Putative peroxin 13

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative peroxin 13

Gene product:

peroxin 13, putative

Species:

Leishmania major

UniProt:

Q4QDL4_LEIMA

TriTrypDb:

LmjF.19.0070 , LMJLV39_190005600 , LMJSD75_190005500

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	3
GO:0031090	organelle membrane	3	2
GO:0031903	microbody membrane	5	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0046860	glycosome membrane	7	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QDL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDL4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006996	organelle organization	4	2
GO:0007031	peroxisome organization	5	2
GO:0009987	cellular process	1	2
GO:0015919	peroxisomal membrane transport	5	2
GO:0016043	cellular component organization	3	2
GO:0043574	peroxisomal transport	4	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.535
CLV_NRD_NRD_1	174	176	PF00675	0.630
CLV_NRD_NRD_1	323	325	PF00675	0.500
CLV_NRD_NRD_1	395	397	PF00675	0.407
CLV_NRD_NRD_1	448	450	PF00675	0.330
CLV_NRD_NRD_1	5	7	PF00675	0.344
CLV_PCSK_FUR_1	172	176	PF00082	0.634
CLV_PCSK_FUR_1	321	325	PF00082	0.479
CLV_PCSK_KEX2_1	174	176	PF00082	0.630
CLV_PCSK_KEX2_1	321	323	PF00082	0.507
CLV_PCSK_KEX2_1	395	397	PF00082	0.364
CLV_PCSK_KEX2_1	448	450	PF00082	0.332
CLV_PCSK_KEX2_1	5	7	PF00082	0.344
CLV_PCSK_SKI1_1	323	327	PF00082	0.527
DEG_APCC_DBOX_1	291	299	PF00400	0.361
DEG_Nend_Nbox_1	1	3	PF02207	0.557
DEG_SPOP_SBC_1	31	35	PF00917	0.217
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.351
DOC_MAPK_gen_1	195	205	PF00069	0.446
DOC_MAPK_gen_1	290	298	PF00069	0.313
DOC_MAPK_gen_1	5	12	PF00069	0.532
DOC_MAPK_MEF2A_6	292	300	PF00069	0.343
DOC_USP7_MATH_1	108	112	PF00917	0.519
DOC_USP7_MATH_1	145	149	PF00917	0.463
DOC_USP7_MATH_1	239	243	PF00917	0.399
DOC_USP7_MATH_1	386	390	PF00917	0.745
DOC_USP7_MATH_1	409	413	PF00917	0.494
DOC_USP7_MATH_1	428	432	PF00917	0.543
DOC_WW_Pin1_4	150	155	PF00397	0.577
DOC_WW_Pin1_4	165	170	PF00397	0.407
LIG_14-3-3_CanoR_1	238	248	PF00244	0.422
LIG_14-3-3_CanoR_1	347	355	PF00244	0.743
LIG_14-3-3_CanoR_1	5	11	PF00244	0.534
LIG_Actin_WH2_1	202	220	PF00022	0.311
LIG_Actin_WH2_2	205	220	PF00022	0.412
LIG_BIR_III_4	331	335	PF00653	0.728
LIG_BRCT_BRCA1_1	25	29	PF00533	0.217
LIG_BRCT_BRCA1_1	32	36	PF00533	0.195
LIG_DCNL_PONY_1	1	4	PF03556	0.556
LIG_DLG_GKlike_1	246	254	PF00625	0.394
LIG_eIF4E_1	83	89	PF01652	0.574
LIG_FHA_1	208	214	PF00498	0.401
LIG_FHA_1	265	271	PF00498	0.521
LIG_FHA_1	33	39	PF00498	0.217
LIG_FHA_1	392	398	PF00498	0.568
LIG_FHA_2	354	360	PF00498	0.751
LIG_FHA_2	363	369	PF00498	0.755
LIG_GBD_Chelix_1	205	213	PF00786	0.659
LIG_IBAR_NPY_1	107	109	PF08397	0.489
LIG_LIR_Apic_2	403	407	PF02991	0.479
LIG_LIR_Gen_1	33	44	PF02991	0.418
LIG_LIR_Gen_1	454	463	PF02991	0.641
LIG_LIR_Nem_3	13	18	PF02991	0.698
LIG_LIR_Nem_3	26	32	PF02991	0.184
LIG_LIR_Nem_3	33	39	PF02991	0.313
LIG_LIR_Nem_3	330	336	PF02991	0.765
LIG_LIR_Nem_3	454	459	PF02991	0.561
LIG_PDZ_Class_1	461	466	PF00595	0.654
LIG_Pex14_1	370	374	PF04695	0.742
LIG_Pex14_2	224	228	PF04695	0.376
LIG_PTB_Apo_2	103	110	PF02174	0.451
LIG_PTB_Phospho_1	103	109	PF10480	0.422
LIG_SH2_CRK	333	337	PF00017	0.766
LIG_SH2_CRK	404	408	PF00017	0.507
LIG_SH2_SRC	427	430	PF00017	0.530
LIG_SH2_STAP1	232	236	PF00017	0.358
LIG_SH2_STAP1	342	346	PF00017	0.732
LIG_SH2_STAP1	402	406	PF00017	0.561
LIG_SH2_STAT3	402	405	PF00017	0.561
LIG_TRAF2_1	168	171	PF00917	0.480
LIG_TRAF2_1	242	245	PF00917	0.346
LIG_TYR_ITIM	22	27	PF00017	0.217
LIG_WRC_WIRS_1	100	105	PF05994	0.702
MOD_CDK_SPxxK_3	165	172	PF00069	0.617
MOD_CK1_1	113	119	PF00069	0.735
MOD_CK1_1	122	128	PF00069	0.692
MOD_CK1_1	285	291	PF00069	0.604
MOD_CK1_1	34	40	PF00069	0.410
MOD_CK1_1	345	351	PF00069	0.697
MOD_CK1_1	353	359	PF00069	0.610
MOD_CK1_1	412	418	PF00069	0.400
MOD_CK1_1	442	448	PF00069	0.402
MOD_CK2_1	165	171	PF00069	0.591
MOD_CK2_1	216	222	PF00069	0.463
MOD_CK2_1	239	245	PF00069	0.407
MOD_CK2_1	335	341	PF00069	0.647
MOD_CK2_1	346	352	PF00069	0.656
MOD_CK2_1	362	368	PF00069	0.622
MOD_CK2_1	428	434	PF00069	0.436
MOD_CMANNOS	291	294	PF00535	0.511
MOD_Cter_Amidation	446	449	PF01082	0.422
MOD_GlcNHglycan	218	221	PF01048	0.494
MOD_GlcNHglycan	241	244	PF01048	0.559
MOD_GlcNHglycan	274	277	PF01048	0.646
MOD_GlcNHglycan	284	287	PF01048	0.573
MOD_GlcNHglycan	388	391	PF01048	0.693
MOD_GlcNHglycan	45	48	PF01048	0.547
MOD_GlcNHglycan	57	60	PF01048	0.731
MOD_GlcNHglycan	79	82	PF01048	0.662
MOD_GlcNHglycan	85	88	PF01048	0.671
MOD_GlcNHglycan	96	99	PF01048	0.621
MOD_GSK3_1	282	289	PF00069	0.585
MOD_GSK3_1	30	37	PF00069	0.217
MOD_GSK3_1	342	349	PF00069	0.629
MOD_GSK3_1	90	97	PF00069	0.665
MOD_N-GLC_1	113	118	PF02516	0.762
MOD_N-GLC_1	165	170	PF02516	0.636
MOD_N-GLC_1	391	396	PF02516	0.571
MOD_NEK2_1	135	140	PF00069	0.800
MOD_NEK2_1	30	35	PF00069	0.217
MOD_NEK2_1	4	9	PF00069	0.524
MOD_NEK2_1	89	94	PF00069	0.684
MOD_NEK2_2	342	347	PF00069	0.687
MOD_PIKK_1	127	133	PF00454	0.741
MOD_PIKK_1	264	270	PF00454	0.716
MOD_PIKK_1	335	341	PF00454	0.716
MOD_PIKK_1	380	386	PF00454	0.742
MOD_PKA_1	323	329	PF00069	0.591
MOD_PKA_1	5	11	PF00069	0.405
MOD_PKA_2	323	329	PF00069	0.620
MOD_PKA_2	346	352	PF00069	0.668
MOD_PKA_2	353	359	PF00069	0.750
MOD_PKA_2	386	392	PF00069	0.624
MOD_PKA_2	4	10	PF00069	0.411
MOD_PKB_1	321	329	PF00069	0.596
MOD_Plk_1	113	119	PF00069	0.762
MOD_Plk_1	342	348	PF00069	0.635
MOD_Plk_1	362	368	PF00069	0.676
MOD_Plk_2-3	362	368	PF00069	0.632
MOD_Plk_4	14	20	PF00069	0.631
MOD_Plk_4	227	233	PF00069	0.489
MOD_Plk_4	6	12	PF00069	0.552
MOD_Plk_4	99	105	PF00069	0.609
MOD_ProDKin_1	150	156	PF00069	0.746
MOD_ProDKin_1	165	171	PF00069	0.505
MOD_SUMO_rev_2	8	18	PF00179	0.387
TRG_DiLeu_BaEn_3	13	19	PF01217	0.380
TRG_ENDOCYTIC_2	231	234	PF00928	0.448
TRG_ENDOCYTIC_2	24	27	PF00928	0.338
TRG_ENDOCYTIC_2	333	336	PF00928	0.734
TRG_ENDOCYTIC_2	398	401	PF00928	0.483
TRG_ER_diArg_1	172	175	PF00400	0.524
TRG_ER_diArg_1	321	324	PF00400	0.719
TRG_ER_diArg_1	395	397	PF00400	0.527
TRG_ER_diArg_1	4	6	PF00400	0.430
TRG_NES_CRM1_1	204	215	PF08389	0.600
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.624
TRG_PTS1	463	466	PF00515	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9X6	Leptomonas seymouri	70%	100%
A0A0S4J170	Bodo saltans	26%	100%
A0A1X0P6F7	Trypanosomatidae	36%	100%
A0A3S7WV91	Leishmania donovani	88%	100%
A0A422NCY3	Trypanosoma rangeli	31%	100%
A4H9W4	Leishmania braziliensis	78%	100%
E9AGQ9	Leishmania infantum	90%	100%
E9ARV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%