Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QDM1_LEIMA

TriTrypDb:

LmjF.18.1670 , LMJLV39_180022700 , LMJSD75_180022900

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.724
CLV_NRD_NRD_1	141	143	PF00675	0.663
CLV_NRD_NRD_1	261	263	PF00675	0.704
CLV_NRD_NRD_1	455	457	PF00675	0.680
CLV_NRD_NRD_1	471	473	PF00675	0.491
CLV_NRD_NRD_1	79	81	PF00675	0.706
CLV_PCSK_KEX2_1	141	143	PF00082	0.663
CLV_PCSK_KEX2_1	261	263	PF00082	0.713
CLV_PCSK_KEX2_1	267	269	PF00082	0.657
CLV_PCSK_KEX2_1	455	457	PF00082	0.680
CLV_PCSK_KEX2_1	471	473	PF00082	0.491
CLV_PCSK_KEX2_1	79	81	PF00082	0.687
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.595
CLV_PCSK_SKI1_1	119	123	PF00082	0.621
CLV_PCSK_SKI1_1	358	362	PF00082	0.723
CLV_PCSK_SKI1_1	89	93	PF00082	0.626
DEG_APCC_DBOX_1	8	16	PF00400	0.677
DEG_SCF_FBW7_1	307	314	PF00400	0.646
DEG_SCF_FBW7_2	433	440	PF00400	0.608
DOC_CKS1_1	111	116	PF01111	0.615
DOC_CKS1_1	308	313	PF01111	0.645
DOC_CKS1_1	434	439	PF01111	0.655
DOC_CYCLIN_RxL_1	534	544	PF00134	0.502
DOC_MAPK_gen_1	455	461	PF00069	0.668
DOC_MAPK_gen_1	468	478	PF00069	0.507
DOC_PP1_SILK_1	533	538	PF00149	0.521
DOC_PP4_FxxP_1	111	114	PF00568	0.505
DOC_PP4_FxxP_1	210	213	PF00568	0.702
DOC_USP7_MATH_1	106	110	PF00917	0.680
DOC_USP7_MATH_1	190	194	PF00917	0.630
DOC_USP7_MATH_1	240	244	PF00917	0.670
DOC_USP7_MATH_1	311	315	PF00917	0.677
DOC_USP7_MATH_1	403	407	PF00917	0.586
DOC_USP7_MATH_1	477	481	PF00917	0.706
DOC_USP7_MATH_1	519	523	PF00917	0.686
DOC_USP7_MATH_1	85	89	PF00917	0.622
DOC_WW_Pin1_4	110	115	PF00397	0.643
DOC_WW_Pin1_4	162	167	PF00397	0.589
DOC_WW_Pin1_4	211	216	PF00397	0.718
DOC_WW_Pin1_4	301	306	PF00397	0.666
DOC_WW_Pin1_4	307	312	PF00397	0.648
DOC_WW_Pin1_4	362	367	PF00397	0.682
DOC_WW_Pin1_4	433	438	PF00397	0.663
DOC_WW_Pin1_4	444	449	PF00397	0.649
DOC_WW_Pin1_4	496	501	PF00397	0.675
DOC_WW_Pin1_4	515	520	PF00397	0.597
DOC_WW_Pin1_4	73	78	PF00397	0.609
LIG_14-3-3_CanoR_1	123	129	PF00244	0.618
LIG_14-3-3_CanoR_1	37	41	PF00244	0.563
LIG_14-3-3_CanoR_1	44	52	PF00244	0.578
LIG_14-3-3_CanoR_1	446	454	PF00244	0.587
LIG_14-3-3_CanoR_1	526	535	PF00244	0.728
LIG_BRCT_BRCA1_1	479	483	PF00533	0.639
LIG_Clathr_ClatBox_1	373	377	PF01394	0.670
LIG_FHA_1	163	169	PF00498	0.650
LIG_FHA_1	248	254	PF00498	0.707
LIG_FHA_1	311	317	PF00498	0.560
LIG_FHA_1	379	385	PF00498	0.740
LIG_FHA_1	425	431	PF00498	0.732
LIG_FHA_1	448	454	PF00498	0.680
LIG_FHA_1	553	559	PF00498	0.637
LIG_FHA_2	125	131	PF00498	0.622
LIG_FHA_2	363	369	PF00498	0.612
LIG_FHA_2	434	440	PF00498	0.665
LIG_FHA_2	509	515	PF00498	0.732
LIG_IRF3_LxIS_1	316	322	PF10401	0.569
LIG_LIR_Apic_2	109	114	PF02991	0.670
LIG_LIR_Apic_2	207	213	PF02991	0.684
LIG_LIR_Apic_2	322	328	PF02991	0.681
LIG_LIR_Gen_1	480	490	PF02991	0.588
LIG_LIR_Nem_3	336	341	PF02991	0.639
LIG_LIR_Nem_3	480	486	PF02991	0.584
LIG_LYPXL_S_1	340	344	PF13949	0.649
LIG_LYPXL_yS_3	341	344	PF13949	0.650
LIG_PCNA_yPIPBox_3	221	231	PF02747	0.569
LIG_PTAP_UEV_1	57	62	PF05743	0.656
LIG_RPA_C_Fungi	540	552	PF08784	0.574
LIG_SH2_NCK_1	325	329	PF00017	0.680
LIG_SH2_NCK_1	46	50	PF00017	0.504
LIG_SH2_SRC	56	59	PF00017	0.644
LIG_SH2_STAP1	46	50	PF00017	0.614
LIG_SH2_STAT5	325	328	PF00017	0.779
LIG_SH2_STAT5	46	49	PF00017	0.642
LIG_SH3_1	268	274	PF00018	0.588
LIG_SH3_2	174	179	PF14604	0.661
LIG_SH3_2	521	526	PF14604	0.600
LIG_SH3_2	58	63	PF14604	0.665
LIG_SH3_3	171	177	PF00018	0.716
LIG_SH3_3	209	215	PF00018	0.696
LIG_SH3_3	268	274	PF00018	0.700
LIG_SH3_3	305	311	PF00018	0.722
LIG_SH3_3	339	345	PF00018	0.678
LIG_SH3_3	35	41	PF00018	0.573
LIG_SH3_3	406	412	PF00018	0.580
LIG_SH3_3	426	432	PF00018	0.619
LIG_SH3_3	518	524	PF00018	0.654
LIG_SH3_3	55	61	PF00018	0.573
LIG_SH3_3	555	561	PF00018	0.512
LIG_SUMO_SIM_anti_2	474	481	PF11976	0.566
LIG_SUMO_SIM_par_1	304	310	PF11976	0.581
LIG_TRAF2_1	127	130	PF00917	0.621
LIG_TRAF2_1	436	439	PF00917	0.717
LIG_TRFH_1	102	106	PF08558	0.626
LIG_TRFH_1	341	345	PF08558	0.567
LIG_WW_3	523	527	PF00397	0.684
MOD_CDK_SPK_2	211	216	PF00069	0.699
MOD_CDK_SPxK_1	73	79	PF00069	0.597
MOD_CDK_SPxxK_3	73	80	PF00069	0.612
MOD_CK1_1	110	116	PF00069	0.626
MOD_CK1_1	131	137	PF00069	0.693
MOD_CK1_1	162	168	PF00069	0.645
MOD_CK1_1	193	199	PF00069	0.655
MOD_CK1_1	234	240	PF00069	0.629
MOD_CK1_1	314	320	PF00069	0.610
MOD_CK1_1	353	359	PF00069	0.709
MOD_CK1_1	481	487	PF00069	0.643
MOD_CK1_1	493	499	PF00069	0.582
MOD_CK1_1	529	535	PF00069	0.720
MOD_CK1_1	550	556	PF00069	0.590
MOD_CK2_1	124	130	PF00069	0.620
MOD_CK2_1	193	199	PF00069	0.668
MOD_CK2_1	433	439	PF00069	0.637
MOD_CK2_1	508	514	PF00069	0.733
MOD_Cter_Amidation	77	80	PF01082	0.680
MOD_GlcNHglycan	170	173	PF01048	0.569
MOD_GlcNHglycan	236	239	PF01048	0.718
MOD_GlcNHglycan	242	245	PF01048	0.657
MOD_GlcNHglycan	362	365	PF01048	0.824
MOD_GlcNHglycan	4	7	PF01048	0.512
MOD_GlcNHglycan	47	50	PF01048	0.548
MOD_GlcNHglycan	483	486	PF01048	0.627
MOD_GlcNHglycan	528	531	PF01048	0.677
MOD_GlcNHglycan	569	572	PF01048	0.641
MOD_GlcNHglycan	58	61	PF01048	0.616
MOD_GSK3_1	106	113	PF00069	0.630
MOD_GSK3_1	124	131	PF00069	0.457
MOD_GSK3_1	158	165	PF00069	0.602
MOD_GSK3_1	193	200	PF00069	0.683
MOD_GSK3_1	24	31	PF00069	0.648
MOD_GSK3_1	242	249	PF00069	0.680
MOD_GSK3_1	307	314	PF00069	0.688
MOD_GSK3_1	315	322	PF00069	0.625
MOD_GSK3_1	352	359	PF00069	0.735
MOD_GSK3_1	477	484	PF00069	0.647
MOD_GSK3_1	508	515	PF00069	0.611
MOD_GSK3_1	525	532	PF00069	0.611
MOD_GSK3_1	543	550	PF00069	0.485
MOD_N-GLC_1	234	239	PF02516	0.697
MOD_N-GLC_1	246	251	PF02516	0.582
MOD_N-GLC_1	65	70	PF02516	0.611
MOD_NEK2_1	107	112	PF00069	0.687
MOD_NEK2_1	168	173	PF00069	0.571
MOD_NEK2_1	231	236	PF00069	0.580
MOD_NEK2_1	283	288	PF00069	0.641
MOD_NEK2_1	319	324	PF00069	0.678
MOD_NEK2_1	45	50	PF00069	0.614
MOD_NEK2_1	478	483	PF00069	0.656
MOD_NEK2_1	541	546	PF00069	0.594
MOD_NEK2_1	547	552	PF00069	0.569
MOD_NEK2_2	375	380	PF00069	0.617
MOD_PIKK_1	128	134	PF00454	0.678
MOD_PKA_1	149	155	PF00069	0.517
MOD_PKA_2	231	237	PF00069	0.625
MOD_PKA_2	36	42	PF00069	0.640
MOD_PKA_2	525	531	PF00069	0.787
MOD_PKA_2	62	68	PF00069	0.686
MOD_Plk_1	206	212	PF00069	0.599
MOD_Plk_1	246	252	PF00069	0.589
MOD_Plk_4	547	553	PF00069	0.631
MOD_ProDKin_1	110	116	PF00069	0.643
MOD_ProDKin_1	162	168	PF00069	0.592
MOD_ProDKin_1	211	217	PF00069	0.717
MOD_ProDKin_1	301	307	PF00069	0.666
MOD_ProDKin_1	362	368	PF00069	0.681
MOD_ProDKin_1	433	439	PF00069	0.664
MOD_ProDKin_1	444	450	PF00069	0.646
MOD_ProDKin_1	496	502	PF00069	0.679
MOD_ProDKin_1	515	521	PF00069	0.597
MOD_ProDKin_1	73	79	PF00069	0.611
MOD_SUMO_for_1	136	139	PF00179	0.697
MOD_SUMO_rev_2	193	202	PF00179	0.674
TRG_DiLeu_BaEn_1	474	479	PF01217	0.651
TRG_DiLeu_BaEn_4	465	471	PF01217	0.540
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.580
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.607
TRG_ENDOCYTIC_2	102	105	PF00928	0.626
TRG_ENDOCYTIC_2	191	194	PF00928	0.717
TRG_ENDOCYTIC_2	341	344	PF00928	0.650
TRG_ER_diArg_1	261	263	PF00400	0.693
TRG_ER_diArg_1	454	456	PF00400	0.678
TRG_ER_diArg_1	470	472	PF00400	0.490
TRG_ER_diArg_1	79	81	PF00400	0.687
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.720
TRG_Pf-PMV_PEXEL_1	537	542	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WV70	Leishmania donovani	77%	86%
A4H9R9	Leishmania braziliensis	40%	95%
A4HY38	Leishmania infantum	78%	86%
E9ARV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%