Putative Qb-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qb-SNARE protein, putative

Species:

Leishmania major

UniProt:

Q4QDM0_LEIMA

TriTrypDb:

LmjF.19.0010 , LMJLV39_190005000 , LMJSD75_190005000

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	14
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

Q4QDM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDM0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0022406	membrane docking	2	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0048278	vesicle docking	4	2
GO:0048284	organelle fusion	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0140056	organelle localization by membrane tethering	3	2

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.593
CLV_NRD_NRD_1	108	110	PF00675	0.389
CLV_NRD_NRD_1	159	161	PF00675	0.418
CLV_NRD_NRD_1	257	259	PF00675	0.317
CLV_NRD_NRD_1	59	61	PF00675	0.284
CLV_NRD_NRD_1	82	84	PF00675	0.344
CLV_PCSK_KEX2_1	108	110	PF00082	0.353
CLV_PCSK_KEX2_1	147	149	PF00082	0.384
CLV_PCSK_KEX2_1	159	161	PF00082	0.367
CLV_PCSK_KEX2_1	257	259	PF00082	0.314
CLV_PCSK_KEX2_1	82	84	PF00082	0.411
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.505
CLV_PCSK_PC7_1	253	259	PF00082	0.351
CLV_PCSK_SKI1_1	257	261	PF00082	0.329
CLV_PCSK_SKI1_1	27	31	PF00082	0.353
CLV_PCSK_SKI1_1	75	79	PF00082	0.375
CLV_PCSK_SKI1_1	83	87	PF00082	0.345
DEG_APCC_DBOX_1	151	159	PF00400	0.579
DEG_APCC_DBOX_1	59	67	PF00400	0.587
DEG_APCC_KENBOX_2	85	89	PF00400	0.528
DOC_MAPK_gen_1	89	100	PF00069	0.529
DOC_MAPK_MEF2A_6	219	227	PF00069	0.484
DOC_USP7_MATH_1	93	97	PF00917	0.577
DOC_USP7_UBL2_3	193	197	PF12436	0.552
DOC_USP7_UBL2_3	260	264	PF12436	0.627
DOC_USP7_UBL2_3	86	90	PF12436	0.531
LIG_14-3-3_CanoR_1	108	116	PF00244	0.629
LIG_14-3-3_CanoR_1	257	263	PF00244	0.472
LIG_Actin_WH2_2	248	266	PF00022	0.499
LIG_AP2alpha_2	16	18	PF02296	0.523
LIG_BIR_II_1	1	5	PF00653	0.632
LIG_BIR_III_3	1	5	PF00653	0.590
LIG_CaM_IQ_9	140	156	PF13499	0.622
LIG_FHA_1	239	245	PF00498	0.654
LIG_FHA_1	247	253	PF00498	0.616
LIG_FHA_2	137	143	PF00498	0.642
LIG_FHA_2	183	189	PF00498	0.561
LIG_FHA_2	67	73	PF00498	0.488
LIG_LIR_Gen_1	15	26	PF02991	0.602
LIG_LIR_Nem_3	15	21	PF02991	0.634
LIG_LIR_Nem_3	285	290	PF02991	0.257
LIG_LRP6_Inhibitor_1	54	60	PF00058	0.281
LIG_PCNA_yPIPBox_3	253	263	PF02747	0.508
LIG_Pex14_2	288	292	PF04695	0.381
LIG_SH2_GRB2like	112	115	PF00017	0.480
LIG_SH2_STAP1	112	116	PF00017	0.481
LIG_SH2_STAT5	274	277	PF00017	0.279
LIG_SUMO_SIM_anti_2	173	180	PF11976	0.594
LIG_SUMO_SIM_par_1	280	285	PF11976	0.202
LIG_TRAF2_1	139	142	PF00917	0.667
LIG_TRAF2_1	185	188	PF00917	0.553
LIG_TRAF2_1	69	72	PF00917	0.624
LIG_UBA3_1	155	161	PF00899	0.647
LIG_WRC_WIRS_1	259	264	PF05994	0.510
MOD_CK1_1	165	171	PF00069	0.562
MOD_CK2_1	136	142	PF00069	0.625
MOD_CK2_1	182	188	PF00069	0.723
MOD_CK2_1	66	72	PF00069	0.488
MOD_Cter_Amidation	106	109	PF01082	0.382
MOD_Cter_Amidation	145	148	PF01082	0.353
MOD_GlcNHglycan	116	119	PF01048	0.383
MOD_GlcNHglycan	164	167	PF01048	0.511
MOD_GSK3_1	132	139	PF00069	0.518
MOD_N-GLC_1	162	167	PF02516	0.446
MOD_N-GLC_2	41	43	PF02516	0.293
MOD_NEK2_1	176	181	PF00069	0.601
MOD_NEK2_1	263	268	PF00069	0.578
MOD_PIKK_1	107	113	PF00454	0.518
MOD_PKA_2	107	113	PF00069	0.543
MOD_Plk_1	177	183	PF00069	0.592
MOD_Plk_1	66	72	PF00069	0.520
MOD_Plk_2-3	136	142	PF00069	0.650
MOD_Plk_4	258	264	PF00069	0.494
MOD_SUMO_for_1	4	7	PF00179	0.702
TRG_DiLeu_BaEn_1	72	77	PF01217	0.589
TRG_ER_diArg_1	158	160	PF00400	0.596
TRG_ER_diArg_1	257	259	PF00400	0.515
TRG_ER_diArg_1	82	84	PF00400	0.689
TRG_NES_CRM1_1	68	81	PF08389	0.467
TRG_NLS_MonoCore_2	88	93	PF00514	0.572
TRG_NLS_MonoExtC_3	88	93	PF00514	0.544
TRG_NLS_MonoExtN_4	86	93	PF00514	0.614
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9J7	Leptomonas seymouri	70%	92%
A0A0S4IV64	Bodo saltans	43%	86%
A0A0S4IVZ4	Bodo saltans	36%	89%
A0A0S4IZ68	Bodo saltans	42%	89%
A0A1X0P6H2	Trypanosomatidae	55%	91%
A0A3R7LL06	Trypanosoma rangeli	50%	91%
A0A3S7WV65	Leishmania donovani	92%	100%
A4H9V8	Leishmania braziliensis	76%	92%
A4HY40	Leishmania infantum	92%	100%
D0A0C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	91%
E9ARV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	92%
V5BS89	Trypanosoma cruzi	52%	91%