J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDL2_LEIMA

TriTrypDb:

LmjF.19.0090 , LMJLV39_190005800 , LMJSD75_190005700

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QDL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.296
CLV_C14_Caspase3-7	294	298	PF00656	0.303
CLV_NRD_NRD_1	155	157	PF00675	0.667
CLV_NRD_NRD_1	16	18	PF00675	0.367
CLV_NRD_NRD_1	172	174	PF00675	0.671
CLV_NRD_NRD_1	184	186	PF00675	0.549
CLV_NRD_NRD_1	298	300	PF00675	0.577
CLV_PCSK_KEX2_1	16	18	PF00082	0.367
CLV_PCSK_KEX2_1	183	185	PF00082	0.552
CLV_PCSK_KEX2_1	195	197	PF00082	0.524
CLV_PCSK_KEX2_1	265	267	PF00082	0.586
CLV_PCSK_KEX2_1	393	395	PF00082	0.451
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.622
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.586
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.487
CLV_PCSK_PC7_1	191	197	PF00082	0.616
CLV_PCSK_SKI1_1	16	20	PF00082	0.459
CLV_PCSK_SKI1_1	195	199	PF00082	0.587
CLV_PCSK_SKI1_1	235	239	PF00082	0.603
CLV_PCSK_SKI1_1	88	92	PF00082	0.256
DEG_SPOP_SBC_1	250	254	PF00917	0.449
DOC_MAPK_gen_1	333	341	PF00069	0.393
DOC_MAPK_gen_1	85	95	PF00069	0.476
DOC_MAPK_MEF2A_6	335	343	PF00069	0.390
DOC_PP2B_LxvP_1	113	116	PF13499	0.399
DOC_USP7_UBL2_3	261	265	PF12436	0.433
DOC_WW_Pin1_4	157	162	PF00397	0.522
DOC_WW_Pin1_4	251	256	PF00397	0.462
LIG_14-3-3_CanoR_1	251	255	PF00244	0.424
LIG_14-3-3_CanoR_1	314	323	PF00244	0.403
LIG_14-3-3_CanoR_1	65	73	PF00244	0.608
LIG_14-3-3_CanoR_1	9	15	PF00244	0.657
LIG_Actin_WH2_2	357	375	PF00022	0.444
LIG_eIF4E_1	89	95	PF01652	0.411
LIG_FHA_1	143	149	PF00498	0.376
LIG_FHA_1	228	234	PF00498	0.436
LIG_FHA_1	245	251	PF00498	0.403
LIG_FHA_1	352	358	PF00498	0.281
LIG_FHA_2	270	276	PF00498	0.455
LIG_FHA_2	67	73	PF00498	0.616
LIG_IRF3_LxIS_1	99	105	PF10401	0.287
LIG_LIR_Gen_1	140	148	PF02991	0.344
LIG_LIR_Gen_1	223	233	PF02991	0.328
LIG_LIR_Gen_1	288	298	PF02991	0.293
LIG_LIR_Gen_1	71	77	PF02991	0.589
LIG_LIR_Nem_3	140	146	PF02991	0.342
LIG_LIR_Nem_3	203	208	PF02991	0.435
LIG_LIR_Nem_3	223	229	PF02991	0.348
LIG_LIR_Nem_3	236	241	PF02991	0.304
LIG_LIR_Nem_3	288	293	PF02991	0.285
LIG_LIR_Nem_3	331	337	PF02991	0.369
LIG_LIR_Nem_3	71	76	PF02991	0.620
LIG_Pex14_2	87	91	PF04695	0.432
LIG_SH2_CRK	143	147	PF00017	0.411
LIG_SH2_CRK	205	209	PF00017	0.449
LIG_SH2_CRK	226	230	PF00017	0.323
LIG_SH2_CRK	334	338	PF00017	0.388
LIG_SH2_NCK_1	290	294	PF00017	0.395
LIG_SH2_PTP2	347	350	PF00017	0.281
LIG_SH2_SRC	290	293	PF00017	0.389
LIG_SH2_STAP1	107	111	PF00017	0.360
LIG_SH2_STAT5	302	305	PF00017	0.340
LIG_SH2_STAT5	347	350	PF00017	0.269
LIG_SH2_STAT5	89	92	PF00017	0.411
LIG_SH3_3	124	130	PF00018	0.504
LIG_SUMO_SIM_par_1	98	103	PF11976	0.366
LIG_TRAF2_1	165	168	PF00917	0.462
LIG_TRAF2_1	282	285	PF00917	0.313
LIG_TRAF2_1	389	392	PF00917	0.586
LIG_TYR_ITIM	224	229	PF00017	0.304
LIG_UBA3_1	237	245	PF00899	0.424
LIG_UBA3_1	364	373	PF00899	0.569
LIG_UBA3_1	99	106	PF00899	0.331
LIG_WRC_WIRS_1	329	334	PF05994	0.383
MOD_CK1_1	160	166	PF00069	0.542
MOD_CK1_1	249	255	PF00069	0.398
MOD_CK2_1	66	72	PF00069	0.609
MOD_DYRK1A_RPxSP_1	251	255	PF00069	0.461
MOD_GlcNHglycan	119	122	PF01048	0.603
MOD_GlcNHglycan	21	25	PF01048	0.350
MOD_GlcNHglycan	316	319	PF01048	0.598
MOD_GlcNHglycan	81	85	PF01048	0.358
MOD_GSK3_1	138	145	PF00069	0.408
MOD_GSK3_1	246	253	PF00069	0.438
MOD_LATS_1	312	318	PF00433	0.382
MOD_N-GLC_1	152	157	PF02516	0.712
MOD_NEK2_1	100	105	PF00069	0.364
MOD_NEK2_1	152	157	PF00069	0.501
MOD_NEK2_1	20	25	PF00069	0.553
MOD_NEK2_1	363	368	PF00069	0.423
MOD_NEK2_1	372	377	PF00069	0.540
MOD_NEK2_2	328	333	PF00069	0.453
MOD_PIKK_1	228	234	PF00454	0.314
MOD_PIKK_1	372	378	PF00454	0.559
MOD_PIKK_1	66	72	PF00454	0.605
MOD_PKA_2	155	161	PF00069	0.384
MOD_PKA_2	250	256	PF00069	0.459
MOD_Plk_4	138	144	PF00069	0.381
MOD_ProDKin_1	157	163	PF00069	0.523
MOD_ProDKin_1	251	257	PF00069	0.461
MOD_SUMO_for_1	18	21	PF00179	0.652
MOD_SUMO_for_1	260	263	PF00179	0.400
MOD_SUMO_rev_2	131	139	PF00179	0.385
MOD_SUMO_rev_2	164	171	PF00179	0.514
MOD_SUMO_rev_2	284	289	PF00179	0.324
MOD_SUMO_rev_2	386	395	PF00179	0.647
TRG_DiLeu_BaEn_1	72	77	PF01217	0.600
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.575
TRG_ENDOCYTIC_2	143	146	PF00928	0.338
TRG_ENDOCYTIC_2	205	208	PF00928	0.444
TRG_ENDOCYTIC_2	226	229	PF00928	0.325
TRG_ENDOCYTIC_2	290	293	PF00928	0.319
TRG_ENDOCYTIC_2	301	304	PF00928	0.318
TRG_ENDOCYTIC_2	334	337	PF00928	0.370
TRG_ENDOCYTIC_2	347	350	PF00928	0.220
TRG_ER_diArg_1	16	18	PF00400	0.598
TRG_ER_diArg_1	183	185	PF00400	0.351
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L0	Leptomonas seymouri	73%	100%
A0A0S4IRI9	Bodo saltans	48%	92%
A0A1X0P6G2	Trypanosomatidae	56%	100%
A0A3S5IQZ2	Trypanosoma rangeli	57%	100%
A0A3S7WV59	Leishmania donovani	95%	100%
A4H9W6	Leishmania braziliensis	85%	100%
D0A0B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AGR1	Leishmania infantum	95%	100%
E9ARW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5C1R6	Trypanosoma cruzi	56%	100%