DNA translocase FtsK

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDL9_LEIMA

TriTrypDb:

LmjF.19.0020 , LMJLV39_190005100 , LMJSD75_190005100

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDL9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_1	128	134	PF00400	0.556
DOC_CKS1_1	128	133	PF01111	0.536
DOC_CKS1_1	29	34	PF01111	0.787
DOC_USP7_MATH_1	170	174	PF00917	0.676
DOC_USP7_MATH_1	201	205	PF00917	0.632
DOC_USP7_MATH_1	53	57	PF00917	0.671
DOC_WW_Pin1_4	127	132	PF00397	0.534
DOC_WW_Pin1_4	15	20	PF00397	0.645
DOC_WW_Pin1_4	28	33	PF00397	0.663
LIG_14-3-3_CanoR_1	151	156	PF00244	0.643
LIG_14-3-3_CanoR_1	224	231	PF00244	0.575
LIG_14-3-3_CanoR_1	236	243	PF00244	0.533
LIG_14-3-3_CanoR_1	245	249	PF00244	0.649
LIG_14-3-3_CanoR_1	3	12	PF00244	0.596
LIG_14-3-3_CanoR_1	98	103	PF00244	0.514
LIG_BRCT_BRCA1_1	189	193	PF00533	0.652
LIG_FHA_1	143	149	PF00498	0.627
LIG_MAD2	98	106	PF02301	0.478
LIG_Pex14_2	221	225	PF04695	0.616
LIG_PTAP_UEV_1	46	51	PF05743	0.518
LIG_SH2_GRB2like	179	182	PF00017	0.550
LIG_SH2_STAT5	92	95	PF00017	0.466
LIG_SH3_3	125	131	PF00018	0.504
LIG_SH3_3	137	143	PF00018	0.531
LIG_SH3_3	26	32	PF00018	0.811
LIG_SH3_3	44	50	PF00018	0.658
LIG_SH3_3	63	69	PF00018	0.644
LIG_SH3_3	75	81	PF00018	0.572
LIG_SH3_3	84	90	PF00018	0.555
LIG_SH3_3	99	105	PF00018	0.400
LIG_SUMO_SIM_par_1	92	97	PF11976	0.437
LIG_TRAF2_1	56	59	PF00917	0.714
LIG_WW_3	104	108	PF00397	0.516
MOD_CDC14_SPxK_1	20	23	PF00782	0.588
MOD_CDK_SPxK_1	17	23	PF00069	0.585
MOD_CK1_1	154	160	PF00069	0.598
MOD_CK1_1	204	210	PF00069	0.639
MOD_CK1_1	247	253	PF00069	0.637
MOD_CK2_1	37	43	PF00069	0.581
MOD_CK2_1	53	59	PF00069	0.593
MOD_GlcNHglycan	121	124	PF01048	0.521
MOD_GlcNHglycan	172	175	PF01048	0.748
MOD_GlcNHglycan	206	209	PF01048	0.562
MOD_GlcNHglycan	232	235	PF01048	0.504
MOD_GlcNHglycan	238	241	PF01048	0.544
MOD_GlcNHglycan	47	50	PF01048	0.514
MOD_GlcNHglycan	6	9	PF01048	0.712
MOD_GSK3_1	127	134	PF00069	0.650
MOD_GSK3_1	147	154	PF00069	0.617
MOD_GSK3_1	24	31	PF00069	0.767
MOD_GSK3_1	37	44	PF00069	0.495
MOD_NEK2_1	193	198	PF00069	0.618
MOD_PIKK_1	106	112	PF00454	0.597
MOD_PIKK_1	172	178	PF00454	0.634
MOD_PIKK_1	193	199	PF00454	0.603
MOD_PIKK_1	244	250	PF00454	0.650
MOD_PIKK_1	37	43	PF00454	0.595
MOD_PK_1	98	104	PF00069	0.567
MOD_PKA_2	106	112	PF00069	0.600
MOD_PKA_2	214	220	PF00069	0.717
MOD_PKA_2	225	231	PF00069	0.477
MOD_PKA_2	244	250	PF00069	0.432
MOD_PKA_2	4	10	PF00069	0.659
MOD_Plk_2-3	54	60	PF00069	0.682
MOD_ProDKin_1	127	133	PF00069	0.536
MOD_ProDKin_1	15	21	PF00069	0.645
MOD_ProDKin_1	28	34	PF00069	0.659
TRG_ER_diArg_1	2	5	PF00400	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE1	Leptomonas seymouri	74%	68%
A0A1X0P6F6	Trypanosomatidae	38%	77%
A0A3Q8IB46	Leishmania donovani	92%	100%
A0A3R7JZB4	Trypanosoma rangeli	37%	76%
A4H9V9	Leishmania braziliensis	84%	100%
A4HY41	Leishmania infantum	92%	100%
E9ARV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	68%
V5BBT3	Trypanosoma cruzi	33%	76%