Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDM5_LEIMA

TriTrypDb:

LmjF.18.1630 , LMJLV39_180022200 , LMJSD75_180022400

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QDM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDM5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005509	calcium ion binding	5	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.594
CLV_C14_Caspase3-7	223	227	PF00656	0.586
CLV_NRD_NRD_1	104	106	PF00675	0.546
CLV_NRD_NRD_1	236	238	PF00675	0.495
CLV_NRD_NRD_1	74	76	PF00675	0.433
CLV_NRD_NRD_1	85	87	PF00675	0.463
CLV_NRD_NRD_1	92	94	PF00675	0.478
CLV_PCSK_KEX2_1	236	238	PF00082	0.489
CLV_PCSK_KEX2_1	74	76	PF00082	0.441
CLV_PCSK_KEX2_1	80	82	PF00082	0.460
CLV_PCSK_KEX2_1	85	87	PF00082	0.493
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.515
CLV_PCSK_PC7_1	81	87	PF00082	0.501
CLV_PCSK_SKI1_1	110	114	PF00082	0.659
CLV_PCSK_SKI1_1	154	158	PF00082	0.446
DEG_APCC_DBOX_1	153	161	PF00400	0.517
DEG_APCC_DBOX_1	172	180	PF00400	0.284
DEG_SCF_FBW7_2	122	129	PF00400	0.595
DOC_CKS1_1	187	192	PF01111	0.577
DOC_PP1_RVXF_1	129	136	PF00149	0.382
DOC_PP1_RVXF_1	31	38	PF00149	0.419
DOC_USP7_MATH_1	164	168	PF00917	0.438
DOC_USP7_MATH_1	169	173	PF00917	0.365
DOC_USP7_MATH_1	97	101	PF00917	0.604
DOC_USP7_UBL2_3	106	110	PF12436	0.602
DOC_USP7_UBL2_3	83	87	PF12436	0.616
DOC_WW_Pin1_4	122	127	PF00397	0.603
DOC_WW_Pin1_4	186	191	PF00397	0.533
LIG_14-3-3_CanoR_1	140	146	PF00244	0.426
LIG_CaM_NSCaTE_8	209	216	PF13499	0.490
LIG_deltaCOP1_diTrp_1	134	138	PF00928	0.336
LIG_FHA_1	12	18	PF00498	0.418
LIG_FHA_1	140	146	PF00498	0.426
LIG_FHA_1	39	45	PF00498	0.507
LIG_FHA_2	1	7	PF00498	0.489
LIG_FHA_2	123	129	PF00498	0.614
LIG_FHA_2	180	186	PF00498	0.472
LIG_FHA_2	187	193	PF00498	0.470
LIG_FHA_2	219	225	PF00498	0.483
LIG_FHA_2	246	252	PF00498	0.661
LIG_FHA_2	50	56	PF00498	0.416
LIG_LIR_Apic_2	214	220	PF02991	0.493
LIG_LIR_Gen_1	134	139	PF02991	0.332
LIG_LIR_Gen_1	22	32	PF02991	0.404
LIG_LIR_Nem_3	134	138	PF02991	0.336
LIG_LIR_Nem_3	22	28	PF02991	0.381
LIG_PDZ_Class_3	251	256	PF00595	0.578
LIG_Rb_LxCxE_1	134	153	PF01857	0.352
LIG_SH2_NCK_1	18	22	PF00017	0.396
LIG_SH2_PTP2	217	220	PF00017	0.504
LIG_SH2_STAT5	217	220	PF00017	0.504
LIG_SH3_3	109	115	PF00018	0.682
LIG_SH3_3	184	190	PF00018	0.442
LIG_SH3_3	4	10	PF00018	0.581
LIG_SUMO_SIM_par_1	120	125	PF11976	0.570
LIG_SUMO_SIM_par_1	174	182	PF11976	0.541
LIG_TRAF2_1	126	129	PF00917	0.481
LIG_TRAF2_1	220	223	PF00917	0.496
LIG_UBA3_1	24	33	PF00899	0.451
LIG_WRC_WIRS_1	34	39	PF05994	0.398
MOD_CK1_1	11	17	PF00069	0.431
MOD_CK2_1	122	128	PF00069	0.591
MOD_CK2_1	186	192	PF00069	0.490
MOD_CK2_1	208	214	PF00069	0.380
MOD_CK2_1	218	224	PF00069	0.604
MOD_Cter_Amidation	103	106	PF01082	0.688
MOD_GlcNHglycan	166	170	PF01048	0.595
MOD_GlcNHglycan	99	102	PF01048	0.507
MOD_GSK3_1	165	172	PF00069	0.456
MOD_GSK3_1	8	15	PF00069	0.452
MOD_NEK2_1	195	200	PF00069	0.582
MOD_NEK2_1	38	43	PF00069	0.519
MOD_PIKK_1	218	224	PF00454	0.569
MOD_PKA_1	110	116	PF00069	0.695
MOD_PKA_2	104	110	PF00069	0.617
MOD_PKA_2	139	145	PF00069	0.424
MOD_PKA_2	245	251	PF00069	0.606
MOD_PKA_2	97	103	PF00069	0.586
MOD_Plk_1	165	171	PF00069	0.442
MOD_Plk_1	38	44	PF00069	0.562
MOD_Plk_4	104	110	PF00069	0.611
MOD_Plk_4	195	201	PF00069	0.463
MOD_Plk_4	213	219	PF00069	0.443
MOD_Plk_4	33	39	PF00069	0.399
MOD_Plk_4	8	14	PF00069	0.452
MOD_ProDKin_1	122	128	PF00069	0.597
MOD_ProDKin_1	186	192	PF00069	0.531
MOD_SUMO_for_1	79	82	PF00179	0.505
MOD_SUMO_rev_2	123	133	PF00179	0.492
TRG_DiLeu_BaEn_1	192	197	PF01217	0.545
TRG_DiLeu_BaEn_4	152	158	PF01217	0.455
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.413
TRG_ER_diArg_1	73	75	PF00400	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL1	Leptomonas seymouri	75%	100%
A0A0S4IRK8	Bodo saltans	48%	84%
A0A1X0P7F4	Trypanosomatidae	61%	98%
A0A3S7WVC9	Leishmania donovani	96%	100%
A0A422NPY0	Trypanosoma rangeli	57%	99%
A4H9R5	Leishmania braziliensis	85%	100%
A4HY34	Leishmania infantum	96%	100%
D0A550	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	70%
E9ARU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5D4P1	Trypanosoma cruzi	58%	99%