Clathrin light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDL0_LEIMA

TriTrypDb:

LmjF.19.0110 , LMJLV39_190006000 , LMJSD75_190005900

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0030117	membrane coat	3	6
GO:0030118	clathrin coat	4	6
GO:0030120	vesicle coat	4	6
GO:0030125	clathrin vesicle coat	5	6
GO:0030130	clathrin coat of trans-Golgi network vesicle	6	6
GO:0030132	clathrin coat of coated pit	4	6
GO:0032991	protein-containing complex	1	6
GO:0098796	membrane protein complex	2	6
GO:0098797	plasma membrane protein complex	3	6

Expansion

Sequence features

Q4QDL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDL0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006886	intracellular protein transport	4	6
GO:0008104	protein localization	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0016192	vesicle-mediated transport	4	6
GO:0033036	macromolecule localization	2	6
GO:0045184	establishment of protein localization	3	6
GO:0046907	intracellular transport	3	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051641	cellular localization	2	6
GO:0051649	establishment of localization in cell	3	6
GO:0070727	cellular macromolecule localization	3	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	92	94	PF00082	0.500
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.349
CLV_PCSK_SKI1_1	148	152	PF00082	0.349
CLV_PCSK_SKI1_1	74	78	PF00082	0.313
DEG_APCC_DBOX_1	147	155	PF00400	0.349
DEG_Nend_UBRbox_3	1	3	PF02207	0.694
DOC_CKS1_1	38	43	PF01111	0.722
DOC_PP4_MxPP_1	16	19	PF00568	0.635
DOC_USP7_MATH_1	27	31	PF00917	0.674
DOC_USP7_MATH_2	41	47	PF00917	0.742
DOC_USP7_UBL2_3	101	105	PF12436	0.487
DOC_WW_Pin1_4	154	159	PF00397	0.349
DOC_WW_Pin1_4	2	7	PF00397	0.706
DOC_WW_Pin1_4	31	36	PF00397	0.640
DOC_WW_Pin1_4	37	42	PF00397	0.586
DOC_WW_Pin1_4	9	14	PF00397	0.788
LIG_14-3-3_CanoR_1	142	150	PF00244	0.471
LIG_BRCT_BRCA1_1	21	25	PF00533	0.692
LIG_FHA_2	38	44	PF00498	0.761
LIG_GSK3_LRP6_1	37	42	PF00069	0.514
LIG_LIR_Gen_1	123	132	PF02991	0.417
LIG_LIR_Nem_3	123	128	PF02991	0.417
LIG_SH2_STAT5	85	88	PF00017	0.383
LIG_SH3_3	3	9	PF00018	0.683
LIG_SH3_3	32	38	PF00018	0.724
LIG_TRAF2_1	81	84	PF00917	0.339
LIG_UBA3_1	130	136	PF00899	0.383
MOD_CDK_SPxK_1	154	160	PF00069	0.349
MOD_CDK_SPxxK_3	154	161	PF00069	0.555
MOD_CDK_SPxxK_3	37	44	PF00069	0.761
MOD_CK1_1	141	147	PF00069	0.340
MOD_CK2_1	2	8	PF00069	0.776
MOD_CK2_1	37	43	PF00069	0.675
MOD_DYRK1A_RPxSP_1	31	35	PF00069	0.640
MOD_GlcNHglycan	120	123	PF01048	0.393
MOD_GlcNHglycan	125	128	PF01048	0.393
MOD_GlcNHglycan	151	154	PF01048	0.434
MOD_GlcNHglycan	45	48	PF01048	0.604
MOD_GSK3_1	14	21	PF00069	0.685
MOD_GSK3_1	27	34	PF00069	0.606
MOD_N-GLC_1	154	159	PF02516	0.348
MOD_NEK2_1	25	30	PF00069	0.710
MOD_PKA_2	141	147	PF00069	0.459
MOD_ProDKin_1	154	160	PF00069	0.349
MOD_ProDKin_1	2	8	PF00069	0.704
MOD_ProDKin_1	31	37	PF00069	0.636
MOD_ProDKin_1	9	15	PF00069	0.788
MOD_SUMO_rev_2	113	121	PF00179	0.427
MOD_SUMO_rev_2	73	79	PF00179	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P7W0	Trypanosomatidae	49%	70%
A0A422NCU7	Trypanosoma rangeli	33%	85%
A4H9W8	Leishmania braziliensis	66%	99%
D0A0D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	85%
E9ARW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%