Derlin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Derlin

Gene product:

Der1-like family, putative

Species:

Leishmania major

UniProt:

Q4QDK8_LEIMA

TriTrypDb:

LmjF.19.0130 , LMJLV39_190006200 , LMJSD75_190006100

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0000153	cytoplasmic ubiquitin ligase complex	4	2
GO:0000835	ER ubiquitin ligase complex	3	2
GO:0000836	Hrd1p ubiquitin ligase complex	4	2
GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex	5	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2
GO:0140534	endoplasmic reticulum protein-containing complex	2	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2
GO:0005789	endoplasmic reticulum membrane	4	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QDK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDK8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	12
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010033	response to organic substance	3	2
GO:0010243	response to organonitrogen compound	4	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0030433	ubiquitin-dependent ERAD pathway	6	2
GO:0030968	endoplasmic reticulum unfolded protein response	3	2
GO:0033554	cellular response to stress	3	2
GO:0034976	response to endoplasmic reticulum stress	4	2
GO:0036503	ERAD pathway	5	2
GO:0042221	response to chemical	2	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0050896	response to stimulus	1	12
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0051716	cellular response to stimulus	2	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901698	response to nitrogen compound	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0051787	misfolded protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	132	134	PF00082	0.229
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.229
CLV_PCSK_SKI1_1	183	187	PF00082	0.232
CLV_PCSK_SKI1_1	54	58	PF00082	0.416
DOC_CKS1_1	195	200	PF01111	0.408
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.432
DOC_MAPK_FxFP_2	65	68	PF00069	0.277
DOC_MAPK_MEF2A_6	147	156	PF00069	0.379
DOC_PP4_FxxP_1	205	208	PF00568	0.622
DOC_PP4_FxxP_1	65	68	PF00568	0.260
DOC_USP7_MATH_1	28	32	PF00917	0.355
DOC_USP7_MATH_1	46	50	PF00917	0.301
DOC_WW_Pin1_4	194	199	PF00397	0.426
LIG_14-3-3_CanoR_1	17	21	PF00244	0.475
LIG_14-3-3_CanoR_1	211	216	PF00244	0.620
LIG_14-3-3_CanoR_1	246	251	PF00244	0.604
LIG_14-3-3_CanoR_1	54	62	PF00244	0.208
LIG_AP2alpha_1	5	9	PF02296	0.572
LIG_BIR_II_1	1	5	PF00653	0.520
LIG_BRCT_BRCA1_1	1	5	PF00533	0.624
LIG_BRCT_BRCA1_1	118	122	PF00533	0.388
LIG_BRCT_BRCA1_1	147	151	PF00533	0.323
LIG_eIF4E_1	97	103	PF01652	0.377
LIG_FHA_1	207	213	PF00498	0.708
LIG_FHA_1	55	61	PF00498	0.313
LIG_HP1_1	152	156	PF01393	0.337
LIG_LIR_Gen_1	118	126	PF02991	0.294
LIG_LIR_Gen_1	7	15	PF02991	0.513
LIG_LIR_Gen_1	94	105	PF02991	0.289
LIG_LIR_Nem_3	118	123	PF02991	0.319
LIG_LIR_Nem_3	148	154	PF02991	0.284
LIG_LIR_Nem_3	66	70	PF02991	0.266
LIG_LIR_Nem_3	7	12	PF02991	0.516
LIG_LIR_Nem_3	94	100	PF02991	0.320
LIG_PALB2_WD40_1	4	12	PF16756	0.572
LIG_Pex14_2	142	146	PF04695	0.337
LIG_Pex14_2	226	230	PF04695	0.646
LIG_Pex14_2	5	9	PF04695	0.535
LIG_Pex14_2	65	69	PF04695	0.282
LIG_PTB_Apo_2	61	68	PF02174	0.337
LIG_REV1ctd_RIR_1	179	186	PF16727	0.308
LIG_SH2_CRK	97	101	PF00017	0.388
LIG_SH2_STAT5	116	119	PF00017	0.345
LIG_SH2_STAT5	179	182	PF00017	0.339
LIG_SH2_STAT5	61	64	PF00017	0.370
LIG_SH2_STAT5	79	82	PF00017	0.419
LIG_SH3_3	218	224	PF00018	0.662
LIG_TRAF2_1	135	138	PF00917	0.454
LIG_WRC_WIRS_1	117	122	PF05994	0.295
LIG_WRC_WIRS_1	212	217	PF05994	0.595
MOD_CK1_1	145	151	PF00069	0.386
MOD_CK1_1	238	244	PF00069	0.650
MOD_GlcNHglycan	107	110	PF01048	0.355
MOD_GlcNHglycan	147	150	PF01048	0.341
MOD_GlcNHglycan	238	241	PF01048	0.468
MOD_GlcNHglycan	26	29	PF01048	0.405
MOD_GSK3_1	16	23	PF00069	0.436
MOD_GSK3_1	24	31	PF00069	0.231
MOD_GSK3_1	246	253	PF00069	0.691
MOD_GSK3_1	36	43	PF00069	0.156
MOD_N-GLC_1	63	68	PF02516	0.332
MOD_NEK2_1	142	147	PF00069	0.306
MOD_NEK2_1	20	25	PF00069	0.351
MOD_NEK2_1	75	80	PF00069	0.240
MOD_PKA_2	16	22	PF00069	0.475
MOD_PKA_2	236	242	PF00069	0.640
MOD_Plk_1	137	143	PF00069	0.454
MOD_Plk_1	63	69	PF00069	0.332
MOD_Plk_4	137	143	PF00069	0.469
MOD_Plk_4	16	22	PF00069	0.437
MOD_Plk_4	36	42	PF00069	0.122
MOD_Plk_4	75	81	PF00069	0.301
MOD_ProDKin_1	194	200	PF00069	0.426
TRG_ENDOCYTIC_2	179	182	PF00928	0.337
TRG_ENDOCYTIC_2	97	100	PF00928	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV02	Leptomonas seymouri	78%	99%
A0A0S4IV51	Bodo saltans	41%	100%
A0A0S4KDZ1	Bodo saltans	24%	100%
A0A1X0NMT1	Trypanosomatidae	40%	99%
A0A3S5H750	Leishmania donovani	96%	100%
A0A422NV56	Trypanosoma rangeli	45%	100%
A4H9X0	Leishmania braziliensis	90%	100%
D0A9D5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AGR5	Leishmania infantum	96%	100%
E9ARW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B416	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q06397	Oryza sativa subsp. japonica	24%	100%
Q0P5E4	Bos taurus	30%	100%
Q21997	Caenorhabditis elegans	31%	100%
Q4G2J3	Zea mays	30%	100%
Q4G2J4	Zea mays	30%	100%
Q4G2J5	Zea mays	25%	100%
Q4G2J6	Zea mays	26%	100%
Q54IC9	Dictyostelium discoideum	23%	100%
Q54NN1	Dictyostelium discoideum	28%	100%
Q5R9W3	Pongo abelii	26%	100%
Q5RC74	Pongo abelii	31%	100%
Q71SS4	Bos taurus	26%	100%
Q851X7	Oryza sativa subsp. japonica	29%	100%
Q8BNI4	Mus musculus	31%	100%
Q8VZ96	Arabidopsis thaliana	31%	100%
Q8VZU9	Arabidopsis thaliana	27%	95%
Q93561	Caenorhabditis elegans	25%	100%
Q96Q80	Homo sapiens	31%	100%
Q99J56	Mus musculus	26%	100%
Q9BUN8	Homo sapiens	26%	100%
Q9D8K3	Mus musculus	28%	100%
Q9GZP9	Homo sapiens	31%	100%
Q9VQ57	Drosophila melanogaster	29%	100%
Q9ZS88	Arabidopsis thaliana	31%	100%
V5BIJ4	Trypanosoma cruzi	46%	100%