LeishMANIAdb
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Associated kinase of Tb14-3-3

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Associated kinase of Tb14-3-3
Gene product:
Associated kinase of Tb14-3-3, putative
Species:
Leishmania major
UniProt:
Q4QDK7_LEIMA
TriTrypDb:
LmjF.19.0140 , LMJLV39_190006300 , LMJSD75_190006200 *
Length:
631

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 1

Expansion

Sequence features

Q4QDK7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDK7

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 14
GO:0006793 phosphorus metabolic process 3 14
GO:0006796 phosphate-containing compound metabolic process 4 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0007165 signal transduction 2 2
GO:0008152 metabolic process 1 14
GO:0009987 cellular process 1 14
GO:0016310 phosphorylation 5 14
GO:0018105 peptidyl-serine phosphorylation 6 2
GO:0018193 peptidyl-amino acid modification 5 2
GO:0018209 peptidyl-serine modification 6 2
GO:0019538 protein metabolic process 3 14
GO:0035556 intracellular signal transduction 3 2
GO:0036211 protein modification process 4 14
GO:0043170 macromolecule metabolic process 3 14
GO:0043412 macromolecule modification 4 14
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 14
GO:0046777 protein autophosphorylation 6 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0071704 organic substance metabolic process 2 14
GO:1901564 organonitrogen compound metabolic process 3 14
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 14
GO:0003824 catalytic activity 1 14
GO:0004672 protein kinase activity 3 14
GO:0004674 protein serine/threonine kinase activity 4 4
GO:0004683 calmodulin-dependent protein kinase activity 5 2
GO:0005488 binding 1 14
GO:0005515 protein binding 2 2
GO:0005516 calmodulin binding 3 2
GO:0005524 ATP binding 5 14
GO:0008017 microtubule binding 5 2
GO:0008092 cytoskeletal protein binding 3 2
GO:0009931 calcium-dependent protein serine/threonine kinase activity 5 2
GO:0010857 calcium-dependent protein kinase activity 4 2
GO:0015631 tubulin binding 4 2
GO:0016301 kinase activity 4 14
GO:0016740 transferase activity 2 14
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 14
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 14
GO:0017076 purine nucleotide binding 4 14
GO:0030554 adenyl nucleotide binding 5 14
GO:0032553 ribonucleotide binding 3 14
GO:0032555 purine ribonucleotide binding 4 14
GO:0032559 adenyl ribonucleotide binding 5 14
GO:0035639 purine ribonucleoside triphosphate binding 4 14
GO:0036094 small molecule binding 2 14
GO:0042802 identical protein binding 3 2
GO:0042803 protein homodimerization activity 4 2
GO:0043167 ion binding 2 14
GO:0043168 anion binding 3 14
GO:0046983 protein dimerization activity 3 2
GO:0097159 organic cyclic compound binding 2 14
GO:0097367 carbohydrate derivative binding 2 14
GO:0140096 catalytic activity, acting on a protein 2 14
GO:1901265 nucleoside phosphate binding 3 14
GO:1901363 heterocyclic compound binding 2 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 22 26 PF00656 0.473
CLV_NRD_NRD_1 403 405 PF00675 0.550
CLV_NRD_NRD_1 436 438 PF00675 0.568
CLV_NRD_NRD_1 451 453 PF00675 0.598
CLV_NRD_NRD_1 472 474 PF00675 0.544
CLV_PCSK_KEX2_1 186 188 PF00082 0.239
CLV_PCSK_KEX2_1 219 221 PF00082 0.215
CLV_PCSK_KEX2_1 315 317 PF00082 0.257
CLV_PCSK_KEX2_1 403 405 PF00082 0.562
CLV_PCSK_KEX2_1 436 438 PF00082 0.568
CLV_PCSK_KEX2_1 451 453 PF00082 0.598
CLV_PCSK_KEX2_1 472 474 PF00082 0.544
CLV_PCSK_KEX2_1 83 85 PF00082 0.231
CLV_PCSK_PC1ET2_1 186 188 PF00082 0.239
CLV_PCSK_PC1ET2_1 219 221 PF00082 0.231
CLV_PCSK_PC1ET2_1 315 317 PF00082 0.273
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.206
CLV_PCSK_PC7_1 215 221 PF00082 0.231
CLV_PCSK_SKI1_1 109 113 PF00082 0.288
CLV_PCSK_SKI1_1 149 153 PF00082 0.280
CLV_PCSK_SKI1_1 162 166 PF00082 0.281
CLV_PCSK_SKI1_1 280 284 PF00082 0.242
CLV_PCSK_SKI1_1 486 490 PF00082 0.697
CLV_PCSK_SKI1_1 509 513 PF00082 0.628
CLV_PCSK_SKI1_1 515 519 PF00082 0.609
CLV_PCSK_SKI1_1 618 622 PF00082 0.208
DEG_Nend_UBRbox_3 1 3 PF02207 0.677
DOC_CKS1_1 227 232 PF01111 0.237
DOC_CKS1_1 287 292 PF01111 0.294
DOC_CKS1_1 39 44 PF01111 0.302
DOC_MAPK_gen_1 162 171 PF00069 0.294
DOC_MAPK_gen_1 568 576 PF00069 0.204
DOC_MAPK_JIP1_4 165 171 PF00069 0.241
DOC_PP2B_LxvP_1 206 209 PF13499 0.253
DOC_PP4_FxxP_1 612 615 PF00568 0.204
DOC_USP7_MATH_1 185 189 PF00917 0.214
DOC_USP7_MATH_1 292 296 PF00917 0.324
DOC_USP7_MATH_1 484 488 PF00917 0.583
DOC_USP7_MATH_1 513 517 PF00917 0.600
DOC_USP7_MATH_1 519 523 PF00917 0.638
DOC_USP7_MATH_1 530 534 PF00917 0.532
DOC_USP7_UBL2_3 311 315 PF12436 0.239
DOC_USP7_UBL2_3 56 60 PF12436 0.263
DOC_WW_Pin1_4 193 198 PF00397 0.329
DOC_WW_Pin1_4 226 231 PF00397 0.261
DOC_WW_Pin1_4 269 274 PF00397 0.383
DOC_WW_Pin1_4 286 291 PF00397 0.187
DOC_WW_Pin1_4 295 300 PF00397 0.237
DOC_WW_Pin1_4 314 319 PF00397 0.370
DOC_WW_Pin1_4 38 43 PF00397 0.242
DOC_WW_Pin1_4 397 402 PF00397 0.601
DOC_WW_Pin1_4 404 409 PF00397 0.603
DOC_WW_Pin1_4 425 430 PF00397 0.530
DOC_WW_Pin1_4 457 462 PF00397 0.540
DOC_WW_Pin1_4 472 477 PF00397 0.543
DOC_WW_Pin1_4 480 485 PF00397 0.555
DOC_WW_Pin1_4 486 491 PF00397 0.528
DOC_WW_Pin1_4 509 514 PF00397 0.546
DOC_WW_Pin1_4 515 520 PF00397 0.536
DOC_WW_Pin1_4 526 531 PF00397 0.494
LIG_14-3-3_CanoR_1 220 230 PF00244 0.232
LIG_14-3-3_CanoR_1 284 290 PF00244 0.280
LIG_14-3-3_CanoR_1 31 37 PF00244 0.208
LIG_14-3-3_CanoR_1 344 352 PF00244 0.474
LIG_14-3-3_CanoR_1 413 420 PF00244 0.656
LIG_14-3-3_CanoR_1 425 429 PF00244 0.485
LIG_14-3-3_CanoR_1 451 456 PF00244 0.557
LIG_14-3-3_CanoR_1 503 513 PF00244 0.625
LIG_14-3-3_CanoR_1 623 630 PF00244 0.211
LIG_Actin_WH2_2 75 92 PF00022 0.247
LIG_APCC_ABBA_1 111 116 PF00400 0.244
LIG_BRCT_BRCA1_1 265 269 PF00533 0.204
LIG_BRCT_BRCA1_1 578 582 PF00533 0.288
LIG_Clathr_ClatBox_1 112 116 PF01394 0.204
LIG_Dynein_DLC8_1 239 245 PF01221 0.215
LIG_FHA_1 142 148 PF00498 0.232
LIG_FHA_1 252 258 PF00498 0.227
LIG_FHA_1 421 427 PF00498 0.526
LIG_FHA_1 541 547 PF00498 0.695
LIG_FHA_1 548 554 PF00498 0.616
LIG_FHA_2 20 26 PF00498 0.347
LIG_FHA_2 243 249 PF00498 0.223
LIG_FHA_2 98 104 PF00498 0.225
LIG_LIR_Apic_2 229 235 PF02991 0.294
LIG_LIR_Gen_1 108 118 PF02991 0.242
LIG_LIR_Gen_1 144 152 PF02991 0.204
LIG_LIR_Gen_1 236 247 PF02991 0.214
LIG_LIR_Gen_1 261 270 PF02991 0.227
LIG_LIR_Gen_1 317 328 PF02991 0.246
LIG_LIR_Nem_3 100 104 PF02991 0.245
LIG_LIR_Nem_3 108 114 PF02991 0.305
LIG_LIR_Nem_3 144 148 PF02991 0.207
LIG_LIR_Nem_3 236 242 PF02991 0.228
LIG_LIR_Nem_3 245 250 PF02991 0.342
LIG_LIR_Nem_3 261 265 PF02991 0.271
LIG_LIR_Nem_3 281 286 PF02991 0.126
LIG_LIR_Nem_3 317 323 PF02991 0.266
LIG_Pex14_2 111 115 PF04695 0.211
LIG_Pex14_2 238 242 PF04695 0.204
LIG_REV1ctd_RIR_1 112 121 PF16727 0.347
LIG_SH2_CRK 145 149 PF00017 0.229
LIG_SH2_CRK 320 324 PF00017 0.231
LIG_SH2_CRK 34 38 PF00017 0.380
LIG_SH2_PTP2 262 265 PF00017 0.287
LIG_SH2_PTP2 46 49 PF00017 0.347
LIG_SH2_SRC 46 49 PF00017 0.231
LIG_SH2_SRC 66 69 PF00017 0.199
LIG_SH2_STAP1 143 147 PF00017 0.258
LIG_SH2_STAT3 143 146 PF00017 0.204
LIG_SH2_STAT3 21 24 PF00017 0.282
LIG_SH2_STAT5 104 107 PF00017 0.286
LIG_SH2_STAT5 143 146 PF00017 0.244
LIG_SH2_STAT5 21 24 PF00017 0.287
LIG_SH2_STAT5 262 265 PF00017 0.287
LIG_SH2_STAT5 46 49 PF00017 0.253
LIG_SH2_STAT5 57 60 PF00017 0.141
LIG_SH2_STAT5 611 614 PF00017 0.204
LIG_SH2_STAT5 66 69 PF00017 0.181
LIG_SH3_3 194 200 PF00018 0.316
LIG_SH3_3 267 273 PF00018 0.389
LIG_SH3_3 36 42 PF00018 0.212
LIG_SH3_3 387 393 PF00018 0.472
LIG_SH3_3 423 429 PF00018 0.550
LIG_SUMO_SIM_anti_2 85 90 PF11976 0.230
LIG_SUMO_SIM_par_1 199 204 PF11976 0.295
LIG_TRAF2_1 394 397 PF00917 0.698
LIG_TYR_ITIM 260 265 PF00017 0.287
LIG_UBA3_1 67 72 PF00899 0.231
LIG_WRC_WIRS_1 98 103 PF05994 0.215
MOD_CDC14_SPxK_1 428 431 PF00782 0.522
MOD_CDK_SPK_2 193 198 PF00069 0.203
MOD_CDK_SPK_2 226 231 PF00069 0.204
MOD_CDK_SPxK_1 397 403 PF00069 0.541
MOD_CDK_SPxK_1 425 431 PF00069 0.519
MOD_CDK_SPxK_1 472 478 PF00069 0.546
MOD_CDK_SPxK_1 480 486 PF00069 0.549
MOD_CDK_SPxK_1 509 515 PF00069 0.564
MOD_CDK_SPxK_1 526 532 PF00069 0.497
MOD_CDK_SPxxK_3 286 293 PF00069 0.355
MOD_CDK_SPxxK_3 397 404 PF00069 0.600
MOD_CDK_SPxxK_3 457 464 PF00069 0.542
MOD_CK1_1 272 278 PF00069 0.347
MOD_CK1_1 295 301 PF00069 0.326
MOD_CK1_1 314 320 PF00069 0.350
MOD_CK1_1 346 352 PF00069 0.496
MOD_CK1_1 409 415 PF00069 0.604
MOD_CK1_1 440 446 PF00069 0.651
MOD_CK1_1 491 497 PF00069 0.537
MOD_CK1_1 533 539 PF00069 0.585
MOD_CK1_1 544 550 PF00069 0.502
MOD_CK2_1 275 281 PF00069 0.280
MOD_CK2_1 97 103 PF00069 0.221
MOD_Cter_Amidation 217 220 PF01082 0.215
MOD_DYRK1A_RPxSP_1 404 408 PF00069 0.538
MOD_DYRK1A_RPxSP_1 425 429 PF00069 0.566
MOD_DYRK1A_RPxSP_1 486 490 PF00069 0.558
MOD_DYRK1A_RPxSP_1 515 519 PF00069 0.552
MOD_DYRK1A_RPxSP_1 526 530 PF00069 0.545
MOD_GlcNHglycan 131 134 PF01048 0.355
MOD_GlcNHglycan 265 268 PF01048 0.259
MOD_GlcNHglycan 294 297 PF01048 0.275
MOD_GlcNHglycan 345 348 PF01048 0.475
MOD_GlcNHglycan 353 356 PF01048 0.432
MOD_GlcNHglycan 408 411 PF01048 0.643
MOD_GlcNHglycan 444 447 PF01048 0.622
MOD_GlcNHglycan 453 456 PF01048 0.527
MOD_GlcNHglycan 464 467 PF01048 0.509
MOD_GlcNHglycan 486 489 PF01048 0.574
MOD_GlcNHglycan 497 500 PF01048 0.482
MOD_GlcNHglycan 515 518 PF01048 0.629
MOD_GlcNHglycan 521 524 PF01048 0.642
MOD_GlcNHglycan 532 535 PF01048 0.521
MOD_GlcNHglycan 543 546 PF01048 0.530
MOD_GSK3_1 129 136 PF00069 0.300
MOD_GSK3_1 137 144 PF00069 0.260
MOD_GSK3_1 261 268 PF00069 0.241
MOD_GSK3_1 282 289 PF00069 0.249
MOD_GSK3_1 409 416 PF00069 0.630
MOD_GSK3_1 420 427 PF00069 0.574
MOD_GSK3_1 437 444 PF00069 0.531
MOD_GSK3_1 480 487 PF00069 0.730
MOD_GSK3_1 491 498 PF00069 0.483
MOD_GSK3_1 505 512 PF00069 0.579
MOD_GSK3_1 515 522 PF00069 0.532
MOD_GSK3_1 526 533 PF00069 0.539
MOD_GSK3_1 535 542 PF00069 0.601
MOD_GSK3_1 596 603 PF00069 0.204
MOD_LATS_1 435 441 PF00433 0.561
MOD_N-GLC_1 275 280 PF02516 0.347
MOD_N-GLC_1 539 544 PF02516 0.748
MOD_N-GLC_1 576 581 PF02516 0.288
MOD_NEK2_1 128 133 PF00069 0.390
MOD_NEK2_1 201 206 PF00069 0.360
MOD_NEK2_1 242 247 PF00069 0.241
MOD_NEK2_1 265 270 PF00069 0.221
MOD_NEK2_1 304 309 PF00069 0.347
MOD_NEK2_1 343 348 PF00069 0.490
MOD_NEK2_1 395 400 PF00069 0.697
MOD_NEK2_1 462 467 PF00069 0.547
MOD_NEK2_1 505 510 PF00069 0.665
MOD_NEK2_1 576 581 PF00069 0.329
MOD_NEK2_2 420 425 PF00069 0.629
MOD_PIKK_1 240 246 PF00454 0.242
MOD_PIKK_1 622 628 PF00454 0.204
MOD_PKA_1 451 457 PF00069 0.590
MOD_PKA_2 334 340 PF00069 0.470
MOD_PKA_2 343 349 PF00069 0.428
MOD_PKA_2 414 420 PF00069 0.659
MOD_PKA_2 424 430 PF00069 0.554
MOD_PKA_2 435 441 PF00069 0.565
MOD_PKA_2 451 457 PF00069 0.557
MOD_PKA_2 491 497 PF00069 0.561
MOD_PKA_2 622 628 PF00069 0.204
MOD_Plk_1 201 207 PF00069 0.376
MOD_Plk_2-3 601 607 PF00069 0.204
MOD_Plk_4 258 264 PF00069 0.219
MOD_Plk_4 304 310 PF00069 0.334
MOD_Plk_4 32 38 PF00069 0.349
MOD_Plk_4 334 340 PF00069 0.423
MOD_Plk_4 601 607 PF00069 0.214
MOD_Plk_4 97 103 PF00069 0.215
MOD_ProDKin_1 193 199 PF00069 0.329
MOD_ProDKin_1 226 232 PF00069 0.261
MOD_ProDKin_1 269 275 PF00069 0.383
MOD_ProDKin_1 286 292 PF00069 0.187
MOD_ProDKin_1 295 301 PF00069 0.237
MOD_ProDKin_1 314 320 PF00069 0.370
MOD_ProDKin_1 38 44 PF00069 0.242
MOD_ProDKin_1 397 403 PF00069 0.603
MOD_ProDKin_1 404 410 PF00069 0.603
MOD_ProDKin_1 425 431 PF00069 0.532
MOD_ProDKin_1 457 463 PF00069 0.540
MOD_ProDKin_1 472 478 PF00069 0.546
MOD_ProDKin_1 480 486 PF00069 0.549
MOD_ProDKin_1 509 515 PF00069 0.548
MOD_ProDKin_1 526 532 PF00069 0.496
MOD_SUMO_for_1 164 167 PF00179 0.271
MOD_SUMO_for_1 82 85 PF00179 0.204
MOD_SUMO_rev_2 131 140 PF00179 0.234
MOD_SUMO_rev_2 158 166 PF00179 0.204
TRG_DiLeu_BaEn_1 108 113 PF01217 0.215
TRG_DiLeu_BaEn_1 63 68 PF01217 0.215
TRG_DiLeu_BaEn_4 137 143 PF01217 0.288
TRG_DiLeu_BaEn_4 361 367 PF01217 0.488
TRG_DiLeu_BaLyEn_6 212 217 PF01217 0.231
TRG_ENDOCYTIC_2 145 148 PF00928 0.229
TRG_ENDOCYTIC_2 239 242 PF00928 0.232
TRG_ENDOCYTIC_2 247 250 PF00928 0.344
TRG_ENDOCYTIC_2 262 265 PF00928 0.355
TRG_ENDOCYTIC_2 320 323 PF00928 0.278
TRG_ENDOCYTIC_2 34 37 PF00928 0.385
TRG_ER_diArg_1 450 452 PF00400 0.586
TRG_ER_diArg_1 456 459 PF00400 0.565
TRG_ER_diArg_1 471 473 PF00400 0.519
TRG_ER_diLys_1 628 631 PF00400 0.518

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1M7 Leptomonas seymouri 82% 98%
A0A0S4IX25 Bodo saltans 46% 97%
A0A0S4J320 Bodo saltans 24% 100%
A0A0S4JVD7 Bodo saltans 25% 100%
A0A1X0P6L8 Trypanosomatidae 67% 100%
A0A3R7LU08 Trypanosoma rangeli 64% 100%
A0A3S7WV74 Leishmania donovani 98% 100%
A0A3S7WY10 Leishmania donovani 26% 100%
A0A3S7X8Z8 Leishmania donovani 25% 100%
A0A422P2B2 Trypanosoma rangeli 25% 100%
A4H459 Leishmania braziliensis 29% 100%
A4H4S9 Leishmania braziliensis 27% 100%
A4H9X1 Leishmania braziliensis 91% 100%
A4HCD7 Leishmania braziliensis 29% 100%
A4IB02 Leishmania infantum 25% 100%
D0A0D2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 99%
E9AET0 Leishmania major 25% 100%
E9AGR6 Leishmania infantum 98% 100%
E9AH34 Leishmania infantum 26% 100%
E9ARW5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9AWL2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
Q42396 Arabidopsis thaliana 28% 100%
Q4QAV8 Leishmania major 26% 100%
Q4QIV8 Leishmania major 25% 100%
Q4QJJ0 Leishmania major 27% 100%
Q7TNJ7 Rattus norvegicus 28% 100%
V5DTI3 Trypanosoma cruzi 65% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS