Putative QA-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania major

UniProt:

Q4QDK9_LEIMA

TriTrypDb:

LmjF.19.0120 , LMJLV39_190006100 , LMJSD75_190006000

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	11
GO:0031201	SNARE complex	3	2
GO:0031982	vesicle	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QDK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDK9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006886	intracellular protein transport	4	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0022406	membrane docking	2	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0048278	vesicle docking	4	2
GO:0048284	organelle fusion	5	2
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0140056	organelle localization by membrane tethering	3	2
GO:0016192	vesicle-mediated transport	4	5

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.609
CLV_NRD_NRD_1	197	199	PF00675	0.263
CLV_NRD_NRD_1	202	204	PF00675	0.266
CLV_NRD_NRD_1	43	45	PF00675	0.328
CLV_NRD_NRD_1	90	92	PF00675	0.380
CLV_PCSK_FUR_1	41	45	PF00082	0.386
CLV_PCSK_KEX2_1	197	199	PF00082	0.253
CLV_PCSK_KEX2_1	43	45	PF00082	0.413
CLV_PCSK_KEX2_1	90	92	PF00082	0.407
CLV_PCSK_PC7_1	39	45	PF00082	0.408
CLV_PCSK_SKI1_1	78	82	PF00082	0.430
DOC_MAPK_gen_1	41	49	PF00069	0.561
DOC_USP7_MATH_1	111	115	PF00917	0.662
DOC_USP7_MATH_1	23	27	PF00917	0.612
DOC_USP7_MATH_1	63	67	PF00917	0.543
LIG_14-3-3_CanoR_1	197	203	PF00244	0.535
LIG_14-3-3_CanoR_1	93	97	PF00244	0.650
LIG_BIR_III_2	62	66	PF00653	0.638
LIG_Clathr_ClatBox_1	83	87	PF01394	0.490
LIG_CtBP_PxDLS_1	123	127	PF00389	0.690
LIG_FHA_1	173	179	PF00498	0.470
LIG_FHA_1	43	49	PF00498	0.563
LIG_FHA_2	115	121	PF00498	0.726
LIG_FHA_2	30	36	PF00498	0.573
LIG_FHA_2	87	93	PF00498	0.613
LIG_LIR_Gen_1	159	164	PF02991	0.624
LIG_LIR_Nem_3	159	163	PF02991	0.623
LIG_LIR_Nem_3	201	205	PF02991	0.536
LIG_PCNA_yPIPBox_3	46	60	PF02747	0.587
LIG_PCNA_yPIPBox_3	71	84	PF02747	0.566
LIG_SH2_STAT3	74	77	PF00017	0.587
LIG_SUMO_SIM_par_1	222	228	PF11976	0.412
LIG_TRAF2_1	156	159	PF00917	0.669
MOD_CK1_1	114	120	PF00069	0.710
MOD_CK1_1	66	72	PF00069	0.595
MOD_CK2_1	100	106	PF00069	0.703
MOD_CK2_1	114	120	PF00069	0.727
MOD_CK2_1	139	145	PF00069	0.703
MOD_CK2_1	180	186	PF00069	0.470
MOD_CK2_1	23	29	PF00069	0.649
MOD_CK2_1	51	57	PF00069	0.540
MOD_CK2_1	58	64	PF00069	0.594
MOD_CK2_1	86	92	PF00069	0.620
MOD_GlcNHglycan	141	144	PF01048	0.531
MOD_GlcNHglycan	208	211	PF01048	0.454
MOD_GSK3_1	124	131	PF00069	0.632
MOD_GSK3_1	172	179	PF00069	0.474
MOD_GSK3_1	18	25	PF00069	0.600
MOD_N-GLC_1	124	129	PF02516	0.542
MOD_N-GLC_1	176	181	PF02516	0.286
MOD_NEK2_1	42	47	PF00069	0.498
MOD_NEK2_2	23	28	PF00069	0.624
MOD_PIKK_1	111	117	PF00454	0.664
MOD_PKA_2	172	178	PF00069	0.507
MOD_PKA_2	42	48	PF00069	0.552
MOD_PKA_2	92	98	PF00069	0.628
MOD_Plk_2-3	100	106	PF00069	0.699
MOD_Plk_2-3	128	134	PF00069	0.681
MOD_Plk_2-3	180	186	PF00069	0.536
MOD_Plk_2-3	58	64	PF00069	0.622
MOD_SUMO_rev_2	147	156	PF00179	0.670
TRG_DiLeu_BaEn_1	180	185	PF01217	0.536
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.570
TRG_ENDOCYTIC_2	157	160	PF00928	0.619
TRG_ER_diArg_1	197	200	PF00400	0.526
TRG_ER_diArg_1	39	42	PF00400	0.615
TRG_ER_diArg_1	43	46	PF00400	0.615
TRG_NES_CRM1_1	145	159	PF08389	0.556
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K8	Leptomonas seymouri	74%	100%
A0A0S4IVI2	Bodo saltans	37%	93%
A0A1X0P7H4	Trypanosomatidae	43%	96%
A0A3Q8IJV6	Leishmania donovani	94%	100%
A0A422ND16	Trypanosoma rangeli	45%	97%
A4H9W9	Leishmania braziliensis	81%	100%
E9AGR4	Leishmania infantum	94%	100%
E9ARW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q5RBW6	Pongo abelii	26%	83%
V5BBT6	Trypanosoma cruzi	47%	97%