Putative Qb-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qb-SNARE protein, putative

Species:

Leishmania major

UniProt:

Q4QDM0_LEIMA

TriTrypDb:

LmjF.19.0010 , LMJLV39_190005000 , LMJSD75_190005000

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

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Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	14
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	14

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Expansion

Sequence features

Q4QDM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDM0

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0022406	membrane docking	2	2

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Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.593
CLV_NRD_NRD_1	108	110	PF00675	0.389
CLV_NRD_NRD_1	159	161	PF00675	0.418
CLV_NRD_NRD_1	257	259	PF00675	0.317
CLV_NRD_NRD_1	59	61	PF00675	0.284
CLV_NRD_NRD_1	82	84	PF00675	0.344
CLV_PCSK_KEX2_1	108	110	PF00082	0.353
CLV_PCSK_KEX2_1	147	149	PF00082	0.384
CLV_PCSK_KEX2_1	159	161	PF00082	0.367
CLV_PCSK_KEX2_1	257	259	PF00082	0.314

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9J7	Leptomonas seymouri	70%	92%
A0A0S4IV64	Bodo saltans	43%	86%
A0A0S4IVZ4	Bodo saltans	36%	89%
A0A0S4IZ68	Bodo saltans	42%	89%
A0A1X0P6H2	Trypanosomatidae	55%	91%
A0A3R7LL06	Trypanosoma rangeli	50%	91%
A0A3S7WV65	Leishmania donovani	92%	100%
A4H9V8	Leishmania braziliensis	76%	92%
A4HY40	Leishmania infantum	92%	100%
D0A0C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	91%

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