	PF00400	0.541
DEG_Nend_UBRbox_2	1	3	PF02207	0.407
DEG_SPOP_SBC_1	159	163	PF00917	0.510
DOC_CDC14_PxL_1	30	38	PF14671	0.545
DOC_CYCLIN_RxL_1	82	90	PF00134	0.598
DOC_MAPK_gen_1	194	203	PF00069	0.324
DOC_USP7_MATH_1	115	119	PF00917	0.557
DOC_USP7_MATH_1	159	163	PF00917	0.530
DOC_USP7_MATH_1	212	216	PF00917	0.464
DOC_WW_Pin1_4	155	160	PF00397	0.510
LIG_14-3-3_CanoR_1	176	181	PF00244	0.555
LIG_BIR_III_2	156	160	PF00653	0.563
LIG_BRCT_BRCA1_1	161	165	PF00533	0.538
LIG_FHA_1	64	70	PF00498	0.539
LIG_FHA_2	15	21	PF00498	0.474
LIG_FHA_2	79	85	PF00498	0.578
LIG_GBD_Chelix_1	61	69	PF00786	0.331
LIG_LIR_Apic_2	17	21	PF02991	0.548
LIG_LYPXL_yS_3	33	36	PF13949	0.530
LIG_SH2_CRK	108	112	PF00017	0.370
LIG_SH2_PTP2	18	21	PF00017	0.390
LIG_SH2_SRC	18	21	PF00017	0.390
LIG_SH2_STAP1	108	112	PF00017	0.370
LIG_SH2_STAP1	143	147	PF00017	0.431
LIG_SH2_STAT5	18	21	PF00017	0.495
LIG_SH2_STAT5	39	42	PF00017	0.421
LIG_SH2_STAT5	59	62	PF00017	0.253
LIG_SUMO_SIM_par_1	199	205	PF11976	0.516
LIG_UBA3_1	97	104	PF00899	0.447
MOD_CK1_1	219	225	PF00069	0.519
MOD_CK2_1	14	20	PF00069	0.563
MOD_CK2_1	142	148	PF00069	0.484
MOD_CK2_1	78	84	PF00069	0.566
MOD_GlcNHglycan	144	147	PF01048	0.534
MOD_GlcNHglycan	181	184	PF01048	0.439
MOD_GlcNHglycan	221	224	PF01048	0.581
MOD_GlcNHglycan	45	48	PF01048	0.501
MOD_GlcNHglycan	78	81	PF01048	0.502
MOD_GSK3_1	10	17	PF00069	0.398
MOD_GSK3_1	155	162	PF00069	0.530
MOD_GSK3_1	212	219	PF00069	0.423
MOD_GSK3_1	76	83	PF00069	0.532
MOD_NEK2_1	1	6	PF00069	0.507
MOD_NEK2_1	160	165	PF00069	0.566
MOD_NEK2_1	178	183	PF00069	0.355
MOD_NEK2_1	216	221	PF00069	0.403
MOD_NEK2_1	87	92	PF00069	0.532
MOD_NEK2_2	23	28	PF00069	0.478
MOD_NEK2_2	99	104	PF00069	0.414
MOD_PIKK_1	115	121	PF00454	0.574
MOD_PIKK_1	78	84	PF00454	0.574
MOD_PKA_2	63	69	PF00069	0.555
MOD_PKA_2	87	93	PF00069	0.564
MOD_Plk_1	1	7	PF00069	0.545
MOD_Plk_4	14	20	PF00069	0.436
MOD_Plk_4	216	222	PF00069	0.412
MOD_ProDKin_1	155	161	PF00069	0.509
TRG_ENDOCYTIC_2	108	111	PF00928	0.382
TRG_ENDOCYTIC_2	33	36	PF00928	0.386
TRG_ER_diArg_1	55	57	PF00400	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M1	Leptomonas seymouri	47%	100%
A0A0S4IUU2	Bodo saltans	28%	98%
A0A1X0P852	Trypanosomatidae	37%	99%
A0A3R7NTK0	Trypanosoma rangeli	34%	100%
A0A3S7WV54	Leishmania donovani	91%	100%
A4H9R4	Leishmania braziliensis	71%	100%
A4HY33	Leishmania infantum	91%	100%
D0A552	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9ARU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%