Putative chaperone protein DNAj

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania major

UniProt:

Q4QDM3_LEIMA

TriTrypDb:

LmjF.18.1650 , LMJLV39_180022400 , LMJSD75_180022600

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.596
CLV_NRD_NRD_1	192	194	PF00675	0.538
CLV_NRD_NRD_1	207	209	PF00675	0.282
CLV_NRD_NRD_1	62	64	PF00675	0.689
CLV_NRD_NRD_1	66	68	PF00675	0.632
CLV_PCSK_KEX2_1	111	113	PF00082	0.596
CLV_PCSK_KEX2_1	192	194	PF00082	0.538
CLV_PCSK_KEX2_1	207	209	PF00082	0.282
CLV_PCSK_KEX2_1	61	63	PF00082	0.695
CLV_PCSK_KEX2_1	66	68	PF00082	0.627
CLV_PCSK_PC7_1	62	68	PF00082	0.701
CLV_PCSK_SKI1_1	192	196	PF00082	0.584
CLV_PCSK_SKI1_1	357	361	PF00082	0.477
CLV_PCSK_SKI1_1	471	475	PF00082	0.531
DEG_SCF_FBW7_1	487	494	PF00400	0.685
DEG_SPOP_SBC_1	491	495	PF00917	0.705
DOC_CKS1_1	335	340	PF01111	0.530
DOC_CYCLIN_RxL_1	279	287	PF00134	0.500
DOC_CYCLIN_RxL_1	518	528	PF00134	0.432
DOC_CYCLIN_yCln2_LP_2	16	22	PF00134	0.681
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.513
DOC_MAPK_gen_1	108	116	PF00069	0.580
DOC_MAPK_gen_1	207	214	PF00069	0.466
DOC_MAPK_gen_1	535	543	PF00069	0.424
DOC_MAPK_MEF2A_6	207	214	PF00069	0.439
DOC_MAPK_MEF2A_6	259	268	PF00069	0.432
DOC_MAPK_MEF2A_6	430	437	PF00069	0.476
DOC_MAPK_NFAT4_5	430	438	PF00069	0.472
DOC_PP2B_LxvP_1	523	526	PF13499	0.313
DOC_USP7_MATH_1	244	248	PF00917	0.488
DOC_USP7_MATH_1	260	264	PF00917	0.351
DOC_USP7_MATH_1	297	301	PF00917	0.471
DOC_USP7_MATH_1	37	41	PF00917	0.702
DOC_USP7_MATH_1	97	101	PF00917	0.664
DOC_USP7_UBL2_3	496	500	PF12436	0.753
DOC_WW_Pin1_4	164	169	PF00397	0.532
DOC_WW_Pin1_4	224	229	PF00397	0.487
DOC_WW_Pin1_4	334	339	PF00397	0.549
DOC_WW_Pin1_4	487	492	PF00397	0.678
DOC_WW_Pin1_4	495	500	PF00397	0.753
DOC_WW_Pin1_4	506	511	PF00397	0.713
DOC_WW_Pin1_4	95	100	PF00397	0.659
LIG_14-3-3_CanoR_1	156	162	PF00244	0.515
LIG_14-3-3_CanoR_1	211	219	PF00244	0.435
LIG_14-3-3_CanoR_1	282	287	PF00244	0.509
LIG_14-3-3_CanoR_1	301	311	PF00244	0.202
LIG_14-3-3_CanoR_1	419	424	PF00244	0.509
LIG_14-3-3_CanoR_1	492	499	PF00244	0.732
LIG_14-3-3_CanoR_1	513	517	PF00244	0.577
LIG_14-3-3_CanoR_1	549	558	PF00244	0.476
LIG_APCC_ABBA_1	226	231	PF00400	0.541
LIG_APCC_ABBAyCdc20_2	393	399	PF00400	0.475
LIG_BH_BH3_1	73	89	PF00452	0.619
LIG_BRCT_BRCA1_1	314	318	PF00533	0.456
LIG_Clathr_ClatBox_1	283	287	PF01394	0.394
LIG_DLG_GKlike_1	419	427	PF00625	0.385
LIG_FHA_1	11	17	PF00498	0.641
LIG_FHA_1	165	171	PF00498	0.488
LIG_FHA_1	189	195	PF00498	0.515
LIG_FHA_1	320	326	PF00498	0.511
LIG_FHA_1	378	384	PF00498	0.423
LIG_FHA_1	422	428	PF00498	0.528
LIG_FHA_1	520	526	PF00498	0.395
LIG_FHA_1	553	559	PF00498	0.249
LIG_FHA_2	303	309	PF00498	0.515
LIG_FHA_2	411	417	PF00498	0.316
LIG_FHA_2	44	50	PF00498	0.755
LIG_FHA_2	492	498	PF00498	0.711
LIG_FHA_2	81	87	PF00498	0.653
LIG_LIR_Gen_1	246	254	PF02991	0.472
LIG_LIR_Gen_1	315	325	PF02991	0.481
LIG_LIR_Gen_1	409	416	PF02991	0.467
LIG_LIR_Gen_1	71	81	PF02991	0.623
LIG_LIR_Nem_3	246	251	PF02991	0.414
LIG_LIR_Nem_3	315	321	PF02991	0.429
LIG_LIR_Nem_3	343	349	PF02991	0.476
LIG_LIR_Nem_3	409	414	PF02991	0.469
LIG_LIR_Nem_3	517	523	PF02991	0.358
LIG_LIR_Nem_3	537	541	PF02991	0.139
LIG_LIR_Nem_3	562	568	PF02991	0.296
LIG_LIR_Nem_3	71	77	PF02991	0.533
LIG_NRBOX	326	332	PF00104	0.491
LIG_PAM2_1	499	511	PF00658	0.548
LIG_Pex14_1	314	318	PF04695	0.462
LIG_SH2_CRK	520	524	PF00017	0.330
LIG_SH2_CRK	538	542	PF00017	0.230
LIG_SH2_GRB2like	248	251	PF00017	0.498
LIG_SH2_SRC	572	575	PF00017	0.424
LIG_SH2_STAP1	147	151	PF00017	0.360
LIG_SH2_STAP1	248	252	PF00017	0.445
LIG_SH2_STAP1	257	261	PF00017	0.438
LIG_SH2_STAP1	423	427	PF00017	0.557
LIG_SH2_STAP1	572	576	PF00017	0.313
LIG_SH2_STAT3	295	298	PF00017	0.493
LIG_SH2_STAT5	147	150	PF00017	0.313
LIG_SH2_STAT5	248	251	PF00017	0.431
LIG_SH2_STAT5	423	426	PF00017	0.511
LIG_SH3_3	383	389	PF00018	0.527
LIG_SUMO_SIM_anti_2	262	269	PF11976	0.437
LIG_SUMO_SIM_par_1	193	198	PF11976	0.538
LIG_SUMO_SIM_par_1	282	287	PF11976	0.411
LIG_TRAF2_1	571	574	PF00917	0.423
LIG_TYR_ITIM	518	523	PF00017	0.430
MOD_CDC14_SPxK_1	227	230	PF00782	0.502
MOD_CDK_SPK_2	487	492	PF00069	0.547
MOD_CDK_SPK_2	495	500	PF00069	0.806
MOD_CDK_SPxK_1	224	230	PF00069	0.492
MOD_CDK_SPxxK_3	334	341	PF00069	0.531
MOD_CDK_SPxxK_3	506	513	PF00069	0.596
MOD_CK1_1	320	326	PF00069	0.500
MOD_CK1_1	495	501	PF00069	0.760
MOD_CK1_1	509	515	PF00069	0.617
MOD_CK1_1	552	558	PF00069	0.249
MOD_CK2_1	182	188	PF00069	0.394
MOD_CK2_1	302	308	PF00069	0.534
MOD_CK2_1	419	425	PF00069	0.483
MOD_CK2_1	491	497	PF00069	0.802
MOD_GlcNHglycan	158	161	PF01048	0.502
MOD_GlcNHglycan	184	187	PF01048	0.464
MOD_GlcNHglycan	204	207	PF01048	0.520
MOD_GlcNHglycan	527	530	PF01048	0.394
MOD_GlcNHglycan	551	554	PF01048	0.358
MOD_GlcNHglycan	577	580	PF01048	0.575
MOD_GSK3_1	39	46	PF00069	0.737
MOD_GSK3_1	406	413	PF00069	0.461
MOD_GSK3_1	421	428	PF00069	0.525
MOD_GSK3_1	486	493	PF00069	0.732
MOD_GSK3_1	521	528	PF00069	0.397
MOD_GSK3_1	557	564	PF00069	0.456
MOD_LATS_1	519	525	PF00433	0.424
MOD_NEK2_1	155	160	PF00069	0.556
MOD_NEK2_1	414	419	PF00069	0.467
MOD_NEK2_2	314	319	PF00069	0.464
MOD_NEK2_2	561	566	PF00069	0.457
MOD_PIKK_1	10	16	PF00454	0.696
MOD_PIKK_1	212	218	PF00454	0.493
MOD_PIKK_1	37	43	PF00454	0.725
MOD_PIKK_1	377	383	PF00454	0.545
MOD_PKA_2	155	161	PF00069	0.509
MOD_PKA_2	491	497	PF00069	0.700
MOD_PKA_2	512	518	PF00069	0.544
MOD_Plk_1	454	460	PF00069	0.446
MOD_Plk_1	561	567	PF00069	0.424
MOD_Plk_4	320	326	PF00069	0.481
MOD_Plk_4	374	380	PF00069	0.481
MOD_Plk_4	406	412	PF00069	0.559
MOD_ProDKin_1	164	170	PF00069	0.523
MOD_ProDKin_1	224	230	PF00069	0.492
MOD_ProDKin_1	334	340	PF00069	0.550
MOD_ProDKin_1	487	493	PF00069	0.683
MOD_ProDKin_1	495	501	PF00069	0.747
MOD_ProDKin_1	506	512	PF00069	0.703
MOD_ProDKin_1	95	101	PF00069	0.657
MOD_SUMO_rev_2	528	537	PF00179	0.419
TRG_DiLeu_BaEn_1	64	69	PF01217	0.679
TRG_DiLeu_BaEn_2	373	379	PF01217	0.483
TRG_DiLeu_BaEn_4	455	461	PF01217	0.390
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.487
TRG_ENDOCYTIC_2	248	251	PF00928	0.416
TRG_ENDOCYTIC_2	411	414	PF00928	0.388
TRG_ENDOCYTIC_2	520	523	PF00928	0.312
TRG_ENDOCYTIC_2	538	541	PF00928	0.312
TRG_ENDOCYTIC_2	572	575	PF00928	0.296
TRG_ER_diArg_1	192	194	PF00400	0.547
TRG_ER_diArg_1	207	209	PF00400	0.323
TRG_ER_diArg_1	61	63	PF00400	0.736
TRG_ER_diArg_1	65	67	PF00400	0.696
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HST8	Leptomonas seymouri	46%	99%
A0A1X0P804	Trypanosomatidae	27%	97%
A0A3Q8IB64	Leishmania donovani	92%	100%
A0A3R7KJ25	Trypanosoma rangeli	26%	94%
A4HY36	Leishmania infantum	92%	100%
D0A549	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ARV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B4A5	Trypanosoma cruzi	27%	100%
V5DRP2	Trypanosoma cruzi	24%	79%